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Items: 15


Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism.

Valli A, Morotti M, Zois CE, Albers PK, Soga T, Feldinger K, Fischer R, Frejno M, McIntyre A, Bridges E, Haider S, Buffa FM, Baban D, Rodriguez M, Yanes O, Whittington HJ, Lake HA, Zervou S, Lygate CA, Kessler BM, Harris AL.

Mol Cancer Res. 2019 Jul;17(7):1531-1544. doi: 10.1158/1541-7786.MCR-18-0315. Epub 2019 Mar 18.


Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion.

Whittington HJ, Ostrowski PJ, McAndrew DJ, Cao F, Shaw A, Eykyn TR, Lake HA, Tyler J, Schneider JE, Neubauer S, Zervou S, Lygate CA.

Cardiovasc Res. 2018 May 1;114(6):858-869. doi: 10.1093/cvr/cvy054.


Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine.

Faller KME, Atzler D, McAndrew DJ, Zervou S, Whittington HJ, Simon JN, Aksentijevic D, Ten Hove M, Choe CU, Isbrandt D, Casadei B, Schneider JE, Neubauer S, Lygate CA.

Cardiovasc Res. 2018 Mar 1;114(3):417-430. doi: 10.1093/cvr/cvx242.


Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.

Zervou S, Whittington HJ, Ostrowski PJ, Cao F, Tyler J, Lake HA, Neubauer S, Lygate CA.

PLoS One. 2017 Aug 14;12(8):e0182994. doi: 10.1371/journal.pone.0182994. eCollection 2017.


Validation of diffusion tensor MRI measurements of cardiac microstructure with structure tensor synchrotron radiation imaging.

Teh I, McClymont D, Zdora MC, Whittington HJ, Davidoiu V, Lee J, Lygate CA, Rau C, Zanette I, Schneider JE.

J Cardiovasc Magn Reson. 2017 Mar 10;19(1):31. doi: 10.1186/s12968-017-0342-x.


Evaluation of non-Gaussian diffusion in cardiac MRI.

McClymont D, Teh I, Carruth E, Omens J, McCulloch A, Whittington HJ, Kohl P, Grau V, Schneider JE.

Magn Reson Med. 2017 Sep;78(3):1174-1186. doi: 10.1002/mrm.26466. Epub 2016 Sep 26.


Resolving Fine Cardiac Structures in Rats with High-Resolution Diffusion Tensor Imaging.

Teh I, McClymont D, Burton RA, Maguire ML, Whittington HJ, Lygate CA, Kohl P, Schneider JE.

Sci Rep. 2016 Jul 28;6:30573. doi: 10.1038/srep30573.


Protective Effect of Creatine Elevation against Ischaemia Reperfusion Injury Is Retained in the Presence of Co-Morbidities and during Cardioplegia.

Whittington HJ, McAndrew DJ, Cross RL, Neubauer S, Lygate CA.

PLoS One. 2016 Jan 14;11(1):e0146429. doi: 10.1371/journal.pone.0146429. eCollection 2016.


Prospective acceleration of diffusion tensor imaging with compressed sensing using adaptive dictionaries.

McClymont D, Teh I, Whittington HJ, Grau V, Schneider JE.

Magn Reson Med. 2016 Jul;76(1):248-58. doi: 10.1002/mrm.25876. Epub 2015 Aug 24.


Augmentation of Creatine in the Heart.

Zervou S, Whittington HJ, Russell AJ, Lygate CA.

Mini Rev Med Chem. 2016;16(1):19-28. Review.


Dipeptidyl peptidase-4 inhibitors and GLP-1 reduce myocardial infarct size in a glucose-dependent manner.

Hausenloy DJ, Whittington HJ, Wynne AM, Begum SS, Theodorou L, Riksen N, Mocanu MM, Yellon DM.

Cardiovasc Diabetol. 2013 Oct 22;12:154. doi: 10.1186/1475-2840-12-154.


Cardioprotection in the aging, diabetic heart: the loss of protective Akt signalling.

Whittington HJ, Harding I, Stephenson CI, Bell R, Hausenloy DJ, Mocanu MM, Yellon DM.

Cardiovasc Res. 2013 Sep 1;99(4):694-704. doi: 10.1093/cvr/cvt140. Epub 2013 May 30.


Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon.

Whittington HJ, Hall AR, McLaughlin CP, Hausenloy DJ, Yellon DM, Mocanu MM.

Cardiovasc Drugs Ther. 2013 Feb;27(1):5-16. doi: 10.1007/s10557-012-6425-x.


The diabetic heart: too sweet for its own good?

Whittington HJ, Babu GG, Mocanu MM, Yellon DM, Hausenloy DJ.

Cardiol Res Pract. 2012;2012:845698. doi: 10.1155/2012/845698. Epub 2012 Feb 22.


Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus.

Hang JQ, Yang Y, Harris SF, Leveque V, Whittington HJ, Rajyaguru S, Ao-Ieong G, McCown MF, Wong A, Giannetti AM, Le Pogam S, Talamás F, Cammack N, Nájera I, Klumpp K.

J Biol Chem. 2009 Jun 5;284(23):15517-29. doi: 10.1074/jbc.M808889200. Epub 2009 Feb 26.

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