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Items: 49

1.

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids.

Dekkers JF, Whittle JR, Vaillant F, Chen HR, Dawson C, Liu K, Geurts M, Herold MJ, Clevers H, Lindeman GJ, Visvader JE.

J Natl Cancer Inst. 2019 Oct 7. pii: djz196. doi: 10.1093/jnci/djz196. [Epub ahead of print]

PMID:
31589320
2.

Preoperative systemic inflammation and perioperative myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery.

Ackland GL, Abbott TEF, Cain D, Edwards MR, Sultan P, Karmali SN, Fowler AJ, Whittle JR, MacDonald NJ, Reyes A, Paredes LG, Stephens RCM, Del Arroyo AG, Woldman S, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E, Pearse RM.

Br J Anaesth. 2019 Feb;122(2):180-187. doi: 10.1016/j.bja.2018.09.002. Epub 2018 Oct 2.

3.

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer.

Lok SW, Whittle JR, Vaillant F, Teh CE, Lo LL, Policheni AN, Bergin ART, Desai J, Ftouni S, Gandolfo LC, Liew D, Liu HK, Mann GB, Moodie K, Murugasu A, Pal B, Roberts AW, Rosenthal MA, Shackleton K, Silva MJ, Siow ZR, Smyth GK, Taylor L, Travers A, Yeo B, Yeung MM, Bujak AZ, Dawson SJ, Gray DHD, Visvader JE, Lindeman GJ.

Cancer Discov. 2019 Mar;9(3):354-369. doi: 10.1158/2159-8290.CD-18-1151. Epub 2018 Dec 5.

PMID:
30518523
4.

A phase I trial to determine safety and pharmacokinetics of ASLAN002, an oral MET superfamily kinase inhibitor, in patients with advanced or metastatic solid cancers.

Roohullah A, Cooper A, Lomax AJ, Aung J, Barge A, Chow L, McHale M, Desai J, Whittle JR, Tran B, de Souza P, Horvath LG.

Invest New Drugs. 2018 Oct;36(5):886-894. doi: 10.1007/s10637-018-0588-7. Epub 2018 May 16.

PMID:
29766337
5.

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer.

Merino D, Whittle JR, Vaillant F, Serrano A, Gong JN, Giner G, Maragno AL, Chanrion M, Schneider E, Pal B, Li X, Dewson G, Gräsel J, Liu K, Lalaoui N, Segal D, Herold MJ, Huang DCS, Smyth GK, Geneste O, Lessene G, Visvader JE, Lindeman GJ.

Sci Transl Med. 2017 Aug 2;9(401). pii: eaam7049. doi: 10.1126/scitranslmed.aam7049.

PMID:
28768804
6.

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses.

Joyce MG, Wheatley AK, Thomas PV, Chuang GY, Soto C, Bailer RT, Druz A, Georgiev IS, Gillespie RA, Kanekiyo M, Kong WP, Leung K, Narpala SN, Prabhakaran MS, Yang ES, Zhang B, Zhang Y, Asokan M, Boyington JC, Bylund T, Darko S, Lees CR, Ransier A, Shen CH, Wang L, Whittle JR, Wu X, Yassine HM, Santos C, Matsuoka Y, Tsybovsky Y, Baxa U; NISC Comparative Sequencing Program, Mullikin JC, Subbarao K, Douek DC, Graham BS, Koup RA, Ledgerwood JE, Roederer M, Shapiro L, Kwong PD, Mascola JR, McDermott AB.

Cell. 2016 Jul 28;166(3):609-623. doi: 10.1016/j.cell.2016.06.043. Epub 2016 Jul 21.

7.

First in human nanotechnology doxorubicin delivery system to target epidermal growth factor receptors in recurrent glioblastoma.

Whittle JR, Lickliter JD, Gan HK, Scott AM, Simes J, Solomon BJ, MacDiarmid JA, Brahmbhatt H, Rosenthal MA.

J Clin Neurosci. 2015 Dec;22(12):1889-94. doi: 10.1016/j.jocn.2015.06.005. Epub 2015 Aug 13.

PMID:
26279503
8.

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site.

Kanekiyo M, Bu W, Joyce MG, Meng G, Whittle JR, Baxa U, Yamamoto T, Narpala S, Todd JP, Rao SS, McDermott AB, Koup RA, Rossmann MG, Mascola JR, Graham BS, Cohen JI, Nabel GJ.

Cell. 2015 Aug 27;162(5):1090-100. doi: 10.1016/j.cell.2015.07.043. Epub 2015 Aug 13.

9.

H5N1 Vaccine-Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin Stem.

Wheatley AK, Whittle JR, Lingwood D, Kanekiyo M, Yassine HM, Ma SS, Narpala SR, Prabhakaran MS, Matus-Nicodemos RA, Bailer RT, Nabel GJ, Graham BS, Ledgerwood JE, Koup RA, McDermott AB.

J Immunol. 2015 Jul 15;195(2):602-10. doi: 10.4049/jimmunol.1402835. Epub 2015 Jun 15.

10.

Patient-derived xenograft models of breast cancer and their predictive power.

Whittle JR, Lewis MT, Lindeman GJ, Visvader JE.

Breast Cancer Res. 2015 Feb 10;17:17. doi: 10.1186/s13058-015-0523-1. Review.

11.

Histone deacetylase inhibitors in cancer: what have we learned?

Whittle JR, Desai J.

Cancer. 2015 Apr 15;121(8):1164-7. doi: 10.1002/cncr.29177. Epub 2014 Dec 23. No abstract available.

12.

Coinfection with Streptococcus pneumoniae modulates the B cell response to influenza virus.

Wolf AI, Strauman MC, Mozdzanowska K, Whittle JR, Williams KL, Sharpe AH, Weiser JN, Caton AJ, Hensley SE, Erikson J.

J Virol. 2014 Oct;88(20):11995-2005. doi: 10.1128/JVI.01833-14. Epub 2014 Aug 6.

13.

Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages.

Whittle JR, Wheatley AK, Wu L, Lingwood D, Kanekiyo M, Ma SS, Narpala SR, Yassine HM, Frank GM, Yewdell JW, Ledgerwood JE, Wei CJ, McDermott AB, Graham BS, Koup RA, Nabel GJ.

J Virol. 2014 Apr;88(8):4047-57. doi: 10.1128/JVI.03422-13. Epub 2014 Feb 5.

14.

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies.

Kanekiyo M, Wei CJ, Yassine HM, McTamney PM, Boyington JC, Whittle JR, Rao SS, Kong WP, Wang L, Nabel GJ.

Nature. 2013 Jul 4;499(7456):102-6. doi: 10.1038/nature12202. Epub 2013 May 22.

PMID:
23698367
15.

Structural and genetic basis for development of broadly neutralizing influenza antibodies.

Lingwood D, McTamney PM, Yassine HM, Whittle JR, Guo X, Boyington JC, Wei CJ, Nabel GJ.

Nature. 2012 Sep 27;489(7417):566-70. doi: 10.1038/nature11371. Epub 2012 Aug 29.

PMID:
22932267
16.

Elicitation of broadly neutralizing influenza antibodies in animals with previous influenza exposure.

Wei CJ, Yassine HM, McTamney PM, Gall JG, Whittle JR, Boyington JC, Nabel GJ.

Sci Transl Med. 2012 Aug 15;4(147):147ra114. doi: 10.1126/scitranslmed.3004273.

17.

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.

Whittle JR, Zhang R, Khurana S, King LR, Manischewitz J, Golding H, Dormitzer PR, Haynes BF, Walter EB, Moody MA, Kepler TB, Liao HX, Harrison SC.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14216-21. doi: 10.1073/pnas.1111497108. Epub 2011 Aug 8.

18.

Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat.

Whittle JR, Schwartz TU.

J Cell Biol. 2010 Aug 9;190(3):347-61. doi: 10.1083/jcb.201003092.

19.

The nuclear pore complex has entered the atomic age.

Brohawn SG, Partridge JR, Whittle JR, Schwartz TU.

Structure. 2009 Sep 9;17(9):1156-68. doi: 10.1016/j.str.2009.07.014. Review.

20.

Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element.

Whittle JR, Schwartz TU.

J Biol Chem. 2009 Oct 9;284(41):28442-52. doi: 10.1074/jbc.M109.023580. Epub 2009 Aug 11.

21.

Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation.

Whittle JR, Powell MJ, Popov VM, Shirley LA, Wang C, Pestell RG.

Trends Endocrinol Metab. 2007 Nov;18(9):356-64. Epub 2007 Oct 26. Review.

PMID:
17964799
22.

Discovery of genes with highly restricted expression patterns in the Drosophila wing disc using DNA oligonucleotide microarrays.

Butler MJ, Jacobsen TL, Cain DM, Jarman MG, Hubank M, Whittle JR, Phillips R, Simcox A.

Development. 2003 Feb;130(4):659-70.

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27.

Recent studies on xanthine oxidase and related enzymes.

Bray RC, Bennett B, Burke JF, Chovnick A, Doyle WA, Howes BD, Lowe DJ, Richards RL, Turner NA, Ventom A, Whittle JR.

Biochem Soc Trans. 1996 Feb;24(1):99-105. Review. No abstract available.

PMID:
8674784
28.

Engineering and expression in Drosophila melanogaster of a xanthine dehydrogenase (rosy) variant.

Doyle WA, Burke JF, Chovnick A, Dutton FL, Russell C, Whittle JR, Bray RC.

Biochem Soc Trans. 1996 Feb;24(1):31S. No abstract available.

PMID:
8674698
29.
30.

A novel genetic assay for mutations which affect post-embryonic development or the behaviour of adult flies.

Phillips RG, Lineruth-Davis K, Whittle JR.

Biochem Soc Trans. 1996 Feb;24(1):108S. No abstract available.

PMID:
8674588
32.

Use of rosy mutant strains of Drosophila melanogaster to probe the structure and function of xanthine dehydrogenase.

Hughes RK, Doyle WA, Chovnick A, Whittle JR, Burke JF, Bray RC.

Biochem J. 1992 Jul 15;285 ( Pt 2):507-13.

33.

Establishment of imaginal discs and histoblast nests in Drosophila.

Simcox AA, Hersperger E, Shearn A, Whittle JR, Cohen SM.

Mech Dev. 1991 Mar;34(1):11-20. Erratum in: Mech Dev 1991 Aug;35(1):73.

PMID:
1911392
34.

The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs.

Phillips RG, Roberts IJ, Ingham PW, Whittle JR.

Development. 1990 Sep;110(1):105-14.

35.

Pattern formation in imaginal discs.

Whittle JR.

Semin Cell Biol. 1990 Jun;1(3):241-52. Review.

PMID:
2103892
36.

Imaginal discs can be recovered from cultured embryos mutant for the segment-polarity genes engrailed, naked and patched but not from wingless.

Simcox AA, Roberts IJ, Hersperger E, Gribbin MC, Shearn A, Whittle JR.

Development. 1989 Dec;107(4):715-22.

37.

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched.

Nakano Y, Guerrero I, Hidalgo A, Taylor A, Whittle JR, Ingham PW.

Nature. 1989 Oct 12;341(6242):508-13.

PMID:
2797178
38.

Mutational dissection of gene expression in the abdominal region of the bithorax complex of Drosophila in imaginal tissue.

Tiong SY, Gribbin MC, Whittle JR.

Roux Arch Dev Biol. 1988 May;197(3):131-140. doi: 10.1007/BF00427916.

PMID:
28305557
40.

Brista: a gene involved in the specification and differentiation of distal cephalic and thoracic structures in Drosophila melanogaster.

Sunkel CE, Whittle JR.

Roux Arch Dev Biol. 1987 Feb;196(2):124-132. doi: 10.1007/BF00402034.

PMID:
28305467
41.
42.

Recessive lethal mutations within the bithorax-complex in Drosophila.

Tiong S, Bone LM, Whittle JR.

Mol Gen Genet. 1985;200(2):335-42.

PMID:
3929021
43.

Genetic dissection of cell determination, a complex system in biology.

Whittle JR.

Sci Prog. 1984 Summer;69(274):235-56. No abstract available.

PMID:
6440295
45.

Genetic analysis of the mutation female-lethal in Drosophila melanogaster.

Marshall T, Whittle JR.

Genet Res. 1978 Oct;32(2):103-11. No abstract available.

PMID:
105968
46.

Clonal analysis of a genetically caused duplication of the anterior wing in Drosophila melanogaster.

Whittle JR.

Dev Biol. 1976 Jul 15;51(2):257-68. No abstract available.

PMID:
821799
47.

Cortical morphogenesis in Paramecium aurelia: mutants affecting cell shape.

Whittle JR, Chen-Shan L.

Genet Res. 1972 Jun;19(3):271-9. No abstract available.

PMID:
5075807
48.

Background genetics.

Whittle JR.

Postgrad Med J. 1972 Apr;48(559):195-8. No abstract available.

49.

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