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Items: 15


Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1.

Atkins SL, Motaib S, Wiser LC, Hopcraft SE, Hardy PB, Shackelford J, Foote P, Wade AH, Damania B, Pagano JS, Pearce KH, Whitehurst CB.

Antiviral Res. 2019 Nov 8;173:104649. doi: 10.1016/j.antiviral.2019.104649. [Epub ahead of print]


Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells.

Kobayashi E, Hwang D, Bheda-Malge A, Whitehurst CB, Kabanov AV, Kondo S, Aga M, Yoshizaki T, Pagano JS, Sokolsky M, Shakelford J.

Int J Mol Sci. 2019 Jul 31;20(15). pii: E3733. doi: 10.3390/ijms20153733.


The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models.

Fowler KA, Li K, Whitehurst CB, Bruce DW, Moorman NJ, Aubé J, Coghill JM.

Biol Blood Marrow Transplant. 2019 Jun;25(6):1062-1074. doi: 10.1016/j.bbmt.2019.01.022. Epub 2019 Jan 19.


Antiviral Drugs for EBV.

Pagano JS, Whitehurst CB, Andrei G.

Cancers (Basel). 2018 Jun 13;10(6). pii: E197. doi: 10.3390/cancers10060197.


The Translesion Polymerase Pol η Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1.

Dyson OF, Pagano JS, Whitehurst CB.

J Virol. 2017 Sep 12;91(19). pii: e00600-17. doi: 10.1128/JVI.00600-17. Print 2017 Oct 1.


Knockout of Epstein-Barr virus BPLF1 retards B-cell transformation and lymphoma formation in humanized mice.

Whitehurst CB, Li G, Montgomery SA, Montgomery ND, Su L, Pagano JS.

MBio. 2015 Oct 20;6(5):e01574-15. doi: 10.1128/mBio.01574-15.


LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1.

Bentz GL, Moss CR 2nd, Whitehurst CB, Moody CA, Pagano JS.

J Virol. 2015 Aug;89(15):7465-77. doi: 10.1128/JVI.00711-15. Epub 2015 May 6.


The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity.

Kumar R, Whitehurst CB, Pagano JS.

J Virol. 2014 Jun;88(11):6411-22. doi: 10.1128/JVI.00536-14. Epub 2014 Mar 26.


Maribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase.

Whitehurst CB, Sanders MK, Law M, Wang FZ, Xiong J, Dittmer DP, Pagano JS.

J Virol. 2013 May;87(9):5311-5. doi: 10.1128/JVI.03505-12. Epub 2013 Feb 28.


Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites.

Whitehurst CB, Vaziri C, Shackelford J, Pagano JS.

J Virol. 2012 Aug;86(15):8097-106. doi: 10.1128/JVI.00588-12. Epub 2012 May 23.


Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9.

Bentz GL, Whitehurst CB, Pagano JS.

J Virol. 2011 Oct;85(19):10144-53. doi: 10.1128/JVI.05035-11. Epub 2011 Jul 27.


Maribavir inhibits epstein-barr virus transcription in addition to viral DNA replication.

Wang FZ, Roy D, Gershburg E, Whitehurst CB, Dittmer DP, Pagano JS.

J Virol. 2009 Dec;83(23):12108-17. doi: 10.1128/JVI.01575-09. Epub 2009 Sep 16.


The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity.

Whitehurst CB, Ning S, Bentz GL, Dufour F, Gershburg E, Shackelford J, Langelier Y, Pagano JS.

J Virol. 2009 May;83(9):4345-53. doi: 10.1128/JVI.02195-08. Epub 2009 Feb 25.


Location and role of free cysteinyl residues in the Sindbis virus E1 and E2 glycoproteins.

Whitehurst CB, Soderblom EJ, West ML, Hernandez R, Goshe MB, Brown DT.

J Virol. 2007 Jun;81(12):6231-40. Epub 2007 Apr 4.


Single and multiple deletions in the transmembrane domain of the Sindbis virus E2 glycoprotein identify a region critical for normal virus growth.

Whitehurst CB, Willis JH, Sinodis CN, Hernandez R, Brown DT.

Virology. 2006 Mar 30;347(1):199-207. Epub 2006 Jan 4.

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