Format

Send to

Choose Destination
Antimicrob Agents Chemother. 2019 Oct 22;63(11). pii: e00846-19. doi: 10.1128/AAC.00846-19. Print 2019 Nov.

CreC Sensor Kinase Activation Enhances Growth of Escherichia coli in the Presence of Cephalosporins and Carbapenems.

Author information

1
School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
2
School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom matthewb.avison@bris.ac.uk.

Abstract

Mutants with enhanced growth in the presence of an antibiotic are more difficult to identify than mutants where the antibiotic's MIC increases, because they are not amenable to lethal selection in vitro We report that activatory mutations in the CreC signal sensor enhance growth of Escherichia coli in the presence of cefoxitin, cefotaxime, and meropenem, without increasing their MICs. Enhanced growth is dependent on overproduction of the inner membrane cre regulon protein CreD.

KEYWORDS:

fitness; tolerance; two-component system

PMID:
31451505
PMCID:
PMC6811401
[Available on 2020-04-22]
DOI:
10.1128/AAC.00846-19

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center