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Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection.

Misumi I, Cook KD, Mitchell JE, Lund MM, Vick SC, Lee RH, Uchimura T, Bergmeier W, Mieczkowski P, Pardo-Manuel de Villena F, Ting JPY, Whitmire JK.

Cell Rep. 2019 Apr 30;27(5):1387-1396.e5. doi: 10.1016/j.celrep.2019.04.004.


Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses.

Yamane D, Feng H, Rivera-Serrano EE, Selitsky SR, Hirai-Yuki A, Das A, McKnight KL, Misumi I, Hensley L, Lovell W, González-López O, Suzuki R, Matsuda M, Nakanishi H, Ohto-Nakanishi T, Hishiki T, Wauthier E, Oikawa T, Morita K, Reid LM, Sethupathy P, Kohara M, Whitmire JK, Lemon SM.

Nat Microbiol. 2019 Jul;4(7):1096-1104. doi: 10.1038/s41564-019-0425-6. Epub 2019 Apr 15.


Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection.

Misumi I, Starmer J, Uchimura T, Beck MA, Magnuson T, Whitmire JK.

Cell Rep. 2019 Apr 9;27(2):514-524.e5. doi: 10.1016/j.celrep.2019.03.030.


The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity.

Uchimura T, Oyama Y, Deng M, Guo H, Wilson JE, Rampanelli E, Cook KD, Misumi I, Tan X, Chen L, Johnson B, Tam J, Chou WC, Brickey WJ, Petrucelli A, Whitmire JK, Ting JPY.

Immunity. 2018 Dec 18;49(6):1049-1061.e6. doi: 10.1016/j.immuni.2018.10.008.


Murine Models of Hepatitis A Virus Infection.

Hirai-Yuki A, Whitmire JK, Joyce M, Tyrrell DL, Lemon SM.

Cold Spring Harb Perspect Med. 2019 Jan 2;9(1). pii: a031674. doi: 10.1101/cshperspect.a031674. Review.


NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.

Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM.

Nat Immunol. 2017 Dec;18(12):1299-1309. doi: 10.1038/ni.3853. Epub 2017 Oct 2.


TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions.

Das A, Hirai-Yuki A, González-López O, Rhein B, Moller-Tank S, Brouillette R, Hensley L, Misumi I, Lovell W, Cullen JM, Whitmire JK, Maury W, Lemon SM.

mBio. 2017 Sep 5;8(5). pii: e00969-17. doi: 10.1128/mBio.00969-17.


Biliary Secretion of Quasi-Enveloped Human Hepatitis A Virus.

Hirai-Yuki A, Hensley L, Whitmire JK, Lemon SM.

mBio. 2016 Dec 6;7(6). pii: e01998-16. doi: 10.1128/mBio.01998-16.


MAVS-dependent host species range and pathogenicity of human hepatitis A virus.

Hirai-Yuki A, Hensley L, McGivern DR, González-López O, Das A, Feng H, Sun L, Wilson JE, Hu F, Feng Z, Lovell W, Misumi I, Ting JP, Montgomery S, Cullen J, Whitmire JK, Lemon SM.

Science. 2016 Sep 30;353(6307):1541-1545. Epub 2016 Sep 15.


LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8+ T Cell Responses.

Cook KD, Whitmire JK.

J Immunol. 2016 Jul 1;197(1):119-27. doi: 10.4049/jimmunol.1401594. Epub 2016 May 20.


Epigenetic Dysfunction in Turner Syndrome Immune Cells.

Thrasher BJ, Hong LK, Whitmire JK, Su MA.

Curr Allergy Asthma Rep. 2016 May;16(5):36. doi: 10.1007/s11882-016-0612-y. Review.


DCAF1 controls T-cell function via p53-dependent and -independent mechanisms.

Guo Z, Kong Q, Liu C, Zhang S, Zou L, Yan F, Whitmire JK, Xiong Y, Chen X, Wan YY.

Nat Commun. 2016 Jan 5;7:10307. doi: 10.1038/ncomms10307.


The Mouse Universal Genotyping Array: From Substrains to Subspecies.

Morgan AP, Fu CP, Kao CY, Welsh CE, Didion JP, Yadgary L, Hyacinth L, Ferris MT, Bell TA, Miller DR, Giusti-Rodriguez P, Nonneman RJ, Cook KD, Whitmire JK, Gralinski LE, Keller M, Attie AD, Churchill GA, Petkov P, Sullivan PF, Brennan JR, McMillan L, Pardo-Manuel de Villena F.

G3 (Bethesda). 2015 Dec 18;6(2):263-79. doi: 10.1534/g3.115.022087.


IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF.

Kang S, Keener AB, Jones SZ, Benschop RJ, Caro-Maldonado A, Rathmell JC, Clarke SH, Matsushima GK, Whitmire JK, Vilen BJ.

J Immunol. 2016 Jan 1;196(1):196-206. doi: 10.4049/jimmunol.1402527. Epub 2015 Nov 30.


Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.

Maltez VI, Tubbs AL, Cook KD, Aachoui Y, Falcone EL, Holland SM, Whitmire JK, Miao EA.

Immunity. 2015 Nov 17;43(5):987-97. doi: 10.1016/j.immuni.2015.10.010. Epub 2015 Nov 10.


T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.

Cook KD, Shpargel KB, Starmer J, Whitfield-Larry F, Conley B, Allard DE, Rager JE, Fry RC, Davenport ML, Magnuson T, Whitmire JK, Su MA.

Immunity. 2015 Oct 20;43(4):703-14. doi: 10.1016/j.immuni.2015.09.002. Epub 2015 Sep 29.


NK cells inhibit humoral immunity by reducing the abundance of CD4+ T follicular helper cells during a chronic virus infection.

Cook KD, Kline HC, Whitmire JK.

J Leukoc Biol. 2015 Aug;98(2):153-62. doi: 10.1189/jlb.4HI1214-594R. Epub 2015 May 18.


NK cells and their ability to modulate T cells during virus infections.

Cook KD, Waggoner SN, Whitmire JK.

Crit Rev Immunol. 2014;34(5):359-88. Review.


Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.

Yamane D, McGivern DR, Wauthier E, Yi M, Madden VJ, Welsch C, Antes I, Wen Y, Chugh PE, McGee CE, Widman DG, Misumi I, Bandyopadhyay S, Kim S, Shimakami T, Oikawa T, Whitmire JK, Heise MT, Dittmer DP, Kao CC, Pitson SM, Merrill AH Jr, Reid LM, Lemon SM.

Nat Med. 2014 Aug;20(8):927-35. doi: 10.1038/nm.3610. Epub 2014 Jul 27.


Editorial: Not all roads to T cell memory go through STAT4 and T-bet.

Whitmire JK.

J Leukoc Biol. 2014 May;95(5):699-701. No abstract available.


IFN-λ exerts opposing effects on T cell responses depending on the chronicity of the virus infection.

Misumi I, Whitmire JK.

J Immunol. 2014 Apr 15;192(8):3596-606. doi: 10.4049/jimmunol.1301705. Epub 2014 Mar 19.


B cell depletion curtails CD4+ T cell memory and reduces protection against disseminating virus infection.

Misumi I, Whitmire JK.

J Immunol. 2014 Feb 15;192(4):1597-608. doi: 10.4049/jimmunol.1302661. Epub 2014 Jan 22.


Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection.

Misumi I, Alirezaei M, Eam B, Su MA, Whitton JL, Whitmire JK.

J Immunol. 2013 Dec 1;191(11):5655-68. doi: 10.4049/jimmunol.1301215. Epub 2013 Oct 21.


GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling.

Wang Y, Misumi I, Gu AD, Curtis TA, Su L, Whitmire JK, Wan YY.

Nat Immunol. 2013 Jul;14(7):714-22. doi: 10.1038/ni.2623. Epub 2013 May 26.


The depletion of NK cells prevents T cell exhaustion to efficiently control disseminating virus infection.

Cook KD, Whitmire JK.

J Immunol. 2013 Jan 15;190(2):641-9. doi: 10.4049/jimmunol.1202448. Epub 2012 Dec 12.


Induction and function of virus-specific CD4+ T cell responses.

Whitmire JK.

Virology. 2011 Mar 15;411(2):216-28. doi: 10.1016/j.virol.2010.12.015. Epub 2011 Jan 14. Review.


A multivalent vaccination strategy for the prevention of Old World arenavirus infection in humans.

Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Kotturi MF, Sette A, Buchmeier MJ.

J Virol. 2010 Oct;84(19):9947-56. doi: 10.1128/JVI.00672-10. Epub 2010 Jul 28.


Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.

Kemball CC, Harkins S, Whitmire JK, Flynn CT, Feuer R, Whitton JL.

PLoS Pathog. 2009 Oct;5(10):e1000618. doi: 10.1371/journal.ppat.1000618. Epub 2009 Oct 16.


Mice deficient in stem cell antigen-1 (Sca1, Ly-6A/E) develop normal primary and memory CD4+ and CD8+ T-cell responses to virus infection.

Whitmire JK, Eam B, Whitton JL.

Eur J Immunol. 2009 Jun;39(6):1494-504. doi: 10.1002/eji.200838959.


Requirement of B cells for generating CD4+ T cell memory.

Whitmire JK, Asano MS, Kaech SM, Sarkar S, Hannum LG, Shlomchik MJ, Ahmed R.

J Immunol. 2009 Feb 15;182(4):1868-76. doi: 10.4049/jimmunol.0802501.


Detection of intracellular cytokines by flow cytometry.

Foster B, Prussin C, Liu F, Whitmire JK, Whitton JL.

Curr Protoc Immunol. 2007 Aug;Chapter 6:Unit 6.24. doi: 10.1002/0471142735.im0624s78.


Tentative T cells: memory cells are quick to respond, but slow to divide.

Whitmire JK, Eam B, Whitton JL.

PLoS Pathog. 2008 Apr 11;4(4):e1000041. doi: 10.1371/journal.ppat.1000041.


Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.

Iannacone M, Sitia G, Isogawa M, Whitmire JK, Marchese P, Chisari FV, Ruggeri ZM, Guidotti LG.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):629-34. doi: 10.1073/pnas.0711200105. Epub 2008 Jan 9.


Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1.

Crocker SJ, Frausto RF, Whitmire JK, Benning N, Milner R, Whitton JL.

Am J Pathol. 2007 Dec;171(6):1762-73. Epub 2007 Nov 30.


Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency.

Frausto RF, Crocker SJ, Eam B, Whitmire JK, Whitton JL.

J Neuroimmunol. 2007 Dec;192(1-2):124-33. Epub 2007 Oct 26.


Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memory.

Whitmire JK, Eam B, Benning N, Whitton JL.

J Immunol. 2007 Jul 15;179(2):1190-7.


HLA-A2-restricted protection against lethal lymphocytic choriomeningitis.

Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Ting JP, Bui HH, Sette A, Buchmeier MJ.

J Virol. 2007 Mar;81(5):2307-17. Epub 2006 Dec 13.


Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice.

Crocker SJ, Whitmire JK, Frausto RF, Chertboonmuang P, Soloway PD, Whitton JL, Campbell IL.

Am J Pathol. 2006 Dec;169(6):2104-16.


Precursor frequency, nonlinear proliferation, and functional maturation of virus-specific CD4+ T cells.

Whitmire JK, Benning N, Whitton JL.

J Immunol. 2006 Mar 1;176(5):3028-36.


Cutting edge: early IFN-gamma signaling directly enhances primary antiviral CD4+ T cell responses.

Whitmire JK, Benning N, Whitton JL.

J Immunol. 2005 Nov 1;175(9):5624-8.


The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens.

Kitchen SG, Whitmire JK, Jones NR, Galic Z, Kitchen CM, Ahmed R, Zack JA.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3794-9. Epub 2005 Feb 24.


The regulation and maturation of antiviral immune responses.

Whitton JL, Slifka MK, Liu F, Nussbaum AK, Whitmire JK.

Adv Virus Res. 2004;63:181-238. Review. No abstract available.


CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection.

Kitchen SG, Jones NR, LaForge S, Whitmire JK, Vu BA, Galic Z, Brooks DG, Brown SJ, Kitchen CM, Zack JA.

Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8727-32. Epub 2004 Jun 1.


Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection.

Shedlock DJ, Whitmire JK, Tan J, MacDonald AS, Ahmed R, Shen H.

J Immunol. 2003 Feb 15;170(4):2053-63.


A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes.

Shen H, Whitmire JK, Fan X, Shedlock DJ, Kaech SM, Ahmed R.

J Immunol. 2003 Feb 1;170(3):1443-51.


Role of lymphotoxin alpha in T-cell responses during an acute viral infection.

Suresh M, Lanier G, Large MK, Whitmire JK, Altman JD, Ruddle NH, Ahmed R.

J Virol. 2002 Apr;76(8):3943-51.


Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory.

Suresh M, Whitmire JK, Harrington LE, Larsen CP, Pearson TC, Altman JD, Ahmed R.

J Immunol. 2001 Nov 15;167(10):5565-73.


Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance.

Williams MA, Tan JT, Adams AB, Durham MM, Shirasugi N, Whitmire JK, Harrington LE, Ahmed R, Pearson TC, Larsen CP.

J Immunol. 2001 Nov 1;167(9):4987-95.

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