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Items: 44


Molecular determinants of epistasis in HIV-1 protease: Elucidating the interdependence of L89V and L90M mutations in resistance.

Henes M, Kosovrasti K, Lockbaum GJ, Leidner F, Nachum GS, Nalivaika EA, Bolon DNA, Kurt Yilmaz N, Schiffer CA, Whitfield TW.

Biochemistry. 2019 Aug 6. doi: 10.1021/acs.biochem.9b00446. [Epub ahead of print]


Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution.

Boucher JI, Whitfield TW, Dauphin A, Nachum G, Hollins C, Zeldovich KB, Swanstrom R, Schiffer CA, Luban J, Bolon DNA.

Mol Biol Evol. 2019 Apr 1;36(4):798-810. doi: 10.1093/molbev/msz022.


Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness.

Canale AS, Venev SV, Whitfield TW, Caffrey DR, Marasco WA, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Zeldovich KB, Wang JP, Bolon DNA.

J Mol Biol. 2018 Apr 13;430(8):1098-1115. doi: 10.1016/j.jmb.2018.02.009. Epub 2018 Feb 18.


Elucidating the Interdependence of Drug Resistance from Combinations of Mutations.

Ragland DA, Whitfield TW, Lee SK, Swanstrom R, Zeldovich KB, Kurt-Yilmaz N, Schiffer CA.

J Chem Theory Comput. 2017 Nov 14;13(11):5671-5682. doi: 10.1021/acs.jctc.7b00601. Epub 2017 Oct 9.


Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies.

Hall LL, Byron M, Carone DM, Whitfield TW, Pouliot GP, Fischer A, Jones P, Lawrence JB.

Cell Rep. 2017 Mar 21;18(12):2943-2956. doi: 10.1016/j.celrep.2017.02.072.


Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis.

Wu H, Gordon JA, Whitfield TW, Tai PW, van Wijnen AJ, Stein JL, Stein GS, Lian JB.

Biochim Biophys Acta Gene Regul Mech. 2017 Apr;1860(4):438-449. doi: 10.1016/j.bbagrm.2017.01.003. Epub 2017 Jan 8.


Structural Basis of the Disorder in the Tandem Zinc Finger Domain of the RNA-Binding Protein Tristetraprolin.

Tavella D, Deveau LM, Whitfield TW, Massi F.

J Chem Theory Comput. 2016 Oct 11;12(10):4717-4725. Epub 2016 Sep 9.


Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon Differentiation.

Grandy RA, Whitfield TW, Wu H, Fitzgerald MP, VanOudenhove JJ, Zaidi SK, Montecino MA, Lian JB, van Wijnen AJ, Stein JL, Stein GS.

Mol Cell Biol. 2015 Dec 7;36(4):615-27. doi: 10.1128/MCB.00877-15. Print 2016 Feb 15.


The cutlery effect: do designed products for people with disabilities stigmatise them?

Renda G, Jackson S, Kuys B, Whitfield TW.

Disabil Rehabil Assist Technol. 2016 Nov;11(8):661-7. doi: 10.3109/17483107.2015.1042077. Epub 2015 May 4.


Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells.

Trombly DJ, Whitfield TW, Padmanabhan S, Gordon JA, Lian JB, van Wijnen AJ, Zaidi SK, Stein JL, Stein GS.

BMC Genomics. 2015 Apr 17;16:309. doi: 10.1186/s12864-015-1445-0.


κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake.

Whitfield TW Jr, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF.

J Neurosci. 2015 Mar 11;35(10):4296-305. doi: 10.1523/JNEUROSCI.1978-13.2015.


The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter.

Barutcu AR, Tai PW, Wu H, Gordon JA, Whitfield TW, Dobson JR, Imbalzano AN, Lian JB, van Wijnen AJ, Stein JL, Stein GS.

Nucleic Acids Res. 2014;42(16):10360-72. doi: 10.1093/nar/gku712. Epub 2014 Aug 12.


Epigenetic landscape during osteoblastogenesis defines a differentiation-dependent Runx2 promoter region.

Tai PW, Wu H, Gordon JA, Whitfield TW, Barutcu AR, van Wijnen AJ, Lian JB, Stein GS, Stein JL.

Gene. 2014 Oct 15;550(1):1-9. doi: 10.1016/j.gene.2014.05.044. Epub 2014 Jun 2.


Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization.

Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF.

PLoS One. 2014 May 9;9(5):e97216. doi: 10.1371/journal.pone.0097216. eCollection 2014.


Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis.

Wu H, Whitfield TW, Gordon JA, Dobson JR, Tai PW, van Wijnen AJ, Stein JL, Stein GS, Lian JB.

Genome Biol. 2014 Mar 21;15(3):R52. doi: 10.1186/gb-2014-15-3-r52.


Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake.

Schlosburg JE, Whitfield TW Jr, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF.

J Neurosci. 2013 Dec 4;33(49):19384-92. doi: 10.1523/JNEUROSCI.1979-13.2013.


The mere exposure effect for consumer products as a consequence of existing familiarity and controlled exposure.

Hekkert P, Thurgood C, Whitfield TW.

Acta Psychol (Amst). 2013 Oct;144(2):411-7. doi: 10.1016/j.actpsy.2013.07.015. Epub 2013 Sep 4.


Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction.

Kallupi M, Wee S, Edwards S, Whitfield TW Jr, Oleata CS, Luu G, Schmeichel BE, Koob GF, Roberto M.

Biol Psychiatry. 2013 Oct 1;74(7):520-8. doi: 10.1016/j.biopsych.2013.04.028. Epub 2013 Jun 14.


Addiction as a stress surfeit disorder.

Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW Jr, George O.

Neuropharmacology. 2014 Jan;76 Pt B:370-82. doi: 10.1016/j.neuropharm.2013.05.024. Epub 2013 Jun 6. Review.


Relapse to cocaine-seeking after abstinence is regulated by cAMP-dependent protein kinase A in the prefrontal cortex.

Sun WL, Coleman NT, Zelek-Molik A, Barry SM, Whitfield TW Jr, McGinty JF.

Addict Biol. 2014 Jan;19(1):77-86. doi: 10.1111/adb.12043. Epub 2013 Mar 6.


Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors.

Wang J, Zhuang J, Iyer S, Lin X, Whitfield TW, Greven MC, Pierce BG, Dong X, Kundaje A, Cheng Y, Rando OJ, Birney E, Myers RM, Noble WS, Snyder M, Weng Z.

Genome Res. 2012 Sep;22(9):1798-812. doi: 10.1101/gr.139105.112.


Functional analysis of transcription factor binding sites in human promoters.

Whitfield TW, Wang J, Collins PJ, Partridge EC, Aldred SF, Trinklein ND, Myers RM, Weng Z.

Genome Biol. 2012 Sep 26;13(9):R50. doi: 10.1186/gb-2012-13-9-r50.


Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats.

Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW Jr, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF.

J Neurosci. 2012 May 30;32(22):7563-71. doi: 10.1523/JNEUROSCI.0069-12.2012.


Towards a visual recognition threshold: new instrument shows humans identify animals with only 1ms of visual exposure.

Thurgood C, Whitfield TW, Patterson J.

Vision Res. 2011 Sep 1;51(17):1966-71. doi: 10.1016/j.visres.2011.07.008. Epub 2011 Jul 19.


A machine learning approach for the prediction of protein surface loop flexibility.

Hwang H, Vreven T, Whitfield TW, Wiehe K, Weng Z.

Proteins. 2011 Aug;79(8):2467-74. doi: 10.1002/prot.23070. Epub 2011 Jun 1.


A combined experimental and theoretical study of ion solvation in liquid N-methylacetamide.

Yu H, Mazzanti CL, Whitfield TW, Koeppe RE, Andersen OS, Roux B.

J Am Chem Soc. 2010 Aug 11;132(31):10847-56. doi: 10.1021/ja103270w.


Development of a light-emitting diode tachistoscope.

Thurgood C, Patterson J, Simpson D, Whitfield TW.

Rev Sci Instrum. 2010 Mar;81(3):035117. doi: 10.1063/1.3327837.


Simulating Monovalent and Divalent Ions in Aqueous Solution Using a Drude Polarizable Force Field.

Yu H, Whitfield TW, Harder E, Lamoureux G, Vorobyov I, Anisimov VM, Mackerell AD Jr, Roux B.

J Chem Theory Comput. 2010;6(3):774-786.


Identification of functional modules that correlate with phenotypic difference: the influence of network topology.

Hung JH, Whitfield TW, Yang TH, Hu Z, Weng Z, DeLisi C.

Genome Biol. 2010;11(2):R23. doi: 10.1186/gb-2010-11-2-r23. Epub 2010 Feb 26.


Brain-derived neurotrophic factor and cocaine addiction.

McGinty JF, Whitfield TW Jr, Berglind WJ.

Brain Res. 2010 Feb 16;1314:183-93. doi: 10.1016/j.brainres.2009.08.078. Epub 2009 Sep 2. Review.


A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens.

Berglind WJ, Whitfield TW Jr, LaLumiere RT, Kalivas PW, McGinty JF.

J Neurosci. 2009 Mar 25;29(12):3715-9. doi: 10.1523/JNEUROSCI.5457-08.2009.


A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats.

Berglind WJ, See RE, Fuchs RA, Ghee SM, Whitfield TW Jr, Miller SW, McGinty JF.

Eur J Neurosci. 2007 Aug;26(3):757-66. Epub 2007 Jul 25.


A theoretical study of aqueous solvation of K comparing ab initio, polarizable, and fixed-charge models.

Whitfield TW, Varma S, Harder E, Lamoureux G, Rempe SB, Roux B.

J Chem Theory Comput. 2007;3(6):2068-2082.


Structural properties of liquid N-methylacetamide via ab initio, path integral, and classical molecular dynamics.

Whitfield TW, Crain J, Martyna GJ.

J Chem Phys. 2006 Mar 7;124(9):94503.


Structure and hydrogen bonding in neat N-methylacetamide: classical molecular dynamics and Raman spectroscopy studies of a liquid of peptidic fragments.

Whitfield TW, Martyna GJ, Allison S, Bates SP, Vass H, Crain J.

J Phys Chem B. 2006 Mar 2;110(8):3624-37.


Gravitational smoothing as a global optimization strategy.

Whitfield TW, Straub JE.

J Comput Chem. 2002 Aug;23(11):1100-3.


Enhanced sampling in numerical path integration: an approximation for the quantum statistical density matrix based on the nonextensive thermostatistics.

Whitfield TW, Straub JE.

Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Dec;64(6 Pt 2):066115. Epub 2001 Nov 20.


A multidimensional scaling analysis of the techniques that physiotherapists use.

Turner PA, Whitfield TW.

Physiother Res Int. 1997;2(4):237-54.


Physiotherapists' use of evidence based practice: a cross-national study.

Turner P, Whitfield TW.

Physiother Res Int. 1997;2(1):17-29.


Color psychology: a critical review.

Whitfield TW, Wiltshire TJ.

Genet Soc Gen Psychol Monogr. 1990 Nov;116(4):385-411. Review.


Salient features of color space.

Whitfield TW.

Percept Psychophys. 1981 Feb;29(2):87-90. No abstract available.


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