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Items: 31


CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.

Fennell BJ, McDonnell B, Tam AS, Chang L, Steven J, Broadbent ID, Gao H, Kieras E, Alley J, Luxenberg D, Edmonds J, Fitz LJ, Miao W, Whitters MJ, Medley QG, Guo YJ, Darmanin-Sheehan A, Autin B, Shúilleabháin DN, Cummins E, King A, Krebs MR, Grace C, Hickling TP, Boisvert A, Zhong X, McKenna M, Francis C, Olland S, Bloom L, Paulsen J, Somers W, Jensen A, Lin L, Finlay WJ, Cunningham O.

MAbs. 2013 Nov-Dec;5(6):882-95. doi: 10.4161/mabs.26201. Epub 2013 Aug 21.


Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells.

Carrier Y, Whitters MJ, Miyashiro JS, LaBranche TP, Ramon HE, Benoit SE, Ryan MS, Keegan SP, Guay H, Douhan J, Collins M, Dunussi-Joannopoulos K, Medley QG.

Eur J Immunol. 2012 Jun;42(6):1393-404. doi: 10.1002/eji.201142162.


A simple high-throughput purification method for hit identification in protein screening.

Cummins E, Luxenberg DP, McAleese F, Widom A, Fennell BJ, Darmanin-Sheehan A, Whitters MJ, Bloom L, Gill D, Cunningham O.

J Immunol Methods. 2008 Nov 30;339(1):38-46. doi: 10.1016/j.jim.2008.07.016. Epub 2008 Aug 27.


The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex.

Wright JF, Bennett F, Li B, Brooks J, Luxenberg DP, Whitters MJ, Tomkinson KN, Fitz LJ, Wolfman NM, Collins M, Dunussi-Joannopoulos K, Chatterjee-Kishore M, Carreno BM.

J Immunol. 2008 Aug 15;181(4):2799-805.


An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment.

Liang SC, Long AJ, Bennett F, Whitters MJ, Karim R, Collins M, Goldman SJ, Dunussi-Joannopoulos K, Williams CM, Wright JF, Fouser LA.

J Immunol. 2007 Dec 1;179(11):7791-9.


Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis.

Young DA, Hegen M, Ma HL, Whitters MJ, Albert LM, Lowe L, Senices M, Wu PW, Sibley B, Leathurby Y, Brown TP, Nickerson-Nutter C, Keith JC Jr, Collins M.

Arthritis Rheum. 2007 Apr;56(4):1152-63.


Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells.

Wright JF, Guo Y, Quazi A, Luxenberg DP, Bennett F, Ross JF, Qiu Y, Whitters MJ, Tomkinson KN, Dunussi-Joannopoulos K, Carreno BM, Collins M, Wolfman NM.

J Biol Chem. 2007 May 4;282(18):13447-55. Epub 2007 Mar 13.


Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.

Stephens GL, McHugh RS, Whitters MJ, Young DA, Luxenberg D, Carreno BM, Collins M, Shevach EM.

J Immunol. 2004 Oct 15;173(8):5008-20.


Tumor cells secreting IL-13 but not IL-13Ralpha2 fusion protein have reduced tumorigenicity in vivo.

Ma HL, Whitters MJ, Jacobson BA, Donaldson DD, Collins M, Dunussi-Joannopoulos K.

Int Immunol. 2004 Jul;16(7):1009-17. Epub 2004 Jun 7.


IL-21 and IL-21 receptor: a new cytokine pathway modulates innate and adaptive immunity.

Collins M, Whitters MJ, Young DA.

Immunol Res. 2003;28(2):131-40. Review.


IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma.

Ma HL, Whitters MJ, Konz RF, Senices M, Young DA, Grusby MJ, Collins M, Dunussi-Joannopoulos K.

J Immunol. 2003 Jul 15;171(2):608-15.


IL-21 induces the apoptosis of resting and activated primary B cells.

Mehta DS, Wurster AL, Whitters MJ, Young DA, Collins M, Grusby MJ.

J Immunol. 2003 Apr 15;170(8):4111-8.


Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2.

Wood N, Whitters MJ, Jacobson BA, Witek J, Sypek JP, Kasaian M, Eppihimer MJ, Unger M, Tanaka T, Goldman SJ, Collins M, Donaldson DD, Grusby MJ.

J Exp Med. 2003 Mar 17;197(6):703-9.


Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response.

Chiaramonte MG, Mentink-Kane M, Jacobson BA, Cheever AW, Whitters MJ, Goad ME, Wong A, Collins M, Donaldson DD, Grusby MJ, Wynn TA.

J Exp Med. 2003 Mar 17;197(6):687-701.


Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells.

Wurster AL, Rodgers VL, Satoskar AR, Whitters MJ, Young DA, Collins M, Grusby MJ.

J Exp Med. 2002 Oct 7;196(7):969-77.


IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.

Kasaian MT, Whitters MJ, Carter LL, Lowe LD, Jussif JM, Deng B, Johnson KA, Witek JS, Senices M, Konz RF, Wurster AL, Donaldson DD, Collins M, Young DA, Grusby MJ.

Immunity. 2002 Apr;16(4):559-69.


CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.

McHugh RS, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collins M, Byrne MC.

Immunity. 2002 Feb;16(2):311-23.


Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).

Griffin MD, Hong DK, Holman PO, Lee KM, Whitters MJ, O'Herrin SM, Fallarino F, Collins M, Segal DM, Gajewski TF, Kranz DM, Bluestone JA.

J Immunol. 2000 May 1;164(9):4433-42.


Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor.

Waldner H, Whitters MJ, Sobel RA, Collins M, Kuchroo VK.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3412-7.


IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis.

Young DA, Lowe LD, Booth SS, Whitters MJ, Nicholson L, Kuchroo VK, Collins M.

J Immunol. 2000 Apr 1;164(7):3563-72.


The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1.

Donaldson DD, Whitters MJ, Fitz LJ, Neben TY, Finnerty H, Henderson SL, O'Hara RM Jr, Beier DR, Turner KJ, Wood CR, Collins M.

J Immunol. 1998 Sep 1;161(5):2317-24.


Transfection of TCR alpha-chains into suppressor and T helper cell hybridomas. Production of suppressor factors with predicted antigen specificity.

Kuchroo VK, Byrne MC, Greenfield E, Whitters MJ, Nalefsky EA, Rao A, Collins M, Dorf ME.

J Immunol. 1995 May 15;154(10):5030-8.


T cell receptor alpha-chain defines the antigen specificity of antigen-specific suppressor factor but does not impart genetic restriction.

O'Hara RM Jr, Byrne MC, Kuchroo VK, Nagelin A, Whitters MJ, Jayaraman S, Henderson SL, Dorf ME, Collins M.

J Immunol. 1995 Mar 1;154(5):2075-81.


Hamster cDNA homologs to the mouse immunoglobulin kappa constant and Igk-V 45.1 genes.

Whitters MJ, Collins M.

Immunogenetics. 1995;42(3):227-8. No abstract available.


Hamster cDNA homologs to the mouse immunoglobulin IgG2 constant and Igh-VH10 genes.

Collins M, Whitters MJ.

Immunogenetics. 1995;42(3):225-6. No abstract available.


T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice.

Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL, et al.

J Exp Med. 1994 May 1;179(5):1659-64.


T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function.

Kuchroo VK, Byrne MC, Atsumi Y, Greenfield E, Connolly JB, Whitters MJ, O'Hara RM Jr, Collins M, Dorf ME.

Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8700-4.


Expression of functional alpha beta T cell receptor gene rearrangements in suppressor T cell hybridomas correlates with antigen binding, but not with suppressor cell function.

Collins M, Kuchroo VK, Whitters MJ, O'Hara RM Jr, Kelleher K, Kubo RT, Dorf ME.

J Immunol. 1990 Nov 1;145(9):2809-19.


Novel regulators of bone formation: molecular clones and activities.

Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA.

Science. 1988 Dec 16;242(4885):1528-34.


Transcriptional activation of an embryonic globin gene in adult erythroid cells in vivo.

Ginder GD, Whitters MJ, Pohlman JK, Burns LJ.

Prog Clin Biol Res. 1985;191:463-74.


Activation of a chicken embryonic globin gene in adult erythroid cells by 5-azacytidine and sodium butyrate.

Ginder GD, Whitters MJ, Pohlman JK.

Proc Natl Acad Sci U S A. 1984 Jul;81(13):3954-8.

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