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Alveolar Macrophage Apoptosis-Associated Bacterial Killing Helps Prevent Murine Pneumonia.

Preston JA, Bewley MA, Marriott HM, Houghton AM, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR, Craig RW, van Rooijen N, Bingle CD, Read RC, Mitchell TJ, Whyte MKB, Shapiro SD, Dockrell DH.

Am J Respir Crit Care Med. 2019 Jan 16. doi: 10.1164/rccm.201804-0646OC. [Epub ahead of print]


PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo.

Loynes CA, Lee JA, Robertson AL, Steel MJ, Ellett F, Feng Y, Levy BD, Whyte MKB, Renshaw SA.

Sci Adv. 2018 Sep 5;4(9):eaar8320. doi: 10.1126/sciadv.aar8320. eCollection 2018 Sep.


The role of neutrophils in cancer.

Grecian R, Whyte MKB, Walmsley SR.

Br Med Bull. 2018 Dec 1;128(1):5-14. doi: 10.1093/bmb/ldy029.


Facilitation of IL-22 production from innate lymphoid cells by prostaglandin E2 prevents experimental lung neutrophilic inflammation.

Felton JM, Duffin R, Robb CT, Crittenden S, Anderton SM, Howie SEM, Whyte MKB, Rossi AG, Yao C.

Thorax. 2018 Nov;73(11):1081-1084. doi: 10.1136/thoraxjnl-2017-211097. Epub 2018 Mar 24.


Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.

Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):739-750. doi: 10.1164/rccm.201705-0903OC.


Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo.

Dickinson RS, Murphy F, Doherty C, Williams S, Mirchandani A, Willson J, Scotti JS, Preston G, Schofield CJ, Whyte MKB, Walmsley SR.

Wellcome Open Res. 2017 Oct 26;2:104. doi: 10.12688/wellcomeopenres.12871.1. eCollection 2017.


Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

Allen RJ, Porte J, Braybrooke R, Flores C, Fingerlin TE, Oldham JM, Guillen-Guio B, Ma SF, Okamoto T, John AE, Obeidat M, Yang IV, Henry A, Hubbard RB, Navaratnam V, Saini G, Thompson N, Booth HL, Hart SP, Hill MR, Hirani N, Maher TM, McAnulty RJ, Millar AB, Molyneaux PL, Parfrey H, Rassl DM, Whyte MKB, Fahy WA, Marshall RP, Oballa E, Bossé Y, Nickle DC, Sin DD, Timens W, Shrine N, Sayers I, Hall IP, Noth I, Schwartz DA, Tobin MD, Wain LV, Jenkins RG.

Lancet Respir Med. 2017 Nov;5(11):869-880. doi: 10.1016/S2213-2600(17)30387-9. Epub 2017 Oct 20.


Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis.

Gray RD, Hardisty G, Regan KH, Smith M, Robb CT, Duffin R, Mackellar A, Felton JM, Paemka L, McCullagh BN, Lucas CD, Dorward DA, McKone EF, Cooke G, Donnelly SC, Singh PK, Stoltz DA, Haslett C, McCray PB, Whyte MKB, Rossi AG, Davidson DJ.

Thorax. 2018 Feb;73(2):134-144. doi: 10.1136/thoraxjnl-2017-210134. Epub 2017 Sep 15.


Identification of Staphylococcus aureus Factors Required for Pathogenicity and Growth in Human Blood.

Connolly J, Boldock E, Prince LR, Renshaw SA, Whyte MK, Foster SJ.

Infect Immun. 2017 Oct 18;85(11). pii: e00337-17. doi: 10.1128/IAI.00337-17. Print 2017 Nov.


Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.

Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR.

J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14.


NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival.

Prince LR, Prosseda SD, Higgins K, Carlring J, Prestwich EC, Ogryzko NV, Rahman A, Basran A, Falciani F, Taylor P, Renshaw SA, Whyte MKB, Sabroe I.

Blood. 2017 Aug 24;130(8):1014-1025. doi: 10.1182/blood-2017-03-770164. Epub 2017 Jun 21.


Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.

Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH.

Am J Respir Crit Care Med. 2017 Oct 1;196(7):845-855. doi: 10.1164/rccm.201608-1714OC.


Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.


Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

Bewley MA, Belchamber KB, Chana KK, Budd RC, Donaldson G, Wedzicha JA, Brightling CE, Kilty I, Donnelly LE, Barnes PJ, Singh D, Whyte MK, Dockrell DH; COPDMAP.

PLoS One. 2016 Sep 28;11(9):e0163139. doi: 10.1371/journal.pone.0163139. eCollection 2016.


Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen.

Robertson AL, Ogryzko NV, Henry KM, Loynes CA, Foulkes MJ, Meloni MM, Wang X, Ford C, Jackson M, Ingham PW, Wilson HL, Farrow SN, Solari R, Flower RJ, Jones S, Whyte MK, Renshaw SA.

Dis Model Mech. 2016 Jun 1;9(6):621-32. doi: 10.1242/dmm.024935. Epub 2016 Apr 14.


Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression.

Jones R, McDonald KE, Willson JA, Ghesquière B, Sammut D, Daniel E, Harris AJ, Lewis A, Thompson AA, Dickinson RS, Plant T, Murphy F, Sadiku P, Keevil BG, Carmeliet P, Whyte MK, Newell-Price J, Walmsley SR.

Blood. 2016 May 26;127(21):2641-4. doi: 10.1182/blood-2016-02-696922. Epub 2016 Mar 22. No abstract available.


Development of a Consensus Statement for the Definition, Diagnosis, and Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis Using the Delphi Technique.

Maher TM, Whyte MK, Hoyles RK, Parfrey H, Ochiai Y, Mathieson N, Turnbull A, Williamson N, Bennett BM.

Adv Ther. 2015 Oct;32(10):929-43. doi: 10.1007/s12325-015-0249-6. Epub 2015 Oct 23.


The regulation of pulmonary inflammation by the hypoxia-inducible factor-hydroxylase oxygen-sensing pathway.

Whyte MK, Walmsley SR.

Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S271-6. doi: 10.1513/AnnalsATS.201403-108AW. Review.


Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation.

Bewley MA, Naughton M, Preston J, Mitchell A, Holmes A, Marriott HM, Read RC, Mitchell TJ, Whyte MK, Dockrell DH.

MBio. 2014 Oct 7;5(5):e01710-14. doi: 10.1128/mBio.01710-14.


Is the social volcano still dormant? Trends in Chinese attitudes toward inequality.

Whyte MK, Im DK.

Soc Sci Res. 2014 Nov;48:62-76. doi: 10.1016/j.ssresearch.2014.05.008. Epub 2014 May 21.


Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.

Prince LR, Maxwell NC, Gill SK, Dockrell DH, Sabroe I, McGreal EP, Kotecha S, Whyte MK.

PLoS One. 2014 Aug 12;9(8):e103059. doi: 10.1371/journal.pone.0103059. eCollection 2014.


Experimental validation of the hyperpolarized 129 Xe chemical shift saturation recovery technique in healthy volunteers and subjects with interstitial lung disease.

Stewart NJ, Leung G, Norquay G, Marshall H, Parra-Robles J, Murphy PS, Schulte RF, Elliot C, Condliffe R, Griffiths PD, Kiely DG, Whyte MK, Wolber J, Wild JM.

Magn Reson Med. 2015 Jul;74(1):196-207. doi: 10.1002/mrm.25400. Epub 2014 Aug 8.


A local circadian clock calls time on lung inflammation.

Thompson AA, Walmsley SR, Whyte MK.

Nat Med. 2014 Aug;20(8):809-11. doi: 10.1038/nm.3649.


HIF-mediated innate immune responses: cell signaling and therapeutic implications.

Harris AJ, Thompson AR, Whyte MK, Walmsley SR.

Hypoxia (Auckl). 2014 May 24;2:47-58. eCollection 2014. Review.


Neutrophil energetics and oxygen sensing.

Walmsley SR, Whyte MK.

Blood. 2014 May 1;123(18):2753-4. doi: 10.1182/blood-2014-03-560409.


A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.

Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR, Irimia D, Rainger GE, Kadirkamanathan V, Whyte MK, Renshaw SA.

Sci Transl Med. 2014 Feb 26;6(225):225ra29. doi: 10.1126/scitranslmed.3007672.


Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.

Burgon J, Robertson AL, Sadiku P, Wang X, Hooper-Greenhill E, Prince LR, Walker P, Hoggett EE, Ward JR, Farrow SN, Zuercher WJ, Jeffrey P, Savage CO, Ingham PW, Hurlstone AF, Whyte MK, Renshaw SA.

J Immunol. 2014 Feb 15;192(4):1796-805. doi: 10.4049/jimmunol.1300087. Epub 2014 Jan 15.


Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MK, Walmsley SR.

Blood. 2014 Jan 16;123(3):366-76. doi: 10.1182/blood-2013-05-500207. Epub 2013 Nov 6.


The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis.

O'Dwyer DN, Armstrong ME, Trujillo G, Cooke G, Keane MP, Fallon PG, Simpson AJ, Millar AB, McGrath EE, Whyte MK, Hirani N, Hogaboam CM, Donnelly SC.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1442-50. doi: 10.1164/rccm.201304-0760OC.


Zebrafish as a model for the study of neutrophil biology.

Henry KM, Loynes CA, Whyte MK, Renshaw SA.

J Leukoc Biol. 2013 Oct;94(4):633-42. doi: 10.1189/jlb.1112594. Epub 2013 Mar 5. Review.


Hypoxia, the HIF pathway and neutrophilic inflammatory responses.

Thompson AA, Binham J, Plant T, Whyte MK, Walmsley SR.

Biol Chem. 2013 Apr;394(4):471-7. doi: 10.1515/hsz-2012-0335. Review.


Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.

Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MK, Walmsley SR, Higgins KR, Vogel SN, Wilson HL, Prince LR, Prestwich EC, Sabroe RA, Parker LC, Sabroe I.

J Leukoc Biol. 2013 Jan;93(1):7-19. doi: 10.1189/jlb.0512250. Epub 2012 Aug 17.


Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model.

Holmes GR, Dixon G, Anderson SR, Reyes-Aldasoro CC, Elks PM, Billings SA, Whyte MK, Kadirkamanathan V, Renshaw SA.

Adv Hematol. 2012;2012:792163. doi: 10.1155/2012/792163. Epub 2012 Jul 29.


Pneumococcal pneumonia: mechanisms of infection and resolution.

Dockrell DH, Whyte MKB, Mitchell TJ.

Chest. 2012 Aug;142(2):482-491. doi: 10.1378/chest.12-0210. Review.


A method for the in vivo measurement of zebrafish tissue neutrophil lifespan.

Dixon G, Elks PM, Loynes CA, Whyte MK, Renshaw SA.

ISRN Hematol. 2012;2012:915868. doi: 10.5402/2012/915868. Epub 2012 Jul 16.


Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.

Daigneault M, De Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MK, Dockrell DH.

PLoS Pathog. 2012;8(7):e1002814. doi: 10.1371/journal.ppat.1002814. Epub 2012 Jul 19.


Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.

Kiss J, Mollenhauer M, Walmsley SR, Kirchberg J, Radhakrishnan P, Niemietz T, Dudda J, Steinert G, Whyte MK, Carmeliet P, Mazzone M, Weitz J, Schneider M.

J Immunol. 2012 Aug 15;189(4):1955-65. doi: 10.4049/jimmunol.1103471. Epub 2012 Jul 11.


A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia.

Marriott HM, Daigneault M, Thompson AA, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MK, Dockrell DH.

Thorax. 2012 Nov;67(11):985-92. doi: 10.1136/thoraxjnl-2012-201591. Epub 2012 Jun 26.


Pellino-1 selectively regulates epithelial cell responses to rhinovirus.

Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK, Sabroe I.

J Virol. 2012 Jun;86(12):6595-604. doi: 10.1128/JVI.06755-11. Epub 2012 Apr 18.


Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AA, Walmsley SR, Renshaw SA, Sabroe I, Chambers RC, Dockrell DH, Whyte MK.

Thorax. 2012 Sep;67(9):796-803. doi: 10.1136/thoraxjnl-2011-200863. Epub 2012 Apr 11.


Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin.

Prince LR, Graham KJ, Connolly J, Anwar S, Ridley R, Sabroe I, Foster SJ, Whyte MK.

PLoS One. 2012;7(2):e31506. doi: 10.1371/journal.pone.0031506. Epub 2012 Feb 15.


Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages.

Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJ, Iannelli F, Pozzi G, Mitchell TJ, Whyte MK, Sabroe I, Dockrell DH.

Infect Immun. 2012 Mar;80(3):1140-9. doi: 10.1128/IAI.05697-11. Epub 2011 Dec 12.


The Anti-Apoptotic Effect of Respiratory Syncytial Virus on Human Peripheral Blood Neutrophils is Mediated by a Monocyte Derived Soluble Factor.

Coleman CM, Plant K, Newton S, Hobson L, Whyte MK, Everard ML.

Open Virol J. 2011;5:114-23. doi: 10.2174/1874357901105010114. Epub 2011 Oct 18.


Alpha-nicotinic acetylcholine receptor and tobacco smoke exposure: effects on bronchial hyperresponsiveness in children.

Torjussen TM, Lødrup Carlsen KC, Munthe-Kaas MC, Mowinckel P, Carlsen KH, Helms PJ, Gerritsen J, Whyte MK, Lenney W, Undlien DE, Shianna KV, Zhu G, Pillai SG.

Pediatr Allergy Immunol. 2012 Feb;23(1):40-9. doi: 10.1111/j.1399-3038.2011.01222.x. Epub 2011 Oct 21.


The role of TLRs in neutrophil activation.

Prince LR, Whyte MK, Sabroe I, Parker LC.

Curr Opin Pharmacol. 2011 Aug;11(4):397-403. doi: 10.1016/j.coph.2011.06.007. Epub 2011 Jul 6. Review.


Idiopathic pulmonary fibrosis.

Hoo ZH, Whyte MK.

Thorax. 2012 Aug;67(8):742-6. doi: 10.1136/thoraxjnl-2011-200515. Epub 2011 Jun 22. Review.


TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.

McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH, Whyte MK.

J Leukoc Biol. 2011 Nov;90(5):855-65. doi: 10.1189/jlb.0211062. Epub 2011 May 11.


Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model.

Elks PM, van Eeden FJ, Dixon G, Wang X, Reyes-Aldasoro CC, Ingham PW, Whyte MK, Walmsley SR, Renshaw SA.

Blood. 2011 Jul 21;118(3):712-22. doi: 10.1182/blood-2010-12-324186. Epub 2011 May 9.


Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae.

Bewley MA, Pham TK, Marriott HM, Noirel J, Chu HP, Ow SY, Ryazanov AG, Read RC, Whyte MK, Chain B, Wright PC, Dockrell DH.

Mol Cell Proteomics. 2011 Jun;10(6):M111.008193. doi: 10.1074/mcp.M111.008193. Epub 2011 Apr 7.


Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.

Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P, Whyte MK.

J Clin Invest. 2011 Mar;121(3):1053-63. doi: 10.1172/JCI43273. Epub 2011 Feb 7.

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