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Items: 13

1.

Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.

Gillooly KM, Pattoli MA, Taylor TL, Chen L, Cheng L, Gregor KR, Whitney GS, Susulic V, Watterson SH, Kempson J, Pitts WJ, Booth-Lute H, Yang G, Davies P, Kukral DW, Strnad J, McIntyre KW, Darienzo CJ, Salter-Cid L, Yang Z, Wang-Iverson DB, Burke JR.

J Pharmacol Exp Ther. 2009 Nov;331(2):349-60. doi: 10.1124/jpet.109.156018. Epub 2009 Aug 3.

PMID:
19652024
2.

Selective Itk inhibitors block T-cell activation and murine lung inflammation.

Lin TA, McIntyre KW, Das J, Liu C, O'Day KD, Penhallow B, Hung CY, Whitney GS, Shuster DJ, Yang X, Townsend R, Postelnek J, Spergel SH, Lin J, Moquin RV, Furch JA, Kamath AV, Zhang H, Marathe PH, Perez-Villar JJ, Doweyko A, Killar L, Dodd JH, Barrish JC, Wityak J, Kanner SB.

Biochemistry. 2004 Aug 31;43(34):11056-62.

PMID:
15323564
3.

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.

Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB.

Biochemistry. 2002 Aug 27;41(34):10732-40.

PMID:
12186560
4.

CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1.

Perez-Villar JJ, Whitney GS, Bowen MA, Hewgill DH, Aruffo AA, Kanner SB.

Mol Cell Biol. 1999 Apr;19(4):2903-12.

5.

Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains.

Kobarg J, Whitney GS, Palmer D, Aruffo A, Bowen MA.

Eur J Immunol. 1997 Nov;27(11):2971-80.

PMID:
9394826
6.

Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding.

Bowen MA, Bajorath J, D'Egidio M, Whitney GS, Palmer D, Kobarg J, Starling GC, Siadak AW, Aruffo A.

Eur J Immunol. 1997 Jun;27(6):1469-78.

PMID:
9209500
7.

Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms.

Bowen MA, Whitney GS, Neubauer M, Starling GC, Palmer D, Zhang J, Nowak NJ, Shows TB, Aruffo A.

J Immunol. 1997 Feb 1;158(3):1149-56.

PMID:
9013954
8.

The Ly-1.1 and Ly-1.2 epitopes of murine CD5 map to the membrane distal scavenger receptor cysteine-rich domain.

Starling GC, Llewellyn MB, Whitney GS, Aruffo A.

Tissue Antigens. 1997 Jan;49(1):1-6.

PMID:
9027958
9.

Characterization of mouse CD6 with novel monoclonal antibodies which enhance the allogeneic mixed leukocyte reaction.

Starling GC, Whitney GS, Siadak AW, Llewellyn MB, Bowen MA, Farr AG, Aruffo AA.

Eur J Immunol. 1996 Apr;26(4):738-46.

PMID:
8625962
10.

The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site.

Whitney GS, Starling GC, Bowen MA, Modrell B, Siadak AW, Aruffo A.

J Biol Chem. 1995 Aug 4;270(31):18187-90.

11.

Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK.

Whitney GS, Chan PY, Blake J, Cosand WL, Neubauer MG, Aruffo A, Kanner SB.

DNA Cell Biol. 1993 Nov;12(9):823-30.

PMID:
7692878
12.

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

Plowman GD, Culouscou JM, Whitney GS, Green JM, Carlton GW, Foy L, Neubauer MG, Shoyab M.

Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1746-50.

13.

Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.

Plowman GD, Whitney GS, Neubauer MG, Green JM, McDonald VL, Todaro GJ, Shoyab M.

Proc Natl Acad Sci U S A. 1990 Jul;87(13):4905-9.

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