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Items: 1 to 50 of 70

1.

Hairless regulates p53 target genes to exert tumor suppressive functions in glioblastoma.

Brook L, Palade P, Maatough A, Whitfield GK, Emeterio LS, Hsieh D, Hsieh JC.

J Cell Biochem. 2019 Jan;120(1):533-543. doi: 10.1002/jcb.27408. Epub 2018 Sep 7.

PMID:
30191601
2.

Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review.

Rady I, Bloch MB, Chamcheu RN, Banang Mbeumi S, Anwar MR, Mohamed H, Babatunde AS, Kuiate JR, Noubissi FK, El Sayed KA, Whitfield GK, Chamcheu JC.

Oxid Med Cell Longev. 2018 Jul 30;2018:1826170. doi: 10.1155/2018/1826170. eCollection 2018. Review.

3.

Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines.

Sabir MS, Haussler MR, Mallick S, Kaneko I, Lucas DA, Haussler CA, Whitfield GK, Jurutka PW.

Genes Nutr. 2018 Jul 11;13:19. doi: 10.1186/s12263-018-0605-7. eCollection 2018.

4.

Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling.

Chamcheu JC, Rady I, Chamcheu RN, Siddique AB, Bloch MB, Banang Mbeumi S, Babatunde AS, Uddin MB, Noubissi FK, Jurutka PW, Liu YY, Spiegelman VS, Whitfield GK, El Sayed KA.

Int J Mol Sci. 2018 Jun 16;19(6). pii: E1791. doi: 10.3390/ijms19061791.

5.

Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis.

Karrys A, Rady I, Chamcheu RN, Sabir MS, Mallick S, Chamcheu JC, Jurutka PW, Haussler MR, Whitfield GK.

Nutrients. 2018 Feb 4;10(2). pii: E174. doi: 10.3390/nu10020174.

6.

SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation.

Sabir MS, Khan Z, Hu C, Galligan MA, Dussik CM, Mallick S, Stone AD, Batie SF, Jacobs ET, Whitfield GK, Haussler MR, Heck MC, Jurutka PW.

J Steroid Biochem Mol Biol. 2017 Sep;172:117-129. doi: 10.1016/j.jsbmb.2017.06.010. Epub 2017 Jun 19.

7.

Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers.

Maatough A, Whitfield GK, Brook L, Hsieh D, Palade P, Hsieh JC.

J Cell Biochem. 2018 Jan;119(1):69-80. doi: 10.1002/jcb.26164. Epub 2017 Jun 14. Review.

PMID:
28543886
8.

Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership.

Kollitz EM, Zhang G, Hawkins MB, Whitfield GK, Reif DM, Kullman SW.

PLoS One. 2016 Dec 12;11(12):e0168278. doi: 10.1371/journal.pone.0168278. eCollection 2016.

9.

The Mammalian Hairless Protein as a DNA Binding Phosphoprotein.

Brook L, Whitfield GK, Hsieh D, Bither RD, Hsieh JC.

J Cell Biochem. 2017 Feb;118(2):341-350. doi: 10.1002/jcb.25641. Epub 2016 Sep 21.

PMID:
27355563
10.

1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age.

Haussler MR, Whitfield GK, Haussler CA, Sabir MS, Khan Z, Sandoval R, Jurutka PW.

Vitam Horm. 2016;100:165-230. doi: 10.1016/bs.vh.2015.11.005. Epub 2016 Jan 13.

PMID:
26827953
11.

FGF23 gene regulation by 1,25-dihydroxyvitamin D: opposing effects in adipocytes and osteocytes.

Kaneko I, Saini RK, Griffin KP, Whitfield GK, Haussler MR, Jurutka PW.

J Endocrinol. 2015 Sep;226(3):155-66. doi: 10.1530/JOE-15-0225. Epub 2015 Jul 6.

12.

1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D.

Kaneko I, Sabir MS, Dussik CM, Whitfield GK, Karrys A, Hsieh JC, Haussler MR, Meyer MB, Pike JW, Jurutka PW.

FASEB J. 2015 Sep;29(9):4023-35. doi: 10.1096/fj.14-269811. Epub 2015 Jun 12.

PMID:
26071405
13.

Molecular cloning, functional characterization, and evolutionary analysis of vitamin D receptors isolated from basal vertebrates.

Kollitz EM, Zhang G, Hawkins MB, Whitfield GK, Reif DM, Kullman SW.

PLoS One. 2015 Apr 9;10(4):e0122853. doi: 10.1371/journal.pone.0122853. eCollection 2015.

14.

Resveratrol potentiates vitamin D and nuclear receptor signaling.

Dampf Stone A, Batie SF, Sabir MS, Jacobs ET, Lee JH, Whitfield GK, Haussler MR, Jurutka PW.

J Cell Biochem. 2015 Jun;116(6):1130-43. doi: 10.1002/jcb.25070.

PMID:
25536521
15.

Functional diversification of vitamin D receptor paralogs in teleost fish after a whole genome duplication event.

Kollitz EM, Hawkins MB, Whitfield GK, Kullman SW.

Endocrinology. 2014 Dec;155(12):4641-54. doi: 10.1210/en.2014-1505. Epub 2014 Oct 3.

16.

Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin.

Austin HR, Hoss E, Batie SF, Moffet EW, Jurutka PW, Haussler MR, Whitfield GK.

Biochem Biophys Res Commun. 2014 Jan 24;443(4):1275-9. doi: 10.1016/j.bbrc.2013.12.128. Epub 2014 Jan 3.

PMID:
24393842
17.

Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes.

Hsieh JC, Estess RC, Kaneko I, Whitfield GK, Jurutka PW, Haussler MR.

J Endocrinol. 2014 Jan 8;220(2):165-78. doi: 10.1530/JOE-13-0212. Print 2014 Feb.

18.

Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin.

Hoss E, Austin HR, Batie SF, Jurutka PW, Haussler MR, Whitfield GK.

Arch Dermatol Res. 2013 Dec;305(10):867-78. doi: 10.1007/s00403-013-1390-1. Epub 2013 Jul 10.

PMID:
23839497
19.

1,25-dihydroxyvitamin D(3) regulation of fibroblast growth factor-23 expression in bone cells: evidence for primary and secondary mechanisms modulated by leptin and interleukin-6.

Saini RK, Kaneko I, Jurutka PW, Forster R, Hsieh A, Hsieh JC, Haussler MR, Whitfield GK.

Calcif Tissue Int. 2013 Apr;92(4):339-53. doi: 10.1007/s00223-012-9683-5. Epub 2012 Dec 22.

20.

Molecular mechanisms of vitamin D action.

Haussler MR, Whitfield GK, Kaneko I, Haussler CA, Hsieh D, Hsieh JC, Jurutka PW.

Calcif Tissue Int. 2013 Feb;92(2):77-98. doi: 10.1007/s00223-012-9619-0. Epub 2012 Jul 11. Review.

PMID:
22782502
21.

The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis.

Haussler MR, Whitfield GK, Kaneko I, Forster R, Saini R, Hsieh JC, Haussler CA, Jurutka PW.

Rev Endocr Metab Disord. 2012 Mar;13(1):57-69. doi: 10.1007/s11154-011-9199-8. Review.

22.

EpiphaNet: An Interactive Tool to Support Biomedical Discoveries.

Cohen T, Whitfield GK, Schvaneveldt RW, Mukund K, Rindflesch T.

J Biomed Discov Collab. 2010 Sep 21;5:21-49.

23.

Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle.

Hsieh JC, Slater SA, Whitfield GK, Dawson JL, Hsieh G, Sheedy C, Haussler CA, Haussler MR.

J Cell Biochem. 2010 Jun 1;110(3):671-86. doi: 10.1002/jcb.22578.

24.

The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging.

Haussler MR, Haussler CA, Whitfield GK, Hsieh JC, Thompson PD, Barthel TK, Bartik L, Egan JB, Wu Y, Kubicek JL, Lowmiller CL, Moffet EW, Forster RE, Jurutka PW.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):88-97. doi: 10.1016/j.jsbmb.2010.03.019. Epub 2010 Mar 20.

25.

Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention.

Bartik L, Whitfield GK, Kaczmarska M, Lowmiller CL, Moffet EW, Furmick JK, Hernandez Z, Haussler CA, Haussler MR, Jurutka PW.

J Nutr Biochem. 2010 Dec;21(12):1153-61. doi: 10.1016/j.jnutbio.2009.09.012. Epub 2010 Feb 12.

26.

Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention.

Haussler MR, Haussler CA, Bartik L, Whitfield GK, Hsieh JC, Slater S, Jurutka PW.

Nutr Rev. 2008 Oct;66(10 Suppl 2):S98-112. doi: 10.1111/j.1753-4887.2008.00093.x. Review.

PMID:
18844852
27.

Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligands.

Jurutka PW, Bartik L, Whitfield GK, Mathern DR, Barthel TK, Gurevich M, Hsieh JC, Kaczmarska M, Haussler CA, Haussler MR.

J Bone Miner Res. 2007 Dec;22 Suppl 2:V2-10. doi: 10.1359/jbmr.07s216.

28.

1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism.

Barthel TK, Mathern DR, Whitfield GK, Haussler CA, Hopper HA 4th, Hsieh JC, Slater SA, Hsieh G, Kaczmarska M, Jurutka PW, Kolek OI, Ghishan FK, Haussler MR.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):381-8. Epub 2007 Feb 12.

PMID:
17293108
29.

Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4.

Jurutka PW, Thompson PD, Whitfield GK, Eichhorst KR, Hall N, Dominguez CE, Hsieh JC, Haussler CA, Haussler MR.

J Cell Biochem. 2005 Apr 1;94(5):917-43.

PMID:
15578590
30.

Phosphorylation of human vitamin D receptor serine-182 by PKA suppresses 1,25(OH)2D3-dependent transactivation.

Hsieh JC, Dang HT, Galligan MA, Whitfield GK, Haussler CA, Jurutka PW, Haussler MR.

Biochem Biophys Res Commun. 2004 Nov 12;324(2):801-9.

PMID:
15474498
31.

Two basic amino acids C-terminal of the proximal box specify functional binding of the vitamin D receptor to its rat osteocalcin deoxyribonucleic acid-responsive element.

Hsieh JC, Whitfield GK, Jurutka PW, Haussler CA, Thatcher ML, Thompson PD, Dang HT, Galligan MA, Oza AK, Haussler MR.

Endocrinology. 2003 Nov;144(11):5065-80. Epub 2003 Jul 24.

PMID:
12960019
32.

Cloning of a functional vitamin D receptor from the lamprey (Petromyzon marinus), an ancient vertebrate lacking a calcified skeleton and teeth.

Whitfield GK, Dang HT, Schluter SF, Bernstein RM, Bunag T, Manzon LA, Hsieh G, Dominguez CE, Youson JH, Haussler MR, Marchalonis JJ.

Endocrinology. 2003 Jun;144(6):2704-16.

PMID:
12746335
33.

Rapid evolutionary emergence of the combinatorial recognition repertoire.

Marchalonis JJ, Whitfield GK, Schluter SF.

Integr Comp Biol. 2003 Apr;43(2):347-59. doi: 10.1093/icb/43.2.347.

PMID:
21680443
34.

Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements.

Thompson PD, Jurutka PW, Whitfield GK, Myskowski SM, Eichhorst KR, Dominguez CE, Haussler CA, Haussler MR.

Biochem Biophys Res Commun. 2002 Dec 20;299(5):730-8.

PMID:
12470639
35.

Vitamin D receptor as an intestinal bile acid sensor.

Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, Mangelsdorf DJ.

Science. 2002 May 17;296(5571):1313-6.

36.

Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptor.

Jurutka PW, MacDonald PN, Nakajima S, Hsieh JC, Thompson PD, Whitfield GK, Galligan MA, Haussler CA, Haussler MR.

J Cell Biochem. 2002;85(2):435-57.

PMID:
11948698
37.

Molecular nature of the vitamin D receptor and its role in regulation of gene expression.

Jurutka PW, Whitfield GK, Hsieh JC, Thompson PD, Haussler CA, Haussler MR.

Rev Endocr Metab Disord. 2001 Apr;2(2):203-16. Review. No abstract available.

PMID:
11705326
38.

Distinct retinoid X receptor activation function-2 residues mediate transactivation in homodimeric and vitamin D receptor heterodimeric contexts.

Thompson PD, Remus LS, Hsieh JC, Jurutka PW, Whitfield GK, Galligan MA, Encinas Dominguez C, Haussler CA, Haussler MR.

J Mol Endocrinol. 2001 Oct;27(2):211-27.

PMID:
11564604
39.

Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene.

Whitfield GK, Remus LS, Jurutka PW, Zitzer H, Oza AK, Dang HT, Haussler CA, Galligan MA, Thatcher ML, Encinas Dominguez C, Haussler MR.

Mol Cell Endocrinol. 2001 May 25;177(1-2):145-59.

PMID:
11377830
40.

The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB.

Jurutka PW, Remus LS, Whitfield GK, Thompson PD, Hsieh JC, Zitzer H, Tavakkoli P, Galligan MA, Dang HT, Haussler CA, Haussler MR.

Mol Endocrinol. 2000 Mar;14(3):401-20.

PMID:
10707958
41.

Biochemical evidence for a 170-kilodalton, AF-2-dependent vitamin D receptor/retinoid X receptor coactivator that is highly expressed in osteoblasts.

Jurutka PW, Remus LS, Whitfield GK, Galligan MA, Haussler CA, Haussler MR.

Biochem Biophys Res Commun. 2000 Jan 27;267(3):813-9.

PMID:
10673374
42.

Steroid hormone receptors: evolution, ligands, and molecular basis of biologic function.

Whitfield GK, Jurutka PW, Haussler CA, Haussler MR.

J Cell Biochem. 1999;Suppl 32-33:110-22. Review.

PMID:
10629110
43.

Characterization of unique DNA-binding and transcriptional-activation functions in the carboxyl-terminal extension of the zinc finger region in the human vitamin D receptor.

Hsieh JC, Whitfield GK, Oza AK, Dang HT, Price JN, Galligan MA, Jurutka PW, Thompson PD, Haussler CA, Haussler MR.

Biochemistry. 1999 Dec 7;38(49):16347-58.

PMID:
10587460
44.

Vitamin D receptor displays DNA binding and transactivation as a heterodimer with the retinoid X receptor, but not with the thyroid hormone receptor.

Thompson PD, Hsieh JC, Whitfield GK, Haussler CA, Jurutka PW, Galligan MA, Tillman JB, Spindler SR, Haussler MR.

J Cell Biochem. 1999 Dec 1;75(3):462-80.

PMID:
10536369
45.

Suppression of ANP gene transcription by liganded vitamin D receptor: involvement of specific receptor domains.

Chen S, Wu J, Hsieh JC, Whitfield GK, Jurutka PW, Haussler MR, Gardner DG.

Hypertension. 1998 Jun;31(6):1338-42.

PMID:
9622151
47.

The nuclear vitamin D receptor: biological and molecular regulatory properties revealed.

Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH, Dominguez CE, Jurutka PW.

J Bone Miner Res. 1998 Mar;13(3):325-49. Review. No abstract available.

48.

The vitamin D hormone and its nuclear receptor: molecular actions and disease states.

Haussler MR, Haussler CA, Jurutka PW, Thompson PD, Hsieh JC, Remus LS, Selznick SH, Whitfield GK.

J Endocrinol. 1997 Sep;154 Suppl:S57-73. Review.

PMID:
9379138
50.

Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D3: point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner.

Whitfield GK, Selznick SH, Haussler CA, Hsieh JC, Galligan MA, Jurutka PW, Thompson PD, Lee SM, Zerwekh JE, Haussler MR.

Mol Endocrinol. 1996 Dec;10(12):1617-31.

PMID:
8961271

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