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Pharmacology of the single isomer, esuberaprost (beraprost-314d) on pulmonary vascular tone, IP receptors and human smooth muscle proliferation in pulmonary hypertension.

Shen L, Patel JA, Norel X, Moledina S, Whittle BJ, von Kessler K, Sista P, Clapp LH.

Biochem Pharmacol. 2019 Aug;166:242-252. doi: 10.1016/j.bcp.2019.05.026. Epub 2019 May 31.


Prostanoid EP₂ Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells.

Patel JA, Shen L, Hall SM, Benyahia C, Norel X, McAnulty RJ, Moledina S, Silverstein AM, Whittle BJ, Clapp LH.

Int J Mol Sci. 2018 Aug 12;19(8). pii: E2372. doi: 10.3390/ijms19082372.


Elongator mutation in mice induces neurodegeneration and ataxia-like behavior.

Kojic M, Gaik M, Kiska B, Salerno-Kochan A, Hunt S, Tedoldi A, Mureev S, Jones A, Whittle B, Genovesi LA, Adolphe C, Brown DL, Stow JL, Alexandrov K, Sah P, Glatt S, Wainwright BJ.

Nat Commun. 2018 Aug 10;9(1):3195. doi: 10.1038/s41467-018-05765-6.


A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.

Oakes SR, Gallego-Ortega D, Stanford PM, Junankar S, Au WWY, Kikhtyak Z, von Korff A, Sergio CM, Law AMK, Castillo LE, Allerdice SL, Young AIJ, Piggin C, Whittle B, Bertram E, Naylor MJ, Roden DL, Donovan J, Korennykh A, Goodnow CC, O'Bryan MK, Ormandy CJ.

PLoS Genet. 2017 Nov 8;13(11):e1007072. doi: 10.1371/journal.pgen.1007072. eCollection 2017 Nov.


Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1.

Tuure L, Hämäläinen M, Whittle BJ, Moilanen E.

Front Pharmacol. 2017 Sep 21;8:646. doi: 10.3389/fphar.2017.00646. eCollection 2017.


Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.

Lu H, Galeano MCR, Ott E, Kaeslin G, Kausalya PJ, Kramer C, Ortiz-Brüchle N, Hilger N, Metzis V, Hiersche M, Tay SY, Tunningley R, Vij S, Courtney AD, Whittle B, Wühl E, Vester U, Hartleben B, Neuber S, Frank V, Little MH, Epting D, Papathanasiou P, Perkins AC, Wright GD, Hunziker W, Gee HY, Otto EA, Zerres K, Hildebrandt F, Roy S, Wicking C, Bergmann C.

Nat Genet. 2017 Jul;49(7):1025-1034. doi: 10.1038/ng.3871. Epub 2017 May 22.


Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion.

Wu Z, Liang R, Ohnesorg T, Cho V, Lam W, Abhayaratna WP, Gatenby PA, Perera C, Zhang Y, Whittle B, Sinclair A, Goodnow CC, Field M, Andrews TD, Cook MC.

PLoS Genet. 2016 May 26;12(5):e1006067. doi: 10.1371/journal.pgen.1006067. eCollection 2016 May.


Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr.

Thoms JA, Knezevic K, Liu JJ, Glaros EN, Thai T, Qiao Q, Campbell H, Packham D, Huang Y, Papathanasiou P, Tunningley R, Whittle B, Yeung AW, Chandrakanthan V, Hesson L, Chen V, Wong JW, Purton LE, Ward RL, Thomas SR, Pimanda JE.

Mol Cell Biol. 2016 Mar 31;36(8):1222-36. doi: 10.1128/MCB.01035-15. Print 2016 Apr.


Comparison of predicted and actual consequences of missense mutations.

Miosge LA, Field MA, Sontani Y, Cho V, Johnson S, Palkova A, Balakishnan B, Liang R, Zhang Y, Lyon S, Beutler B, Whittle B, Bertram EM, Enders A, Goodnow CC, Andrews TD.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5189-98. doi: 10.1073/pnas.1511585112. Epub 2015 Aug 12.


The use of dried blood spot sampling for the measurement of HbA1c: a cross-sectional study.

Mastronardi CA, Whittle B, Tunningley R, Neeman T, Paz-Filho G.

BMC Clin Pathol. 2015 Jul 8;15:13. doi: 10.1186/s12907-015-0013-5. eCollection 2015.


Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers.

Rahimpour A, Koay HF, Enders A, Clanchy R, Eckle SB, Meehan B, Chen Z, Whittle B, Liu L, Fairlie DP, Goodnow CC, McCluskey J, Rossjohn J, Uldrich AP, Pellicci DG, Godfrey DI.

J Exp Med. 2015 Jun 29;212(7):1095-108. doi: 10.1084/jem.20142110. Epub 2015 Jun 22.


A de novo Mutation in KMT2A (MLL) in monozygotic twins with Wiedemann-Steiner syndrome.

Dunkerton S, Field M, Cho V, Bertram E, Whittle B, Groves A, Goel H.

Am J Med Genet A. 2015 Sep;167A(9):2182-7. doi: 10.1002/ajmg.a.37130. Epub 2015 Apr 30.


LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.

Liu Y, DeBoer K, de Kretser DM, O'Donnell L, O'Connor AE, Merriner DJ, Okuda H, Whittle B, Jans DA, Efthymiadis A, McLachlan RI, Ormandy CJ, Goodnow CC, Jamsai D, O'Bryan MK.

PLoS Genet. 2015 Mar 17;11(3):e1005090. doi: 10.1371/journal.pgen.1005090. eCollection 2015 Mar.


Reducing the search space for causal genetic variants with VASP.

Field MA, Cho V, Cook MC, Enders A, Vinuesa CG, Whittle B, Andrews TD, Goodnow CC.

Bioinformatics. 2015 Jul 15;31(14):2377-9. doi: 10.1093/bioinformatics/btv135. Epub 2015 Mar 8.


A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred.

Taupin D, Lam W, Rangiah D, McCallum L, Whittle B, Zhang Y, Andrews D, Field M, Goodnow CC, Cook MC.

Hum Genome Var. 2015 Apr 16;2:15013. doi: 10.1038/hgv.2015.13. eCollection 2015.


Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.

Han BY, Wu S, Foo CS, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC, Cyster JG.

Elife. 2014 Oct 24;3. doi: 10.7554/eLife.03549.


Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100.

Lee CE, Fulcher DA, Whittle B, Chand R, Fewings N, Field M, Andrews D, Goodnow CC, Cook MC.

Blood. 2014 Nov 6;124(19):2964-72. doi: 10.1182/blood-2014-06-578542. Epub 2014 Sep 18.


Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.

Enders A, Short A, Miosge LA, Bergmann H, Sontani Y, Bertram EM, Whittle B, Balakishnan B, Yoshida K, Sjollema G, Field MA, Andrews TD, Hagiwara H, Goodnow CC.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4513-8. doi: 10.1073/pnas.1402739111. Epub 2014 Mar 10.


Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.

Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP.

Elife. 2013 Dec 12;2:e01020. doi: 10.7554/eLife.01020.


A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse.

Jamsai D, Clark BJ, Smith SJ, Whittle B, Goodnow CC, Ormandy CJ, O'Bryan MK.

PLoS One. 2013 Oct 21;8(10):e77311. doi: 10.1371/journal.pone.0077311. eCollection 2013.


RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility.

O'Bryan MK, Clark BJ, McLaughlin EA, D'Sylva RJ, O'Donnell L, Wilce JA, Sutherland J, O'Connor AE, Whittle B, Goodnow CC, Ormandy CJ, Jamsai D.

PLoS Genet. 2013;9(7):e1003628. doi: 10.1371/journal.pgen.1003628. Epub 2013 Jul 25.


Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins.

Orie NN, Ledwozyw A, Williams DJ, Whittle BJ, Clapp LH.

Prostaglandins Other Lipid Mediat. 2013 Oct;106:1-7. doi: 10.1016/j.prostaglandins.2013.07.003. Epub 2013 Jul 18.


Single nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition.

Delerue F, Sjollema G, Whittle B, Krüger S, Andrews D, Götz J.

J Alzheimers Dis. 2013;36(2):349-63. doi: 10.3233/JAD-130089.


Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease.

Caruana G, Farlie PG, Hart AH, Bagheri-Fam S, Wallace MJ, Dobbie MS, Gordon CT, Miller KA, Whittle B, Abud HE, Arkell RM, Cole TJ, Harley VR, Smyth IM, Bertram JF.

PLoS One. 2013;8(3):e55429. doi: 10.1371/journal.pone.0055429. Epub 2013 Mar 1.


Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.

Bull KR, Rimmer AJ, Siggs OM, Miosge LA, Roots CM, Enders A, Bertram EM, Crockford TL, Whittle B, Potter PK, Simon MM, Mallon AM, Brown SD, Beutler B, Goodnow CC, Lunter G, Cornall RJ.

PLoS Genet. 2013;9(1):e1003219. doi: 10.1371/journal.pgen.1003219. Epub 2013 Jan 31.


B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.

Bergmann H, Yabas M, Short A, Miosge L, Barthel N, Teh CE, Roots CM, Bull KR, Jeelall Y, Horikawa K, Whittle B, Balakishnan B, Sjollema G, Bertram EM, Mackay F, Rimmer AJ, Cornall RJ, Field MA, Andrews TD, Goodnow CC, Enders A.

J Exp Med. 2013 Jan 14;210(1):31-40. doi: 10.1084/jem.20121076. Epub 2012 Dec 24.


RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.

Lo JC, Jamsai D, O'Connor AE, Borg C, Clark BJ, Whisstock JC, Field MC, Adams V, Ishikawa T, Aitken RJ, Whittle B, Goodnow CC, Ormandy CJ, O'Bryan MK.

PLoS Genet. 2012;8(10):e1002969. doi: 10.1371/journal.pgen.1002969. Epub 2012 Oct 4.


Autoimmunity in primary antibody deficiency is associated with protein tyrosine phosphatase nonreceptor type 22 (PTPN22).

Chew GY, Sinha U, Gatenby PA, DeMalmanche T, Adelstein S, Garsia R, Hissaria P, French MA, Wilson A, Whittle B, Kirkpatrick P, Riminton DS, Fulcher DA, Cook MC.

J Allergy Clin Immunol. 2013 Apr;131(4):1130-5, 1135.e1. doi: 10.1016/j.jaci.2012.06.023. Epub 2012 Jul 31.


Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.

Andrews TD, Whittle B, Field MA, Balakishnan B, Zhang Y, Shao Y, Cho V, Kirk M, Singh M, Xia Y, Hager J, Winslade S, Sjollema G, Beutler B, Enders A, Goodnow CC.

Open Biol. 2012 May;2(5):120061. doi: 10.1098/rsob.120061.


An essential role for katanin p80 and microtubule severing in male gamete production.

O'Donnell L, Rhodes D, Smith SJ, Merriner DJ, Clark BJ, Borg C, Whittle B, O'Connor AE, Smith LB, McNally FJ, de Kretser DM, Goodnow CC, Ormandy CJ, Jamsai D, O'Bryan MK.

PLoS Genet. 2012;8(5):e1002698. doi: 10.1371/journal.pgen.1002698. Epub 2012 May 24.


Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist.

Whittle BJ, Silverstein AM, Mottola DM, Clapp LH.

Biochem Pharmacol. 2012 Jul 1;84(1):68-75. doi: 10.1016/j.bcp.2012.03.012. Epub 2012 Mar 27.


ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice.

Liu X, Dobbie M, Tunningley R, Whittle B, Zhang Y, Ittner LM, Götz J.

J Biomed Biotechnol. 2011;2011:130947. doi: 10.1155/2011/130947. Epub 2011 Dec 15. Review.


The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus.

Cluny NL, Naylor RJ, Whittle BA, Javid FA.

Arch Pharm Res. 2011 Sep;34(9):1509-17. doi: 10.1007/s12272-011-0913-6. Epub 2011 Oct 6.


ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes.

Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A.

Nat Immunol. 2011 May;12(5):441-9. doi: 10.1038/ni.2011. Epub 2011 Mar 20.


Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease.

Nguyen N, Judd LM, Kalantzis A, Whittle B, Giraud AS, van Driel IR.

Am J Physiol Gastrointest Liver Physiol. 2011 Jan;300(1):G1-11. doi: 10.1152/ajpgi.00343.2010. Epub 2010 Oct 14. Review.


Bulk segregation mapping of mutations in closely related strains of mice.

Xia Y, Won S, Du X, Lin P, Ross C, La Vine D, Wiltshire S, Leiva G, Vidal SM, Whittle B, Goodnow CC, Koziol J, Moresco EM, Beutler B.

Genetics. 2010 Dec;186(4):1139-46. doi: 10.1534/genetics.110.121160. Epub 2010 Oct 5.


Protocols to assess the gastrointestinal side effects resulting from inhibition of cyclo-oxygenase isoforms.

Whittle BJ.

Methods Mol Biol. 2010;644:189-200. doi: 10.1007/978-1-59745-364-6_16.


New light on the anti-colitic actions of therapeutic aminosalicylates: the role of heme oxygenase.

Whittle BJ, Varga C.

Pharmacol Rep. 2010 May-Jun;62(3):548-56. Review.


A recessive screen for genes regulating hematopoietic stem cells.

Papathanasiou P, Tunningley R, Pattabiraman DR, Ye P, Gonda TJ, Whittle B, Hamilton AE, Cridland SO, Lourie R, Perkins AC.

Blood. 2010 Dec 23;116(26):5849-58. doi: 10.1182/blood-2010-04-269951. Epub 2010 Jul 7.


Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

Randall KL, Lambe T, Johnson AL, Treanor B, Kucharska E, Domaschenz H, Whittle B, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG, Batista FD, Cornall RJ, Goodnow CC.

Nat Immunol. 2009 Dec;10(12):1283-91. doi: 10.1038/ni.1820. Epub 2009 Nov 8. Erratum in: Nat Immunol. 2010 Jul;11(7):644. Johnson, Andy [corrected to Johnson, Andy L].


Mouse strains with point mutations in TAP1 and TAP2.

Theodoratos A, Whittle B, Enders A, Tscharke DC, Roots CM, Goodnow CC, Fahrer AM.

Immunol Cell Biol. 2010 Jan;88(1):72-8. doi: 10.1038/icb.2009.61. Epub 2009 Sep 1.


Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL.

Wu Z, Jia X, de la Cruz L, Su XC, Marzolf B, Troisch P, Zak D, Hamilton A, Whittle B, Yu D, Sheahan D, Bertram E, Aderem A, Otting G, Goodnow CC, Hoyne GF.

Immunity. 2008 Dec 19;29(6):863-75. doi: 10.1016/j.immuni.2008.11.004.


The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus.

Cluny NL, Naylor RJ, Whittle BA, Javid FA.

Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):150-6. doi: 10.1111/j.1742-7843.2008.00253.x.


The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis.

Horváth K, Varga C, Berkó A, Pósa A, László F, Whittle BJ.

Eur J Pharmacol. 2008 Mar 10;581(3):315-23. doi: 10.1016/j.ejphar.2007.12.004. Epub 2007 Dec 14.


Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase.

Whittle BJ, Varga C, Berko A, Horvath K, Posa A, Riley JP, Lundeen KA, Fourie AM, Dunford PJ.

Br J Pharmacol. 2008 Mar;153(5):983-91. Epub 2007 Dec 24.


A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development.

Gosling KM, Makaroff LE, Theodoratos A, Kim YH, Whittle B, Rui L, Wu H, Hong NA, Kennedy GC, Fritz JA, Yates AL, Goodnow CC, Fahrer AM.

Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12445-50. Epub 2007 Jul 17.


Modulation by heme and zinc protoporphyrin of colonic heme oxygenase-1 and experimental inflammatory bowel disease in the rat.

Varga C, Laszlo F, Fritz P, Cavicchi M, Lamarque D, Horvath K, Posa A, Berko A, Whittle BJ.

Eur J Pharmacol. 2007 Apr 30;561(1-3):164-71. Epub 2007 Jan 20.


Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta.

Whittle BJ, Varga C, Pósa A, Molnár A, Collin M, Thiemermann C.

Br J Pharmacol. 2006 Mar;147(5):575-82.


Nitric oxide-modulating agents for gastrointestinal disorders.

Whittle BJ.

Expert Opin Investig Drugs. 2005 Nov;14(11):1347-58. Review.


Endotoxin can decrease isolated rat parotid acinar cell amylase secretion in a nitric oxide-independent manner.

Barta A, Tarján I, Kittel A, Horváth K, Pósa A, László F, Kovács A, Varga G, Zelles T, Whittle BJ.

Eur J Pharmacol. 2005 Nov 7;524(1-3):169-73. Epub 2005 Oct 25.


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