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Items: 1 to 50 of 124

1.

Publisher Correction: Molecular and functional variation in iPSC-derived sensory neurons.

Schwartzentruber J, Foskolou S, Kilpinen H, Rodrigues J, Alasoo K, Knights AJ, Patel M, Goncalves A, Ferreira R, Benn CL, Wilbrey A, Bictash M, Impey E, Cao L, Lainez S, Loucif AJ, Whiting PJ; HIPSCI Consortium, Gutteridge A, Gaffney DJ.

Nat Genet. 2019 Jul;51(7):1190. doi: 10.1038/s41588-019-0445-4.

PMID:
31160811
2.

Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.

Magno L, Lessard CB, Martins M, Lang V, Cruz P, Asi Y, Katan M, Bilsland J, Lashley T, Chakrabarty P, Golde TE, Whiting PJ.

Alzheimers Res Ther. 2019 Feb 2;11(1):16. doi: 10.1186/s13195-019-0469-0.

3.

Molecular and functional variation in iPSC-derived sensory neurons.

Schwartzentruber J, Foskolou S, Kilpinen H, Rodrigues J, Alasoo K, Knights AJ, Patel M, Goncalves A, Ferreira R, Benn CL, Wilbrey A, Bictash M, Impey E, Cao L, Lainez S, Loucif AJ, Whiting PJ; HIPSCI Consortium, Gutteridge A, Gaffney DJ.

Nat Genet. 2018 Jan;50(1):54-61. doi: 10.1038/s41588-017-0005-8. Epub 2017 Dec 11. Erratum in: Nat Genet. 2019 Jul;51(7):1190.

4.

Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage.

Choudhary P, Booth H, Gutteridge A, Surmacz B, Louca I, Steer J, Kerby J, Whiting PJ.

Stem Cells Transl Med. 2017 Feb;6(2):490-501. doi: 10.5966/sctm.2016-0088. Epub 2016 Aug 24.

5.

A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells.

Choudhary P, Whiting PJ.

Stem Cell Res Ther. 2016 Sep 2;7(1):127. doi: 10.1186/s13287-016-0380-6.

6.

Targeting the cAMP and Transforming Growth Factor-β Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium.

Choudhary P, Gutteridge A, Impey E, Storer RI, Owen RM, Whiting PJ, Bictash M, Benn CL.

Stem Cells Transl Med. 2016 Jul;5(7):925-37. doi: 10.5966/sctm.2015-0247. Epub 2016 Apr 25.

7.

A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells.

Choudhary P, Dodsworth BT, Sidders B, Gutteridge A, Michaelides C, Duckworth JK, Whiting PJ, Benn CL.

PLoS One. 2015 Jun 29;10(6):e0130379. doi: 10.1371/journal.pone.0130379. eCollection 2015.

8.

6-Sulphated chondroitins have a positive influence on axonal regeneration.

Lin R, Rosahl TW, Whiting PJ, Fawcett JW, Kwok JC.

PLoS One. 2011;6(7):e21499. doi: 10.1371/journal.pone.0021499. Epub 2011 Jul 1.

9.

Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.

Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR.

J Psychopharmacol. 2007 Jun;21(4):384-91. Epub 2006 Nov 8.

PMID:
17092983
10.

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

Camargo LM, Collura V, Rain JC, Mizuguchi K, Hermjakob H, Kerrien S, Bonnert TP, Whiting PJ, Brandon NJ.

Mol Psychiatry. 2007 Jan;12(1):74-86. Epub 2006 Oct 17.

PMID:
17043677
11.

A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor.

Rosahl TW, Wingrove PB, Hunt V, Fradley RL, Lawrence JM, Heavens RP, Treacey P, Usala M, Macaulay A, Bonnert TP, Whiting PJ, Wafford KA.

Mol Cell Neurosci. 2006 Sep;33(1):47-56. Epub 2006 Jul 25.

PMID:
16870468
12.

Mechanisms of anabolic androgenic steroid inhibition of mammalian epsilon-subunit-containing GABAA receptors.

Jones BL, Whiting PJ, Henderson LP.

J Physiol. 2006 Jun 15;573(Pt 3):571-93. Epub 2006 Mar 16.

13.

GABA-A receptors: a viable target for novel anxiolytics?

Whiting PJ.

Curr Opin Pharmacol. 2006 Feb;6(1):24-9. Epub 2005 Dec 15. Review.

PMID:
16359919
14.

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.

Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR, Malloy MP, Chubb JE, Huston E, Baillie GS, Thomson PA, Hill EV, Brandon NJ, Rain JC, Camargo LM, Whiting PJ, Houslay MD, Blackwood DH, Muir WJ, Porteous DJ.

Science. 2005 Nov 18;310(5751):1187-91.

15.

Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.

Dias R, Sheppard WF, Fradley RL, Garrett EM, Stanley JL, Tye SJ, Goodacre S, Lincoln RJ, Cook SM, Conley R, Hallett D, Humphries AC, Thompson SA, Wafford KA, Street LJ, Castro JL, Whiting PJ, Rosahl TW, Atack JR, McKernan RM, Dawson GR, Reynolds DS.

J Neurosci. 2005 Nov 16;25(46):10682-8.

16.

Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.

Brandon NJ, Schurov I, Camargo LM, Handford EJ, Duran-Jimeniz B, Hunt P, Millar JK, Porteous DJ, Shearman MS, Whiting PJ.

Mol Cell Neurosci. 2005 Apr;28(4):613-24.

PMID:
15797709
17.

Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression.

Guscott M, Bristow LJ, Hadingham K, Rosahl TW, Beer MS, Stanton JA, Bromidge F, Owens AP, Huscroft I, Myers J, Rupniak NM, Patel S, Whiting PJ, Hutson PH, Fone KC, Biello SM, Kulagowski JJ, McAllister G.

Neuropharmacology. 2005 Mar;48(4):492-502.

PMID:
15755477
18.

Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1.

Hayashi MA, Portaro FC, Bastos MF, Guerreiro JR, Oliveira V, Gorrão SS, Tambourgi DV, Sant'Anna OA, Whiting PJ, Camargo LM, Konno K, Brandon NJ, Camargo AC.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3828-33. Epub 2005 Feb 23.

19.

gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions.

Boehm SL 2nd, Ponomarev I, Jennings AW, Whiting PJ, Rosahl TW, Garrett EM, Blednov YA, Harris RA.

Biochem Pharmacol. 2004 Oct 15;68(8):1581-602. Review.

PMID:
15451402
20.

Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment.

Schurov IL, Handford EJ, Brandon NJ, Whiting PJ.

Mol Psychiatry. 2004 Dec;9(12):1100-10.

PMID:
15381924
21.

Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors.

Thompson SA, Wheat L, Brown NA, Wingrove PB, Pillai GV, Whiting PJ, Adkins C, Woodward CH, Smith AJ, Simpson PB, Collins I, Wafford KA.

Br J Pharmacol. 2004 May;142(1):97-106. Epub 2004 Apr 20.

22.

Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.

Brandon NJ, Handford EJ, Schurov I, Rain JC, Pelling M, Duran-Jimeniz B, Camargo LM, Oliver KR, Beher D, Shearman MS, Whiting PJ.

Mol Cell Neurosci. 2004 Jan;25(1):42-55.

PMID:
14962739
23.

The GABAA receptor gene family: new opportunities for drug development.

Whiting PJ.

Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. Review.

PMID:
14579514
24.

Activity of chlormethiazole at human recombinant GABA(A) and NMDA receptors.

Usala M, Thompson SA, Whiting PJ, Wafford KA.

Br J Pharmacol. 2003 Nov;140(6):1045-50. Epub 2003 Oct 6.

25.

Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

Reynolds DS, Rosahl TW, Cirone J, O'Meara GF, Haythornthwaite A, Newman RJ, Myers J, Sur C, Howell O, Rutter AR, Atack J, Macaulay AJ, Hadingham KL, Hutson PH, Belelli D, Lambert JJ, Dawson GR, McKernan R, Whiting PJ, Wafford KA.

J Neurosci. 2003 Sep 17;23(24):8608-17.

26.

GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?

Whiting PJ.

Drug Discov Today. 2003 May 15;8(10):445-50. Review.

PMID:
12801796
27.

GABA(A) alpha 1 subunit knock-out mice do not show a hyperlocomotor response following amphetamine or cocaine treatment.

Reynolds DS, O'Meara GF, Newman RJ, Bromidge FA, Atack JR, Whiting PJ, Rosahl TW, Dawson GR.

Neuropharmacology. 2003 Feb;44(2):190-8.

PMID:
12623217
28.

Effects of ginsenosides on GABA(A) receptor channels expressed in Xenopus oocytes.

Choi SE, Choi S, Lee JH, Whiting PJ, Lee SM, Nah SY.

Arch Pharm Res. 2003 Jan;26(1):28-33.

PMID:
12568354
29.

Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs.

Blednov YA, Jung S, Alva H, Wallace D, Rosahl T, Whiting PJ, Harris RA.

J Pharmacol Exp Ther. 2003 Jan;304(1):30-6.

PMID:
12490572
30.

Overexpression of the GABA(A) receptor epsilon subunit results in insensitivity to anaesthetics.

Thompson SA, Bonnert TP, Cagetti E, Whiting PJ, Wafford KA.

Neuropharmacology. 2002 Sep;43(4):662-8.

PMID:
12367611
31.

Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors.

Brown N, Kerby J, Bonnert TP, Whiting PJ, Wafford KA.

Br J Pharmacol. 2002 Aug;136(7):965-74.

32.

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.

Collinson N, Kuenzi FM, Jarolimek W, Maubach KA, Cothliff R, Sur C, Smith A, Otu FM, Howell O, Atack JR, McKernan RM, Seabrook GR, Dawson GR, Whiting PJ, Rosahl TW.

J Neurosci. 2002 Jul 1;22(13):5572-80.

33.

Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors.

Thompson SA, Wingrove PB, Connelly L, Whiting PJ, Wafford KA.

Mol Pharmacol. 2002 Apr;61(4):861-9.

PMID:
11901225
34.

Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors.

Wingrove PB, Safo P, Wheat L, Thompson SA, Wafford KA, Whiting PJ.

Eur J Pharmacol. 2002 Feb 15;437(1-2):31-9.

PMID:
11864636
35.

Climatic and agricultural contributions to changing loads in two watersheds in Ohio.

Moog DB, Whiting PJ.

J Environ Qual. 2002 Jan-Feb;31(1):83-9.

PMID:
11837448
36.

Climatic and agricultural factors in nutrient exports from two watersheds in Ohio.

Moog DB, Whiting PJ.

J Environ Qual. 2002 Jan-Feb;31(1):72-83.

PMID:
11837447
37.

Radionuclides as indicators of sediment transport in agricultural watersheds that drain to Lake Erie.

Matisoff G, Bonniwell EC, Whiting PJ.

J Environ Qual. 2002 Jan-Feb;31(1):62-72.

PMID:
11837446
38.

Soil erosion and sediment sources in an Ohio watershed using beryllium-7, cesium-137, and lead-210.

Matisoff G, Bonniwell EC, Whiting PJ.

J Environ Qual. 2002 Jan-Feb;31(1):54-61.

PMID:
11837444
39.

Transport of rare earth element-tagged soil particles in response to thunderstorm runoff.

Matisoff G, Ketterer ME, Wilson CG, Layman R, Whiting PJ.

Environ Sci Technol. 2001 Aug 15;35(16):3356-62.

PMID:
11529577
40.

alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential.

Adkins CE, Pillai GV, Kerby J, Bonnert TP, Haldon C, McKernan RM, Gonzalez JE, Oades K, Whiting PJ, Simpson PB.

J Biol Chem. 2001 Oct 19;276(42):38934-9. Epub 2001 Aug 8.

41.

Ribozyme-mediated reduction of the GABA(A) receptor alpha1 subunit.

Subramaniam JR, Corsi L, Vicini S, Whiting PJ, Neale JH.

Brain Res Mol Brain Res. 2001 Aug 15;92(1-2):149-56.

PMID:
11483251
42.

Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice.

Sur C, Wafford KA, Reynolds DS, Hadingham KL, Bromidge F, Macaulay A, Collinson N, O'Meara G, Howell O, Newman R, Myers J, Atack JR, Dawson GR, McKernan RM, Whiting PJ, Rosahl TW.

J Neurosci. 2001 May 15;21(10):3409-18.

43.

Lack of consistent behavioural effects of Maudsley reactive and non-reactive rats in a number of animal tests of anxiety and activity.

Paterson A, Whiting PJ, Gray JA, Flint J, Dawson GR.

Psychopharmacology (Berl). 2001 Apr;154(4):336-42.

PMID:
11349385
44.

Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.

Casula MA, Bromidge FA, Pillai GV, Wingrove PB, Martin K, Maubach K, Seabrook GR, Whiting PJ, Hadingham KL.

J Neurochem. 2001 Apr;77(2):445-51.

45.

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ, Castro JL, Ragan CI, Dawson GR, Whiting PJ.

Nat Neurosci. 2000 Jun;3(6):587-92.

PMID:
10816315
46.

Agonist activation and alpha-bungarotoxin inhibition of wild type and mutant alpha7 nicotinic acetylcholine receptors.

Kempsill FE, Covernton PJ, Whiting PJ, Connolly JG.

Eur J Pharmacol. 1999 Nov 3;383(3):347-59.

PMID:
10594329
47.

Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation.

Thompson SA, Smith MZ, Wingrove PB, Whiting PJ, Wafford KA.

Br J Pharmacol. 1999 Jul;127(6):1349-58.

48.

theta, a novel gamma-aminobutyric acid type A receptor subunit.

Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ.

Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9891-6.

49.

Molecular and functional diversity of the expanding GABA-A receptor gene family.

Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Thompson SA, Wafford KA.

Ann N Y Acad Sci. 1999 Apr 30;868:645-53. Review.

PMID:
10414349
50.

The GABA-A receptor gene family: new targets for therapeutic intervention.

Whiting PJ.

Neurochem Int. 1999 May;34(5):387-90. Review.

PMID:
10397366

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