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Plectin controls biliary tree architecture and stability in cholestasis.

Jirouskova M, Nepomucka K, Oyman-Eyrilmez G, Kalendova A, Havelkova H, Sarnova L, Chalupsky K, Schuster B, Benada O, Miksatkova P, Kuchar M, Fabian O, Sedlacek R, Wiche G, Gregor M.

J Hepatol. 2018 May;68(5):1006-1017. doi: 10.1016/j.jhep.2017.12.011. Epub 2017 Dec 20.


An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin.

Meier SM, Kreutz D, Winter L, Klose MHM, Cseh K, Weiss T, Bileck A, Alte B, Mader JC, Jana S, Chatterjee A, Bhattacharyya A, Hejl M, Jakupec MA, Heffeter P, Berger W, Hartinger CG, Keppler BK, Wiche G, Gerner C.

Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8267-8271. doi: 10.1002/anie.201702242. Epub 2017 May 26.


Functional and Genetic Analysis of Plectin in Skin and Muscle.

Rezniczek GA, Winter L, Walko G, Wiche G.

Methods Enzymol. 2016;569:235-59. doi: 10.1016/bs.mie.2015.05.003. Epub 2015 May 29.


Schwann Cell Expressed Nogo-B Modulates Axonal Branching of Adult Sensory Neurons Through the Nogo-B Receptor NgBR.

Eckharter C, Junker N, Winter L, Fischer I, Fogli B, Kistner S, Pfaller K, Zheng B, Wiche G, Klimaschewski L, Schweigreiter R.

Front Cell Neurosci. 2015 Nov 23;9:454. doi: 10.3389/fncel.2015.00454. eCollection 2015.


The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes.

Almeida FV, Walko G, McMillan JR, McGrath JA, Wiche G, Barber AH, Connelly JT.

J Cell Sci. 2015 Dec 15;128(24):4475-86. doi: 10.1242/jcs.173435. Epub 2015 Nov 2.


Plectin reinforces vascular integrity by mediating crosstalk between the vimentin and the actin networks.

Osmanagic-Myers S, Rus S, Wolfram M, Brunner D, Goldmann WH, Bonakdar N, Fischer I, Reipert S, Zuzuarregui A, Walko G, Wiche G.

J Cell Sci. 2015 Nov 15;128(22):4138-50. doi: 10.1242/jcs.172056. Epub 2015 Oct 30.


Plectin isoform 1-dependent nuclear docking of desmin networks affects myonuclear architecture and expression of mechanotransducers.

Staszewska I, Fischer I, Wiche G.

Hum Mol Genet. 2015 Dec 20;24(25):7373-89. doi: 10.1093/hmg/ddv438. Epub 2015 Oct 20.


Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle.

Winter L, Kuznetsov AV, Grimm M, Zeöld A, Fischer I, Wiche G.

Hum Mol Genet. 2015 Aug 15;24(16):4530-44. doi: 10.1093/hmg/ddv184. Epub 2015 May 27.


Molecular architecture and function of the hemidesmosome.

Walko G, Castañón MJ, Wiche G.

Cell Tissue Res. 2015 Jun;360(3):529-44. doi: 10.1007/s00441-015-2216-6. Epub 2015 May 29. Review.


In vivo characterization of human myofibrillar myopathy genes in zebrafish.

Bührdel JB, Hirth S, Kessler M, Westphal S, Forster M, Manta L, Wiche G, Schoser B, Schessl J, Schröder R, Clemen CS, Eichinger L, Fürst DO, van der Ven PF, Rottbauer W, Just S.

Biochem Biophys Res Commun. 2015 May 29;461(2):217-23. doi: 10.1016/j.bbrc.2015.03.149. Epub 2015 Apr 9.


Mutation in exon 1a of PLEC, leading to disruption of plectin isoform 1a, causes autosomal-recessive skin-only epidermolysis bullosa simplex.

Gostyńska KB, Nijenhuis M, Lemmink H, Pas HH, Pasmooij AM, Lang KK, Castañón MJ, Wiche G, Jonkman MF.

Hum Mol Genet. 2015 Jun 1;24(11):3155-62. doi: 10.1093/hmg/ddv066. Epub 2015 Feb 24.


Structural insights into Ca2+-calmodulin regulation of Plectin 1a-integrin β4 interaction in hemidesmosomes.

Song JG, Kostan J, Drepper F, Knapp B, de Almeida Ribeiro E Jr, Konarev PV, Grishkovskaya I, Wiche G, Gregor M, Svergun DI, Warscheid B, Djinović-Carugo K.

Structure. 2015 Mar 3;23(3):558-570. doi: 10.1016/j.str.2015.01.011. Epub 2015 Feb 19.


Keratins Stabilize Hemidesmosomes through Regulation of β4-Integrin Turnover.

Seltmann K, Cheng F, Wiche G, Eriksson JE, Magin TM.

J Invest Dermatol. 2015 Jun;135(6):1609-1620. doi: 10.1038/jid.2015.46. Epub 2015 Feb 10.


Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization.

Szabo S, Wögenstein KL, Österreicher CH, Guldiken N, Chen Y, Doler C, Wiche G, Boor P, Haybaeck J, Strnad P, Fuchs P.

J Hepatol. 2015 Jun;62(6):1357-66. doi: 10.1016/j.jhep.2015.01.007. Epub 2015 Jan 21.


Molecular architecture and function of the hemidesmosome.

Walko G, Castañón MJ, Wiche G.

Cell Tissue Res. 2015 May;360(2):363-78. doi: 10.1007/s00441-014-2061-z. Epub 2014 Dec 9. Review.


Networking and anchoring through plectin: a key to IF functionality and mechanotransduction.

Wiche G, Osmanagic-Myers S, Castañón MJ.

Curr Opin Cell Biol. 2015 Feb;32:21-9. doi: 10.1016/ Epub 2014 Oct 29. Review.


Determining the mechanical properties of plectin in mouse myoblasts and keratinocytes.

Bonakdar N, Schilling A, Spörrer M, Lennert P, Mainka A, Winter L, Walko G, Wiche G, Fabry B, Goldmann WH.

Exp Cell Res. 2015 Feb 15;331(2):331-7. doi: 10.1016/j.yexcr.2014.10.001. Epub 2014 Oct 14.


Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes.

Mihailovska E, Raith M, Valencia RG, Fischer I, Al Banchaabouchi M, Herbst R, Wiche G.

Mol Biol Cell. 2014 Dec 15;25(25):4130-49. doi: 10.1091/mbc.E14-06-1174. Epub 2014 Oct 15.


Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules.

Wögenstein KL, Szabo S, Lunova M, Wiche G, Haybaeck J, Strnad P, Boor P, Wagner M, Fuchs P.

PLoS One. 2014 Sep 18;9(9):e108323. doi: 10.1371/journal.pone.0108323. eCollection 2014.


Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance.

Molt S, Bührdel JB, Yakovlev S, Schein P, Orfanos Z, Kirfel G, Winter L, Wiche G, van der Ven PF, Rottbauer W, Just S, Belkin AM, Fürst DO.

J Cell Sci. 2014 Aug 15;127(Pt 16):3578-92. doi: 10.1242/jcs.152157. Epub 2014 Jun 24.


Vimentin intermediate filament and plectin provide a scaffold for invadopodia, facilitating cancer cell invasion and extravasation for metastasis.

Sutoh Yoneyama M, Hatakeyama S, Habuchi T, Inoue T, Nakamura T, Funyu T, Wiche G, Ohyama C, Tsuboi S.

Eur J Cell Biol. 2014 Apr;93(4):157-69. doi: 10.1016/j.ejcb.2014.03.002. Epub 2014 Apr 15.


Silencing GFAP isoforms in astrocytoma cells disturbs laminin-dependent motility and cell adhesion.

Moeton M, Kanski R, Stassen OM, Sluijs JA, Geerts D, van Tijn P, Wiche G, van Strien ME, Hol EM.

FASEB J. 2014 Jul;28(7):2942-54. doi: 10.1096/fj.13-245837. Epub 2014 Apr 2.


Chemical chaperone ameliorates pathological protein aggregation in plectin-deficient muscle.

Winter L, Staszewska I, Mihailovska E, Fischer I, Goldmann WH, Schröder R, Wiche G.

J Clin Invest. 2014 Mar;124(3):1144-57.


Mechanosensing through focal adhesion-anchored intermediate filaments.

Gregor M, Osmanagic-Myers S, Burgstaller G, Wolfram M, Fischer I, Walko G, Resch GP, Jörgl A, Herrmann H, Wiche G.

FASEB J. 2014 Feb;28(2):715-29. doi: 10.1096/fj.13-231829. Epub 2013 Dec 17.


Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer.

Shin SJ, Smith JA, Rezniczek GA, Pan S, Chen R, Brentnall TA, Wiche G, Kelly KA.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19414-9. doi: 10.1073/pnas.1309720110. Epub 2013 Nov 11.


Stabilization of the dystroglycan complex in Cajal bands of myelinating Schwann cells through plectin-mediated anchorage to vimentin filaments.

Walko G, Wögenstein KL, Winter L, Fischer I, Feltri ML, Wiche G.

Glia. 2013 Aug;61(8):1274-87. doi: 10.1002/glia.22514. Epub 2013 Jul 9.


Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers.

Raith M, Valencia RG, Fischer I, Orthofer M, Penninger JM, Spuler S, Rezniczek GA, Wiche G.

Skelet Muscle. 2013 Jun 12;3(1):14. doi: 10.1186/2044-5040-3-14.


Plectin-intermediate filament partnership in skin, skeletal muscle, and peripheral nerve.

Castañón MJ, Walko G, Winter L, Wiche G.

Histochem Cell Biol. 2013 Jul;140(1):33-53. doi: 10.1007/s00418-013-1102-0. Epub 2013 Jun 9. Review.


Intermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytes.

Valencia RG, Walko G, Janda L, Novacek J, Mihailovska E, Reipert S, Andrä-Marobela K, Wiche G.

Mol Biol Cell. 2013 Mar;24(6):768-84. doi: 10.1091/mbc.E12-06-0488. Epub 2013 Jan 30.


Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

Teperino R, Amann S, Bayer M, McGee SL, Loipetzberger A, Connor T, Jaeger C, Kammerer B, Winter L, Wiche G, Dalgaard K, Selvaraj M, Gaster M, Lee-Young RS, Febbraio MA, Knauf C, Cani PD, Aberger F, Penninger JM, Pospisilik JA, Esterbauer H.

Cell. 2012 Oct 12;151(2):414-26. doi: 10.1016/j.cell.2012.09.021.


The many faces of plectin and plectinopathies: pathology and mechanisms.

Winter L, Wiche G.

Acta Neuropathol. 2013 Jan;125(1):77-93. doi: 10.1007/s00401-012-1026-0. Epub 2012 Aug 3. Review.


Fused in sarcoma (FUS) interacts with the cytolinker protein plectin: implications for FUS subcellular localization and function.

Thomsen C, Udhane S, Runnberg R, Wiche G, Ståhlberg A, Aman P.

Exp Cell Res. 2012 Mar 10;318(5):653-61. doi: 10.1016/j.yexcr.2011.12.019. Epub 2012 Jan 4.


Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna.

Walko G, Vukasinovic N, Gross K, Fischer I, Sibitz S, Fuchs P, Reipert S, Jungwirth U, Berger W, Salzer U, Carugo O, Castañón MJ, Wiche G.

PLoS Genet. 2011 Dec;7(12):e1002396. doi: 10.1371/journal.pgen.1002396. Epub 2011 Dec 1.


Plectin isoforms as organizers of intermediate filament cytoarchitecture.

Wiche G, Winter L.

Bioarchitecture. 2011 Jan;1(1):14-20.


Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition.

Cerqua C, Anesti V, Pyakurel A, Liu D, Naon D, Wiche G, Baffa R, Dimmer KS, Scorrano L.

EMBO Rep. 2010 Nov;11(11):854-60. doi: 10.1038/embor.2010.151. Epub 2010 Oct 8.


Keeping the vimentin network under control: cell-matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblasts.

Burgstaller G, Gregor M, Winter L, Wiche G.

Mol Biol Cell. 2010 Oct 1;21(19):3362-75. doi: 10.1091/mbc.E10-02-0094. Epub 2010 Aug 11.


Plectin gene defects lead to various forms of epidermolysis bullosa simplex.

Rezniczek GA, Walko G, Wiche G.

Dermatol Clin. 2010 Jan;28(1):33-41. doi: 10.1016/j.det.2009.10.004. Review. Erratum in: Dermatol Clin. 2010 Apr;28(2):439-41.


BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin.

Steiner-Champliaud MF, Schneider Y, Favre B, Paulhe F, Praetzel-Wunder S, Faulkner G, Konieczny P, Raith M, Wiche G, Adebola A, Liem RK, Langbein L, Sonnenberg A, Fontao L, Borradori L.

Exp Cell Res. 2010 Feb 1;316(3):297-313. doi: 10.1016/j.yexcr.2009.11.010. Epub 2009 Nov 28.


Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity.

Fuchs P, Zörer M, Reipert S, Rezniczek GA, Propst F, Walko G, Fischer I, Bauer J, Leschnik MW, Lüscher B, Thalhammer JG, Lassmann H, Wiche G.

J Biol Chem. 2009 Sep 25;284(39):26502-9. doi: 10.1074/jbc.M109.018150. Epub 2009 Jul 22.


Plectin isoform-dependent regulation of keratin-integrin alpha6beta4 anchorage via Ca2+/calmodulin.

Kostan J, Gregor M, Walko G, Wiche G.

J Biol Chem. 2009 Jul 3;284(27):18525-36. doi: 10.1074/jbc.M109.008474. Epub 2009 May 6.


Plectin contributes to mechanical properties of living cells.

Na S, Chowdhury F, Tay B, Ouyang M, Gregor M, Wang Y, Wiche G, Wang N.

Am J Physiol Cell Physiol. 2009 Apr;296(4):C868-77. doi: 10.1152/ajpcell.00604.2008. Epub 2009 Feb 25.


Muscular integrity--a matter of interlinking distinct structures via plectin.

Konieczny P, Wiche G.

Adv Exp Med Biol. 2008;642:165-75.


Plectin deficiency affects precursor formation and dynamics of vimentin networks.

Spurny R, Gregor M, Castañón MJ, Wiche G.

Exp Cell Res. 2008 Nov 15;314(19):3570-80. doi: 10.1016/j.yexcr.2008.09.012. Epub 2008 Sep 26.


TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

Nery FC, Zeng J, Niland BP, Hewett J, Farley J, Irimia D, Li Y, Wiche G, Sonnenberg A, Breakefield XO.

J Cell Sci. 2008 Oct 15;121(Pt 20):3476-86. doi: 10.1242/jcs.029454. Epub 2008 Sep 30.


High-pressure freezing and low-temperature fixation of cell monolayers grown on sapphire coverslips.

Reipert S, Wiche G.

Methods Cell Biol. 2008;88:165-80. doi: 10.1016/S0091-679X(08)00410-X. Review. No abstract available.


Plectin isoform 1b mediates mitochondrion-intermediate filament network linkage and controls organelle shape.

Winter L, Abrahamsberg C, Wiche G.

J Cell Biol. 2008 Jun 16;181(6):903-11. doi: 10.1083/jcb.200710151. Epub 2008 Jun 9.


Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms.

Konieczny P, Fuchs P, Reipert S, Kunz WS, Zeöld A, Fischer I, Paulin D, Schröder R, Wiche G.

J Cell Biol. 2008 May 19;181(4):667-81. doi: 10.1083/jcb.200711058.


Rapid microwave fixation of cell monolayers preserves microtubule-associated cell structures.

Reipert S, Kotisch H, Wysoudil B, Wiche G.

J Histochem Cytochem. 2008 Jul;56(7):697-709. doi: 10.1369/jhc.7A7370.2008. Epub 2008 Apr 14.


Stress-induced recruitment of epiplakin to keratin networks increases their resistance to hyperphosphorylation-induced disruption.

Spazierer D, Raberger J, Gross K, Fuchs P, Wiche G.

J Cell Sci. 2008 Mar 15;121(Pt 6):825-33. doi: 10.1242/jcs.013755. Epub 2008 Feb 19.


5' trans-splicing repair of the PLEC1 gene.

Wally V, Klausegger A, Koller U, Lochmüller H, Krause S, Wiche G, Mitchell LG, Hintner H, Bauer JW.

J Invest Dermatol. 2008 Mar;128(3):568-74. Epub 2007 Nov 8.

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