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A Two-Center Randomized Trial of an Additional Early Dose of Measles Vaccine: Effects on Mortality and Measles Antibody Levels.

Fisker AB, Nebie E, Schoeps A, Martins C, Rodrigues A, Zakane A, Kagone M, Byberg S, Thysen SM, Tiendrebeogo J, Coulibaly B, Sankoh O, Becher H, Whittle HC, van der Klis FRM, Benn CS, Sie A, Müller O, Aaby P.

Clin Infect Dis. 2018 May 2;66(10):1573-1580. doi: 10.1093/cid/cix1033.


KIR content genotypes associate with carriage of hepatitis B surface antigen, e antigen and HBV viral load in Gambians.

Yindom LM, Mendy M, Bodimeade C, Chambion C, Aka P, Whittle HC, Rowland-Jones SL, Walton R.

PLoS One. 2017 Nov 17;12(11):e0188307. doi: 10.1371/journal.pone.0188307. eCollection 2017.


Negative Correlation between Circulating CD4+FOXP3+CD127- Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not Diphtheria-Tetanus-Pertussis Vaccine Implies a Regulatory Role.

Ndure J, Noho-Konteh F, Adetifa JU, Cox M, Barker F, Le MT, Sanyang LC, Drammeh A, Whittle HC, Clarke E, Plebanski M, Rowland-Jones SL, Flanagan KL.

Front Immunol. 2017 Aug 14;8:921. doi: 10.3389/fimmu.2017.00921. eCollection 2017.


Correlates of Mono- and Dual-Victims of Cybergrooming and Cyberbullying: Evidence from Four Countries.

Wachs S, Whittle HC, Hamilton-Giachritsis C, Wolf KD, Vazsonyi AT, Junger M.

Cyberpsychol Behav Soc Netw. 2018 Feb;21(2):91-98. doi: 10.1089/cyber.2016.0733. Epub 2017 Jun 28.


Campaigns with oral polio vaccine may lower mortality and create unexpected results.

Benn CS, Jacobsen LH, Fisker AB, Rodrigues A, Sartono E, Lund N, Whittle HC, Aaby P.

Vaccine. 2017 Feb 22;35(8):1113-1116. doi: 10.1016/j.vaccine.2016.11.006. Epub 2017 Jan 27.


Does oral polio vaccine have non-specific effects on all-cause mortality? Natural experiments within a randomised controlled trial of early measles vaccine.

Aaby P, Andersen A, Martins CL, Fisker AB, Rodrigues A, Whittle HC, Benn CS.

BMJ Open. 2016 Dec 23;6(12):e013335. doi: 10.1136/bmjopen-2016-013335.


Randomized Trials Comparing Inactivated Vaccine After Medium- or High-titer Measles Vaccine With Standard Titer Measles Vaccine After Inactivated Vaccine: A Meta-analysis.

Aaby P, Ravn H, Benn CS, Rodrigues A, Samb B, Ibrahim SA, Libman MD, Whittle HC.

Pediatr Infect Dis J. 2016 Nov;35(11):1232-1241.


Revaccination with Live Attenuated Vaccines Confer Additional Beneficial Nonspecific Effects on Overall Survival: A Review.

Benn CS, Fisker AB, Whittle HC, Aaby P.

EBioMedicine. 2016 Aug;10:312-7. doi: 10.1016/j.ebiom.2016.07.016. Epub 2016 Jul 15. Review.


Changing oral vaccine to inactivated polio vaccine might increase mortality.

Fish EN, Flanagan KL, Furman D, Klein SL, Kollmann TR, Jeppesen DL, Levy O, Marchant A, Namachivayam S, Netea MG, Plebanski M, Rowland-Jones SL, Selin LK, Shann F, Whittle HC.

Lancet. 2016 Mar 12;387(10023):1054-1055. doi: 10.1016/S0140-6736(16)00661-9. No abstract available.


Correction. The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated.

Jallow S, Leligdowicz A, Kramer HB, Onyango C, Cotten M, Wright C, Whittle HC, McMichael A, Dong T, Kessler BM, Rowland-Jones SL.

Eur J Immunol. 2015 Sep;45(9):2701. doi: 10.1002/eji.201570096. No abstract available.


The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated.

Jallow S, Leligdowicz A, Kramer HB, Onyango C, Cotten M, Wright C, Whittle HC, McMichael A, Dong T, Kessler BM, Rowland-Jones SL.

Eur J Immunol. 2015 Aug;45(8):2232-42. doi: 10.1002/eji.201545451. Epub 2015 Jun 24. Erratum in: Eur J Immunol. 2015 Sep;45(9):2701.


Early virological and immunological events in asymptomatic Epstein-Barr virus infection in African children.

Jayasooriya S, de Silva TI, Njie-jobe J, Sanyang C, Leese AM, Bell AI, McAulay KA, Yanchun P, Long HM, Dong T, Whittle HC, Rickinson AB, Rowland-Jones SL, Hislop AD, Flanagan KL.

PLoS Pathog. 2015 Mar 27;11(3):e1004746. doi: 10.1371/journal.ppat.1004746. eCollection 2015 Mar.


Is early measles vaccination better than later measles vaccination?

Aaby P, Martins CL, Ravn H, Rodrigues A, Whittle HC, Benn CS.

Trans R Soc Trop Med Hyg. 2015 Jan;109(1):16-28. doi: 10.1093/trstmh/tru174. Review.


Measles vaccination in the presence or absence of maternal measles antibody: impact on child survival.

Aaby P, Martins CL, Garly ML, Andersen A, Fisker AB, Claesson MH, Ravn H, Rodrigues A, Whittle HC, Benn CS.

Clin Infect Dis. 2014 Aug 15;59(4):484-92. doi: 10.1093/cid/ciu354. Epub 2014 May 14.


Mortality rates in people dually infected with HIV-1/2 and those infected with either HIV-1 or HIV-2: a systematic review and meta-analysis.

Prince PD, Matser A, van Tienen C, Whittle HC, Schim van der Loeff MF.

AIDS. 2014 Feb 20;28(4):549-58. doi: 10.1097/01.SPC.0000432532.87841.78. Review.


Host iron redistribution as a risk factor for incident tuberculosis in HIV infection: an 11-year retrospective cohort study.

McDermid JM, Hennig BJ, van der Sande M, Hill AV, Whittle HC, Jaye A, Prentice AM.

BMC Infect Dis. 2013 Jan 29;13:48. doi: 10.1186/1471-2334-13-48.


Clinical predictors cannot replace biological predictors in HIV-2 infection in a community setting in West Africa.

Gourlay AJ, van Tienen C, Dave SS, Vincent T, Rowland-Jones SL, Glynn JR, Whittle HC, van der Loeff MF.

Int J Infect Dis. 2012 May;16(5):e337-43. doi: 10.1016/j.ijid.2012.01.001. Epub 2012 Mar 2.


Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial.

Aaby P, Martins CL, Garly ML, Balé C, Andersen A, Rodrigues A, Ravn H, Lisse IM, Benn CS, Whittle HC.

BMJ. 2010 Nov 30;341:c6495. doi: 10.1136/bmj.c6495.


CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa.

Hennig BJ, Velez-Edwards DR, Schim van der Loeff MF, Bisseye C, Edwards TL, Tacconelli A, Novelli G, Aaby P, Kaye S, Scott WK, Jaye A, Whittle HC, Williams SM, Hill AV, Sirugo G.

J Acquir Immune Defic Syndr. 2011 Jan 1;56(1):1-8. doi: 10.1097/QAI.0b013e3181f638ed.


Host genetic factors and vaccine-induced immunity to HBV infection: haplotype analysis.

Ryckman KK, Fielding K, Hill AV, Mendy M, Rayco-Solon P, Sirugo G, van der Sande MA, Waight P, Whittle HC, Hall AJ, Williams SM, Hennig BJ.

PLoS One. 2010 Aug 18;5(8):e12273. doi: 10.1371/journal.pone.0012273. Erratum in: PLoS One. 2011;6(2). doi: 10.1371/annotation/11e67751-207c-4313-b239-3dd32d8ac126.


Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.

Yindom LM, Leligdowicz A, Martin MP, Gao X, Qi Y, Zaman SM, van der Loeff MS, van Tienen C, Jaye A, Aveika A, Worwui A, Diatta M, Vincent T, Whittle HC, Rowland-Jones SL, Walton R, Carrington M.

J Virol. 2010 Aug;84(16):8202-8. doi: 10.1128/JVI.00116-10. Epub 2010 Jun 2.


Polyfunctional CD4(+) and CD8(+) T cell responses to tuberculosis antigens in HIV-1-infected patients before and after anti-retroviral treatment.

Sutherland JS, Young JM, Peterson KL, Sanneh B, Whittle HC, Rowland-Jones SL, Adegbola RA, Jaye A, Ota MO.

J Immunol. 2010 Jun 1;184(11):6537-44. doi: 10.4049/jimmunol.1000399. Epub 2010 Apr 30.


Acquisition of antibody isotypes against Plasmodium falciparum blood stage antigens in a birth cohort.

Duah NO, Miles DJ, Whittle HC, Conway DJ.

Parasite Immunol. 2010 Feb;32(2):125-34. doi: 10.1111/j.1365-3024.2009.01165.x.


Host genetic contribution to the cellular immune response to Chlamydia trachomatis: Heritability estimate from a Gambian twin study.

Bailey RL, Natividad-Sancho A, Fowler A, Peeling RW, Mabey DC, Whittle HC, Jepson AP.

Drugs Today (Barc). 2009 Nov;45 Suppl B:45-50.


Heritability of antibody isotype and subclass responses to Plasmodium falciparum antigens.

Duah NO, Weiss HA, Jepson A, Tetteh KK, Whittle HC, Conway DJ.

PLoS One. 2009 Oct 8;4(10):e7381. doi: 10.1371/journal.pone.0007381.


Mortality in HIV infection is independently predicted by host iron status and SLC11A1 and HP genotypes, with new evidence of a gene-nutrient interaction.

McDermid JM, van der Loeff MF, Jaye A, Hennig BJ, Bates C, Todd J, Sirugo G, Hill AV, Whittle HC, Prentice AM.

Am J Clin Nutr. 2009 Jul;90(1):225-33. doi: 10.3945/ajcn.2009.27709. Epub 2009 May 27.


Changes in malaria indices between 1999 and 2007 in The Gambia: a retrospective analysis.

Ceesay SJ, Casals-Pascual C, Erskine J, Anya SE, Duah NO, Fulford AJ, Sesay SS, Abubakar I, Dunyo S, Sey O, Palmer A, Fofana M, Corrah T, Bojang KA, Whittle HC, Greenwood BM, Conway DJ.

Lancet. 2008 Nov 1;372(9649):1545-54. doi: 10.1016/S0140-6736(08)61654-2.


A call for randomized controlled trials of antiretroviral therapy for HIV-2 infection in West Africa.

Gottlieb GS, Eholié SP, Nkengasong JN, Jallow S, Rowland-Jones S, Whittle HC, Sow PS.

AIDS. 2008 Oct 18;22(16):2069-72; discussion 2073-4. doi: 10.1097/QAD.0b013e32830edd44. No abstract available.


Protective efficacy of standard Edmonston-Zagreb measles vaccination in infants aged 4.5 months: interim analysis of a randomised clinical trial.

Martins CL, Garly ML, Balé C, Rodrigues A, Ravn H, Whittle HC, Lisse IM, Aaby P.

BMJ. 2008 Jul 24;337:a661. doi: 10.1136/bmj.a661.


Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia.

Mendy ME, McConkey SJ, Sande van der MA, Crozier S, Kaye S, Jeffries D, Hall AJ, Whittle HC.

Virol J. 2008 Apr 16;5:49. doi: 10.1186/1743-422X-5-49.


Host genetic factors and vaccine-induced immunity to hepatitis B virus infection.

Hennig BJ, Fielding K, Broxholme J, Diatta M, Mendy M, Moore C, Pollard AJ, Rayco-Solon P, Sirugo G, van der Sande MA, Waight P, Whittle HC, Zaman SM, Hill AV, Hall AJ.

PLoS One. 2008 Mar 26;3(3):e1898. doi: 10.1371/journal.pone.0001898. Erratum in: PLoS One. 2011;6(2). doi: 10.1371/annotation/0d903d46-1104-43b8-ae6b-4f2343bb3357.


Polyfunctional T cell responses are a hallmark of HIV-2 infection.

Duvall MG, Precopio ML, Ambrozak DA, Jaye A, McMichael AJ, Whittle HC, Roederer M, Rowland-Jones SL, Koup RA.

Eur J Immunol. 2008 Feb;38(2):350-63. doi: 10.1002/eji.200737768.


Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection.

Duvall MG, Loré K, Blaak H, Ambrozak DA, Adams WC, Santos K, Geldmacher C, Mascola JR, McMichael AJ, Jaye A, Whittle HC, Rowland-Jones SL, Koup RA.

J Virol. 2007 Dec;81(24):13486-98. Epub 2007 Oct 3.


Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence.

van der Sande MA, Waight PA, Mendy M, Zaman S, Kaye S, Sam O, Kahn A, Jeffries D, Akum AA, Hall AJ, Bah E, McConkey SJ, Hainaut P, Whittle HC.

PLoS One. 2007 Aug 15;2(8):e753.


Risk factors for and clinical outcome of congenital cytomegalovirus infection in a peri-urban West-African birth cohort.

van der Sande MA, Kaye S, Miles DJ, Waight P, Jeffries DJ, Ojuola OO, Palmero M, Pinder M, Ismaili J, Flanagan KL, Aveika AA, Zaman A, Rowland-Jones S, McConkey SJ, Whittle HC, Marchant A.

PLoS One. 2007 Jun 6;2(6):e492.


Out of Africa: what can we learn from HIV-2 about protective immunity to HIV-1?

Rowland-Jones SL, Whittle HC.

Nat Immunol. 2007 Apr;8(4):329-31. Review.


Similar long-term vaccine efficacy of two versus three doses of HBV vaccine in early life.

van der Sande MA, Mendy M, Waight P, Doherty C, McConkey SJ, Hall AJ, Whittle HC.

Vaccine. 2007 Feb 9;25(8):1509-12. Epub 2006 Oct 30.


Prophylactic antibiotics to prevent pneumonia and other complications after measles: community based randomised double blind placebo controlled trial in Guinea-Bissau.

Garly ML, Balé C, Martins CL, Whittle HC, Nielsen J, Lisse IM, Aaby P.

BMJ. 2006 Dec 16;333(7581):1245. Epub 2006 Oct 23. Erratum in: BMJ. 2016 May 27;353:i3040.


Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.

Frodsham AJ, Zhang L, Dumpis U, Taib NA, Best S, Durham A, Hennig BJ, Hellier S, Knapp S, Wright M, Chiaramonte M, Bell JI, Graves M, Whittle HC, Thomas HC, Thursz MR, Hill AV.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9148-53. Epub 2006 Jun 6.


Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection.

Duvall MG, Jaye A, Dong T, Brenchley JM, Alabi AS, Jeffries DJ, van der Sande M, Togun TO, McConkey SJ, Douek DC, McMichael AJ, Whittle HC, Koup RA, Rowland-Jones SL.

J Immunol. 2006 Jun 1;176(11):6973-81.


The role of Chlamydia pneumoniae in acute respiratory tract infections in young children in The Gambia, West Africa.

Weber MW, Gopalakrishna G, Awomoyi A, Cunningham A, Adegbola RA, Falade AG, Ogunlesi OO, Whittle HC, Mulholland EK.

Ann Trop Paediatr. 2006 Jun;26(2):87-94.


Long-term protection against carriage of hepatitis B virus after infant vaccination.

van der Sande MA, Waight P, Mendy M, Rayco-Solon P, Hutt P, Fulford T, Doherty C, McConkey SJ, Jeffries D, Hall AJ, Whittle HC.

J Infect Dis. 2006 Jun 1;193(11):1528-35. Epub 2006 Apr 25.


Sixteen years of HIV surveillance in a West African research clinic reveals divergent epidemic trends of HIV-1 and HIV-2.

van der Loeff MF, Awasana AA, Sarge-Njie R, van der Sande M, Jaye A, Sabally S, Corrah T, McConkey SJ, Whittle HC.

Int J Epidemiol. 2006 Oct;35(5):1322-8. Epub 2006 Mar 16.


Baseline plasma viral load and CD4 cell percentage predict survival in HIV-1- and HIV-2-infected women in a community-based cohort in The Gambia.

Hansmann A, Schim van der Loeff MF, Kaye S, Awasana AA, Sarge-Njie R, O'Donovan D, Ariyoshi K, Alabi A, Milligan P, Whittle HC.

J Acquir Immune Defic Syndr. 2005 Mar 1;38(3):335-41.


EPI vaccines-induced antibody prevalence in 8-9 year-olds in The Gambia.

Viviani S, Mendy M, Jack AD, Hall AJ, Montesano R, Whittle HC.

Trop Med Int Health. 2004 Oct;9(10):1044-9.


Dual HIV-1 and HIV-2 infection in a West African infant.

van der Sande MA, Luong TN, Schim van der Loeff MF, Sabally S, Aveika AA, Corrah T, Sarge-Njie R, Kaye S, Whittle HC.

Ann Trop Paediatr. 2004 Sep;24(3):277-8. No abstract available.


Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa.

Wojnowski L, Turner PC, Pedersen B, Hustert E, Brockmöller J, Mendy M, Whittle HC, Kirk G, Wild CP.

Pharmacogenetics. 2004 Oct;14(10):691-700.


Body mass index at time of HIV diagnosis: a strong and independent predictor of survival.

van der Sande MA, Schim van der Loeff MF, Aveika AA, Sabally S, Togun T, Sarge-Njie R, Alabi AS, Jaye A, Corrah T, Whittle HC.

J Acquir Immune Defic Syndr. 2004 Oct 1;37(2):1288-94.


Incidence of tuberculosis and survival after its diagnosis in patients infected with HIV-1 and HIV-2.

van der Sande MA, Schim van der Loeff MF, Bennett RC, Dowling M, Aveika AA, Togun TO, Sabally S, Jeffries D, Adegbola RA, Sarge-Njie R, Jaye A, Corrah T, McConkey S, Whittle HC.

AIDS. 2004 Sep 24;18(14):1933-41.


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