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Food ingredient safety evaluation: Utility and relevance of toxicokinetic methods.

Kabadi SV, Zang Y, Fisher JW, Smith N, Whiteside C, Aungst J.

Toxicol Appl Pharmacol. 2019 Nov 1;382:114759. doi: 10.1016/j.taap.2019.114759. Epub 2019 Sep 12. Review.


The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer's Disease.

Dugger BN, Whiteside CM, Maarouf CL, Walker DG, Beach TG, Sue LI, Garcia A, Dunckley T, Meechoovet B, Reiman EM, Roher AE.

J Alzheimers Dis. 2016 Oct 4;54(3):1249. No abstract available.


Outbreak of syphilis in men who have sex with men living in rural North Wales (UK) associated with the use of social media.

Thomas DR, Williams CJ, Andrady U, Anderson V, Humphreys S, Midgley CM, Fina L, Craine N, Porter-Jones G, Wilde A, Whiteside C.

Sex Transm Infect. 2016 Aug;92(5):359-64. doi: 10.1136/sextrans-2015-052323. Epub 2016 May 4.


The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer's Disease.

Dugger BN, Whiteside CM, Maarouf CL, Walker DG, Beach TG, Sue LI, Garcia A, Dunckley T, Meechoovet B, Reiman EM, Roher AE.

J Alzheimers Dis. 2016;51(2):345-56. doi: 10.3233/JAD-150859. Erratum in: J Alzheimers Dis. 2016 Oct 4;54(3):1249.


International linkage of two food-borne hepatitis A clusters through traceback of mussels, the Netherlands, 2012.

Boxman IL, Verhoef L, Vennema H, Ngui SL, Friesema IH, Whiteside C, Lees D, Koopmans M.

Euro Surveill. 2016;21(3):30113. doi: 10.2807/1560-7917.ES.2016.21.3.30113.


Neuropathological and biochemical assessments of an Alzheimer's disease patient treated with the γ-secretase inhibitor semagacestat.

Roher AE, Maarouf CL, Kokjohn TA, Whiteside CM, Kalback WM, Serrano G, Belden C, Liebsack C, Jacobson SA, Sabbagh MN, Beach TG.

Am J Neurodegener Dis. 2014 Dec 5;3(3):115-33. eCollection 2014.


Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease.

Maarouf CL, Kokjohn TA, Walker DG, Whiteside CM, Kalback WM, Whetzel A, Sue LI, Serrano G, Jacobson SA, Sabbagh MN, Reiman EM, Beach TG, Roher AE.

PLoS One. 2014 Aug 28;9(8):e105784. doi: 10.1371/journal.pone.0105784. eCollection 2014.


Adalimumab for Crohn's disease in New Zealand--a prospective multicentre experience.

Thomas GR, Lewis-Morris T, Rowbotham D, Whiteside C, Joyce S, Inns S, Schultz M, Gearry RB.

N Z Med J. 2014 Jun 20;127(1396):23-33.


Recent outbreaks of infectious syphilis, United Kingdom, January 2012 to April 2014.

Simms I, Wallace L, Thomas DR, Emmett L, Shankar AG, Vinson M, Padfield S, Andrady U, Whiteside C, Williams CJ, Midgley C, Johnman C, McLellan A, Currie A, Logan J, Leslie G, Licence K, Hughes G.

Euro Surveill. 2014 Jun 19;19(24). pii: 20833. Erratum in: Euro Surveill. 2014;19(24):pii/20833.


Subjects harboring presenilin familial Alzheimer's disease mutations exhibit diverse white matter biochemistry alterations.

Roher AE, Maarouf CL, Malek-Ahmadi M, Wilson J, Kokjohn TA, Daugs ID, Whiteside CM, Kalback WM, Macias MP, Jacobson SA, Sabbagh MN, Ghetti B, Beach TG.

Am J Neurodegener Dis. 2013 Sep 18;2(3):187-207. eCollection 2013.


Understanding the needs of department chairs in academic medicine.

Lieff S, Banack JG, Baker L, Martimianakis MA, Verma S, Whiteside C, Reeves S.

Acad Med. 2013 Jul;88(7):960-6. doi: 10.1097/ACM.0b013e318294ff36.


Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy.

Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G, Belden C, Sabbagh MN, Beach TG.

PLoS One. 2013;8(3):e59735. doi: 10.1371/journal.pone.0059735. Epub 2013 Mar 21.


Molecular Differences and Similarities Between Alzheimer's Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis.

Maarouf CL, Kokjohn TA, Whiteside CM, Macias MP, Kalback WM, Sabbagh MN, Beach TG, Vassar R, Roher AE.

Biochem Insights. 2013 Nov 21;6:1-10. doi: 10.4137/BCI.S13025. eCollection 2013.


Neurochemical profile of dementia pugilistica.

Kokjohn TA, Maarouf CL, Daugs ID, Hunter JM, Whiteside CM, Malek-Ahmadi M, Rodriguez E, Kalback W, Jacobson SA, Sabbagh MN, Beach TG, Roher AE.

J Neurotrauma. 2013 Jun 1;30(11):981-97. doi: 10.1089/neu.2012.2699.


Alzheimer disease periventricular white matter lesions exhibit specific proteomic profile alterations.

Castaño EM, Maarouf CL, Wu T, Leal MC, Whiteside CM, Lue LF, Kokjohn TA, Sabbagh MN, Beach TG, Roher AE.

Neurochem Int. 2013 Jan;62(2):145-56. doi: 10.1016/j.neuint.2012.12.001. Epub 2012 Dec 8.


Biophysiologic and social stress relationships with breast milk feeding pre- and post-discharge from the neonatal intensive care unit.

Purdy IB, Singh N, Le C, Bell C, Whiteside C, Collins M.

J Obstet Gynecol Neonatal Nurs. 2012 May-Jun;41(3):347-57. doi: 10.1111/j.1552-6909.2012.01368.x. Erratum in: J Obstet Gynecol Neonatal Nurs. 2012 Jul-Aug;41(4):580.


O-linked β-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells.

Goldberg H, Whiteside C, Fantus IG.

Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E713-26. doi: 10.1152/ajpendo.00108.2011. Epub 2011 Jun 28.


The epigenetics of Alzheimer's disease--additional considerations.

Rogers J, Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD.

Neurobiol Aging. 2011 Jul;32(7):1196-7. doi: 10.1016/j.neurobiolaging.2011.02.025. Epub 2011 Apr 16. Review.


Epigenetic mechanisms in Alzheimer's disease.

Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J.

Neurobiol Aging. 2011 Jul;32(7):1161-80. doi: 10.1016/j.neurobiolaging.2010.08.017. Epub 2011 Apr 11. Review.


New Zealand Society of Gastroenterology statement on the use of biological therapy in inflammatory bowel disease.

Schultz M, Gearry R, Walmsley R, Day AS, Fraser A, Wyeth J, Barclay M, Clover G, Whiteside C.

N Z Med J. 2010 May 14;123(1314):134-44. Review. No abstract available.


Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells.

Whiteside C, Wang H, Xia L, Munk S, Goldberg HJ, Fantus IG.

Exp Diabetes Res. 2009;2009:910783. doi: 10.1155/2009/910783. Epub 2009 Jul 7.


Probable zoonotic transmission of verocytotoxigenic Escherichia coli O 157 by dogs.

Hogg RA, Holmes JP, Ghebrehewet S, Elders K, Hart J, Whiteside C, Willshaw GA, Cheasty T, Kay A, Lynch K, Pritchard GC.

Vet Rec. 2009 Mar 7;164(10):304-5. No abstract available.


Protein kinase C-beta inhibition attenuates the progression of nephropathy in non-diabetic kidney disease.

Kelly DJ, Edgley AJ, Zhang Y, Thai K, Tan SM, Cox AJ, Advani A, Connelly KA, Whiteside CI, Gilbert RE.

Nephrol Dial Transplant. 2009 Jun;24(6):1782-90. doi: 10.1093/ndt/gfn729. Epub 2009 Jan 20.


Epigenetic changes in Alzheimer's disease: decrements in DNA methylation.

Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J.

Neurobiol Aging. 2010 Dec;31(12):2025-37. doi: 10.1016/j.neurobiolaging.2008.12.005. Epub 2008 Dec 30.


High glucose activates PKC-zeta and NADPH oxidase through autocrine TGF-beta1 signaling in mesangial cells.

Xia L, Wang H, Munk S, Kwan J, Goldberg HJ, Fantus IG, Whiteside CI.

Am J Physiol Renal Physiol. 2008 Dec;295(6):F1705-14. doi: 10.1152/ajprenal.00043.2008. Epub 2008 Sep 24.


A patient notification exercise following infection control failures in a dental surgery.

Mason BW, Cartwright J, Sandham S, Whiteside C, Salmon RL.

Br Dent J. 2008 Aug 23;205(4):E8; discussion 194-5. doi: 10.1038/sj.bdj.2008.656. Epub 2008 Jul 25.


Regulation of mesangial cell alpha-smooth muscle actin expression in 3-dimensional matrix by high glucose and growth factors.

Whiteside C, Munk S, Ispanovic E, Wang H, Goldberg H, Kapus A, Xia L.

Nephron Exp Nephrol. 2008;109(2):e46-56. doi: 10.1159/000142099. Epub 2008 Jul 4.


Ending the sexist blame game.

Herbert C, Whiteside C, McKnight D, Verma S, Wilson L, Hébert PC, Stanbrook MB, Sibbald B, Flegel K, MacDonald N, Attaran A.

CMAJ. 2008 Mar 11;178(6):659, 661. doi: 10.1503/cmaj.080216. English, French. No abstract available.


Protein kinase C isozymes and their selectivity towards ruboxistaurin.

Tang S, Xiao V, Wei L, Whiteside CI, Kotra LP.

Proteins. 2008 Jul;72(1):447-60. doi: 10.1002/prot.21942.


Reactive oxygen species, PKC-beta1, and PKC-zeta mediate high-glucose-induced vascular endothelial growth factor expression in mesangial cells.

Xia L, Wang H, Munk S, Frecker H, Goldberg HJ, Fantus IG, Whiteside CI.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1280-8. Epub 2007 Aug 21.


Bridging the gap in population health for rural and Aboriginal communities: a needs assessment of public health training for rural primary care physicians.

Buxton JA, Ouellette V, Brazier A, Whiteside C, Mathias R, Dawar M, Mulkins A.

Can J Rural Med. 2007 Spring;12(2):81-8.


Structuring communication relationships for interprofessional teamwork (SCRIPT): a Canadian initiative aimed at improving patient-centred care.

Reeves S, Russell A, Zwarenstein M, Kenaszchuk C, Conn LG, Doran D, Sinclair L, Lingard L, Oandasan I, Thorpe K, Austin Z, Beales J, Hindmarsh W, Whiteside C, Hodges B, Nasmith L, Silver I, Miller KL, Vogwill V, Strauss S.

J Interprof Care. 2007 Feb;21(1):111-4. No abstract available.


Protein kinase Czeta is required for oleic acid-induced secretion of glucagon-like peptide-1 by intestinal endocrine L cells.

Iakoubov R, Izzo A, Yeung A, Whiteside CI, Brubaker PL.

Endocrinology. 2007 Mar;148(3):1089-98. Epub 2006 Nov 16.


Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling.

Hsieh TJ, Chen R, Zhang SL, Liu F, Brezniceanu ML, Whiteside CI, Fantus IG, Ingelfinger JR, Hamet P, Chan JS.

Kidney Int. 2006 Mar;69(6):1005-15.


Posttranslational, reversible O-glycosylation is stimulated by high glucose and mediates plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells.

Goldberg HJ, Whiteside CI, Hart GW, Fantus IG.

Endocrinology. 2006 Jan;147(1):222-31. Erratum in: Endocrinology. 2006 Nov;147(11):5490.


In high glucose protein kinase C-zeta activation is required for mesangial cell generation of reactive oxygen species.

Kwan J, Wang H, Munk S, Xia L, Goldberg HJ, Whiteside CI.

Kidney Int. 2005 Dec;68(6):2526-41.


Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression.

Xia L, Wang H, Goldberg HJ, Munk S, Fantus IG, Whiteside CI.

Am J Physiol Renal Physiol. 2006 Feb;290(2):F345-56. Epub 2005 Aug 30.


Mesangial cell-reduced Ca2+ signaling in high glucose is due to inactivation of phospholipase C-beta3 by protein kinase C.

Frecker H, Munk S, Wang H, Whiteside C.

Am J Physiol Renal Physiol. 2005 Nov;289(5):F1078-87. Epub 2005 Jul 5.


The birth of the Canadian Academy of Health Sciences.

Armstrong PW, Dempster LJ, Hawkins DG, Law M, Ogilvie TH, Orchard C, Schechter MT, Sindelar R, Whiteside C.

Clin Invest Med. 2005 Apr;28(2):43-5. No abstract available.


Vascular endothelial growth factor expression and secretion by retinal pigment epithelial cells in high glucose and hypoxia is protein kinase C-dependent.

Young TA, Wang H, Munk S, Hammoudi DS, Young DS, Mandelcorn MS, Whiteside CI.

Exp Eye Res. 2005 May;80(5):651-62. Epub 2005 Jan 4.


The prognostic relevance of estimates of proliferative activity in early breast cancer.

Heatley MK, Maxwell P, Whiteside C, Ewing P, Toner PG.

Histopathology. 2005 Jan;46(1):110-1. No abstract available.


Effect of periodic letters on evidence-based drug therapy on prescribing behaviour: a randomized trial.

Dormuth CR, Maclure M, Bassett K, Jauca C, Whiteside C, Wright JM.

CMAJ. 2004 Oct 26;171(9):1057-61.


High glucose-suppressed endothelin-1 Ca2+ signaling via NADPH oxidase and diacylglycerol-sensitive protein kinase C isozymes in mesangial cells.

Hua H, Munk S, Goldberg H, Fantus IG, Whiteside CI.

J Biol Chem. 2003 Sep 5;278(36):33951-62. Epub 2003 Jun 23.


Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction.

Hua H, Munk S, Whiteside CI.

Am J Physiol Renal Physiol. 2003 Feb;284(2):F303-12. Epub 2002 Sep 17.


Mesangial cell protein kinase C isozyme activation in the diabetic milieu.

Whiteside CI, Dlugosz JA.

Am J Physiol Renal Physiol. 2002 Jun;282(6):F975-80. Review.


Mesangial cell filamentous actin disassembly and hypocontractility in high glucose are mediated by PKC-zeta.

Dlugosz JA, Munk S, Ispanovic E, Goldberg HJ, Whiteside CI.

Am J Physiol Renal Physiol. 2002 Jan;282(1):F151-63.


High glucose-enhanced activation of mesangial cell p38 MAPK by ET-1, ANG II, and platelet-derived growth factor.

Tsiani E, Lekas P, Fantus IG, Dlugosz J, Whiteside C.

Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E161-9.


Insulin, insulin-like growth factor-I, and platelet-derived growth factor activate extracellular signal-regulated kinase by distinct pathways in muscle cells.

Tsakiridis T, Tsiani E, Lekas P, Bergman A, Cherepanov V, Whiteside C, Downey GP.

Biochem Biophys Res Commun. 2001 Oct 19;288(1):205-11.


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