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Species distribution and clinical features of infection and colonisation with non-tuberculous mycobacteria in a tertiary care centre, central Germany, 2006-2016.

Wetzstein N, Hügel C, Wichelhaus TA, Hogardt M, Eickmeier O, Küpper-Tetzel CP, Kann G, Just-Nübling G, Stephan C, Wolf T.

Infection. 2019 May 15. doi: 10.1007/s15010-019-01317-2. [Epub ahead of print]


Overcrowding in a neonatal intermediate care unit: impact on the incidence of multidrug-resistant gram-negative organisms.

Fischer D, Schlößer RL, Kempf VAJ, Wichelhaus TA, Klingebiel T, Philippi S, Falgenhauer L, Imirzalioglu C, Dahl U, Brandt C, Reinheimer C.

BMC Infect Dis. 2019 Apr 29;19(1):357. doi: 10.1186/s12879-019-3981-8.


Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila.

Wesche F, Adihou H, Wichelhaus TA, Bode HB.

Beilstein J Org Chem. 2019 Feb 25;15:535-541. doi: 10.3762/bjoc.15.47. eCollection 2019.


Colonization with multidrug resistant organisms determines the clinical course of patients with acute myeloid leukemia undergoing intensive induction chemotherapy.

Ballo O, Tarazzit I, Stratmann J, Reinheimer C, Hogardt M, Wichelhaus TA, Kempf V, Serve H, Finkelmeier F, Brandts C.

PLoS One. 2019 Jan 23;14(1):e0210991. doi: 10.1371/journal.pone.0210991. eCollection 2019.


Anti-tubercular activity of a natural stilbene and its synthetic derivatives.

Reinheimer C, Büttner D, Proschak E, Bode HB, Kempf VAJ, Wichelhaus TA.

GMS Infect Dis. 2018 Feb 1;6:Doc01. doi: 10.3205/id000036. eCollection 2018.


Bloodstream infections with vancomycin-resistant enterococci are associated with a decreased survival in patients with hematological diseases.

Weber S, Hogardt M, Reinheimer C, Wichelhaus TA, Kempf VAJ, Kessel J, Wolf S, Serve H, Steffen B, Scheich S.

Ann Hematol. 2019 Mar;98(3):763-773. doi: 10.1007/s00277-019-03607-z. Epub 2019 Jan 21.


Noninvasive screening identifies patients at risk for spontaneous bacterial peritonitis caused by multidrug-resistant organisms.

Ferstl PG, Müller M, Filmann N, Hogardt M, Kempf VA, Wichelhaus TA, Lange CM, Vermehren J, Zeuzem S, Reinheimer C, Waidmann O.

Infect Drug Resist. 2018 Nov 2;11:2047-2061. doi: 10.2147/IDR.S172587. eCollection 2018.


Timepoints of vancomycin-resistant Enterococcus colonization predict outcomes of acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplantation.

Scheich S, Weber S, König R, Wilke AC, Lindner S, Reinheimer C, Wichelhaus TA, Hogardt M, A J Kempf V, Kessel J, Martin H, Bug G, Serve H, Steffen B.

Eur J Haematol. 2018 Jul 26. doi: 10.1111/ejh.13151. [Epub ahead of print]


Stenotrophomonas maltophilia colonization during allogeneic hematopoietic stem cell transplantation is associated with impaired survival.

Scheich S, Koenig R, Wilke AC, Lindner S, Reinheimer C, Wichelhaus TA, Hogardt M, Kempf VAJ, Kessel J, Weber S, Martin H, Bug G, Serve H, Steffen B.

PLoS One. 2018 Jul 19;13(7):e0201169. doi: 10.1371/journal.pone.0201169. eCollection 2018.


Bloodstream infections with gram-negative organisms and the impact of multidrug resistance in patients with hematological malignancies.

Scheich S, Weber S, Reinheimer C, Wichelhaus TA, Hogardt M, Kempf VAJ, Kessel J, Serve H, Steffen B.

Ann Hematol. 2018 Nov;97(11):2225-2234. doi: 10.1007/s00277-018-3423-5. Epub 2018 Jul 4.


Bacterial zincophore [S,S]-ethylenediamine-N,N'-disuccinic acid is an effective inhibitor of MBLs.

Proschak A, Kramer J, Proschak E, Wichelhaus TA.

J Antimicrob Chemother. 2018 Feb 1;73(2):425-430. doi: 10.1093/jac/dkx403.


Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases.

Büttner D, Kramer JS, Klingler FM, Wittmann SK, Hartmann MR, Kurz CG, Kohnhäuser D, Weizel L, Brüggerhoff A, Frank D, Steinhilber D, Wichelhaus TA, Pogoryelov D, Proschak E.

ACS Infect Dis. 2018 Mar 9;4(3):360-372. doi: 10.1021/acsinfecdis.7b00129. Epub 2017 Dec 12.


Intestinal carriage of multidrug-resistant bacteria among healthcare professionals in Germany.

Jozsa K, de With K, Kern W, Reinheimer C, Kempf VAJ, Wichelhaus C, Wichelhaus TA.

GMS Infect Dis. 2017 Nov 22;5:Doc07. doi: 10.3205/id000033. eCollection 2017.


Clinical impact of colonization with multidrug-resistant organisms on outcome after allogeneic stem cell transplantation in patients with acute myeloid leukemia.

Scheich S, Lindner S, Koenig R, Reinheimer C, Wichelhaus TA, Hogardt M, Besier S, Kempf VAJ, Kessel J, Martin H, Wilke AC, Serve H, Bug G, Steffen B.

Cancer. 2018 Jan 15;124(2):286-296. doi: 10.1002/cncr.31045. Epub 2017 Sep 28.


Clinical Impact of Colonization with Multidrug-Resistant Organisms on Outcome after Autologous Stem Cell Transplantation: A Retrospective Single-Center Study.

Scheich S, Reinheimer C, Brandt C, Wichelhaus TA, Hogardt M, Kempf VAJ, Brunnberg U, Brandts C, Ballo O, von Metzler I, Kessel J, Serve H, Steffen B.

Biol Blood Marrow Transplant. 2017 Sep;23(9):1455-1462. doi: 10.1016/j.bbmt.2017.05.016. Epub 2017 May 18.


Elevated prevalence of multidrug-resistant gram-negative organisms in HIV positive men.

Reinheimer C, Keppler OT, Stephan C, Wichelhaus TA, Friedrichs I, Kempf VA.

BMC Infect Dis. 2017 Mar 13;17(1):206. doi: 10.1186/s12879-017-2286-z.


Prevalence of multidrug-resistant organisms in refugee patients, medical tourists and domestic patients admitted to a German university hospital.

Reinheimer C, Kempf VA, Jozsa K, Wichelhaus TA, Hogardt M, O'Rourke F, Brandt C.

BMC Infect Dis. 2017 Jan 5;17(1):17. doi: 10.1186/s12879-016-2105-y.


Group B streptococcus infections in neonates admitted to a German NICU: Emphasis on screening and adherence to pre-analytical recommendations.

Reinheimer C, Kempf VA, Wittekindt BE, Allendorf A, Wichelhaus TA, Hogardt M, Schlößer RL, Fischer D.

Early Hum Dev. 2016 Dec;103:37-41. doi: 10.1016/j.earlhumdev.2016.07.007. Epub 2016 Jul 29.


Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor.

Friedrich-Rust M, Wanger B, Heupel F, Filmann N, Brodt R, Kempf VA, Kessel J, Wichelhaus TA, Herrmann E, Zeuzem S, Bojunga J.

World J Gastroenterol. 2016 Apr 28;22(16):4201-10. doi: 10.3748/wjg.v22.i16.4201.


Evaluation of Various Culture Media for Detection of Rapidly Growing Mycobacteria from Patients with Cystic Fibrosis.

Preece CL, Wichelhaus TA, Perry A, Jones AL, Cummings SP, Perry JD, Hogardt M.

J Clin Microbiol. 2016 Jul;54(7):1797-1803. doi: 10.1128/JCM.00471-16. Epub 2016 Apr 20.


The Presentation, Diagnosis, and Treatment of Sexually Transmitted Infections.

Wagenlehner FM, Brockmeyer NH, Discher T, Friese K, Wichelhaus TA.

Dtsch Arztebl Int. 2016 Jan 11;113(1-02):11-22. doi: 10.3238/arztebl.2016.0011. Review.


Author's reply: Is there a need for special treatment of refugees at hospital admission?

Kempf VA, Heudorf U, C Reinheimer, Göttig S, Hogardt M, Wichelhaus TA, O'Rourke F, Brandt C, Krackhardt B, Karathana M, Kleinkauf N, Zinn C.

Euro Surveill. 2016;21(7):pii=30138. doi: 10.2807/1560-7917.ES.2016.21.7.30138. No abstract available.


Multidrug-resistant organisms detected in refugee patients admitted to a University Hospital, Germany June‒December 2015.

Reinheimer C, Kempf VA, Göttig S, Hogardt M, Wichelhaus TA, O'Rourke F, Brandt C.

Euro Surveill. 2016;21(2). doi: 10.2807/1560-7917.ES.2016.21.2.30110.


CipA of Acinetobacter baumannii Is a Novel Plasminogen Binding and Complement Inhibitory Protein.

Koenigs A, Stahl J, Averhoff B, Göttig S, Wichelhaus TA, Wallich R, Zipfel PF, Kraiczy P.

J Infect Dis. 2016 May 1;213(9):1388-99. doi: 10.1093/infdis/jiv601. Epub 2015 Dec 17.


Probing metallo-β-lactamases with molecular fragments identified by consensus docking.

Klingler FM, Moser D, Büttner D, Wichelhaus TA, Löhr F, Dötsch V, Proschak E.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5243-6. doi: 10.1016/j.bmcl.2015.09.056. Epub 2015 Sep 28.


Correction to Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.

Klingler FM, Wichelhaus TA, Frank D, Cuesta-Bernal J, El-Delik J, Müller HF, Sjuts H, Göttig S, Koenigs A, Pos KM, Pogoryelov D, Proschak E.

J Med Chem. 2015 Aug 13;58(15):6320. doi: 10.1021/acs.jmedchem.5b01097. Epub 2015 Jul 30. No abstract available.


β-D-Glucan Screening for Detection of Invasive Fungal Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.

Koltze A, Rath P, Schöning S, Steinmann J, Wichelhaus TA, Bader P, Bochennek K, Lehrnbecher T.

J Clin Microbiol. 2015 Aug;53(8):2605-10. doi: 10.1128/JCM.00747-15. Epub 2015 Jun 3.


S2k guideline* "Diagnosis and therapy of syphilis"--short version.

Schöfer H, Weberschock T, Bräuninger W, Bremer V, Dreher A, Enders M, Esser S, Hamouda O, Hagedorn HJ, Handrick W, Krause W, Mayr C, Münstermann D, Nast A, Ochsendorf F, Petry U, Potthoff A, Prange H, Rieg S, Schneede P, Sing A, Weber J, Wichelhaus TA, Brockmeyer N.

J Dtsch Dermatol Ges. 2015 May;13(5):472-80. doi: 10.1111/ddg.12574. No abstract available.


Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.

Klingler FM, Wichelhaus TA, Frank D, Cuesta-Bernal J, El-Delik J, Müller HF, Sjuts H, Göttig S, Koenigs A, Pos KM, Pogoryelov D, Proschak E.

J Med Chem. 2015 Apr 23;58(8):3626-30. doi: 10.1021/jm501844d. Epub 2015 Apr 13. Erratum in: J Med Chem. 2015 Aug 13;58(15):6320.


In vivo horizontal gene transfer of the carbapenemase OXA-48 during a nosocomial outbreak.

Göttig S, Gruber TM, Stecher B, Wichelhaus TA, Kempf VA.

Clin Infect Dis. 2015 Jun 15;60(12):1808-15. doi: 10.1093/cid/civ191. Epub 2015 Mar 10.


Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo.

Fuchs S, Hsieh LT, Saarberg W, Erdelmeier CA, Wichelhaus TA, Schaefer L, Koch E, Fürst R.

J Cell Mol Med. 2015 May;19(5):1021-32. doi: 10.1111/jcmm.12493. Epub 2015 Mar 5.


Pathogenicity of pan-drug-resistant Serratia marcescens harbouring blaNDM-1.

Gruber TM, Göttig S, Mark L, Christ S, Kempf VA, Wichelhaus TA, Hamprecht A.

J Antimicrob Chemother. 2015 Apr;70(4):1026-30. doi: 10.1093/jac/dku482. Epub 2014 Dec 2.


Heterogeneity of host TLR2 stimulation by Staphylocoocus aureus isolates.

Hilmi D, Parcina M, Stollewerk D, Ostrop J, Josten M, Meilaender A, Zaehringer U, Wichelhaus TA, Bierbaum G, Heeg K, Wolz C, Bekeredjian-Ding I.

PLoS One. 2014 May 8;9(5):e96416. doi: 10.1371/journal.pone.0096416. eCollection 2014.


Antimicrobial susceptibility and molecular epidemiology of Neisseria gonorrhoeae in Germany.

Horn NN, Kresken M, Körber-Irrgang B, Göttig S, Wichelhaus C, Wichelhaus TA; Working Party Antimicrobial Resistance of the Paul Ehrlich Society for Chemotherapy.

Int J Med Microbiol. 2014 Jul;304(5-6):586-91. doi: 10.1016/j.ijmm.2014.04.001. Epub 2014 Apr 19.


Novel promising linezolid analogues: rational design, synthesis and biological evaluation.

De Rosa M, Zanfardino A, Notomista E, Wichelhaus TA, Saturnino C, Varcamonti M, Soriente A.

Eur J Med Chem. 2013 Nov;69:779-85. doi: 10.1016/j.ejmech.2013.09.035. Epub 2013 Sep 25.


Multidrug-resistant bacteria in geriatric clinics, nursing homes, and ambulant care--prevalence and risk factors.

Gruber I, Heudorf U, Werner G, Pfeifer Y, Imirzalioglu C, Ackermann H, Brandt C, Besier S, Wichelhaus TA.

Int J Med Microbiol. 2013 Dec;303(8):405-9. doi: 10.1016/j.ijmm.2013.05.002. Epub 2013 May 10.


Detection of NDM-7 in Germany, a new variant of the New Delhi metallo-β-lactamase with increased carbapenemase activity.

Göttig S, Hamprecht AG, Christ S, Kempf VA, Wichelhaus TA.

J Antimicrob Chemother. 2013 Aug;68(8):1737-40. doi: 10.1093/jac/dkt088. Epub 2013 Apr 3.


[Systemic and local antibiotic therapy of conservative and operative treatment of spondylodiscitis].

Fleege C, Wichelhaus TA, Rauschmann M.

Orthopade. 2012 Sep;41(9):727-35. doi: 10.1007/s00132-012-1920-0. German.


Surface-associated motility, a common trait of clinical isolates of Acinetobacter baumannii, depends on 1,3-diaminopropane.

Skiebe E, de Berardinis V, Morczinek P, Kerrinnes T, Faber F, Lepka D, Hammer B, Zimmermann O, Ziesing S, Wichelhaus TA, Hunfeld KP, Borgmann S, Gröbner S, Higgins PG, Seifert H, Busse HJ, Witte W, Pfeifer Y, Wilharm G.

Int J Med Microbiol. 2012 Jul;302(3):117-28. doi: 10.1016/j.ijmm.2012.03.003. Epub 2012 May 3.


Preventing the spread of multidrug-resistant gram-negative pathogens: recommendations of an expert panel of the German Society For Hygiene and Microbiology.

Mattner F, Bange FC, Meyer E, Seifert H, Wichelhaus TA, Chaberny IF.

Dtsch Arztebl Int. 2012 Jan;109(3):39-45. doi: 10.3238/arztebl.2012.0039. Epub 2012 Jan 20. Review.


Diagnosis and treatment of Staphylococcus aureus infections of the skin and mucous membranes.

Schöfer H, Bruns R, Effendy I, Hartmann M, Jappe U, Plettenberg A, Reimann H, Seifert H, Shah P, Sunderkötter C, Weberschock T, Wichelhaus TA, Nast A; German Society of Dermatology (DDG)/ Professional Association of German Dermatologists (BVDD); Infectious Diseases Society of Germany (DGI); German Society for Hygiene and Microbiology (DGHM); German Society for Pediatric Infectious Diseases (DGPI); Paul Ehrlich Society for Chemotherapy (PEG).

J Dtsch Dermatol Ges. 2011 Nov;9(11):953-67. doi: 10.1111/j.1610-0387.2011.07786.x. English, German. No abstract available.


Molecular characterization of blaNDM-1 in an Acinetobacter baumannii strain isolated in Germany in 2007.

Pfeifer Y, Wilharm G, Zander E, Wichelhaus TA, Göttig S, Hunfeld KP, Seifert H, Witte W, Higgins PG.

J Antimicrob Chemother. 2011 Sep;66(9):1998-2001. doi: 10.1093/jac/dkr256. Epub 2011 Jun 21.


NDM-2 carbapenemase in Acinetobacter baumannii from Egypt.

Kaase M, Nordmann P, Wichelhaus TA, Gatermann SG, Bonnin RA, Poirel L.

J Antimicrob Chemother. 2011 Jun;66(6):1260-2. doi: 10.1093/jac/dkr135. Epub 2011 Mar 21.


Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice.

Pfeilschifter W, Czech-Zechmeister B, Sujak M, Foerch C, Wichelhaus TA, Pfeilschifter J.

Exp Transl Stroke Med. 2011 Mar 9;3:2. doi: 10.1186/2040-7378-3-2.


Global spread of New Delhi metallo-β-lactamase 1.

Göttig S, Pfeifer Y, Wichelhaus TA, Zacharowski K, Bingold T, Averhoff B, Brandt C, Kempf VA.

Lancet Infect Dis. 2010 Dec;10(12):828-9. doi: 10.1016/S1473-3099(10)70275-9. No abstract available.


Antimicrobial activities of trimethoprim/sulfamethoxazole, 5-iodo-2'-deoxyuridine and rifampicin against Staphylococcus aureus.

Zander J, Besier S, Faetke S, Saum SH, Müller V, Wichelhaus TA.

Int J Antimicrob Agents. 2010 Dec;36(6):562-5. doi: 10.1016/j.ijantimicag.2010.08.007. Epub 2010 Oct 13.


Multistep virtual screening for rapid and efficient identification of non-nucleoside bacterial thymidine kinase inhibitors.

Zander J, Hartenfeller M, Hähnke V, Proschak E, Besier S, Wichelhaus TA, Schneider G.

Chemistry. 2010 Aug 16;16(31):9630-7. doi: 10.1002/chem.201001347.


Synergistic antimicrobial activities of folic acid antagonists and nucleoside analogs.

Zander J, Besier S, Ackermann H, Wichelhaus TA.

Antimicrob Agents Chemother. 2010 Mar;54(3):1226-31. doi: 10.1128/AAC.00705-09. Epub 2009 Dec 22.


Integrated detection of extended-spectrum-beta-lactam resistance by DNA microarray-based genotyping of TEM, SHV, and CTX-M genes.

Leinberger DM, Grimm V, Rubtsova M, Weile J, Schröppel K, Wichelhaus TA, Knabbe C, Schmid RD, Bachmann TT.

J Clin Microbiol. 2010 Feb;48(2):460-71. doi: 10.1128/JCM.00765-09. Epub 2009 Dec 9.


Thymidine-dependent Staphylococcus aureus small-colony variants: human pathogens that are relevant not only in cases of cystic fibrosis lung disease.

Besier S, Zander J, Siegel E, Saum SH, Hunfeld KP, Ehrhart A, Brade V, Wichelhaus TA.

J Clin Microbiol. 2008 Nov;46(11):3829-32. doi: 10.1128/JCM.01440-08. Epub 2008 Oct 1.

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