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Items: 1 to 50 of 179

1.

Tau Uptake in Agrammatic Primary Progressive Aphasia with and without Apraxia of Speech.

Utianski RL, Whitwell JL, Schwarz CG, Duffy JR, Botha H, Clark HM, Machulda MM, Senjem ML, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA.

Eur J Neurol. 2018 Jun 23. doi: 10.1111/ene.13733. [Epub ahead of print]

PMID:
29935044
2.

Disrupted functional connectivity in primary progressive apraxia of speech.

Botha H, Utianski RL, Whitwell JL, Duffy JR, Clark HM, Strand EA, Machulda MM, Tosakulwong N, Knopman DS, Petersen RC, Jack CR Jr, Josephs KA, Jones DT.

Neuroimage Clin. 2018 Mar 3;18:617-629. doi: 10.1016/j.nicl.2018.02.036. eCollection 2018.

3.

Non-right handed primary progressive apraxia of speech.

Botha H, Duffy JR, Whitwell JL, Strand EA, Machulda MM, Spychalla AJ, Tosakulwong N, Senjem ML, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA.

J Neurol Sci. 2018 Jul 15;390:246-254. doi: 10.1016/j.jns.2018.05.007. Epub 2018 May 7.

PMID:
29801898
4.

Clinical and imaging progression over 10 years in a patient with primary progressive apraxia of speech and autopsy-confirmed corticobasal degeneration.

Tetzloff KA, Duffy JR, Strand EA, Machulda MM, Boland SM, Utianski RL, Botha H, Senjem ML, Schwarz CG, Josephs KA, Whitwell JL.

Neurocase. 2018 Apr;24(2):111-120. doi: 10.1080/13554794.2018.1477963. Epub 2018 May 25.

PMID:
29799310
5.

Alzheimer's disease neuroimaging.

Whitwell JL.

Curr Opin Neurol. 2018 May 11. doi: 10.1097/WCO.0000000000000570. [Epub ahead of print]

PMID:
29762152
6.

Regional Distribution, Asymmetry, and Clinical Correlates of Tau Uptake on [18F]AV-1451 PET in Atypical Alzheimer's Disease.

Tetzloff KA, Graff-Radford J, Martin PR, Tosakulwong N, Machulda MM, Duffy JR, Clark HM, Senjem ML, Schwarz CG, Spychalla AJ, Drubach DA, Jack CR, Lowe VJ, Josephs KA, Whitwell JL.

J Alzheimers Dis. 2018;62(4):1713-1724. doi: 10.3233/JAD-170740.

PMID:
29614676
7.

Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease.

Whitwell JL, Graff-Radford J, Tosakulwong N, Weigand SD, Machulda MM, Senjem ML, Spychalla AJ, Vemuri P, Jones DT, Drubach DA, Knopman DS, Boeve BF, Ertekin-Taner N, Petersen RC, Lowe VJ, Jack CR Jr, Josephs KA.

Alzheimers Dement. 2018 Mar 30. pii: S1552-5260(18)30074-8. doi: 10.1016/j.jalz.2018.02.020. [Epub ahead of print]

PMID:
29605222
8.

Molecular neuroimaging in primary progressive aphasia with predominant agraphia.

Utianski RL, Duffy JR, Savica R, Whitwell JL, Machulda MM, Josephs KA.

Neurocase. 2018 Apr;24(2):121-123. doi: 10.1080/13554794.2018.1454963. Epub 2018 Mar 23.

PMID:
29569990
9.

[18F] AV-1451 uptake in corticobasal syndrome: the influence of beta-amyloid and clinical presentation.

Ali F, Whitwell JL, Martin PR, Senjem ML, Knopman DS, Jack CR, Lowe VJ, Petersen RC, Boeve BF, Josephs KA.

J Neurol. 2018 May;265(5):1079-1088. doi: 10.1007/s00415-018-8815-x. Epub 2018 Mar 1.

PMID:
29497818
10.

[18 F]AV-1451 tau-PET and primary progressive aphasia.

Josephs KA, Martin PR, Botha H, Schwarz CG, Duffy JR, Clark HM, Machulda MM, Graff-Radford J, Weigand SD, Senjem ML, Utianski RL, Drubach DA, Boeve BF, Jones DT, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Whitwell JL.

Ann Neurol. 2018 Mar;83(3):599-611. doi: 10.1002/ana.25183. Epub 2018 Mar 13.

PMID:
29451323
11.

Multimodal neuroimaging provides insights into the biology of Alzheimer's disease.

Whitwell JL.

Brain. 2018 Feb 1;141(2):326-329. doi: 10.1093/brain/awy001. No abstract available.

PMID:
29390126
12.

Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech.

Utianski RL, Whitwell JL, Schwarz CG, Senjem ML, Tosakulwong N, Duffy JR, Clark HM, Machulda MM, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA.

Cortex. 2018 Feb;99:358-374. doi: 10.1016/j.cortex.2017.12.021. Epub 2018 Jan 2.

PMID:
29353121
13.

[18 F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease.

Whitwell JL, Graff-Radford J, Tosakulwong N, Weigand SD, Machulda M, Senjem ML, Schwarz CG, Spychalla AJ, Jones DT, Drubach DA, Knopman DS, Boeve BF, Ertekin-Taner N, Petersen RC, Lowe VJ, Jack CR Jr, Josephs KA.

Ann Neurol. 2018 Feb;83(2):248-257. doi: 10.1002/ana.25142. Epub 2018 Feb 6.

PMID:
29323751
14.

Pittsburgh Compound B and AV-1451 positron emission tomography assessment of molecular pathologies of Alzheimer's disease in progressive supranuclear palsy.

Whitwell JL, Ahlskog JE, Tosakulwong N, Senjem ML, Spychalla AJ, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA.

Parkinsonism Relat Disord. 2018 Mar;48:3-9. doi: 10.1016/j.parkreldis.2017.12.016. Epub 2017 Dec 13.

PMID:
29254665
15.

Longitudinal structural and molecular neuroimaging in agrammatic primary progressive aphasia.

Tetzloff KA, Duffy JR, Clark HM, Strand EA, Machulda MM, Schwarz CG, Senjem ML, Reid RI, Spychalla AJ, Tosakulwong N, Lowe VJ, Jack CR Jr, Josephs KA, Whitwell JL.

Brain. 2018 Jan 1;141(1):302-317. doi: 10.1093/brain/awx293.

PMID:
29228180
16.

Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech.

Whitwell JL, Weigand SD, Duffy JR, Clark HM, Strand EA, Machulda MM, Spychalla AJ, Senjem ML, Jack CR Jr, Josephs KA.

Neurology. 2017 Nov 28;89(22):2271-2279. doi: 10.1212/WNL.0000000000004685. Epub 2017 Nov 1.

PMID:
29093069
17.

Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study.

Josephs KA, Dickson DW, Tosakulwong N, Weigand SD, Murray ME, Petrucelli L, Liesinger AM, Senjem ML, Spychalla AJ, Knopman DS, Parisi JE, Petersen RC, Jack CR Jr, Whitwell JL.

Lancet Neurol. 2017 Nov;16(11):917-924. doi: 10.1016/S1474-4422(17)30284-3. Epub 2017 Sep 11.

PMID:
28919059
18.

Uptake of AV-1451 in meningiomas.

Bruinsma TJ, Johnson DR, Fang P, Senjem M, Josephs KA, Whitwell JL, Boeve BF, Pandey MK, Kantarci K, Jones DT, Vemuri P, Murray M, Graff-Radford J, Schwarz CG, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ.

Ann Nucl Med. 2017 Dec;31(10):736-743. doi: 10.1007/s12149-017-1205-0. Epub 2017 Sep 8.

PMID:
28887599
19.

Which ante mortem clinical features predict progressive supranuclear palsy pathology?

Respondek G, Kurz C, Arzberger T, Compta Y, Englund E, Ferguson LW, Gelpi E, Giese A, Irwin DJ, Meissner WG, Nilsson C, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Whitwell JL, Antonini A, Bhatia KP, Bordelon Y, Corvol JC, Colosimo C, Dodel R, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris H, Nestor P, Oertel WH, Rabinovici GD, Rowe JB, van Eimeren T, Wenning GK, Boxer A, Golbe LI, Litvan I, Stamelou M, Höglinger GU; Movement Disorder Society-Endorsed PSP Study Group.

Mov Disord. 2017 Jul;32(7):995-1005. doi: 10.1002/mds.27034. Epub 2017 May 13. Review.

PMID:
28500752
20.

Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?

Whitwell JL, Höglinger GU, Antonini A, Bordelon Y, Boxer AL, Colosimo C, van Eimeren T, Golbe LI, Kassubek J, Kurz C, Litvan I, Pantelyat A, Rabinovici G, Respondek G, Rominger A, Rowe JB, Stamelou M, Josephs KA; Movement Disorder Society-endorsed PSP Study Group.

Mov Disord. 2017 Jul;32(7):955-971. doi: 10.1002/mds.27038. Epub 2017 May 13. Review.

PMID:
28500751
21.

Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.

Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I; Movement Disorder Society-endorsed PSP Study Group.

Mov Disord. 2017 Jun;32(6):853-864. doi: 10.1002/mds.26987. Epub 2017 May 3.

22.

Temporal acoustic measures distinguish primary progressive apraxia of speech from primary progressive aphasia.

Duffy JR, Hanley H, Utianski R, Clark H, Strand E, Josephs KA, Whitwell JL.

Brain Lang. 2017 May;168:84-94. doi: 10.1016/j.bandl.2017.01.012. Epub 2017 Feb 7.

23.

Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART).

Josephs KA, Murray ME, Tosakulwong N, Whitwell JL, Knopman DS, Machulda MM, Weigand SD, Boeve BF, Kantarci K, Petrucelli L, Lowe VJ, Jack CR Jr, Petersen RC, Parisi JE, Dickson DW.

Acta Neuropathol. 2017 May;133(5):705-715. doi: 10.1007/s00401-017-1681-2. Epub 2017 Feb 3.

PMID:
28160067
24.

Brain tau deposition linked to systemic causes of death in normal elderly.

Josephs KA, Tosakulwong N, Weigand SD, Murray ME, Whitwell JL, Parisi JE, Dickson DW, Petersen RC.

Neurobiol Aging. 2017 Feb;50:163-166. doi: 10.1016/j.neurobiolaging.2016.11.011. Epub 2016 Nov 24.

25.

Varying Degrees of Temporoparietal Hypometabolism on FDG-PET Reveal Amyloid-Positive Logopenic Primary Progressive Aphasia is not a Homogeneous Clinical Entity.

Krishnan K, Machulda MM, Whitwell JL, Butts AM, Duffy JR, Strand EA, Senjem ML, Spychalla AJ, Jack CR, Lowe VJ, Josephs KA.

J Alzheimers Dis. 2017;55(3):1019-1029.

26.

[18 F]AV-1451 tau positron emission tomography in progressive supranuclear palsy.

Whitwell JL, Lowe VJ, Tosakulwong N, Weigand SD, Senjem ML, Schwarz CG, Spychalla AJ, Petersen RC, Jack CR Jr, Josephs KA.

Mov Disord. 2017 Jan;32(1):124-133. doi: 10.1002/mds.26834. Epub 2016 Oct 27.

27.

Tracking the development of agrammatic aphasia: A tensor-based morphometry study.

Whitwell JL, Duffy JR, Machulda MM, Clark HM, Strand EA, Senjem ML, Gunter JL, Spychalla AJ, Petersen RC, Jack CR Jr, Josephs KA.

Cortex. 2017 May;90:138-148. doi: 10.1016/j.cortex.2016.09.017. Epub 2016 Sep 30.

28.

18F-FDG PET in Posterior Cortical Atrophy and Dementia with Lewy Bodies.

Whitwell JL, Graff-Radford J, Singh TD, Drubach DA, Senjem ML, Spychalla AJ, Tosakulwong N, Lowe VJ, Josephs KA.

J Nucl Med. 2017 Apr;58(4):632-638. doi: 10.2967/jnumed.116.179903. Epub 2016 Sep 29.

29.

[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration.

Josephs KA, Whitwell JL, Tacik P, Duffy JR, Senjem ML, Tosakulwong N, Jack CR, Lowe V, Dickson DW, Murray ME.

Acta Neuropathol. 2016 Dec;132(6):931-933. Epub 2016 Sep 19. No abstract available.

30.

Biomarkers in Randomized Clinical Trials: Magnetic Resonance Imaging.

Whitwell JL.

Front Neurol Neurosci. 2016;39:101-8. doi: 10.1159/000445419. Epub 2016 Jul 26. Review.

PMID:
27463684
31.

Clinical correlates of longitudinal brain atrophy in progressive supranuclear palsy.

Tsai RM, Lobach I, Bang J, Whitwell JL, Senjem ML, Jack CR Jr, Rosen H, Miller B, Boxer AL; AL-108-231 Investigators.

Parkinsonism Relat Disord. 2016 Jul;28:29-35. doi: 10.1016/j.parkreldis.2016.04.006. Epub 2016 Apr 24.

32.

Coprophagia in neurologic disorders.

Josephs KA, Whitwell JL, Parisi JE, Lapid MI.

J Neurol. 2016 May;263(5):1008-1014. doi: 10.1007/s00415-016-8096-1. Epub 2016 Mar 26.

PMID:
27017341
33.

Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech.

Whitwell JL, Weigand SD, Duffy JR, Strand EA, Machulda MM, Senjem ML, Gunter JL, Lowe VJ, Jack CR Jr, Josephs KA.

Neuroimage Clin. 2016 Jan 20;11:90-8. doi: 10.1016/j.nicl.2016.01.014. eCollection 2016.

34.

Uncovering Neuroanatomical Networks Responsible for Abnormal Eating Behavior in Frontotemporal Dementia.

Whitwell JL.

JAMA Neurol. 2016 Mar;73(3):267-8. doi: 10.1001/jamaneurol.2015.4496. No abstract available.

PMID:
26810266
35.

Updated TDP-43 in Alzheimer's disease staging scheme.

Josephs KA, Murray ME, Whitwell JL, Tosakulwong N, Weigand SD, Petrucelli L, Liesinger AM, Petersen RC, Parisi JE, Dickson DW.

Acta Neuropathol. 2016 Apr;131(4):571-85. doi: 10.1007/s00401-016-1537-1. Epub 2016 Jan 25.

36.

Progressive supranuclear palsy: progression and survival.

Arena JE, Weigand SD, Whitwell JL, Hassan A, Eggers SD, Höglinger GU, Litvan I, Josephs KA.

J Neurol. 2016 Feb;263(2):380-389. doi: 10.1007/s00415-015-7990-2. Epub 2015 Dec 24.

PMID:
26705121
37.

Characterizing White Matter Tract Degeneration in Syndromic Variants of Alzheimer's Disease: A Diffusion Tensor Imaging Study.

Madhavan A, Schwarz CG, Duffy JR, Strand EA, Machulda MM, Drubach DA, Kantarci K, Przybelski SA, Reid RI, Senjem ML, Gunter JL, Apostolova LG, Lowe VJ, Petersen RC, Jack CR, Josephs KA, Whitwell JL.

J Alzheimers Dis. 2016;49(3):633-43. doi: 10.3233/JAD-150502.

PMID:
26484918
38.

TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features.

Josephs KA, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Liesinger AM, Petrucelli L, Senjem ML, Ivnik RJ, Parisi JE, Petersen RC, Dickson DW.

Ann Neurol. 2015 Nov;78(5):697-709. doi: 10.1002/ana.24493. Epub 2015 Sep 16.

39.

Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speech.

Botha H, Duffy JR, Whitwell JL, Strand EA, Machulda MM, Schwarz CG, Reid RI, Spychalla AJ, Senjem ML, Jones DT, Lowe V, Jack CR, Josephs KA.

Cortex. 2015 Aug;69:220-36. doi: 10.1016/j.cortex.2015.05.013. Epub 2015 May 27.

40.

Regional β-amyloid burden does not correlate with cognitive or language deficits in Alzheimer's disease presenting as aphasia.

Jung Y, Whitwell JL, Duffy JR, Strand EA, Machulda MM, Senjem ML, Jack CR, Lowe VJ, Josephs KA.

Eur J Neurol. 2016 Feb;23(2):313-9. doi: 10.1111/ene.12761. Epub 2015 Jun 23.

41.

Sample size calculations for clinical trials targeting tauopathies: a new potential disease target.

Whitwell JL, Duffy JR, Strand EA, Machulda MM, Tosakulwong N, Weigand SD, Senjem ML, Spychalla AJ, Gunter JL, Petersen RC, Jack CR Jr, Josephs KA.

J Neurol. 2015 Sep;262(9):2064-72. doi: 10.1007/s00415-015-7821-5. Epub 2015 Jun 17.

42.

Neuropsychological Profiles Differ among the Three Variants of Primary Progressive Aphasia.

Butts AM, Machulda MM, Duffy JR, Strand EA, Whitwell JL, Josephs KA.

J Int Neuropsychol Soc. 2015 Jul;21(6):429-35. doi: 10.1017/S1355617715000399. Epub 2015 Jun 11.

PMID:
26067425
43.

Mixed tau and TDP-43 pathology in a patient with unclassifiable primary progressive aphasia.

Flanagan EP, Duffy JR, Whitwell JL, Vemuri P, Dickson DW, Josephs KA.

Neurocase. 2016;22(1):55-9. doi: 10.1080/13554794.2015.1041534. Epub 2015 May 1.

44.

Clinical, FDG and amyloid PET imaging in posterior cortical atrophy.

Singh TD, Josephs KA, Machulda MM, Drubach DA, Apostolova LG, Lowe VJ, Whitwell JL.

J Neurol. 2015 Jun;262(6):1483-92. doi: 10.1007/s00415-015-7732-5. Epub 2015 Apr 11.

45.

Dominant frontotemporal dementia mutations in 140 cases of primary progressive aphasia and speech apraxia.

Flanagan EP, Baker MC, Perkerson RB, Duffy JR, Strand EA, Whitwell JL, Machulda MM, Rademakers R, Josephs KA.

Dement Geriatr Cogn Disord. 2015;39(5-6):281-6. doi: 10.1159/000375299. Epub 2015 Feb 28.

46.

Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images.

Whitwell JL, Boeve BF, Weigand SD, Senjem ML, Gunter JL, Baker MC, DeJesus-Hernandez M, Knopman DS, Wszolek ZK, Petersen RC, Rademakers R, Jack CR Jr, Josephs KA.

Eur J Neurol. 2015 May;22(5):745-52. doi: 10.1111/ene.12675. Epub 2015 Feb 12.

47.

Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia.

Whitwell JL, Duffy JR, Strand EA, Machulda MM, Senjem ML, Schwarz CG, Reid R, Baker MC, Perkerson RB, Lowe VJ, Rademakers R, Jack CR Jr, Josephs KA.

Brain Lang. 2015 Mar;142:45-53. doi: 10.1016/j.bandl.2015.01.009. Epub 2015 Feb 3.

48.

Primary progressive apraxia of speech: clinical features and acoustic and neurologic correlates.

Duffy JR, Strand EA, Clark H, Machulda M, Whitwell JL, Josephs KA.

Am J Speech Lang Pathol. 2015 May;24(2):88-100. doi: 10.1044/2015_AJSLP-14-0174.

49.

Microbleeds in atypical presentations of Alzheimer's disease: a comparison to dementia of the Alzheimer's type.

Whitwell JL, Kantarci K, Weigand SD, Lundt ES, Gunter JL, Duffy JR, Strand EA, Machulda MM, Spychalla AJ, Drubach DA, Petersen RC, Lowe VJ, Jack CR Jr, Josephs KA.

J Alzheimers Dis. 2015;45(4):1109-17. doi: 10.3233/JAD-142628.

50.

Neuropsychiatric symptoms in primary progressive aphasia and apraxia of speech.

Singh TD, Duffy JR, Strand EA, Machulda MM, Whitwell JL, Josephs KA.

Dement Geriatr Cogn Disord. 2015;39(3-4):228-38. doi: 10.1159/000369062. Epub 2015 Jan 21.

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