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Items: 1 to 50 of 576

1.

Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung.

Du Y, Clair GC, Al Alam D, Danopoulos S, Schnell D, Kitzmiller JA, Misra RS, Bhattacharya S, Warburton D, Mariani TJ, Pryhuber GS, Whitsett JA, Ansong C, Xu Y.

Am J Physiol Lung Cell Mol Physiol. 2019 Jul 3. doi: 10.1152/ajplung.00475.2018. [Epub ahead of print]

PMID:
31268347
2.

Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells.

Ren X, Ustiyan V, Guo M, Wang G, Bolte C, Zhang Y, Xu Y, Whitsett JA, Kalin TV, Kalinichenko VV.

Am J Respir Crit Care Med. 2019 Jun 24. doi: 10.1164/rccm.201812-2312OC. [Epub ahead of print]

PMID:
31233341
3.

Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques.

Schmidt AF, Kannan PS, Bridges JP, Filuta A, Lipps D, Kemp M, Miller LA, Kallapur SG, Xu Y, Whitsett JA, Jobe AH.

Sci Rep. 2019 Jun 21;9(1):9039. doi: 10.1038/s41598-019-45171-6.

4.

Complete Tracheal Ring Deformity: A Translational Genomics Approach to Pathogenesis.

Sinner DI, Carey B, Zgherea D, Kaufman KM, Leesman L, Wood RE, Rutter MJ, de Alarcon A, Elluru RG, Harley JB, Whitsett JA, Trapnell BC.

Am J Respir Crit Care Med. 2019 Jun 19. doi: 10.1164/rccm.201809-1626OC. [Epub ahead of print]

PMID:
31215789
5.

The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia.

Pradhan A, Dunn A, Ustiyan V, Bolte C, Wang G, Whitsett JA, Zhang Y, Porollo A, Hu YC, Xiao R, Szafranski P, Shi D, Stankiewicz P, Kalin TV, Kalinichenko VV.

Am J Respir Crit Care Med. 2019 Jun 14. doi: 10.1164/rccm.201810-1897OC. [Epub ahead of print]

PMID:
31199666
6.

Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth.

Guo M, Du Y, Gokey JJ, Ray S, Bell SM, Adam M, Sudha P, Perl AK, Deshmukh H, Potter SS, Whitsett JA, Xu Y.

Nat Commun. 2019 Jan 3;10(1):37. doi: 10.1038/s41467-018-07770-1.

7.

Airway Epithelial Differentiation and Mucociliary Clearance.

Whitsett JA.

Ann Am Thorac Soc. 2018 Nov;15(Supplement_3):S143-S148. doi: 10.1513/AnnalsATS.201802-128AW.

PMID:
30431340
8.

Building and Regenerating the Lung Cell by Cell.

Whitsett JA, Kalin TV, Xu Y, Kalinichenko VV.

Physiol Rev. 2019 Jan 1;99(1):513-554. doi: 10.1152/physrev.00001.2018. Review.

PMID:
30427276
9.

Neonatal Lung Disease Associated with TBX4 Mutations.

Suhrie K, Pajor NM, Ahlfeld SK, Dawson DB, Dufendach KR, Kitzmiller JA, Leino D, Lombardo RC, Smolarek TA, Rathbun PA, Whitsett JA, Towe C, Wikenheiser-Brokamp KA.

J Pediatr. 2019 Mar;206:286-292.e1. doi: 10.1016/j.jpeds.2018.10.018. Epub 2018 Nov 7.

PMID:
30413314
10.

Cell type-resolved human lung lipidome reveals cellular cooperation in lung function.

Kyle JE, Clair G, Bandyopadhyay G, Misra RS, Zink EM, Bloodsworth KJ, Shukla AK, Du Y, Lillis J, Myers JR, Ashton J, Bushnell T, Cochran M, Deutsch G, Baker ES, Carson JP, Mariani TJ, Xu Y, Whitsett JA, Pryhuber G, Ansong C.

Sci Rep. 2018 Sep 7;8(1):13455. doi: 10.1038/s41598-018-31640-x.

11.

MEG3 is increased in idiopathic pulmonary fibrosis and regulates epithelial cell differentiation.

Gokey JJ, Snowball J, Sridharan A, Speth JP, Black KE, Hariri LP, Perl AT, Xu Y, Whitsett JA.

JCI Insight. 2018 Sep 6;3(17). pii: 122490. doi: 10.1172/jci.insight.122490. eCollection 2018 Sep 6.

12.

KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia.

Zhang C, D'Alessandro A, Wellendorf AM, Mohmoud F, Serrano-Lopez J, Perentesis JP, Komurov K, Alexe G, Stegmaier K, Whitsett JA, Grimes HL, Cancelas JA.

Oncotarget. 2018 Jul 3;9(51):29665-29679. doi: 10.18632/oncotarget.25667. eCollection 2018 Jul 3.

13.

Dissociation, cellular isolation, and initial molecular characterization of neonatal and pediatric human lung tissues.

Bandyopadhyay G, Huyck HL, Misra RS, Bhattacharya S, Wang Q, Mereness J, Lillis J, Myers JR, Ashton J, Bushnell T, Cochran M, Holden-Wiltse J, Katzman P, Deutsch G, Whitsett JA, Xu Y, Mariani TJ, Pryhuber GS.

Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L576-L583. doi: 10.1152/ajplung.00041.2018. Epub 2018 Jul 5.

PMID:
29975103
14.

Active epithelial Hippo signaling in idiopathic pulmonary fibrosis.

Gokey JJ, Sridharan A, Xu Y, Green J, Carraro G, Stripp BR, Perl AT, Whitsett JA.

JCI Insight. 2018 Mar 22;3(6). pii: 98738. doi: 10.1172/jci.insight.98738.

15.

Time-resolved proteome profiling of normal lung development.

Moghieb A, Clair G, Mitchell HD, Kitzmiller J, Zink EM, Kim YM, Petyuk V, Shukla A, Moore RJ, Metz TO, Carson J, McDermott JE, Corley RA, Whitsett JA, Ansong C.

Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L11-L24. doi: 10.1152/ajplung.00316.2017. Epub 2018 Mar 8.

16.

Reconstructing differentiation networks and their regulation from time series single-cell expression data.

Ding J, Aronow BJ, Kaminski N, Kitzmiller J, Whitsett JA, Bar-Joseph Z.

Genome Res. 2018 Jan 9. doi: 10.1101/gr.225979.117. [Epub ahead of print]

17.

Transcription Factors Regulating Embryonic Development of Pulmonary Vasculature.

Bolte C, Whitsett JA, Kalin TV, Kalinichenko VV.

Adv Anat Embryol Cell Biol. 2018;228:1-20. doi: 10.1007/978-3-319-68483-3_1.

PMID:
29288383
18.

FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas.

Milewski D, Balli D, Ustiyan V, Le T, Dienemann H, Warth A, Breuhahn K, Whitsett JA, Kalinichenko VV, Kalin TV.

PLoS Genet. 2017 Dec 21;13(12):e1007097. doi: 10.1371/journal.pgen.1007097. eCollection 2017 Dec.

19.

Alveolar injury and regeneration following deletion of ABCA3.

Rindler TN, Stockman CA, Filuta AL, Brown KM, Snowball JM, Zhou W, Veldhuizen R, Zink EM, Dautel SE, Clair G, Ansong C, Xu Y, Bridges JP, Whitsett JA.

JCI Insight. 2017 Dec 21;2(24). pii: 97381. doi: 10.1172/jci.insight.97381.

20.

EMC3 coordinates surfactant protein and lipid homeostasis required for respiration.

Tang X, Snowball JM, Xu Y, Na CL, Weaver TE, Clair G, Kyle JE, Zink EM, Ansong C, Wei W, Huang M, Lin X, Whitsett JA.

J Clin Invest. 2017 Dec 1;127(12):4314-4325. doi: 10.1172/JCI94152. Epub 2017 Oct 30.

21.

Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.

Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN.

Cell Stem Cell. 2017 Oct 5;21(4):472-488.e10. doi: 10.1016/j.stem.2017.08.014. Epub 2017 Sep 28.

22.

LungMAP: The Molecular Atlas of Lung Development Program.

Ardini-Poleske ME, Clark RF, Ansong C, Carson JP, Corley RA, Deutsch GH, Hagood JS, Kaminski N, Mariani TJ, Potter SS, Pryhuber GS, Warburton D, Whitsett JA, Palmer SM, Ambalavanan N; LungMAP Consortium.

Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L733-L740. doi: 10.1152/ajplung.00139.2017. Epub 2017 Aug 10. Review.

23.

TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury.

Schwanekamp JA, Lorts A, Sargent MA, York AJ, Grimes KM, Fischesser DM, Gokey JJ, Whitsett JA, Conway SJ, Molkentin JD.

PLoS One. 2017 Jul 27;12(7):e0181945. doi: 10.1371/journal.pone.0181945. eCollection 2017.

24.

Understanding Interstitial Lung Disease: It's in the Mucus.

Dickey BF, Whitsett JA.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):12-14. doi: 10.1165/rcmb.2017-0116ED. No abstract available.

25.

Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling.

Brown K, Filuta A, Ludwig MG, Seuwen K, Jaros J, Vidal S, Arora K, Naren AP, Kandasamy K, Parthasarathi K, Offermanns S, Mason RJ, Miller WE, Whitsett JA, Bridges JP.

JCI Insight. 2017 Jun 2;2(11). pii: 93700. doi: 10.1172/jci.insight.93700. eCollection 2017 Jun 2.

26.

The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice.

Sun L, Ren X, Wang IC, Pradhan A, Zhang Y, Flood HM, Han B, Whitsett JA, Kalin TV, Kalinichenko VV.

Sci Signal. 2017 Apr 18;10(475). pii: eaai8583. doi: 10.1126/scisignal.aai8583.

PMID:
28420758
27.

Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development.

Du Y, Kitzmiller JA, Sridharan A, Perl AK, Bridges JP, Misra RS, Pryhuber GS, Mariani TJ, Bhattacharya S, Guo M, Potter SS, Dexheimer P, Aronow B, Jobe AH, Whitsett JA, Xu Y.

Thorax. 2017 May;72(5):481-484. doi: 10.1136/thoraxjnl-2016-209598. Epub 2017 Jan 9.

28.

Spatially-Resolved Proteomics: Rapid Quantitative Analysis of Laser Capture Microdissected Alveolar Tissue Samples.

Clair G, Piehowski PD, Nicola T, Kitzmiller JA, Huang EL, Zink EM, Sontag RL, Orton DJ, Moore RJ, Carson JP, Smith RD, Whitsett JA, Corley RA, Ambalavanan N, Ansong C.

Sci Rep. 2016 Dec 22;6:39223. doi: 10.1038/srep39223.

29.

SLICE: determining cell differentiation and lineage based on single cell entropy.

Guo M, Bao EL, Wagner M, Whitsett JA, Xu Y.

Nucleic Acids Res. 2017 Apr 20;45(7):e54. doi: 10.1093/nar/gkw1278.

30.

Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis.

Xu Y, Mizuno T, Sridharan A, Du Y, Guo M, Tang J, Wikenheiser-Brokamp KA, Perl AT, Funari VA, Gokey JJ, Stripp BR, Whitsett JA.

JCI Insight. 2016 Dec 8;1(20):e90558. doi: 10.1172/jci.insight.90558.

31.

Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens.

Giridhar PV, Bell SM, Sridharan A, Rajavelu P, Kitzmiller JA, Na CL, Kofron M, Brandt EB, Ericksen M, Naren AP, Moon C, Khurana Hershey GK, Whitsett JA.

J Immunol. 2016 Dec 1;197(11):4228-4239. Epub 2016 Oct 28.

32.

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life.

Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM.

JCI Insight. 2016 Jul 21;1(11). pii: e87632.

33.

INFLAMMATION. Modulating pulmonary inflammation.

Whitsett JA, Morrisey EE.

Science. 2016 Feb 12;351(6274):662-3. doi: 10.1126/science.aaf1429. No abstract available.

PMID:
26912844
34.

β-catenin and Kras/Foxm1 signaling pathway are critical to restrict Sox9 in basal cells during pulmonary branching morphogenesis.

Ustiyan V, Zhang Y, Perl AK, Whitsett JA, Kalin TV, Kalinichenko VV.

Dev Dyn. 2016 May;245(5):590-604. doi: 10.1002/dvdy.24393. Epub 2016 Mar 8.

35.

SINCERA: A Pipeline for Single-Cell RNA-Seq Profiling Analysis.

Guo M, Wang H, Potter SS, Whitsett JA, Xu Y.

PLoS Comput Biol. 2015 Nov 24;11(11):e1004575. doi: 10.1371/journal.pcbi.1004575. eCollection 2015 Nov.

36.

Systems biology evaluation of cell-free amniotic fluid transcriptome of term and preterm infants to detect fetal maturity.

Kamath-Rayne BD, Du Y, Hughes M, Wagner EA, Muglia LJ, DeFranco EA, Whitsett JA, Salomonis N, Xu Y.

BMC Med Genomics. 2015 Oct 22;8:67. doi: 10.1186/s12920-015-0138-5.

37.

A favourable prognostic marker for EGFR mutant non-small cell lung cancer: immunohistochemical analysis of MUC5B.

Wakata K, Tsuchiya T, Tomoshige K, Takagi K, Yamasaki N, Matsumoto K, Miyazaki T, Nanashima A, Whitsett JA, Maeda Y, Nagayasu T.

BMJ Open. 2015 Jul 29;5(7):e008366. doi: 10.1136/bmjopen-2015-008366.

38.

'LungGENS': a web-based tool for mapping single-cell gene expression in the developing lung.

Du Y, Guo M, Whitsett JA, Xu Y.

Thorax. 2015 Nov;70(11):1092-4. doi: 10.1136/thoraxjnl-2015-207035. Epub 2015 Jun 30. Review.

39.

Alveolar development and disease.

Whitsett JA, Weaver TE.

Am J Respir Cell Mol Biol. 2015 Jul;53(1):1-7. doi: 10.1165/rcmb.2015-0128PS. Review.

40.

Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation.

Rajavelu P, Chen G, Xu Y, Kitzmiller JA, Korfhagen TR, Whitsett JA.

J Clin Invest. 2015 May;125(5):2021-31. doi: 10.1172/JCI79422. Epub 2015 Apr 13.

41.

A novel PI3K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with A MEK inhibitor.

Ishida N, Fukazawa T, Maeda Y, Yamatsuji T, Kato K, Matsumoto K, Shimo T, Takigawa N, Whitsett JA, Naomoto Y.

Exp Cell Res. 2015 Jul 15;335(2):197-206. doi: 10.1016/j.yexcr.2015.03.019. Epub 2015 Apr 1.

42.

Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.

Metzakopian E, Bouhali K, Alvarez-Saavedra M, Whitsett JA, Picketts DJ, Ang SL.

Development. 2015 Apr 1;142(7):1315-24. doi: 10.1242/dev.115808.

43.

Diseases of pulmonary surfactant homeostasis.

Whitsett JA, Wert SE, Weaver TE.

Annu Rev Pathol. 2015;10:371-93. doi: 10.1146/annurev-pathol-012513-104644. Review.

44.

Respiratory epithelial cells orchestrate pulmonary innate immunity.

Whitsett JA, Alenghat T.

Nat Immunol. 2015 Jan;16(1):27-35. doi: 10.1038/ni.3045. Review.

45.

Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung.

Lange AW, Sridharan A, Xu Y, Stripp BR, Perl AK, Whitsett JA.

J Mol Cell Biol. 2015 Feb;7(1):35-47. doi: 10.1093/jmcb/mju046. Epub 2014 Dec 5.

46.

TGFβ signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium.

McCauley HA, Liu CY, Attia AC, Wikenheiser-Brokamp KA, Zhang Y, Whitsett JA, Guasch G.

Development. 2014 Dec;141(23):4628-39. doi: 10.1242/dev.117804. Epub 2014 Nov 5.

47.

Differential roles of STAT3 in the initiation and growth of lung cancer.

Zhou J, Qu Z, Yan S, Sun F, Whitsett JA, Shapiro SD, Xiao G.

Oncogene. 2015 Jul;34(29):3804-3814. doi: 10.1038/onc.2014.318. Epub 2014 Oct 6.

48.

Foxm1 regulates resolution of hyperoxic lung injury in newborns.

Xia H, Ren X, Bolte CS, Ustiyan V, Zhang Y, Shah TA, Kalin TV, Whitsett JA, Kalinichenko VV.

Am J Respir Cell Mol Biol. 2015 May;52(5):611-21. doi: 10.1165/rcmb.2014-0091OC.

49.

SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene.

Cheng XH, Black M, Ustiyan V, Le T, Fulford L, Sridharan A, Medvedovic M, Kalinichenko VV, Whitsett JA, Kalin TV.

PLoS Genet. 2014 Sep 25;10(9):e1004656. doi: 10.1371/journal.pgen.1004656. eCollection 2014 Sep.

50.

Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.

Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE.

Cell Stem Cell. 2014 Aug 7;15(2):123-38. doi: 10.1016/j.stem.2014.07.012. Review.

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