Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 13

1.

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.

De S, Whiten DR, Ruggeri FS, Hughes C, Rodrigues M, Sideris DI, Taylor CG, Aprile FA, Muyldermans S, Knowles TPJ, Vendruscolo M, Bryant C, Blennow K, Skoog I, Kern S, Zetterberg H, Klenerman D.

Acta Neuropathol Commun. 2019 Jul 26;7(1):120. doi: 10.1186/s40478-019-0777-4.

2.

Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates.

Scheidt T, Łapińska U, Kumita JR, Whiten DR, Klenerman D, Wilson MR, Cohen SIA, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ, Arosio P.

Sci Adv. 2019 Apr 17;5(4):eaau3112. doi: 10.1126/sciadv.aau3112. eCollection 2019 Apr.

3.

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, Vendruscolo M, Klenerman D.

Nat Commun. 2019 Apr 4;10(1):1541. doi: 10.1038/s41467-019-09477-3.

4.

Quantifying Co-Oligomer Formation by α-Synuclein.

Iljina M, Dear AJ, Garcia GA, De S, Tosatto L, Flagmeier P, Whiten DR, Michaels TCT, Frenkel D, Dobson CM, Knowles TPJ, Klenerman D.

ACS Nano. 2018 Nov 27;12(11):10855-10866. doi: 10.1021/acsnano.8b03575. Epub 2018 Oct 29.

5.

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.

Whiten DR, Zuo Y, Calo L, Choi ML, De S, Flagmeier P, Wirthensohn DC, Kundel F, Ranasinghe RT, Sanchez SE, Athauda D, Lee SF, Dobson CM, Gandhi S, Spillantini MG, Klenerman D, Horrocks MH.

Chembiochem. 2018 Oct 4;19(19):2033-2038. doi: 10.1002/cbic.201800209. Epub 2018 Sep 11.

6.

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.

Whiten DR, Cox D, Horrocks MH, Taylor CG, De S, Flagmeier P, Tosatto L, Kumita JR, Ecroyd H, Dobson CM, Klenerman D, Wilson MR.

Cell Rep. 2018 Jun 19;23(12):3492-3500. doi: 10.1016/j.celrep.2018.05.074.

7.

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.

Ludtmann MHR, Angelova PR, Horrocks MH, Choi ML, Rodrigues M, Baev AY, Berezhnov AV, Yao Z, Little D, Banushi B, Al-Menhali AS, Ranasinghe RT, Whiten DR, Yapom R, Dolt KS, Devine MJ, Gissen P, Kunath T, Jaganjac M, Pavlov EV, Klenerman D, Abramov AY, Gandhi S.

Nat Commun. 2018 Jun 12;9(1):2293. doi: 10.1038/s41467-018-04422-2.

8.

Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates.

Kundel F, Tosatto L, Whiten DR, Wirthensohn DC, Horrocks MH, Klenerman D.

FEBS J. 2018 Oct;285(19):3604-3630. doi: 10.1111/febs.14409. Epub 2018 Mar 4. Review.

PMID:
29453901
9.

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.

Cox D, Whiten DR, Brown JWP, Horrocks MH, San Gil R, Dobson CM, Klenerman D, van Oijen AM, Ecroyd H.

J Biol Chem. 2018 Mar 23;293(12):4486-4497. doi: 10.1074/jbc.M117.813865. Epub 2018 Jan 30.

10.

Inhibiting the Ca2+ Influx Induced by Human CSF.

Drews A, De S, Flagmeier P, Wirthensohn DC, Chen WH, Whiten DR, Rodrigues M, Vincke C, Muyldermans S, Paterson RW, Slattery CF, Fox NC, Schott JM, Zetterberg H, Dobson CM, Gandhi S, Klenerman D.

Cell Rep. 2017 Dec 12;21(11):3310-3316. doi: 10.1016/j.celrep.2017.11.057.

11.

Clusterin protects neurons against intracellular proteotoxicity.

Gregory JM, Whiten DR, Brown RA, Barros TP, Kumita JR, Yerbury JJ, Satapathy S, McDade K, Smith C, Luheshi LM, Dobson CM, Wilson MR.

Acta Neuropathol Commun. 2017 Nov 7;5(1):81. doi: 10.1186/s40478-017-0481-1.

12.

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation.

Zeineddine R, Whiten DR, Farrawell NE, McAlary L, Hanspal MA, Kumita JR, Wilson MR, Yerbury JJ.

Prion. 2017 May 4;11(3):195-204. doi: 10.1080/19336896.2017.1314426. Epub 2017 May 9.

13.

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking.

Whiten DR, San Gil R, McAlary L, Yerbury JJ, Ecroyd H, Wilson MR.

Sci Rep. 2016 Aug 12;6:31138. doi: 10.1038/srep31138.

Supplemental Content

Loading ...
Support Center