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A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.

Krystal AD, Pizzagalli DA, Smoski M, Mathew SJ, Nurnberger J Jr, Lisanby SH, Iosifescu D, Murrough JW, Yang H, Weiner RD, Calabrese JR, Sanacora G, Hermes G, Keefe RSE, Song A, Goodman W, Szabo ST, Whitton AE, Gao K, Potter WZ.

Nat Med. 2020 Mar 30. doi: 10.1038/s41591-020-0806-7. [Epub ahead of print]


Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare.

Carpenter JS, Iorfino F, Cross S, Nichles A, Zmicerevska N, Crouse JJ, Palmer JR, Whitton AE, White D, Naismith SL, Guastella AJ, Hermens DF, Scott J, Scott EM, Hickie IB.

BMJ Open. 2020 Mar 29;10(3):e030985. doi: 10.1136/bmjopen-2019-030985.


Baseline reward processing and ventrostriatal dopamine function are associated with pramipexole response in depression.

Whitton AE, Reinen JM, Slifstein M, Ang YS, McGrath PJ, Iosifescu DV, Abi-Dargham A, Pizzagalli DA, Schneier FR.

Brain. 2020 Feb 1;143(2):701-710. doi: 10.1093/brain/awaa002.


Radiation Necrosis Following Stereotactic Radiosurgery for Trigeminal Neuralgia.

Wang AP, Suryavanshi T, Marcucci M, Fong C, Whitton AC, Reddy KKV.

Can J Neurol Sci. 2020 Feb 10:1-3. doi: 10.1017/cjn.2020.24. [Epub ahead of print] No abstract available.


Optimizing Whole Brain Radiation Therapy Dose and Fractionation: Results From a Prospective Phase 3 Trial (NCCTG N107C [Alliance]/CEC.3).

Trifiletti DM, Ballman KV, Brown PD, Anderson SK, Carrero XW, Cerhan JH, Whitton AC, Greenspoon J, Parney IF, Laack NN, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D.

Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):255-260. doi: 10.1016/j.ijrobp.2019.10.024. Epub 2019 Oct 22. Erratum in: Int J Radiat Oncol Biol Phys. 2020 Apr 1;106(5):1111.


Experimental sleep disruption and reward learning: moderating role of positive affect responses.

Finan PH, Whitton AE, Letzen JE, Remeniuk B, Robinson ML, Irwin MR, Pizzagalli DA, Smith MT.

Sleep. 2019 May 1;42(5). pii: zsz026. doi: 10.1093/sleep/zsz026.


Pretreatment Rostral Anterior Cingulate Cortex Connectivity With Salience Network Predicts Depression Recovery: Findings From the EMBARC Randomized Clinical Trial.

Whitton AE, Webb CA, Dillon DG, Kayser J, Rutherford A, Goer F, Fava M, McGrath P, Weissman M, Parsey R, Adams P, Trombello JM, Cooper C, Deldin P, Oquendo MA, McInnis MG, Carmody T, Bruder G, Trivedi MH, Pizzagalli DA.

Biol Psychiatry. 2019 May 15;85(10):872-880. doi: 10.1016/j.biopsych.2018.12.007. Epub 2018 Dec 19.


Potent Dopamine D2 Antagonists Block the Reward-Enhancing Effects of Nicotine in Smokers With Schizophrenia.

Whitton AE, Green AI, Pizzagalli DA, Roth RM, Williams JM, Brunette MF.

Schizophr Bull. 2019 Oct 24;45(6):1300-1308. doi: 10.1093/schbul/sby185.


Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder.

Tan A, Costi S, Morris LS, Van Dam NT, Kautz M, Whitton AE, Friedman AK, Collins KA, Ahle G, Chadha N, Do B, Pizzagalli DA, Iosifescu DV, Nestler EJ, Han MH, Murrough JW.

Mol Psychiatry. 2018 Nov 1. doi: 10.1038/s41380-018-0283-2. [Epub ahead of print]


The Future Is Now-Prospective Study of Radiosurgery for More Than 4 Brain Metastases to Start in 2018!

Roberge D, Brown PD, Whitton A, O'Callaghan C, Leis A, Greenspoon J, Smith GL, Hu JJ, Nichol A, Winch C, Chan MD.

Front Oncol. 2018 Sep 13;8:380. doi: 10.3389/fonc.2018.00380. eCollection 2018.


Dopamine Release in Antidepressant-Naive Major Depressive Disorder: A Multimodal [11C]-(+)-PHNO Positron Emission Tomography and Functional Magnetic Resonance Imaging Study.

Schneier FR, Slifstein M, Whitton AE, Pizzagalli DA, Reinen J, McGrath PJ, Iosifescu DV, Abi-Dargham A.

Biol Psychiatry. 2018 Oct 15;84(8):563-573. doi: 10.1016/j.biopsych.2018.05.014. Epub 2018 May 25.


Evidence of a diurnal rhythm in implicit reward learning.

Whitton AE, Mehta M, Ironside ML, Murray G, Pizzagalli DA.

Chronobiol Int. 2018 Aug;35(8):1104-1114. doi: 10.1080/07420528.2018.1459662. Epub 2018 Apr 24.


Electroencephalography Source Functional Connectivity Reveals Abnormal High-Frequency Communication Among Large-Scale Functional Networks in Depression.

Whitton AE, Deccy S, Ironside ML, Kumar P, Beltzer M, Pizzagalli DA.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Jan;3(1):50-58. doi: 10.1016/j.bpsc.2017.07.001. Epub 2017 Jul 13.


Fear Extinction Recall Modulates Human Frontomedial Theta and Amygdala Activity.

Sperl MFJ, Panitz C, Rosso IM, Dillon DG, Kumar P, Hermann A, Whitton AE, Hermann C, Pizzagalli DA, Mueller EM.

Cereb Cortex. 2019 Feb 1;29(2):701-715. doi: 10.1093/cercor/bhx353.


Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation.

Kaiser RH, Treadway MT, Wooten DW, Kumar P, Goer F, Murray L, Beltzer M, Pechtel P, Whitton A, Cohen AL, Alpert NM, El Fakhri G, Normandin MD, Pizzagalli DA.

Cereb Cortex. 2018 Dec 1;28(12):4281-4290. doi: 10.1093/cercor/bhx281.


Amelanotic melanocytoma of the sella mimicking pituitary adenoma.

Lach B, Reddy K, Sommer DD, Whitton AC, Baweja R.

Clin Neuropathol. 2017 Nov/Dec;36(6):283-287. doi: 10.5414/NP301033.


Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial.

Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D.

Lancet Oncol. 2017 Aug;18(8):1049-1060. doi: 10.1016/S1470-2045(17)30441-2. Epub 2017 Jul 4.


Age invariance in rapid facial affective reactions to emotionally valenced stimuli.

Nangle MR, Bailey PE, Henry JD, Khlentzos GS, Varcin KJ, Whitton AE.

Q J Exp Psychol (Hove). 2018 Aug;71(8):1687-1697. doi: 10.1080/17470218.2017.1345960. Epub 2018 Jan 1.


Evaluation of pseudoprogression in patients with glioblastoma.

Kucharczyk MJ, Parpia S, Whitton A, Greenspoon JN.

Neurooncol Pract. 2017 Jun;4(2):120-134. doi: 10.1093/nop/npw021. Epub 2016 Nov 4.


65-year-old female with cerebellopontine angle lesion.

Baweja R, Reddy K, Whitton A, Provias J, Lach B.

Brain Pathol. 2017 Mar;27(2):237-238. doi: 10.1111/bpa.12489. No abstract available.


Acute stress impairs frontocingulate activation during error monitoring in remitted depression.

Whitton AE, Van't Veer A, Kakani P, Dillon DG, Ironside ML, Haile A, Crowley DJ, Pizzagalli DA.

Psychoneuroendocrinology. 2017 Jan;75:164-172. doi: 10.1016/j.psyneuen.2016.10.007. Epub 2016 Oct 17.


Reward Learning, Neurocognition, Social Cognition, and Symptomatology in Psychosis.

Lewandowski KE, Whitton AE, Pizzagalli DA, Norris LA, Ongur D, Hall MH.

Front Psychiatry. 2016 Jun 14;7:100. doi: 10.3389/fpsyt.2016.00100. eCollection 2016.


Differential spatial regulation of BMP molecules is associated with single-suture craniosynostosis.

Whitton A, Hyzy SL, Britt C, Williams JK, Boyan BD, Olivares-Navarrete R.

J Neurosurg Pediatr. 2016 Jul;18(1):83-91. doi: 10.3171/2015.12.PEDS15414. Epub 2016 Apr 1.


Therapeutic Alliance With a Fully Automated Mobile Phone and Web-Based Intervention: Secondary Analysis of a Randomized Controlled Trial.

Clarke J, Proudfoot J, Whitton A, Birch MR, Boyd M, Parker G, Manicavasagar V, Hadzi-Pavlovic D, Fogarty A.

JMIR Ment Health. 2016 Feb 25;3(1):e10. doi: 10.2196/mental.4656.


Blunted neural responses to reward in remitted major depression: A high-density event-related potential study.

Whitton AE, Kakani P, Foti D, Van't Veer A, Haile A, Crowley DJ, Pizzagalli DA.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jan 1;1(1):87-95.


Exploration of Morbidity in a Serial Study of Long-Term Brain Tumor Survivors: A Focus on Pain.

Nayiager T, Duckworth J, Pullenayegum E, Whitton A, Hollenberg R, Horsman J, Furlong W, Spitzer R, Barr R.

J Adolesc Young Adult Oncol. 2015 Sep;4(3):129-36. doi: 10.1089/jayao.2015.0026. Epub 2015 Aug 17.


Breaking Open the Black Box: Isolating the Most Potent Features of a Web and Mobile Phone-Based Intervention for Depression, Anxiety, and Stress.

Whitton AE, Proudfoot J, Clarke J, Birch MR, Parker G, Manicavasagar V, Hadzi-Pavlovic D.

JMIR Ment Health. 2015 Mar 4;2(1):e3. doi: 10.2196/mental.3573. eCollection 2015 Jan-Mar.


Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers.

Peechatka AL, Whitton AE, Farmer SL, Pizzagalli DA, Janes AC.

Drug Alcohol Depend. 2015 Oct 1;155:202-7. doi: 10.1016/j.drugalcdep.2015.07.015. Epub 2015 Jul 23.


Health-related Quality of Life in Long-term Survivors of Brain Tumors in Childhood and Adolescence: A Serial Study Spanning a Decade.

Duckworth J, Nayiager T, Pullenayegum E, Whitton A, Hollenberg R, Horsman J, Furlong W, Spitzer R, Barr RD.

J Pediatr Hematol Oncol. 2015 Jul;37(5):362-7. doi: 10.1097/MPH.0000000000000365.


Reward Responsiveness Varies by Smoking Status in Women with a History of Major Depressive Disorder.

Janes AC, Pedrelli P, Whitton AE, Pechtel P, Douglas S, Martinson MA, Huz I, Fava M, Pizzagalli DA, Evins AE.

Neuropsychopharmacology. 2015 Jul;40(8):1940-6. doi: 10.1038/npp.2015.43. Epub 2015 Feb 9.


Reward processing dysfunction in major depression, bipolar disorder and schizophrenia.

Whitton AE, Treadway MT, Pizzagalli DA.

Curr Opin Psychiatry. 2015 Jan;28(1):7-12. doi: 10.1097/YCO.0000000000000122. Review.


Effects of mental health self-efficacy on outcomes of a mobile phone and web intervention for mild-to-moderate depression, anxiety and stress: secondary analysis of a randomised controlled trial.

Clarke J, Proudfoot J, Birch MR, Whitton AE, Parker G, Manicavasagar V, Harrison V, Christensen H, Hadzi-Pavlovic D.

BMC Psychiatry. 2014 Sep 26;14:272. doi: 10.1186/s12888-014-0272-1.


Left atrial thrombus mimicking atrial myxoma on imaging studies in a patient with cardiac transplant.

Khan N, Whitton A, Hoffman R, Qualtieri J, Dunlap S.

J Cardiol Cases. 2014 Jul 28;10(4):153-154. doi: 10.1016/j.jccase.2014.07.001. eCollection 2014 Oct.


Cognitive and psychophysiological correlates of disgust in obsessive-compulsive disorder.

Whitton AE, Henry JD, Grisham JR.

Br J Clin Psychol. 2015 Mar;54(1):16-33. doi: 10.1111/bjc.12058. Epub 2014 Jun 10.


Evidence of weekly cyclicity in mood and functional impairment in those with a bipolar disorder.

Proudfoot J, Whitton AE, Parker G, Manicavasagar V, Nicholas J, Smith M.

Psychiatry Res. 2014 Aug 30;218(3):290-4. doi: 10.1016/j.psychres.2014.04.047. Epub 2014 May 9.


Fractionated stereotactic radiosurgery with concurrent temozolomide chemotherapy for locally recurrent glioblastoma multiforme: a prospective cohort study.

Greenspoon JN, Sharieff W, Hirte H, Overholt A, Devillers R, Gunnarsson T, Whitton A.

Onco Targets Ther. 2014 Mar 24;7:485-90. doi: 10.2147/OTT.S60358. eCollection 2014.


Disgust, but not anger provocation, enhances levator labii superioris activity during exposure to moral transgressions.

Whitton AE, Henry JD, Rendell PG, Grisham JR.

Biol Psychol. 2014 Feb;96:48-56. doi: 10.1016/j.biopsycho.2013.11.012. Epub 2013 Dec 7.


The technique and cost of radiosurgery for the treatment of 1-3 brain metastases.

Sharieff W, Whitton A, Chow T, Wyman D, Wright J, Greenspoon JN.

Can J Neurol Sci. 2013 Nov;40(6):795-9.


Impact of a mobile phone and web program on symptom and functional outcomes for people with mild-to-moderate depression, anxiety and stress: a randomised controlled trial.

Proudfoot J, Clarke J, Birch MR, Whitton AE, Parker G, Manicavasagar V, Harrison V, Christensen H, Hadzi-Pavlovic D.

BMC Psychiatry. 2013 Nov 18;13:312. doi: 10.1186/1471-244X-13-312.


The relationship between sub-clinical obsessive-compulsive symptoms and social cognition in chronic schizophrenia.

Whitton AE, Henry JD.

Br J Clin Psychol. 2013 Jun;52(2):115-28. doi: 10.1111/bjc.12004. Epub 2012 Oct 12.


Moral rigidity in obsessive-compulsive disorder: do abnormalities in inhibitory control, cognitive flexibility and disgust play a role?

Whitton AE, Henry JD, Grisham JR.

J Behav Ther Exp Psychiatry. 2014 Mar;45(1):152-9. doi: 10.1016/j.jbtep.2013.10.001. Epub 2013 Oct 11.


Use of continuous infusion pumps during radiation treatment.

Bak K, Gutierrez E, Lockhart E, Sharpe M, Green E, Costa S, Hertz S, Kaizer L, Whitton A, Warde P.

J Oncol Pract. 2013 Mar;9(2):107-11. doi: 10.1200/JOP.2012.000717. Review.


Robotic radiosurgery for the treatment of 1-3 brain metastases: a pragmatic application of cost-benefit analysis using willingness-to-pay.

Greenspoon JN, Whitton A, Whelan T, Sharieff W, Wright J, Sussman J, Gafni A.

Technol Cancer Res Treat. 2013 Dec;12(6):517-23. doi: 10.7785/tcrt.2012.500344. Epub 2013 Jun 6.


Technology resource planning in radiation oncology: application of a needs-based analytic framework to radiosurgery planning in Ontario.

Greenspoon JN, O'Reilly D, Wright JR, Whitton A, Sussman J, Birch S.

J Oncol Pract. 2012 Nov;8(6):358-62. doi: 10.1200/JOP.2012.000617. Epub 2012 Jul 24.


Mechanisms underpinning effective peer support: a qualitative analysis of interactions between expert peers and patients newly-diagnosed with bipolar disorder.

Proudfoot JG, Jayawant A, Whitton AE, Parker G, Manicavasagar V, Smith M, Nicholas J.

BMC Psychiatry. 2012 Nov 9;12:196. doi: 10.1186/1471-244X-12-196.


Triggers of mania and depression in young adults with bipolar disorder.

Proudfoot J, Whitton A, Parker G, Doran J, Manicavasagar V, Delmas K.

J Affect Disord. 2012 Dec 20;143(1-3):196-202. doi: 10.1016/j.jad.2012.05.052. Epub 2012 Aug 9.


Effects of adjunctive peer support on perceptions of illness control and understanding in an online psychoeducation program for bipolar disorder: a randomised controlled trial.

Proudfoot J, Parker G, Manicavasagar V, Hadzi-Pavlovic D, Whitton A, Nicholas J, Smith M, Burckhardt R.

J Affect Disord. 2012 Dec 15;142(1-3):98-105. doi: 10.1016/j.jad.2012.04.007. Epub 2012 Aug 2.


PP154. Relationship between recorded and reported snoring during pregnancy: Objective measurement versus questionnaire responses.

Robertson A, Johnson P, Thornton C, Whitton AM, Middleton S, Sullivan C, Hennesssy A.

Pregnancy Hypertens. 2012 Jul;2(3):322. doi: 10.1016/j.preghy.2012.04.265. Epub 2012 Jun 13.


OS093. Prevalance of sleep disordered breathing in pregnancy.

Robertson A, Johnson P, Thornton C, Whitton AM, Sullivan C, Hennesssy A.

Pregnancy Hypertens. 2012 Jul;2(3):228-9. doi: 10.1016/j.preghy.2012.04.094. Epub 2012 Jun 13.


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