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Items: 1 to 50 of 197

1.

Enhanced mitochondrial inhibition by 3,4-dihydroxyphenyl-acetaldehyde (DOPAL)-oligomerized α-synuclein.

Sarafian TA, Yacoub A, Kunz A, Aranki B, Serobyan G, Cohn W, Whitelegge JP, Watson JB.

J Neurosci Res. 2019 Aug 16. doi: 10.1002/jnr.24513. [Epub ahead of print]

PMID:
31420910
2.

Time-Dependent Measurement of Nrf2-Regulated Antioxidant Response to Ionizing Radiation Toward Identifying Potential Protein Biomarkers for Acute Radiation Injury.

Liu K, Singer E, Cohn W, Micewicz ED, McBride WH, Whitelegge JP, Loo JA.

Proteomics Clin Appl. 2019 Aug 16:e1900035. doi: 10.1002/prca.201900035. [Epub ahead of print]

PMID:
31419066
3.

Phenotypic and proteomic characterization of treponemes associated with bovine digital dermatitis.

Nally JE, Hornsby RL, Alt DP, Whitelegge JP.

Vet Microbiol. 2019 Aug;235:35-42. doi: 10.1016/j.vetmic.2019.05.023. Epub 2019 May 30.

PMID:
31282377
4.

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry.

Donnelly DP, Rawlins CM, DeHart CJ, Fornelli L, Schachner LF, Lin Z, Lippens JL, Aluri KC, Sarin R, Chen B, Lantz C, Jung W, Johnson KR, Koller A, Wolff JJ, Campuzano IDG, Auclair JR, Ivanov AR, Whitelegge JP, Paša-Tolić L, Chamot-Rooke J, Danis PO, Smith LM, Tsybin YO, Loo JA, Ge Y, Kelleher NL, Agar JN.

Nat Methods. 2019 Jul;16(7):587-594. doi: 10.1038/s41592-019-0457-0. Epub 2019 Jun 27. Review.

PMID:
31249407
5.

Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling.

Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1269-1279. doi: 10.1016/j.bbalip.2019.06.004. Epub 2019 Jun 5.

PMID:
31176038
6.

Glucose transporter inhibitor-conjugated insulin mitigates hypoglycemia.

Wang J, Yu J, Zhang Y, Kahkoska AR, Wang Z, Fang J, Whitelegge JP, Li S, Buse JB, Gu Z.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10744-10748. doi: 10.1073/pnas.1901967116. Epub 2019 May 16.

PMID:
31097579
7.

Preliminary Characterization of Extracellular Vesicles From Auditory HEI-OC1 Cells.

Kalinec GM, Cohn W, Whitelegge JP, Faull KF, Kalinec F.

Ann Otol Rhinol Laryngol. 2019 Jun;128(6_suppl):52S-60S. doi: 10.1177/0003489419836226.

PMID:
31092033
8.

The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation.

Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D.

Radiat Res. 2019 Apr;191(4):323-334. doi: 10.1667/RR15231.1. Epub 2019 Feb 7.

PMID:
30730284
9.

Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris.

Suades A, Alcaraz A, Cruz E, Álvarez-Marimon E, Whitelegge JP, Manyosa J, Cladera J, Perálvarez-Marín A.

Sci Rep. 2019 Feb 4;9(1):1203. doi: 10.1038/s41598-018-37445-2.

10.

Insights into the structure and molecular topography of the fatty acylated domain of synaptotagmin-1.

Ruchala P, Waring AJ, Cilluffo M, Whitelegge JP, Gundersen CB.

Biochim Biophys Acta Biomembr. 2019 Mar 1;1861(3):677-684. doi: 10.1016/j.bbamem.2018.12.019. Epub 2019 Jan 4.

PMID:
30615859
11.

The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle.

Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL.

Mol Metab. 2019 Mar;21:51-67. doi: 10.1016/j.molmet.2018.11.012. Epub 2018 Dec 4.

12.

Quantitative Measure of Intestinal Permeability Using Blue Food Coloring.

Angarita SAK, Duarte S, Russell TA, Ruchala P, Elliott IA, Whitelegge JP, Zarrinpar A.

J Surg Res. 2019 Jan;233:20-25. doi: 10.1016/j.jss.2018.07.005. Epub 2018 Jul 27.

13.

Proteomics of Bronchoalveolar Lavage Fluid Reveals a Lung Oxidative Stress Response in Murine Herpesvirus-68 Infection.

Bortz E, Wu TT, Patel P, Whitelegge JP, Sun R.

Viruses. 2018 Nov 27;10(12). pii: E670. doi: 10.3390/v10120670.

14.

Investigation of Anti-SOD1 Antibodies Yields New Structural Insight into SOD1 Misfolding and Surprising Behavior of the Antibodies Themselves.

Atlasi RS, Malik R, Corrales CI, Tzeplaeff L, Whitelegge JP, Cashman NR, Bitan G.

ACS Chem Biol. 2018 Sep 21;13(9):2794-2807. doi: 10.1021/acschembio.8b00729. Epub 2018 Aug 30.

15.

HSP70 Copurifies with Zika Virus Particles.

Khachatoorian R, Cohn W, Buzzanco A, Riahi R, Arumugaswami V, Dasgupta A, Whitelegge JP, French SW.

Virology. 2018 Sep;522:228-233. doi: 10.1016/j.virol.2018.07.009. Epub 2018 Jul 25.

16.

Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition.

Saelices L, Chung K, Lee JH, Cohn W, Whitelegge JP, Benson MD, Eisenberg DS.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6741-E6750. doi: 10.1073/pnas.1805131115. Epub 2018 Jun 28.

17.

Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model.

Waldron RT, Su HY, Piplani H, Capri J, Cohn W, Whitelegge JP, Faull KF, Sakkiah S, Abrol R, Yang W, Zhou B, Freeman MR, Pandol SJ, Lugea A.

Cell Mol Gastroenterol Hepatol. 2018 Jan 6;5(4):479-497. doi: 10.1016/j.jcmgh.2018.01.001. eCollection 2018.

18.

COI1-dependent jasmonate signalling affects growth, metabolite production and cell wall protein composition in arabidopsis.

Bömer M, O'Brien JA, Pérez-Salamó I, Krasauskas J, Finch P, Briones A, Daudi A, Souda P, Tsui TL, Whitelegge JP, Paul Bolwell G, Devoto A.

Ann Bot. 2018 Dec 31;122(7):1117-1129. doi: 10.1093/aob/mcy109.

19.

The S-layer biogenesis system of Synechocystis 6803: Role of Sll1180 and Sll1181 (E. coli HlyB and HlyD analogs) as type-I secretion components for Sll1951 export.

Agarwal R, Whitelegge JP, Saini S, Shrivastav AP.

Biochim Biophys Acta Biomembr. 2018 Jul;1860(7):1436-1446. doi: 10.1016/j.bbamem.2018.04.006. Epub 2018 Apr 18.

20.

Peptide Composition of Stroke Causing Emboli Correlate with Serum Markers of Atherosclerosis and Inflammation.

Rao NM, Capri J, Cohn W, Abdaljaleel M, Restrepo L, Gornbein JA, Yong WH, Liebeskind DS, Whitelegge JP.

Front Neurol. 2017 Sep 1;8:427. doi: 10.3389/fneur.2017.00427. eCollection 2017.

21.

Integral membrane proteins: bottom-up, top-down and structural proteomics.

Kar UK, Simonian M, Whitelegge JP.

Expert Rev Proteomics. 2017 Aug;14(8):715-723. doi: 10.1080/14789450.2017.1359545. Epub 2017 Jul 31. Review.

22.

4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues.

Micewicz ED, Kim K, Iwamoto KS, Ratikan JA, Cheng G, Boxx GM, Damoiseaux RD, Whitelegge JP, Ruchala P, Nguyen C, Purbey P, Loo J, Deng G, Jung ME, Sayre JW, Norris AJ, Schaue D, McBride WH.

PLoS One. 2017 Jul 21;12(7):e0181577. doi: 10.1371/journal.pone.0181577. eCollection 2017.

23.

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.

Chai H, Diaz-Castro B, Shigetomi E, Monte E, Octeau JC, Yu X, Cohn W, Rajendran PS, Vondriska TM, Whitelegge JP, Coppola G, Khakh BS.

Neuron. 2017 Aug 2;95(3):531-549.e9. doi: 10.1016/j.neuron.2017.06.029. Epub 2017 Jul 14.

24.

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.

Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS.

J Biol Chem. 2017 Jun 2;292(22):9294-9304. doi: 10.1074/jbc.M116.773069. Epub 2017 Apr 10.

25.

Full Membrane Protein Coverage Digestion and Quantitative Bottom-Up Mass Spectrometry Proteomics.

Capri J, Whitelegge JP.

Methods Mol Biol. 2017;1550:61-67. doi: 10.1007/978-1-4939-6747-6_6.

PMID:
28188523
26.

Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein.

Sarafian TA, Littlejohn K, Yuan S, Fernandez C, Cilluffo M, Koo BK, Whitelegge JP, Watson JB.

J Neurosci Res. 2017 Sep;95(9):1871-1887. doi: 10.1002/jnr.24024. Epub 2017 Jan 24.

27.

Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models.

Ayers JI, McMahon B, Gill S, Lelie HL, Fromholt S, Brown H, Valentine JS, Whitelegge JP, Borchelt DR.

J Neurochem. 2017 Jan;140(1):140-150. doi: 10.1111/jnc.13864. Epub 2016 Nov 25.

28.

Trans-membrane Signaling in Photosynthetic State Transitions: REDOX- AND STRUCTURE-DEPENDENT INTERACTION IN VITRO BETWEEN STT7 KINASE AND THE CYTOCHROME b6f COMPLEX.

Singh SK, Hasan SS, Zakharov SD, Naurin S, Cohn W, Ma J, Whitelegge JP, Cramer WA.

J Biol Chem. 2016 Oct 7;291(41):21740-21750. Epub 2016 Aug 18.

29.

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females.

Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL.

Sci Transl Med. 2016 Apr 13;8(334):334ra54. doi: 10.1126/scitranslmed.aad3815.

30.

Septin oligomerization regulates persistent expression of ErbB2/HER2 in gastric cancer cells.

Marcus EA, Tokhtaeva E, Turdikulova S, Capri J, Whitelegge JP, Scott DR, Sachs G, Berditchevski F, Vagin O.

Biochem J. 2016 Jun 15;473(12):1703-18. doi: 10.1042/BCJ20160203. Epub 2016 Apr 5.

31.

Proteomics Analysis of Brain Meningiomas in Pursuit of Novel Biomarkers of the Aggressive Behavior.

Barkhoudarian G, Whitelegge JP, Kelly DF, Simonian M.

J Proteomics Bioinform. 2016;9(2):53-57.

32.

Translation Control of Swarming Proficiency in Bacillus subtilis by 5-Amino-pentanolylated Elongation Factor P.

Rajkovic A, Hummels KR, Witzky A, Erickson S, Gafken PR, Whitelegge JP, Faull KF, Kearns DB, Ibba M.

J Biol Chem. 2016 May 20;291(21):10976-85. doi: 10.1074/jbc.M115.712091. Epub 2016 Mar 21.

33.

Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.

Cheung K, Senese S, Kuang J, Bui N, Ongpipattanakul C, Gholkar A, Cohn W, Capri J, Whitelegge JP, Torres JZ.

Mol Cell Proteomics. 2016 May;15(5):1658-69. doi: 10.1074/mcp.M115.056465. Epub 2016 Feb 29.

34.

The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division.

Gholkar AA, Senese S, Lo YC, Vides E, Contreras E, Hodara E, Capri J, Whitelegge JP, Torres JZ.

Cell Rep. 2016 Jan 12;14(2):180-8. doi: 10.1016/j.celrep.2015.12.035. Epub 2015 Dec 31.

35.

The Disulfide Bond, but Not Zinc or Dimerization, Controls Initiation and Seeded Growth in Amyotrophic Lateral Sclerosis-linked Cu,Zn Superoxide Dismutase (SOD1) Fibrillation.

Chattopadhyay M, Nwadibia E, Strong CD, Gralla EB, Valentine JS, Whitelegge JP.

J Biol Chem. 2015 Dec 18;290(51):30624-36. doi: 10.1074/jbc.M115.666503. Epub 2015 Oct 28.

36.

Lipid-conjugated Smac analogues.

Micewicz ED, Ratikan JA, Waring AJ, Whitelegge JP, McBride WH, Ruchala P.

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4419-27. doi: 10.1016/j.bmcl.2015.09.017. Epub 2015 Sep 8.

37.

High CO2 Leads to Na,K-ATPase Endocytosis via c-Jun Amino-Terminal Kinase-Induced LMO7b Phosphorylation.

Dada LA, Trejo Bittar HE, Welch LC, Vagin O, Deiss-Yehiely N, Kelly AM, Baker MR, Capri J, Cohn W, Whitelegge JP, Vadász I, Gruenbaum Y, Sznajder JI.

Mol Cell Biol. 2015 Dec;35(23):3962-73. doi: 10.1128/MCB.00813-15. Epub 2015 Sep 14.

38.

The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis.

Chim N, Torres R, Liu Y, Capri J, Batot G, Whitelegge JP, Goulding CW.

Chem Biol. 2015 Aug 20;22(8):1098-107. doi: 10.1016/j.chembiol.2015.07.013. Epub 2015 Aug 13.

39.

Small lipidated anti-obesity compounds derived from neuromedin U.

Micewicz ED, Bahattab OS, Willars GB, Waring AJ, Navab M, Whitelegge JP, McBride WH, Ruchala P.

Eur J Med Chem. 2015 Aug 28;101:616-26. doi: 10.1016/j.ejmech.2015.07.020. Epub 2015 Jul 14.

40.

Cyclic Rhamnosylated Elongation Factor P Establishes Antibiotic Resistance in Pseudomonas aeruginosa.

Rajkovic A, Erickson S, Witzky A, Branson OE, Seo J, Gafken PR, Frietas MA, Whitelegge JP, Faull KF, Navarre W, Darwin AJ, Ibba M.

MBio. 2015 Jun 9;6(3):e00823. doi: 10.1128/mBio.00823-15.

41.

Role of domain swapping in the hetero-oligomeric cytochrome b6f lipoprotein complex.

Agarwal R, Hasan SS, Jones LM, Stofleth JT, Ryan CM, Whitelegge JP, Kehoe DM, Cramer WA.

Biochemistry. 2015 May 26;54(20):3151-63. doi: 10.1021/acs.biochem.5b00279. Epub 2015 May 12.

42.

Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.

Gholkar AA, Senese S, Lo YC, Capri J, Deardorff WJ, Dharmarajan H, Contreras E, Hodara E, Whitelegge JP, Jackson PK, Torres JZ.

Cell Cycle. 2015;14(7):1116-25. doi: 10.4161/15384101.2014.985066.

43.

Septin dynamics are essential for exocytosis.

Tokhtaeva E, Capri J, Marcus EA, Whitelegge JP, Khuzakhmetova V, Bukharaeva E, Deiss-Yehiely N, Dada LA, Sachs G, Fernandez-Salas E, Vagin O.

J Biol Chem. 2015 Feb 27;290(9):5280-97. doi: 10.1074/jbc.M114.616201. Epub 2015 Jan 9.

44.

Combined phosphoproteomics and bioinformatics strategy in deciphering drug resistant related pathways in triple negative breast cancer.

Deng X, Kohanfars M, Hsu HM, Souda P, Capri J, Whitelegge JP, Chang HR.

Int J Proteomics. 2014;2014:390781. doi: 10.1155/2014/390781. Epub 2014 Nov 13.

45.

p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.

Veena MS, Wilken R, Zheng JY, Gholkar A, Venkatesan N, Vira D, Ahmed S, Basak SK, Dalgard CL, Ravichandran S, Batra RK, Kasahara N, Elashoff D, Fishbein MC, Whitelegge JP, Torres JZ, Wang MB, Srivatsan ES.

J Biol Chem. 2014 Dec 12;289(50):34921-37. doi: 10.1074/jbc.M114.568543. Epub 2014 Oct 20.

46.

Structure-function of cyanobacterial outer-membrane protein, Slr1270: homolog of Escherichia coli drug export/colicin import protein, TolC.

Agarwal R, Zakharov S, Hasan SS, Ryan CM, Whitelegge JP, Cramer WA.

FEBS Lett. 2014 Nov 3;588(21):3793-801. doi: 10.1016/j.febslet.2014.08.028. Epub 2014 Sep 13.

47.

Formation of amyloid fibers by monomeric light chain variable domains.

Brumshtein B, Esswein SR, Landau M, Ryan CM, Whitelegge JP, Phillips ML, Cascio D, Sawaya MR, Eisenberg DS.

J Biol Chem. 2014 Oct 3;289(40):27513-25. doi: 10.1074/jbc.M114.585638. Epub 2014 Aug 19.

48.

Identification of a unique Fe-S cluster binding site in a glycyl-radical type microcompartment shell protein.

Thompson MC, Wheatley NM, Jorda J, Sawaya MR, Gidaniyan SD, Ahmed H, Yang Z, McCarty KN, Whitelegge JP, Yeates TO.

J Mol Biol. 2014 Sep 23;426(19):3287-3304. doi: 10.1016/j.jmb.2014.07.018. Epub 2014 Aug 4.

49.

Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability.

Vagin O, Tokhtaeva E, Garay PE, Souda P, Bassilian S, Whitelegge JP, Lewis R, Sachs G, Wheeler L, Aoki R, Fernandez-Salas E.

J Cell Sci. 2014 Aug 1;127(Pt 15):3294-308. doi: 10.1242/jcs.146324. Epub 2014 Jun 13.

50.

Non-repair pathways for minimizing protein isoaspartyl damage in the yeast Saccharomyces cerevisiae.

Patananan AN, Capri J, Whitelegge JP, Clarke SG.

J Biol Chem. 2014 Jun 13;289(24):16936-53. doi: 10.1074/jbc.M114.564385. Epub 2014 Apr 24.

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