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Can early warning scores identify deteriorating patients in pre-hospital settings? A systematic review.

Patel R, Nugawela MD, Edwards HB, Richards A, Le Roux H, Pullyblank A, Whiting P.

Resuscitation. 2018 Aug 29;132:101-111. doi: 10.1016/j.resuscitation.2018.08.028. [Epub ahead of print] Review.


Guidance was developed on how to write a plain language summary for diagnostic test accuracy reviews.

Whiting P, Leeflang M, de Salis I, Mustafa RA, Santesso N, Gopalakrishna G, Cooney G, Jesper E, Thomas J, Davenport C.

J Clin Epidemiol. 2018 Jul 20. pii: S0895-4356(18)30420-7. doi: 10.1016/j.jclinepi.2018.07.008. [Epub ahead of print]


Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS.

Gibbs KL, Kalmar B, Rhymes ER, Fellows AD, Ahmed M, Whiting P, Davies CH, Greensmith L, Schiavo G.

Cell Death Dis. 2018 May 22;9(6):596. doi: 10.1038/s41419-018-0624-8.


Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration.

da Cruz L, Fynes K, Georgiadis O, Kerby J, Luo YH, Ahmado A, Vernon A, Daniels JT, Nommiste B, Hasan SM, Gooljar SB, Carr AF, Vugler A, Ramsden CM, Bictash M, Fenster M, Steer J, Harbinson T, Wilbrey A, Tufail A, Feng G, Whitlock M, Robson AG, Holder GE, Sagoo MS, Loudon PT, Whiting P, Coffey PJ.

Nat Biotechnol. 2018 Apr;36(4):328-337. doi: 10.1038/nbt.4114. Epub 2018 Mar 19.


Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies: The PRISMA-DTA Statement.

McInnes MDF, Moher D, Thombs BD, McGrath TA, Bossuyt PM; the PRISMA-DTA Group, Clifford T, Cohen JF, Deeks JJ, Gatsonis C, Hooft L, Hunt HA, Hyde CJ, Korevaar DA, Leeflang MMG, Macaskill P, Reitsma JB, Rodin R, Rutjes AWS, Salameh JP, Stevens A, Takwoingi Y, Tonelli M, Weeks L, Whiting P, Willis BH.

JAMA. 2018 Jan 23;319(4):388-396. doi: 10.1001/jama.2017.19163.


Quality of family relationships and outcomes of dementia: a systematic review.

Edwards HB, Ijaz S, Whiting PF, Leach V, Richards A, Cullum SJ, Cheston RI, Savović J.

BMJ Open. 2018 Jan 21;8(1):e015538. doi: 10.1136/bmjopen-2016-015538. Review.


Early Warning Scores do not accurately predict mortality in sepsis: A meta-analysis and systematic review of the literature.

Hamilton F, Arnold D, Baird A, Albur M, Whiting P.

J Infect. 2018 Mar;76(3):241-248. doi: 10.1016/j.jinf.2018.01.002. Epub 2018 Jan 11.


Molecular and functional variation in iPSC-derived sensory neurons.

Schwartzentruber J, Foskolou S, Kilpinen H, Rodrigues J, Alasoo K, Knights AJ, Patel M, Goncalves A, Ferreira R, Benn CL, Wilbrey A, Bictash M, Impey E, Cao L, Lainez S, Loucif AJ, Whiting PJ, Gutteridge A, Gaffney DJ; HIPSCI Consortium.

Nat Genet. 2018 Jan;50(1):54-61. doi: 10.1038/s41588-017-0005-8. Epub 2017 Dec 11.


Accuracy of cystatin C for the detection of abnormal renal function in children undergoing chemotherapy for malignancy: a systematic review using individual patient data.

Whiting P, Birnie K, Sterne JAC, Jameson C, Skinner R, Phillips B; Cystatin C in Childhood Cancer Collaboration Group.

Support Care Cancer. 2018 May;26(5):1635-1644. doi: 10.1007/s00520-017-4002-3. Epub 2017 Dec 6.


Predictive values of referrals for transient ischaemic attack from first-contact health care: a systematic review.

Kandiyali R, Lasserson DS, Whiting P, Richards A, Mant J.

Br J Gen Pract. 2017 Dec;67(665):e871-e880. doi: 10.3399/bjgp17X693677. Review.


A proposed framework for developing quality assessment tools.

Whiting P, Wolff R, Mallett S, Simera I, Savović J.

Syst Rev. 2017 Oct 17;6(1):204. doi: 10.1186/s13643-017-0604-6.


Models to predict relapse in psychosis: A systematic review.

Sullivan S, Northstone K, Gadd C, Walker J, Margelyte R, Richards A, Whiting P.

PLoS One. 2017 Sep 21;12(9):e0183998. doi: 10.1371/journal.pone.0183998. eCollection 2017. Review.


Patients at Increased Risk of Major Adverse Events Following Operative Treatment of Distal Radius Fractures: Inpatient versus Outpatient.

Whiting PS, Rice CD, Avilucea FR, Bulka CM, Shen MS, Obremskey WT, Sethi MK.

J Wrist Surg. 2017 Aug;6(3):220-226. doi: 10.1055/s-0037-1599216. Epub 2017 Mar 6.


Outcomes of Distal Femur Nonunions Treated With a Combined Nail/Plate Construct and Autogenous Bone Grafting.

Attum B, Douleh D, Whiting PS, White-Dzuro GA, Dodd AC, Shen MS, Mir HR, Obremskey WT, Sethi MK.

J Orthop Trauma. 2017 Sep;31(9):e301-e304. doi: 10.1097/BOT.0000000000000926.


Damage Control Plating in Open Tibial Shaft Fractures: A Cheaper and Equally Effective Alternative to Spanning External Fixation.

Whiting PS, Mitchell PM, Perdue AM, Silverberg AJ, Greenberg SE, Thakore RV, Sathiyakumar V, Mir HR, Obremskey WT, Sethi MK.

J Surg Orthop Adv. Summer 2017;26(2):86-93.


State of Pelvic and Acetabular Surgery in the Developing World: A Global Survey of Orthopaedic Surgeons at Surgical Implant Generation Network (SIGN) Hospitals.

Whiting PS, Anderson DR, Galat DD, Zirkle LG, Lundy DW, Mir HR.

J Orthop Trauma. 2017 Jul;31(7):e217-e223. doi: 10.1097/BOT.0000000000000826.


What are the risks and benefits of temporarily discontinuing medications to prevent acute kidney injury? A systematic review and meta-analysis.

Whiting P, Morden A, Tomlinson LA, Caskey F, Blakeman T, Tomson C, Stone T, Richards A, Savović J, Horwood J.

BMJ Open. 2017 Apr 7;7(4):e012674. doi: 10.1136/bmjopen-2016-012674. Review.


Comparison of microbiological diagnosis of urinary tract infection in young children by routine health service laboratories and a research laboratory: Diagnostic cohort study.

Birnie K, Hay AD, Wootton M, Howe R, MacGowan A, Whiting P, Lawton M, Delaney B, Downing H, Dudley J, Hollingworth W, Lisles C, Little P, O'Brien K, Pickles T, Rumsby K, Thomas-Jones E, Van der Voort J, Waldron CA, Harman K, Hood K, Butler CC, Sterne JA.

PLoS One. 2017 Feb 15;12(2):e0171113. doi: 10.1371/journal.pone.0171113. eCollection 2017.


Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage.

Choudhary P, Booth H, Gutteridge A, Surmacz B, Louca I, Steer J, Kerby J, Whiting PJ.

Stem Cells Transl Med. 2017 Feb;6(2):490-501. doi: 10.5966/sctm.2016-0088. Epub 2016 Aug 24.


Outcomes of Distal Femur Nonunions Treated with a Combined Nail/Plate Construct and Autogenous Bone Grafting.

Attum B, Douleh D, Whiting PS, White-Dzuro GA, Dodd AC, Shen MS, Obremskey WT, Sethi MK.

J Orthop Trauma. 2016 Dec 26. doi: 10.1097/BOT.0000000000000776. [Epub ahead of print]


Negative Stress Examination Under Anesthesia Reliably Predicts Pelvic Ring Union Without Displacement.

Whiting PS, Auston D, Avilucea FR, Ross D, Archdeacon M, Sciadini M, Collinge CA, Sagi HC, Mir HR.

J Orthop Trauma. 2017 Apr;31(4):189-193. doi: 10.1097/BOT.0000000000000766.


ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions.

Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, Henry D, Altman DG, Ansari MT, Boutron I, Carpenter JR, Chan AW, Churchill R, Deeks JJ, Hróbjartsson A, Kirkham J, Jüni P, Loke YK, Pigott TD, Ramsay CR, Regidor D, Rothstein HR, Sandhu L, Santaguida PL, Schünemann HJ, Shea B, Shrier I, Tugwell P, Turner L, Valentine JC, Waddington H, Waters E, Wells GA, Whiting PF, Higgins JP.

BMJ. 2016 Oct 12;355:i4919. doi: 10.1136/bmj.i4919. No abstract available.


The Gustilo-Anderson classification system as predictor of nonunion and infection in open tibia fractures.

Thakore RV, Francois EL, Nwosu SK, Attum B, Whiting PS, Siuta MA, Benvenuti MA, Smith AK, Shen MS, Mousavi I, Obremskey WT, Sethi MK.

Eur J Trauma Emerg Surg. 2017 Oct;43(5):651-656. doi: 10.1007/s00068-016-0725-y. Epub 2016 Sep 22.


The body of knowledge in thanatology: An outline.

Chapple HS, Bouton BL, Chow AY, Gilbert KR, Kosminsky P, Moore J, Whiting PP.

Death Stud. 2017 Feb;41(2):118-125. doi: 10.1080/07481187.2016.1231000. Epub 2016 Sep 9.


A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells.

Choudhary P, Whiting PJ.

Stem Cell Res Ther. 2016 Sep 2;7(1):127. doi: 10.1186/s13287-016-0380-6.


Integrin-Associated Focal Adhesion Kinase Protects Human Embryonic Stem Cells from Apoptosis, Detachment, and Differentiation.

Vitillo L, Baxter M, Iskender B, Whiting P, Kimber SJ.

Stem Cell Reports. 2016 Aug 9;7(2):167-76. doi: 10.1016/j.stemcr.2016.07.006.


Standardizing and monitoring the delivery of surgical interventions in randomized clinical trials.

Blencowe NS, Mills N, Cook JA, Donovan JL, Rogers CA, Whiting P, Blazeby JM.

Br J Surg. 2016 Sep;103(10):1377-84. doi: 10.1002/bjs.10254. Epub 2016 Jul 27.


The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness.

Hay AD, Birnie K, Busby J, Delaney B, Downing H, Dudley J, Durbaba S, Fletcher M, Harman K, Hollingworth W, Hood K, Howe R, Lawton M, Lisles C, Little P, MacGowan A, O'Brien K, Pickles T, Rumsby K, Sterne JA, Thomas-Jones E, van der Voort J, Waldron CA, Whiting P, Wootton M, Butler CC.

Health Technol Assess. 2016 Jul;20(51):1-294. doi: 10.3310/hta20510.


Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Study.

Hay AD, Sterne JA, Hood K, Little P, Delaney B, Hollingworth W, Wootton M, Howe R, MacGowan A, Lawton M, Busby J, Pickles T, Birnie K, O'Brien K, Waldron CA, Dudley J, Van Der Voort J, Downing H, Thomas-Jones E, Harman K, Lisles C, Rumsby K, Durbaba S, Whiting P, Butler CC.

Ann Fam Med. 2016 Jul;14(4):325-36. doi: 10.1370/afm.1954.


Nappy pad urine samples for investigation and treatment of UTI in young children: the 'DUTY' prospective diagnostic cohort study.

Butler CC, Sterne JA, Lawton M, O'Brien K, Wootton M, Hood K, Hollingworth W, Little P, Delaney BC, van der Voort J, Dudley J, Birnie K, Pickles T, Waldron CA, Downing H, Thomas-Jones E, Lisles C, Rumsby K, Durbaba S, Whiting P, Harman K, Howe R, MacGowan A, Fletcher M, Hay AD.

Br J Gen Pract. 2016 Jul;66(648):e516-24. doi: 10.3399/bjgp16X685873.


Posterior Fixation of APC-2 Pelvic Ring Injuries Decreases Rates of Anterior Plate Failure and Malunion.

Avilucea FR, Whiting PS, Mir H.

J Bone Joint Surg Am. 2016 Jun 1;98(11):944-51. doi: 10.2106/JBJS.15.00723.


Suprapatellar Intramedullary Nail Technique Lowers Rate of Malalignment of Distal Tibia Fractures.

Avilucea FR, Triantafillou K, Whiting PS, Perez EA, Mir HR.

J Orthop Trauma. 2016 Oct;30(10):557-60. doi: 10.1097/BOT.0000000000000631.


Risk Factors for Deep Venous Thrombosis Following Orthopaedic Trauma Surgery: An Analysis of 56,000 patients.

Whiting PS, White-Dzuro GA, Greenberg SE, VanHouten JP, Avilucea FR, Obremskey WT, Sethi MK.

Arch Trauma Res. 2016 Jan 23;5(1):e32915. doi: 10.5812/atr.32915. eCollection 2016 Mar.


Targeting the cAMP and Transforming Growth Factor-β Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium.

Choudhary P, Gutteridge A, Impey E, Storer RI, Owen RM, Whiting PJ, Bictash M, Benn CL.

Stem Cells Transl Med. 2016 Jul;5(7):925-37. doi: 10.5966/sctm.2015-0247. Epub 2016 Apr 25.


Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.

Cao L, McDonnell A, Nitzsche A, Alexandrou A, Saintot PP, Loucif AJ, Brown AR, Young G, Mis M, Randall A, Waxman SG, Stanley P, Kirby S, Tarabar S, Gutteridge A, Butt R, McKernan RM, Whiting P, Ali Z, Bilsland J, Stevens EB.

Sci Transl Med. 2016 Apr 20;8(335):335ra56. doi: 10.1126/scitranslmed.aad7653.


Symptomatic and quality-of-life outcomes after treatment for clinically localised prostate cancer: a systematic review.

Whiting PF, Moore TH, Jameson CM, Davies P, Rowlands MA, Burke M, Beynon R, Savovic J, Donovan JL.

BJU Int. 2016 Aug;118(2):193-204. doi: 10.1111/bju.13499. Epub 2016 May 13. Review.


Quality of relationships as predictors of outcomes in people with dementia: a systematic review protocol.

Edwards HB, Savović J, Whiting P, Leach V, Richards A, Cullum S, Cheston R.

BMJ Open. 2016 Apr 4;6(4):e010835. doi: 10.1136/bmjopen-2015-010835. Review.


The rationale for rating risk of bias should be fully reported: response.

Whiting P, Savović J.

J Clin Epidemiol. 2016 Aug;76:239. doi: 10.1016/j.jclinepi.2016.03.008. Epub 2016 Mar 24. No abstract available.


Pre-operative labs: Wasted dollars or predictors of post-operative cardiac and septic events in orthopaedic trauma patients?

Lakomkin N, Sathiyakumar V, Dodd AC, Jahangir AA, Whiting PS, Obremskey WT, Sethi MK.

Injury. 2016 Jun;47(6):1217-21. doi: 10.1016/j.injury.2016.03.004. Epub 2016 Mar 11.


Body mass index predicts perioperative complications following orthopaedic trauma surgery: an ACS-NSQIP analysis.

Whiting PS, White-Dzuro GA, Avilucea FR, Dodd AC, Lakomkin N, Obremskey WT, Collinge CA, Sethi MK.

Eur J Trauma Emerg Surg. 2017 Apr;43(2):255-264. doi: 10.1007/s00068-016-0642-0. Epub 2016 Feb 15.


Thromboembolic Disease After Orthopedic Trauma.

Whiting PS, Jahangir AA.

Orthop Clin North Am. 2016 Apr;47(2):335-44. doi: 10.1016/j.ocl.2015.09.002. Review.


Management of Distal Tibial Metaphyseal Fractures With the SIGN Intramedullary Nail in 3 Developing Countries.

Stephens KR, Shahab F, Galat D, Anderson D, Shahabuddin, Whiting PS, Lundy DW, Zirkle LG.

J Orthop Trauma. 2015 Dec;29(12):e469-75. doi: 10.1097/BOT.0000000000000396.


Procalcitonin testing to guide antibiotic therapy for the treatment of sepsis in intensive care settings and for suspected bacterial infection in emergency department settings: a systematic review and cost-effectiveness analysis.

Westwood M, Ramaekers B, Whiting P, Tomini F, Joore M, Armstrong N, Ryder S, Stirk L, Severens J, Kleijnen J.

Health Technol Assess. 2015 Nov;19(96):v-xxv, 1-236. doi: 10.3310/hta19960. Review.


Medical Use of Cannabinoids--Reply.

Whiting P, Wolff R.

JAMA. 2015 Oct 27;314(16):1751-2. doi: 10.1001/jama.2015.11447. No abstract available.


The risks and benefits of patients temporarily discontinuing medications in the event of an intercurrent illness: a systematic review protocol.

Morden A, Horwood J, Whiting P, Savovic J, Tomlinson L, Blakeman T, Tomson C, Richards A, Stone T, Caskey F.

Syst Rev. 2015 Oct 24;4:139. doi: 10.1186/s13643-015-0135-y. Review.


Pharmacist independent prescribing in critical care: results of a national questionnaire to establish the 2014 UK position.

Bourne RS, Whiting P, Brown LS, Borthwick M.

Int J Pharm Pract. 2016 Apr;24(2):104-13. doi: 10.1111/ijpp.12219. Epub 2015 Sep 30.


Progressing a human embryonic stem-cell-based regenerative medicine therapy towards the clinic.

Whiting P, Kerby J, Coffey P, da Cruz L, McKernan R.

Philos Trans R Soc Lond B Biol Sci. 2015 Oct 19;370(1680):20140375. doi: 10.1098/rstb.2014.0375. Review.


How well do health professionals interpret diagnostic information? A systematic review.

Whiting PF, Davenport C, Jameson C, Burke M, Sterne JA, Hyde C, Ben-Shlomo Y.

BMJ Open. 2015 Jul 28;5(7):e008155. doi: 10.1136/bmjopen-2015-008155. Review.


Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis.

Whiting P, Al M, Westwood M, Ramos IC, Ryder S, Armstrong N, Misso K, Ross J, Severens J, Kleijnen J.

Health Technol Assess. 2015 Jul;19(58):1-228, v-vi. doi: 10.3310/hta19580. Review.


Risk factors for adverse cardiac events in hip fracture patients: an analysis of NSQIP data.

Sathiyakumar V, Avilucea FR, Whiting PS, Jahangir AA, Mir HR, Obremskey WT, Sethi MK.

Int Orthop. 2016 Mar;40(3):439-45. doi: 10.1007/s00264-015-2832-5. Epub 2015 Jul 21.


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