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Items: 1 to 50 of 107

1.

Frequent and persistent PLCG1 mutations in Sézary cells directly enhance PLCγ1 activity and stimulate NFκB, AP-1 and NFAT signaling. Short title: Gain-of-function PLCG1 mutations in Sézary Syndrome.

Patel VM, Flanagan CE, Martins M, Jones CL, Butler RM, Woollard WJ, Bakr FS, Yoxall A, Begum N, Katan M, Whittaker SJ, Mitchell TJ.

J Invest Dermatol. 2019 Jul 31. pii: S0022-202X(19)32679-X. doi: 10.1016/j.jid.2019.07.693. [Epub ahead of print]

PMID:
31376383
2.

Contribution of STAT3 and RAD23B in Primary Sézary Cells to Histone Deacetylase Inhibitor FK228 Resistance.

Butler RM, McKenzie RC, Jones CL, Flanagan CE, Woollard WJ, Demontis M, Ferreira S, Tosi I, John S, Whittaker SJ, Mitchell TJ.

J Invest Dermatol. 2019 Sep;139(9):1975-1984.e2. doi: 10.1016/j.jid.2019.03.1130. Epub 2019 Mar 22.

PMID:
30910759
3.

British Association of Dermatologists and U.K. Cutaneous Lymphoma Group guidelines for the management of primary cutaneous lymphomas 2018.

Gilson D, Whittaker SJ, Child FJ, Scarisbrick JJ, Illidge TM, Parry EJ, Mohd Mustapa MF, Exton LS, Kanfer E, Rezvani K, Dearden CE, Morris SL.

Br J Dermatol. 2019 Mar;180(3):496-526. doi: 10.1111/bjd.17240. Epub 2018 Dec 17. No abstract available.

PMID:
30561020
4.

Diffuse large B-cell lymphoma developing in erythrodermic cutaneous T-cell lymphoma: a case series.

Chan BCY, Stefanato CM, Moonim MT, Morris SL, Fields P, Dasgupta D, Therianou A, Whittaker SJ.

Br J Dermatol. 2017 Oct;177(4):e138-e140. doi: 10.1111/bjd.15460. Epub 2017 Sep 11. No abstract available.

PMID:
28301708
5.

Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome.

Woollard WJ, Pullabhatla V, Lorenc A, Patel VM, Butler RM, Bayega A, Begum N, Bakr F, Dedhia K, Fisher J, Aguilar-Duran S, Flanagan C, Ghasemi AA, Hoffmann RM, Castillo-Mosquera N, Nuttall EA, Paul A, Roberts CA, Solomonidis EG, Tarrant R, Yoxall A, Beyers CZ, Ferreira S, Tosi I, Simpson MA, de Rinaldis E, Mitchell TJ, Whittaker SJ.

Blood. 2016 Jun 30;127(26):3387-97. doi: 10.1182/blood-2016-02-699843. Epub 2016 Apr 27.

6.

Independent Loss of Methylthioadenosine Phosphorylase (MTAP) in Primary Cutaneous T-Cell Lymphoma.

Woollard WJ, Kalaivani NP, Jones CL, Roper C, Tung L, Lee JJ, Thomas BR, Tosi I, Ferreira S, Beyers CZ, McKenzie RCT, Butler RM, Lorenc A, Whittaker SJ, Mitchell TJ.

J Invest Dermatol. 2016 Jun;136(6):1238-1246. doi: 10.1016/j.jid.2016.01.028. Epub 2016 Feb 9.

7.

Cutaneous Lymphoma International Consortium Study of Outcome in Advanced Stages of Mycosis Fungoides and Sézary Syndrome: Effect of Specific Prognostic Markers on Survival and Development of a Prognostic Model.

Scarisbrick JJ, Prince HM, Vermeer MH, Quaglino P, Horwitz S, Porcu P, Stadler R, Wood GS, Beylot-Barry M, Pham-Ledard A, Foss F, Girardi M, Bagot M, Michel L, Battistella M, Guitart J, Kuzel TM, Martinez-Escala ME, Estrach T, Papadavid E, Antoniou C, Rigopoulos D, Nikolaou V, Sugaya M, Miyagaki T, Gniadecki R, Sanches JA, Cury-Martins J, Miyashiro D, Servitje O, Muniesa C, Berti E, Onida F, Corti L, Hodak E, Amitay-Laish I, Ortiz-Romero PL, Rodríguez-Peralto JL, Knobler R, Porkert S, Bauer W, Pimpinelli N, Grandi V, Cowan R, Rook A, Kim E, Pileri A, Patrizi A, Pujol RM, Wong H, Tyler K, Stranzenbach R, Querfeld C, Fava P, Maule M, Willemze R, Evison F, Morris S, Twigger R, Talpur R, Kim J, Ognibene G, Li S, Tavallaee M, Hoppe RT, Duvic M, Whittaker SJ, Kim YH.

J Clin Oncol. 2015 Nov 10;33(32):3766-73. doi: 10.1200/JCO.2015.61.7142. Epub 2015 Oct 5.

8.

Biliatresone, a Reactive Natural Toxin from Dysphania glomulifera and D. littoralis: Discovery of the Toxic Moiety 1,2-Diaryl-2-Propenone.

Koo KA, Lorent K, Gong W, Windsor P, Whittaker SJ, Pack M, Wells RG, Porter JR.

Chem Res Toxicol. 2015 Aug 17;28(8):1519-21. doi: 10.1021/acs.chemrestox.5b00227. Epub 2015 Jul 20.

9.

Identification of a plant isoflavonoid that causes biliary atresia.

Lorent K, Gong W, Koo KA, Waisbourd-Zinman O, Karjoo S, Zhao X, Sealy I, Kettleborough RN, Stemple DL, Windsor PA, Whittaker SJ, Porter JR, Wells RG, Pack M.

Sci Transl Med. 2015 May 6;7(286):286ra67. doi: 10.1126/scitranslmed.aaa1652.

10.

Prognostic factors, prognostic indices and staging in mycosis fungoides and Sézary syndrome: where are we now?

Scarisbrick JJ, Kim YH, Whittaker SJ, Wood GS, Vermeer MH, Prince HM, Quaglino P.

Br J Dermatol. 2014 Jun;170(6):1226-36. doi: 10.1111/bjd.12909. Review.

PMID:
24641480
11.

Erythroderma is not all psoriasis: a case of Sézary syndrome.

Dubrey SW, Rosser G, Patel K, Whittaker SJ.

Br J Hosp Med (Lond). 2014 Jan;75(1):50-1. No abstract available.

PMID:
24401973
12.

Shellfish-acquired Vibrio cholerae cellulitis and sepsis from a vulnerable leg.

Whittaker SJ.

N Z Med J. 2013 Aug 2;126(1379):95-7.

PMID:
24045356
13.

A cutaneous lymphoma international prognostic index (CLIPi) for mycosis fungoides and Sezary syndrome.

Benton EC, Crichton S, Talpur R, Agar NS, Fields PA, Wedgeworth E, Mitchell TJ, Cox M, Ferreira S, Liu P, Robson A, Calonje E, Stefanato CM, Wilkins B, Scarisbrick J, Wain EM, Child F, Morris S, Duvic M, Whittaker SJ.

Eur J Cancer. 2013 Sep;49(13):2859-68. doi: 10.1016/j.ejca.2013.04.018. Epub 2013 Jun 1.

PMID:
23735705
14.

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis.

Delage B, Luong P, Maharaj L, O'Riain C, Syed N, Crook T, Hatzimichael E, Papoudou-Bai A, Mitchell TJ, Whittaker SJ, Cerio R, Gribben J, Lemoine N, Bomalaski J, Li CF, Joel S, Fitzgibbon J, Chen LT, Szlosarek PW.

Cell Death Dis. 2012 Jul 5;3:e342. doi: 10.1038/cddis.2012.83.

15.

Regulation of T-plastin expression by promoter hypomethylation in primary cutaneous T-cell lymphoma.

Jones CL, Ferreira S, McKenzie RC, Tosi I, Caesar JA, Bagot M, Whittaker SJ, Mitchell TJ.

J Invest Dermatol. 2012 Aug;132(8):2042-9. doi: 10.1038/jid.2012.106. Epub 2012 Apr 12.

16.

Vorinostat combined with bexarotene for treatment of cutaneous T-cell lymphoma: in vitro and phase I clinical evidence supporting augmentation of retinoic acid receptor/retinoid X receptor activation by histone deacetylase inhibition.

Dummer R, Beyer M, Hymes K, Epping MT, Bernards R, Steinhoff M, Sterry W, Kerl H, Heath K, Ahern JD, Hardwick JS, Garcia-Vargas J, Baumann K, Rizvi S, Frankel SR, Whittaker SJ, Assaf C.

Leuk Lymphoma. 2012 Aug;53(8):1501-8. doi: 10.3109/10428194.2012.656625. Epub 2012 Feb 13.

PMID:
22239668
17.

Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1.

McKenzie RC, Jones CL, Tosi I, Caesar JA, Whittaker SJ, Mitchell TJ.

Leukemia. 2012 Feb;26(2):323-31. doi: 10.1038/leu.2011.198. Epub 2011 Aug 5.

PMID:
21818116
18.

Survival outcomes and prognostic factors in mycosis fungoides/Sézary syndrome: validation of the revised International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer staging proposal.

Agar NS, Wedgeworth E, Crichton S, Mitchell TJ, Cox M, Ferreira S, Robson A, Calonje E, Stefanato CM, Wain EM, Wilkins B, Fields PA, Dean A, Webb K, Scarisbrick J, Morris S, Whittaker SJ.

J Clin Oncol. 2010 Nov 1;28(31):4730-9. doi: 10.1200/JCO.2009.27.7665. Epub 2010 Sep 20.

PMID:
20855822
19.

Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma.

Whittaker SJ, Demierre MF, Kim EJ, Rook AH, Lerner A, Duvic M, Scarisbrick J, Reddy S, Robak T, Becker JC, Samtsov A, McCulloch W, Kim YH.

J Clin Oncol. 2010 Oct 10;28(29):4485-91. doi: 10.1200/JCO.2010.28.9066. Epub 2010 Aug 9.

PMID:
20697094
20.

MicroRNA expression in Sezary syndrome: identification, function, and diagnostic potential.

Ballabio E, Mitchell T, van Kester MS, Taylor S, Dunlop HM, Chi J, Tosi I, Vermeer MH, Tramonti D, Saunders NJ, Boultwood J, Wainscoat JS, Pezzella F, Whittaker SJ, Tensen CP, Hatton CS, Lawrie CH.

Blood. 2010 Aug 19;116(7):1105-13. doi: 10.1182/blood-2009-12-256719. Epub 2010 May 6.

21.

Downregulation of Fas gene expression in Sézary syndrome is associated with promoter hypermethylation.

Jones CL, Wain EM, Chu CC, Tosi I, Foster R, McKenzie RC, Whittaker SJ, Mitchell TJ.

J Invest Dermatol. 2010 Apr;130(4):1116-25. doi: 10.1038/jid.2009.301. Epub 2009 Sep 17.

22.

Bexarotene therapy for mycosis fungoides and Sézary syndrome.

Abbott RA, Whittaker SJ, Morris SL, Russell-Jones R, Hung T, Bashir SJ, Scarisbrick JJ.

Br J Dermatol. 2009 Jun;160(6):1299-307. doi: 10.1111/j.1365-2133.2009.09037.x. Epub 2009 Feb 16.

PMID:
19222457
23.

Gastrointestinal manifestations of systemic mastocytosis.

Lee JK, Whittaker SJ, Enns RA, Zetler P.

World J Gastroenterol. 2008 Dec 7;14(45):7005-8. Review.

24.

Fine-mapping chromosomal loss at 9p21: correlation with prognosis in primary cutaneous diffuse large B-cell lymphoma, leg type.

Senff NJ, Zoutman WH, Vermeer MH, Assaf C, Berti E, Cerroni L, Espinet B, de Misa Cabrera RF, Geerts ML, Kempf W, Mitchell TJ, Paulli M, Petrella T, Pimpinelli N, Santucci M, Whittaker SJ, Willemze R, Tensen CP.

J Invest Dermatol. 2009 May;129(5):1149-55. doi: 10.1038/jid.2008.357. Epub 2008 Nov 20.

25.

An unusual case of granulomatous slack skin disease with necrobiosis.

Benton EC, Morris SL, Robson A, Whittaker SJ.

Am J Dermatopathol. 2008 Oct;30(5):462-5. doi: 10.1097/DAD.0b013e3181731dfc.

PMID:
18806490
26.

Cerebellar ataxia in sheep grazing pastures infested with Romulea rosea (onion grass or Guildford grass).

Bourke CA, Bunker EC, Reece RI, Whittaker SJ.

Aust Vet J. 2008 Sep;86(9):354-6. doi: 10.1111/j.1751-0813.2008.00341.x.

PMID:
18782418
27.

Folliculotropic mycosis fungoides (stage IIA) progressing to Sézary syndrome: a case report.

Agar N, Whittaker SJ.

Br J Dermatol. 2008 Nov;159(5):1197-9. doi: 10.1111/j.1365-2133.2008.08802.x. Epub 2008 Sep 1.

PMID:
18764843
28.

A genomic and expression study of AP-1 in primary cutaneous T-cell lymphoma: evidence for dysregulated expression of JUNB and JUND in MF and SS.

Mao X, Orchard G, Mitchell TJ, Oyama N, Russell-Jones R, Vermeer MH, Willemze R, van Doorn R, Tensen CP, Young BD, Whittaker SJ.

J Cutan Pathol. 2008 Oct;35(10):899-910. doi: 10.1111/j.1600-0560.2007.00924.x. Epub 2008 Jun 28.

PMID:
18494816
29.

Genital herpes masquerading as a cutaneous T-cell lymphoma: a report of two cases.

Wain EM, Antony F, Appleton MA, Whittaker SJ, Robson A.

J Cutan Pathol. 2008 Aug;35(8):770-3. doi: 10.1111/j.1600-0560.2007.00899.x. Epub 2008 Apr 17.

PMID:
18422691
30.

An extended outbreak of congenital chondrodysplasia in calves in South East Australia.

Cave JG, McLaren PJ, Whittaker SJ, Rast L, Stephens A, Parker EM.

Aust Vet J. 2008 Apr;86(4):130-5. doi: 10.1111/j.1751-0813.2008.00266.x.

PMID:
18363985
31.

Indeterminate cell histiocytosis responding to total skin electron beam therapy.

Malhomme de la Roche H, Lai-Cheong JE, Calonje E, Davies M, Morris S, Whittaker SJ.

Br J Dermatol. 2008 Apr;158(4):838-40. doi: 10.1111/j.1365-2133.2007.08409.x. Epub 2008 Jan 30. No abstract available.

PMID:
18241280
32.

Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associated acute myeloid leukemia and lymphoblastic T-cell lymphoma.

Metzgeroth G, Walz C, Score J, Siebert R, Schnittger S, Haferlach C, Popp H, Haferlach T, Erben P, Mix J, Müller MC, Beneke H, Müller L, Del Valle F, Aulitzky WE, Wittkowsky G, Schmitz N, Schulte C, Müller-Hermelink K, Hodges E, Whittaker SJ, Diecker F, Döhner H, Schuld P, Hehlmann R, Hochhaus A, Cross NC, Reiter A.

Leukemia. 2007 Jun;21(6):1183-8. Epub 2007 Mar 22.

PMID:
17377585
33.

Palliative care in patients with primary cutaneous lymphoma: symptom burden and characteristics of hospital palliative care team input.

Lebon B, Beynon TA, Whittaker SJ.

Arch Dermatol. 2007 Mar;143(3):423-4. No abstract available.

PMID:
17372114
34.
35.

Erythropoietic protoporphyria in pregnancy.

Madu AE, Whittaker SJ.

J Obstet Gynaecol. 2006 Oct;26(7):687-8. No abstract available.

PMID:
17071441
36.

Molecular staging of lymph nodes from 60 patients with mycosis fungoides and Sézary syndrome: correlation with histopathology and outcome suggests prognostic relevance in mycosis fungoides.

Fraser-Andrews EA, Mitchell T, Ferreira S, Seed PT, Russell-Jones R, Calonje E, Whittaker SJ.

Br J Dermatol. 2006 Oct;155(4):756-62.

PMID:
16965425
37.

Molecular analysis of T-cell receptor beta genes in cutaneous T-cell lymphoma reveals Jbeta1 bias.

Morgan SM, Hodges E, Mitchell TJ, Harris S, Whittaker SJ, Smith JL.

J Invest Dermatol. 2006 Aug;126(8):1893-9. Epub 2006 Jun 1.

38.

Lack of suppressive CD4+CD25+FOXP3+ T cells in advanced stages of primary cutaneous T-cell lymphoma.

Tiemessen MM, Mitchell TJ, Hendry L, Whittaker SJ, Taams LS, John S.

J Invest Dermatol. 2006 Oct;126(10):2217-23. Epub 2006 Jun 1.

39.

Heterogeneous abnormalities of CCND1 and RB1 in primary cutaneous T-Cell lymphomas suggesting impaired cell cycle control in disease pathogenesis.

Mao X, Orchard G, Vonderheid EC, Nowell PC, Bagot M, Bensussan A, Russell-Jones R, Young BD, Whittaker SJ.

J Invest Dermatol. 2006 Jun;126(6):1388-95.

40.

Lymphomatoid papulosis in a patient with atopic eczema on long-term ciclosporin therapy.

Laube S, Stephens M, Smith AG, Whittaker SJ, Tan BB.

Br J Dermatol. 2005 Jun;152(6):1346-8. Review.

PMID:
15949007
41.
42.

BCL2 and JUNB abnormalities in primary cutaneous lymphomas.

Mao X, Orchard G, Lillington DM, Child FJ, Vonderheid EC, Nowell PC, Bagot M, Bensussan A, Russell-Jones R, Young BD, Whittaker SJ.

Br J Dermatol. 2004 Sep;151(3):546-56.

PMID:
15377339
43.

A randomized cross-over study to compare PUVA and extracorporeal photopheresis in the treatment of plaque stage (T2) mycosis fungoides.

Child FJ, Mitchell TJ, Whittaker SJ, Scarisbrick JJ, Seed PT, Russell-Jones R.

Clin Exp Dermatol. 2004 May;29(3):231-6.

PMID:
15115499
44.

Cutaneous malignant melanoma in association with mycosis fungoides.

Evans AV, Scarisbrick JJ, Child FJ, Acland KM, Whittaker SJ, Russell-Jones R.

J Am Acad Dermatol. 2004 May;50(5):701-5.

PMID:
15097953
45.

CD30(+) cutaneous lymphoma in association with atopic eczema.

Fletcher CL, Orchard GE, Hubbard V, Whittaker SJ, Edelson RL, Russell-Jones R.

Arch Dermatol. 2004 Apr;140(4):449-54.

PMID:
15096373
46.

Multiple familial pilomatricomas: an unusual case.

Hubbard VG, Whittaker SJ.

J Cutan Pathol. 2004 Mar;31(3):281-3.

PMID:
14984583
47.

Histopathology and genetics of cutaneous T-cell lymphoma.

Smoller BR, Santucci M, Wood GS, Whittaker SJ.

Hematol Oncol Clin North Am. 2003 Dec;17(6):1277-311. Review.

PMID:
14710885
48.

Joint British Association of Dermatologists and U.K. Cutaneous Lymphoma Group guidelines for the management of primary cutaneous T-cell lymphomas.

Whittaker SJ, Marsden JR, Spittle M, Russell Jones R; British Association of Dermatologists; U.K. Cutaneous Lymphoma Group.

Br J Dermatol. 2003 Dec;149(6):1095-1107. No abstract available.

PMID:
14696593
49.
50.

Microsatellite instability is associated with hypermethylation of the hMLH1 gene and reduced gene expression in mycosis fungoides.

Scarisbrick JJ, Mitchell TJ, Calonje E, Orchard G, Russell-Jones R, Whittaker SJ.

J Invest Dermatol. 2003 Oct;121(4):894-901.

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