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Items: 1 to 50 of 82

1.

Bone Marrow Endothelial Cells Influence Function and Phenotype of Hematopoietic Stem and Progenitor Cells after Mixed Neutron/Gamma Radiation.

Cary L, Noutai D, Salber R, Fadiyimu O, Gross A, Almeida-Porada G, Kidane Y, Whitnall M.

Int J Mol Sci. 2019 Apr 11;20(7). pii: E1795. doi: 10.3390/ijms20071795.

2.

The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates.

Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E.

PLoS One. 2015 Sep 14;10(9):e0135388. doi: 10.1371/journal.pone.0135388. eCollection 2015.

3.

Gastrointestinal acute radiation syndrome in Göttingen minipigs (Sus scrofa domestica).

Elliott TB, Deutz NE, Gulani J, Koch A, Olsen CH, Christensen C, Chappell M, Whitnall MH, Moroni M.

Comp Med. 2014 Dec;64(6):456-63.

4.

Interactions between endothelial cells and T cells modulate responses to mixed neutron/gamma radiation.

Cary LH, Noutai D, Salber RE, Williams MS, Ngudiankama BF, Whitnall MH.

Radiat Res. 2014 Jun;181(6):592-604. doi: 10.1667/RR13550.1. Epub 2014 May 14.

PMID:
24828109
5.

Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: early hematological changes and systemic inflammatory response syndrome in minipig.

Moroni M, Elliott TB, Deutz NE, Olsen CH, Owens R, Christensen C, Lombardini ED, Whitnall MH.

Int J Radiat Biol. 2014 May;90(5):363-72. doi: 10.3109/09553002.2014.892226.

PMID:
24524283
6.

Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury.

Li XH, Ghosh SP, Ha CT, Fu D, Elliott TB, Bolduc DL, Villa V, Whitnall MH, Landauer MR, Xiao M.

Radiat Res. 2013 Dec;180(6):649-57. doi: 10.1667/RR13398.1. Epub 2013 Dec 2.

PMID:
24294967
7.

Evaluation of the gamma-H2AX assay for radiation biodosimetry in a swine model.

Moroni M, Maeda D, Whitnall MH, Bonner WM, Redon CE.

Int J Mol Sci. 2013 Jul 8;14(7):14119-35. doi: 10.3390/ijms140714119.

8.

The Gottingen minipig is a model of the hematopoietic acute radiation syndrome: G-colony stimulating factor stimulates hematopoiesis and enhances survival from lethal total-body γ-irradiation.

Moroni M, Ngudiankama BF, Christensen C, Olsen CH, Owens R, Lombardini ED, Holt RK, Whitnall MH.

Int J Radiat Oncol Biol Phys. 2013 Aug 1;86(5):986-92. doi: 10.1016/j.ijrobp.2013.04.041.

9.

Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia.

Whitnall M, Suryo Rahmanto Y, Huang ML, Saletta F, Lok HC, Gutiérrez L, Lázaro FJ, Fleming AJ, St Pierre TG, Mikhael MR, Ponka P, Richardson DR.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20590-5. doi: 10.1073/pnas.1215349109. Epub 2012 Nov 20.

10.
11.

Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure.

Krivokrysenko VI, Shakhov AN, Singh VK, Bone F, Kononov Y, Shyshynova I, Cheney A, Maitra RK, Purmal A, Whitnall MH, Gudkov AV, Feinstein E.

J Pharmacol Exp Ther. 2012 Nov;343(2):497-508. doi: 10.1124/jpet.112.196071. Epub 2012 Jul 26.

12.

Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation.

Singh VK, Fatanmi OO, Singh PK, Whitnall MH.

Cytokine. 2012 Jun;58(3):406-14. doi: 10.1016/j.cyto.2012.03.011. Epub 2012 Apr 8.

PMID:
22487481
13.

Efficacy of radiation countermeasures depends on radiation quality.

Cary LH, Ngudiankama BF, Salber RE, Ledney GD, Whitnall MH.

Radiat Res. 2012 May;177(5):663-75. Epub 2012 Apr 3.

PMID:
22468705
14.

A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute.

Singh VK, Ducey EJ, Brown DS, Whitnall MH.

Int J Radiat Biol. 2012 Apr;88(4):296-310. doi: 10.3109/09553002.2012.652726. Epub 2012 Feb 9. Review.

PMID:
22191567
15.

Hematological changes as prognostic indicators of survival: similarities between Gottingen minipigs, humans, and other large animal models.

Moroni M, Lombardini E, Salber R, Kazemzedeh M, Nagy V, Olsen C, Whitnall MH.

PLoS One. 2011;6(9):e25210. doi: 10.1371/journal.pone.0025210. Epub 2011 Sep 28.

16.

Hematopoietic radiation syndrome in the Gottingen minipig.

Moroni M, Coolbaugh TV, Lombardini E, Mitchell JM, Moccia KD, Shelton LJ, Nagy V, Whitnall MH.

Radiat Res. 2011 Jul;176(1):89-101. Epub 2011 Apr 26.

PMID:
21520996
17.

Vascular access port implantation and serial blood sampling in a Gottingen minipig (Sus scrofa domestica) model of acute radiation injury.

Moroni M, Coolbaugh TV, Mitchell JM, Lombardini E, Moccia KD, Shelton LJ, Nagy V, Whitnall MH.

J Am Assoc Lab Anim Sci. 2011 Jan;50(1):65-72.

18.

Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling.

Li XH, Fu D, Latif NH, Mullaney CP, Ney PH, Mog SR, Whitnall MH, Srinivasan V, Xiao M.

Haematologica. 2010 Dec;95(12):1996-2004. doi: 10.3324/haematol.2010.026492. Epub 2010 Sep 7.

19.

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol.

Richardson DR, Lane DJ, Becker EM, Huang ML, Whitnall M, Suryo Rahmanto Y, Sheftel AD, Ponka P.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10775-82. doi: 10.1073/pnas.0912925107. Epub 2010 May 21. Review.

20.

Multiple parameter radiation injury assessment using a nonhuman primate radiation model-biodosimetry applications.

Blakely WF, Ossetrova NI, Whitnall MH, Sandgren DJ, Krivokrysenko VI, Shakhov A, Feinstein E.

Health Phys. 2010 Feb;98(2):153-9. doi: 10.1097/HP.0b013e3181b0306d.

PMID:
20065677
21.

Pharmacological countermeasures for the acute radiation syndrome.

Xiao M, Whitnall MH.

Curr Mol Pharmacol. 2009 Jan;2(1):122-33. Review.

PMID:
20021452
22.

The ins and outs of mitochondrial iron-loading: the metabolic defect in Friedreich's ataxia.

Richardson DR, Huang ML, Whitnall M, Becker EM, Ponka P, Suryo Rahmanto Y.

J Mol Med (Berl). 2010 Apr;88(4):323-9. doi: 10.1007/s00109-009-0565-x. Epub 2009 Dec 9. Review.

PMID:
19997898
23.

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant.

Huang ML, Becker EM, Whitnall M, Suryo Rahmanto Y, Ponka P, Richardson DR.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16381-6. doi: 10.1073/pnas.0906784106. Epub 2009 Sep 4.

24.

Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice.

Singh VK, Grace MB, Parekh VI, Whitnall MH, Landauer MR.

Int Immunopharmacol. 2009 Nov;9(12):1401-10. doi: 10.1016/j.intimp.2009.08.012. Epub 2009 Aug 28.

PMID:
19716438
25.

Role of NF-kappaB in hematopoietic niche function of osteoblasts after radiation injury.

Xiao M, Inal CE, Parekh VI, Li XH, Whitnall MH.

Exp Hematol. 2009 Jan;37(1):52-64. doi: 10.1016/j.exphem.2008.09.001. Epub 2008 Oct 26.

PMID:
18954936
26.

The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation.

Whitnall M, Suryo Rahmanto Y, Sutak R, Xu X, Becker EM, Mikhael MR, Ponka P, Richardson DR.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9757-62. doi: 10.1073/pnas.0804261105. Epub 2008 Jul 9.

27.

Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure.

Srinivasan V, Doctrow S, Singh VK, Whitnall MH.

Immunopharmacol Immunotoxicol. 2008;30(2):271-90. doi: 10.1080/08923970801925331 .

PMID:
18569084
28.
29.

Administration of 5-androstenediol to mice: pharmacokinetics and cytokine gene expression.

Singh VK, Grace MB, Jacobsen KO, Chang CM, Parekh VI, Inal CE, Shafran RL, Whitnall AD, Kao TC, Jackson WE 3rd, Whitnall MH.

Exp Mol Pathol. 2008 Apr;84(2):178-88. doi: 10.1016/j.yexmp.2007.12.001. Epub 2007 Dec 27.

PMID:
18262521
30.
31.

Iron: a new target for pharmacological intervention in neurodegenerative diseases.

Whitnall M, Richardson DR.

Semin Pediatr Neurol. 2006 Sep;13(3):186-97. Review.

PMID:
17101458
32.

A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics.

Whitnall M, Howard J, Ponka P, Richardson DR.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6. Epub 2006 Sep 26.

33.

5-androstenediol stimulates multilineage hematopoiesis in rhesus monkeys with radiation-induced myelosuppression.

Stickney DR, Dowding C, Garsd A, Ahlem C, Whitnall M, McKeon M, Reading C, Frincke J.

Int Immunopharmacol. 2006 Nov;6(11):1706-13. Epub 2006 Jul 28.

PMID:
16979125
34.

Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSF.

Singh VK, Shafran RL, Inal CE, Jackson WE 3rd, Whitnall MH.

Immunopharmacol Immunotoxicol. 2005;27(4):521-34.

PMID:
16435574
35.

Molecular specificity of 5-androstenediol as a systemic radioprotectant in mice.

Whitnall MH, Villa V, Seed TM, Benjack J, Miner V, Lewbart ML, Dowding CA, Jackson WE 3rd.

Immunopharmacol Immunotoxicol. 2005;27(1):15-32.

PMID:
15803857
36.

Effects of anesthesia and vehicle injection on circulating blood elements in C3H/HeN male mice.

Jacobsen KO, Villa V, Miner VL, Whitnall MH.

Contemp Top Lab Anim Sci. 2004 Sep;43(5):8-12.

PMID:
15461433
37.

New strategies for the prevention of radiation injury: possible implications for countering radiation hazards of long-term space travel.

Seed T, Kumar S, Whitnall M, Srinivasan V, Singh V, Elliott T, Landauer M, Miller A, Chang CM, Inal C, Deen J, Gehlhaus M, Jackson W 3rd, Hilyard E, Pendergrass J, Toles R, Villa V, Miner V, Stewart M, Benjack J, Danilenko D, Farrell C.

J Radiat Res. 2002 Dec;43 Suppl:S239-44.

38.

Radioprotective efficacy and acute toxicity of 5-androstenediol after subcutaneous or oral administration in mice.

Whitnall MH, Wilhelmsen CL, McKinney L, Miner V, Seed TM, Jackson WE 3rd.

Immunopharmacol Immunotoxicol. 2002 Nov;24(4):595-626.

PMID:
12510793
39.

Protection against gamma-irradiation with 5-androstenediol.

Whitnall MH, Elliott TB, Landauer MR, Wilhelmsen CL, McKinney L, Kumar KS, Srinivasan V, Ledney GD, Seed TM.

Mil Med. 2002 Feb;167(2 Suppl):64-5.

PMID:
11873520
40.

In vivo radioprotection by 5-androstenediol: stimulation of the innate immune system.

Whitnall MH, Inal CE, Jackson WE 3rd, Miner VL, Villa V, Seed TM.

Radiat Res. 2001 Sep;156(3):283-93.

PMID:
11500137
41.

In vivo protection against gamma-irradiation with 5-androstenediol.

Whitnall MH, Elliott TB, Landauer MR, Jackson WE 3rd, Wilhelmsen CL, Mckinney L, Kumar KS, Srinivasan V, Ledney GD, Seed TM.

Exp Biol Med (Maywood). 2001 Jul;226(7):625-7. No abstract available.

PMID:
11444097
42.

Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice.

Whitnall MH, Elliott TB, Harding RA, Inal CE, Landauer MR, Wilhelmsen CL, McKinney L, Miner VL, Jackson WE3rd, Loria RM, Ledney GD, Seed TM.

Int J Immunopharmacol. 2000 Jan;22(1):1-14.

PMID:
10684984
43.
44.

The referral practice of general medical practitioners to the surgical specialties: implications for the future.

McArdle PJ, Whitnall M.

Br J Oral Maxillofac Surg. 1996 Oct;34(5):394-9.

PMID:
8909729
45.

Whole-body irradiation transiently diminishes the adrenocorticotropin response to recombinant human interleukin-1 alpha.

Perlstein RS, Mehta NR, Mougey EH, Whitnall MH, Neta R.

Radiat Res. 1995 Mar;141(3):336-41.

PMID:
7871163
46.

Differences in dispersion of influenza virus lipids and proteins during fusion.

Lowy RJ, Sarkar DP, Whitnall MH, Blumenthal R.

Exp Cell Res. 1995 Feb;216(2):411-21.

PMID:
7843286
47.

Systemically administered histamine H1 and H2 receptor antagonists do not block the ACTH response to bacterial lipopolysaccharide and interleukin-1.

Perlstein RS, Mehta NR, Mougey EH, Neta R, Whitnall MH.

Neuroendocrinology. 1994 Oct;60(4):418-25.

PMID:
7824083
48.

Decreased vasopressin content in parvocellular CRH neurosecretory system of Lewis rats.

Whitnall MH, Anderson KA, Lane CA, Mougey EH, Neta R, Perlstein RS.

Neuroreport. 1994 Aug 15;5(13):1635-7.

PMID:
7819536
49.

Estrogen and hydroxysteroid sulfotransferases in guinea pig adrenal cortex: cellular and subcellular distributions.

Whitnall MH, Driscoll WJ, Lee YC, Strott CA.

Endocrinology. 1993 Nov;133(5):2284-91.

PMID:
8404682

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