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Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids.

Dekkers JF, Whittle JR, Vaillant F, Chen HR, Dawson C, Liu K, Geurts M, Herold MJ, Clevers H, Lindeman GJ, Visvader JE.

J Natl Cancer Inst. 2019 Oct 7. pii: djz196. doi: 10.1093/jnci/djz196. [Epub ahead of print]


Patient expectations for recovery after elective surgery: a common-sense model approach.

Gehring MB, Lerret S, Johnson J, Rieder J, Nelson D, Copeland L, Titan A, Hawn M, Morris M, Whittle J, Burns E.

J Behav Med. 2019 Sep 11. doi: 10.1007/s10865-019-00097-2. [Epub ahead of print]


A systematic review of patient-reported outcome measures used in shoulder instability research.

Whittle JH, Peters SE, Manzanero S, Duke PF.

J Shoulder Elbow Surg. 2019 Sep 5. pii: S1058-2746(19)30474-4. doi: 10.1016/j.jse.2019.07.001. [Epub ahead of print] Review.


Impact of an enhanced recovery pathway on length of stay and complications in elective radical cystectomy: a before and after cohort study.

Dunkman WJ, Manning MW, Whittle J, Hunting J, Rampersaud EN, Inman BA, Thacker JK, Miller TE.

Perioper Med (Lond). 2019 Aug 22;8:9. doi: 10.1186/s13741-019-0120-4. eCollection 2019.


The impact of central IRB's on informed consent readability and trial adherence in SPRINT.

Tamariz L, Gajardo M, Still CH, Gren LH, Clark E, Walsh S, Whittle J, Nord J, Ramsey T, Contreras G; SPRINT Research Group.

Contemp Clin Trials Commun. 2019 Jul 6;15:100407. doi: 10.1016/j.conctc.2019.100407. eCollection 2019 Sep.


Precision Medicine and Precision Public Health: Academic Education and Community Engagement.

Meurer JR, Whittle JC, Lamb KM, Kosasih MA, Dwinell MR, Urrutia RA.

Am J Prev Med. 2019 Aug;57(2):286-289. doi: 10.1016/j.amepre.2019.03.010. No abstract available.


Beyond NIPPV: HVNI Expands Potential Treatment Options For Acute Decompensated Heart Failure.

Haywood ST, Volakis LI, Whittle JS.

Am J Emerg Med. 2019 Aug;37(8):1589. doi: 10.1016/j.ajem.2019.05.021. Epub 2019 May 7. No abstract available.


Comparison of a Potential Hospital Quality Metric With Existing Metrics for Surgical Quality-Associated Readmission.

Graham LA, Mull HJ, Wagner TH, Morris MS, Rosen AK, Richman JS, Whittle J, Burns E, Copeland LA, Itani KMF, Hawn MT.

JAMA Netw Open. 2019 Apr 5;2(4):e191313. doi: 10.1001/jamanetworkopen.2019.1313.


Antifungal Activity in Compounds from the Australian Desert Plant Eremophila alternifolia with Potency Against Cryptococcus spp.

Hossain MA, Biva IJ, Kidd SE, Whittle JD, Griesser HJ, Coad BR.

Antibiotics (Basel). 2019 Mar 31;8(2). pii: E34. doi: 10.3390/antibiotics8020034.


HVNI vs NIPPV in the treatment of acute decompensated heart failure: Subgroup analysis of a multi-center trial in the ED.

Haywood ST, Whittle JS, Volakis LI, Dungan G 2nd, Bublewicz M, Kearney J, Ashe T, Miller TL, Doshi P.

Am J Emerg Med. 2019 Mar 3. pii: S0735-6757(19)30151-2. doi: 10.1016/j.ajem.2019.03.002. [Epub ahead of print]


Preoperative opioid use and postoperative pain associated with surgical readmissions.

Dasinger EA, Graham LA, Wahl TS, Richman JS, Baker SJ, Hawn MT, Hernandez-Boussard T, Rosen AK, Mull HJ, Copeland LA, Whittle JC, Burns EA, Morris MS.

Am J Surg. 2019 Feb 28. pii: S0002-9610(18)31532-0. doi: 10.1016/j.amjsurg.2019.02.033. [Epub ahead of print]


Preoperative systemic inflammation and perioperative myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery.

Ackland GL, Abbott TEF, Cain D, Edwards MR, Sultan P, Karmali SN, Fowler AJ, Whittle JR, MacDonald NJ, Reyes A, Paredes LG, Stephens RCM, Del Arroyo AG, Woldman S, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E, Pearse RM.

Br J Anaesth. 2019 Feb;122(2):180-187. doi: 10.1016/j.bja.2018.09.002. Epub 2018 Oct 2.


A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer.

Lok SW, Whittle JR, Vaillant F, Teh CE, Lo LL, Policheni AN, Bergin ART, Desai J, Ftouni S, Gandolfo LC, Liew D, Liu HK, Mann GB, Moodie K, Murugasu A, Pal B, Roberts AW, Rosenthal MA, Shackleton K, Silva MJ, Siow ZR, Smyth GK, Taylor L, Travers A, Yeo B, Yeung MM, Bujak AZ, Dawson SJ, Gray DHD, Visvader JE, Lindeman GJ.

Cancer Discov. 2019 Mar;9(3):354-369. doi: 10.1158/2159-8290.CD-18-1151. Epub 2018 Dec 5.


Urban and Rural Emergency Department Performance on National Quality Metrics for Sepsis Care in the United States.

Greenwood-Ericksen MB, Rothenberg C, Mohr N, Andrea SD, Slesinger T, Osborn T, Whittle J, Goyal P, Tarrant N, Schuur JD, Yealy DM, Venkatesh A.

J Rural Health. 2019 Sep;35(4):490-497. doi: 10.1111/jrh.12339. Epub 2018 Nov 28.


From embracing to managing risks.

Keen J, Nicklin E, Wickramasekera N, Long A, Randell R, Ginn C, McGinnis E, Willis S, Whittle J.

BMJ Open. 2018 Nov 25;8(11):e022921. doi: 10.1136/bmjopen-2018-022921.


Surgical Prehabilitation: Nutrition and Exercise.

Whittle J, Wischmeyer PE, Grocott MPW, Miller TE.

Anesthesiol Clin. 2018 Dec;36(4):567-580. doi: 10.1016/j.anclin.2018.07.013. Review.


Prognostic relevance of visit-to-visit office blood pressure variability in Systolic Blood Pressure Intervention Trial: Same data, different conclusions?

Chang TI, Reboussin DM, Chertow GM, Cheung AK, Cushman WC, Kostis WJ, Parati G, Riessen E, Shapiro B, Stergiou GS, Tsioufis K, Whelton PK, Whittle J, Wright JT, Papademetriou V.

J Clin Hypertens (Greenwich). 2018 Nov;20(11):1644-1645. doi: 10.1111/jch.13395. Epub 2018 Oct 17. No abstract available.


A missense variant in SLC39A8 is associated with severe idiopathic scoliosis.

Haller G, McCall K, Jenkitkasemwong S, Sadler B, Antunes L, Nikolov M, Whittle J, Upshaw Z, Shin J, Baschal E, Cruchaga C, Harms M, Raggio C, Morcuende JA, Giampietro P, Miller NH, Wise C, Gray RS, Solnica-Krezel L, Knutson M, Dobbs MB, Gurnett CA.

Nat Commun. 2018 Oct 9;9(1):4171. doi: 10.1038/s41467-018-06705-0.


Development of a sandwich ELISA to detect Leishmania 40S ribosomal protein S12 antigen from blood samples of visceral leishmaniasis patients.

Zhang WW, Ghosh AK, Mohamath R, Whittle J, Picone A, Lypaczewski P, Ndao M, Howard RF, Das P, Reed SG, Matlashewski G.

BMC Infect Dis. 2018 Oct 3;18(1):500. doi: 10.1186/s12879-018-3420-2.


Deconstructing Dissections: A Case Report and Review of Blunt Cerebrovascular Injury of the Neck.

Walsh BA, Gregorie WD, Whittle JS.

Case Rep Emerg Med. 2018 Aug 8;2018:6120781. doi: 10.1155/2018/6120781. eCollection 2018.


Association Between Preoperative Proteinuria and Postoperative Acute Kidney Injury and Readmission.

Wahl TS, Graham LA, Morris MS, Richman JS, Hollis RH, Jones CE, Itani KM, Wagner TH, Mull HJ, Whittle JC, Telford GL, Rosen AK, Copeland LA, Burns EA, Hawn MT.

JAMA Surg. 2018 Sep 1;153(9):e182009. doi: 10.1001/jamasurg.2018.2009. Epub 2018 Sep 19.


Quality and safety between ward and board: a biography of artefacts study.

Keen J, Nicklin E, Long A, Randell R, Wickramasekera N, Gates C, Ginn C, McGinnis E, Willis S, Whittle J.

Southampton (UK): NIHR Journals Library; 2018 Jun.


Development of a veteran engagement toolkit for researchers.

Brys NA, Whittle J, Safdar N.

J Comp Eff Res. 2018 Jun;7(6):595-602. doi: 10.2217/cer-2017-0101. Epub 2018 Jun 1.


Gastropericardial Fistula Presenting 27 Years after Bariatric Surgery.

Martin RA, Reuhland B, Carlson LS, Love M, Maxwell RA, Whittle JS.

Clin Pract Cases Emerg Med. 2017 Oct 6;1(4):435-436. doi: 10.5811/cpcem.2017.6.34372. eCollection 2017 Nov. No abstract available.


A phase I trial to determine safety and pharmacokinetics of ASLAN002, an oral MET superfamily kinase inhibitor, in patients with advanced or metastatic solid cancers.

Roohullah A, Cooper A, Lomax AJ, Aung J, Barge A, Chow L, McHale M, Desai J, Whittle JR, Tran B, de Souza P, Horvath LG.

Invest New Drugs. 2018 Oct;36(5):886-894. doi: 10.1007/s10637-018-0588-7. Epub 2018 May 16.


Homeless Status, Postdischarge Health Care Utilization, and Readmission After Surgery.

Titan A, Graham L, Rosen A, Itani K, Copeland LA, Mull HJ, Burns E, Richman J, Kertesz S, Wahl T, Morris M, Whittle J, Telford G, Wilson M, Hawn M.

Med Care. 2018 Jun;56(6):460-469. doi: 10.1097/MLR.0000000000000915.


Association of Postoperative Readmissions With Surgical Quality Using a Delphi Consensus Process to Identify Relevant Diagnosis Codes.

Mull HJ, Graham LA, Morris MS, Rosen AK, Richman JS, Whittle J, Burns E, Wagner TH, Copeland LA, Wahl T, Jones C, Hollis RH, Itani KMF, Hawn MT.

JAMA Surg. 2018 Aug 1;153(8):728-737. doi: 10.1001/jamasurg.2018.0592.


Syncope, Hypotension, and Falls in the Treatment of Hypertension: Results from the Randomized Clinical Systolic Blood Pressure Intervention Trial.

Sink KM, Evans GW, Shorr RI, Bates JT, Berlowitz D, Conroy MB, Felton DM, Gure T, Johnson KC, Kitzman D, Lyles MF, Servilla K, Supiano MA, Whittle J, Wiggers A, Fine LJ.

J Am Geriatr Soc. 2018 Apr;66(4):679-686. doi: 10.1111/jgs.15236. Epub 2018 Mar 30.


Arterial pulse pressure and postoperative morbidity in high-risk surgical patients.

Ackland GL, Abbott TEF, Pearse RM, Karmali SN, Whittle J, Minto G; POM-HR Study Investigators.

Br J Anaesth. 2018 Jan;120(1):94-100. doi: 10.1016/j.bja.2017.11.009. Epub 2017 Nov 21.


Empirically Derived Lessons Learned about What Makes Peer-Led Exercise Groups Flourish.

Fletcher KE, Ertl K, Ruffalo L, Harris L, Whittle J.

Prog Community Health Partnersh. 2017;11(4):379-386. doi: 10.1353/cpr.2017.0045.


High-Velocity Nasal Insufflation in the Treatment of Respiratory Failure: A Randomized Clinical Trial.

Doshi P, Whittle JS, Bublewicz M, Kearney J, Ashe T, Graham R, Salazar S, Ellis TW Jr, Maynard D, Dennis R, Tillotson A, Hill M, Granado M, Gordon N, Dunlap C, Spivey S, Miller TL.

Ann Emerg Med. 2018 Jul;72(1):73-83.e5. doi: 10.1016/j.annemergmed.2017.12.006. Epub 2018 Jan 6.


Cell sheets in cell therapies.

Kirby GTS, Michelmore A, Smith LE, Whittle JD, Short RD.

Cytotherapy. 2018 Feb;20(2):169-180. doi: 10.1016/j.jcyt.2017.11.004. Epub 2017 Dec 15. Review.


Particle aggregates formed during furfuryl methacrylate plasma polymerization affect human mesenchymal stem cell behaviour.

Shirazi HS, Rogers N, Michelmore A, Whittle JD.

Colloids Surf B Biointerfaces. 2018 Jan 1;161:261-268. doi: 10.1016/j.colsurfb.2017.10.065. Epub 2017 Oct 26.


Hemodynamics During Dialysis and Changes in Cognitive Performance.

Wolfgram D, Vogt E, Jahn AL, Smith HM, Sussman J, Visotcky A, Laud P, Whittle J.

WMJ. 2016 Dec;115(6):311-6.


Precision oncology using a clinician-directed, tailored approach to molecular profiling.

Lam M, Tran B, Beck S, Tie J, Herath D, Whittle J, Kwan EM, Fox SB, Fellowes A, Ananda S, Lipton L, Gibbs P, Rosenthal MA, Desai J.

Asia Pac J Clin Oncol. 2018 Feb;14(1):84-90. doi: 10.1111/ajco.12787. Epub 2017 Oct 30.


Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis.

Septimus EJ, Coopersmith CM, Whittle J, Hale CP, Fishman NO, Kim TJ.

Clin Infect Dis. 2017 Oct 16;65(9):1565-1569. doi: 10.1093/cid/cix603.


Influence of metabolic syndrome and race on the relationship between intensive blood pressure control and cardiovascular outcomes in the SPRINT cohort.

Dungan K, Craven TE, Soe K, Wright JT Jr, Basile J, Haley WE, Kressin NR, Rani U, Tamariz L, Whittle J, Wiggers A, Osei K.

Diabetes Obes Metab. 2018 Mar;20(3):629-637. doi: 10.1111/dom.13127. Epub 2017 Nov 9.


Influence of Baseline Diastolic Blood Pressure on Effects of Intensive Compared With Standard Blood Pressure Control.

Beddhu S, Chertow GM, Cheung AK, Cushman WC, Rahman M, Greene T, Wei G, Campbell RC, Conroy M, Freedman BI, Haley W, Horwitz E, Kitzman D, Lash J, Papademetriou V, Pisoni R, Riessen E, Rosendorff C, Watnick SG, Whittle J, Whelton PK; SPRINT Research Group.

Circulation. 2018 Jan 9;137(2):134-143. doi: 10.1161/CIRCULATIONAHA.117.030848. Epub 2017 Oct 11.


Clinical Outcomes by Race and Ethnicity in the Systolic Blood Pressure Intervention Trial (SPRINT): A Randomized Clinical Trial.

Still CH, Rodriguez CJ, Wright JT Jr, Craven TE, Bress AP, Chertow GM, Whelton PK, Whittle JC, Freedman BI, Johnson KC, Foy CG, He J, Kostis JB, Lash JP, Pedley CF, Pisoni R, Powell JR, Wall BM; SPRINT Writing Group.

Am J Hypertens. 2017 Dec 8;31(1):97-107. doi: 10.1093/ajh/hpx138.


Immobilization of vitronectin-binding heparan sulfates onto surfaces to support human pluripotent stem cells.

Yap L, Murali S, Bhakta G, Titmarsh DM, Chen AK, Chiin Sim L, Bardor M, Lim YM, Goh JCH, Oh SKW, Choo ABH, van Wijnen AJ, Robinson DE, Whittle JD, Birch WR, Short RD, Nurcombe V, Cool SM.

J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):1887-1896. doi: 10.1002/jbm.b.33999. Epub 2017 Sep 20.


Boy With Muscle Spasms.

Neal M, Culbertson MC 3rd, Mendiratta S, Smith BC 3rd, Whittle JS.

Ann Emerg Med. 2017 Sep;70(3):432-440. doi: 10.1016/j.annemergmed.2017.03.050. No abstract available.


Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes.

Berlowitz DR, Foy CG, Kazis LE, Bolin LP, Conroy MB, Fitzpatrick P, Gure TR, Kimmel PL, Kirchner K, Morisky DE, Newman J, Olney C, Oparil S, Pajewski NM, Powell J, Ramsey T, Simmons DL, Snyder J, Supiano MA, Weiner DE, Whittle J; SPRINT Research Group.

N Engl J Med. 2017 Aug 24;377(8):733-744. doi: 10.1056/NEJMoa1611179.


Cost-Effectiveness of Intensive versus Standard Blood-Pressure Control.

Bress AP, Bellows BK, King JB, Hess R, Beddhu S, Zhang Z, Berlowitz DR, Conroy MB, Fine L, Oparil S, Morisky DE, Kazis LE, Ruiz-Negrón N, Powell J, Tamariz L, Whittle J, Wright JT Jr, Supiano MA, Cheung AK, Weintraub WS, Moran AE; SPRINT Research Group.

N Engl J Med. 2017 Aug 24;377(8):745-755. doi: 10.1056/NEJMsa1616035.


Patient Navigation for Patients Frequently Visiting the Emergency Department: A Randomized, Controlled Trial.

Seaberg D, Elseroad S, Dumas M, Mendiratta S, Whittle J, Hyatte C, Keys J.

Acad Emerg Med. 2017 Nov;24(11):1327-1333. doi: 10.1111/acem.13280. Epub 2017 Sep 23.


Autonomic regulation of systemic inflammation in humans: A multi-center, blinded observational cohort study.

Ackland GL, Minto G, Clark M, Whittle J, Stephens RCM, Owen T, Prabhu P, Del Arroyo AG.

Brain Behav Immun. 2018 Jan;67:47-53. doi: 10.1016/j.bbi.2017.08.010. Epub 2017 Aug 12.


Preliminary Performance on the New CMS Sepsis-1 National Quality Measure: Early Insights From the Emergency Quality Network (E-QUAL).

Venkatesh AK, Slesinger T, Whittle J, Osborn T, Aaronson E, Rothenberg C, Tarrant N, Goyal P, Yealy DM, Schuur JD.

Ann Emerg Med. 2018 Jan;71(1):10-15.e1. doi: 10.1016/j.annemergmed.2017.06.032. Epub 2017 Aug 5.


Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer.

Merino D, Whittle JR, Vaillant F, Serrano A, Gong JN, Giner G, Maragno AL, Chanrion M, Schneider E, Pal B, Li X, Dewson G, Gräsel J, Liu K, Lalaoui N, Segal D, Herold MJ, Huang DCS, Smyth GK, Geneste O, Lessene G, Visvader JE, Lindeman GJ.

Sci Transl Med. 2017 Aug 2;9(401). pii: eaam7049. doi: 10.1126/scitranslmed.aam7049.


Visit-to-Visit Office Blood Pressure Variability and Cardiovascular Outcomes in SPRINT (Systolic Blood Pressure Intervention Trial).

Chang TI, Reboussin DM, Chertow GM, Cheung AK, Cushman WC, Kostis WJ, Parati G, Raj D, Riessen E, Shapiro B, Stergiou GS, Townsend RR, Tsioufis K, Whelton PK, Whittle J, Wright JT, Papademetriou V; SPRINT Research Group*.

Hypertension. 2017 Oct;70(4):751-758. doi: 10.1161/HYPERTENSIONAHA.117.09788. Epub 2017 Jul 31.


Genomic diagnosis for children with intellectual disability and/or developmental delay.

Bowling KM, Thompson ML, Amaral MD, Finnila CR, Hiatt SM, Engel KL, Cochran JN, Brothers KB, East KM, Gray DE, Kelley WV, Lamb NE, Lose EJ, Rich CA, Simmons S, Whittle JS, Weaver BT, Nesmith AS, Myers RM, Barsh GS, Bebin EM, Cooper GM.

Genome Med. 2017 May 30;9(1):43. doi: 10.1186/s13073-017-0433-1.


Vagal determinants of exercise capacity.

Machhada A, Trapp S, Marina N, Stephens RCM, Whittle J, Lythgoe MF, Kasparov S, Ackland GL, Gourine AV.

Nat Commun. 2017 May 18;8:15097. doi: 10.1038/ncomms15097.

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