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Items: 1 to 50 of 117

1.

Immunization of Alpacas (Lama pacos) with Protein Antigens and Production of Antigen-specific Single Domain Antibodies.

Chow KM, Whiteheart SW, Smiley JR, Sharma S, Boaz K, Coleman MJ, Maynard A, Hersh LB, Vander Kooi CW.

J Vis Exp. 2019 Jan 26;(143). doi: 10.3791/58471.

PMID:
30741259
2.

Autophagy in Platelets.

Banerjee M, Huang Y, Ouseph MM, Joshi S, Pokrovskaya I, Storrie B, Zhang J, Whiteheart SW, Wang QJ.

Methods Mol Biol. 2019;1880:511-528. doi: 10.1007/978-1-4939-8873-0_32.

PMID:
30610718
3.

SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets.

Pokrovskaya ID, Joshi S, Tobin M, Desai R, Aronova MA, Kamykowski JA, Zhang G, Whiteheart SW, Leapman RD, Storrie B.

Blood Adv. 2018 Nov 13;2(21):2947-2958. doi: 10.1182/bloodadvances.2018019158.

4.

Alterations in platelet secretion differentially affect thrombosis and hemostasis.

Joshi S, Banerjee M, Zhang J, Kesaraju A, Pokrovskaya ID, Storrie B, Whiteheart SW.

Blood Adv. 2018 Sep 11;2(17):2187-2198. doi: 10.1182/bloodadvances.2018019166.

5.

BEACHcombing for α-granules.

Whiteheart SW.

Blood. 2018 Mar 1;131(9):949-950. doi: 10.1182/blood-2017-12-820274. No abstract available.

PMID:
29496701
6.

Dynamic cycling of t-SNARE acylation regulates platelet exocytosis.

Zhang J, Huang Y, Chen J, Zhu H, Whiteheart SW.

J Biol Chem. 2018 Mar 9;293(10):3593-3606. doi: 10.1074/jbc.RA117.000140. Epub 2018 Jan 19.

7.

In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi.

Adili R, Voigt EM, Bormann JL, Foss KN, Hurley LJ, Meyer ES, Veldman AJ, Mast KA, West JL, Whiteheart SW, Holinstat M, Larson MK.

Platelets. 2019;30(2):271-279. doi: 10.1080/09537104.2017.1420154. Epub 2017 Dec 29.

PMID:
29286871
8.

Linking kindling to increased glutamate release in the dentate gyrus of the hippocampus through the STXBP5/tomosyn-1 gene.

Batten SR, Matveeva EA, Whiteheart SW, Vanaman TC, Gerhardt GA, Slevin JT.

Brain Behav. 2017 Aug 13;7(9):e00795. doi: 10.1002/brb3.795. eCollection 2017 Sep.

9.

Cellubrevin/vesicle-associated membrane protein-3-mediated endocytosis and trafficking regulate platelet functions.

Banerjee M, Joshi S, Zhang J, Moncman CL, Yadav S, Bouchard BA, Storrie B, Whiteheart SW.

Blood. 2017 Dec 28;130(26):2872-2883. doi: 10.1182/blood-2017-02-768176. Epub 2017 Sep 20.

10.

Fueling Platelets: Where Does the Glucose Come From?

Whiteheart SW.

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1592-1594. doi: 10.1161/ATVBAHA.117.309841. No abstract available.

11.

The ins and outs of endocytic trafficking in platelet functions.

Banerjee M, Whiteheart SW.

Curr Opin Hematol. 2017 Sep;24(5):467-474. doi: 10.1097/MOH.0000000000000366. Review.

12.

Editorial: Platelet Secretion.

Storrie B, Whiteheart SW.

Platelets. 2017 Mar;28(2):107. doi: 10.1080/09537104.2016.1277676. No abstract available.

13.

The nuts and bolts of the platelet release reaction.

Joshi S, Whiteheart SW.

Platelets. 2017 Mar;28(2):129-137. doi: 10.1080/09537104.2016.1240768. Epub 2016 Nov 16. Review.

14.

Respective contributions of single and compound granule fusion to secretion by activated platelets.

Eckly A, Rinckel JY, Proamer F, Ulas N, Joshi S, Whiteheart SW, Gachet C.

Blood. 2016 Nov 24;128(21):2538-2549. Epub 2016 Sep 13.

15.

B-cell-independent sialylation of IgG.

Jones MB, Oswald DM, Joshi S, Whiteheart SW, Orlando R, Cobb BA.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7207-12. doi: 10.1073/pnas.1523968113. Epub 2016 Jun 14.

16.

How Does Protein Disulfide Isomerase Get Into a Thrombus?

Banerjee M, Whiteheart SW.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1056-7. doi: 10.1161/ATVBAHA.116.307625. No abstract available.

17.

Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking.

Huang Y, Joshi S, Xiang B, Kanaho Y, Li Z, Bouchard BA, Moncman CL, Whiteheart SW.

Blood. 2016 Mar 17;127(11):1459-67. doi: 10.1182/blood-2015-05-648550. Epub 2016 Jan 6.

18.

Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion.

Chicka MC, Ren Q, Richards D, Hellman LM, Zhang J, Fried MG, Whiteheart SW.

Biochem J. 2016 Mar 1;473(5):627-39. doi: 10.1042/BJ20151150. Epub 2015 Dec 4.

19.

Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis.

Xiang B, Zhang G, Ye S, Zhang R, Huang C, Liu J, Tao M, Ruan C, Smyth SS, Whiteheart SW, Li Z.

Circulation. 2015 Dec 15;132(24):2334-44. doi: 10.1161/CIRCULATIONAHA.115.018361. Epub 2015 Sep 23.

20.

Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis.

Ouseph MM, Huang Y, Banerjee M, Joshi S, MacDonald L, Zhong Y, Liu H, Li X, Xiang B, Zhang G, Komatsu M, Yue Z, Li Z, Storrie B, Whiteheart SW, Wang QJ.

Blood. 2015 Sep 3;126(10):1224-33. doi: 10.1182/blood-2014-09-598722. Epub 2015 Jul 24. Erratum in: Blood. 2015 Oct 22;126(17):2072. Komatsu, Massaki [corrected to Komatsu, Masaaki].

21.

Platelet secretion paves the way.

Huang Y, Whiteheart SW.

Blood. 2015 Jul 23;126(4):433-4. doi: 10.1182/blood-2015-05-646687.

PMID:
26206945
22.

Platelet secretion and hemostasis require syntaxin-binding protein STXBP5.

Ye S, Huang Y, Joshi S, Zhang J, Yang F, Zhang G, Smyth SS, Li Z, Takai Y, Whiteheart SW.

J Clin Invest. 2014 Oct;124(10):4517-28. doi: 10.1172/JCI75572. Epub 2014 Sep 17.

23.

Granule-mediated release of sphingosine-1-phosphate by activated platelets.

Jonnalagadda D, Sunkara M, Morris AJ, Whiteheart SW.

Biochim Biophys Acta. 2014 Nov;1841(11):1581-9. doi: 10.1016/j.bbalip.2014.08.013. Epub 2014 Aug 23.

24.

TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation.

Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampé R, Brown BD, Amsen D, Whiteheart SW, Blander JM.

Cell. 2014 Jul 31;158(3):506-21. doi: 10.1016/j.cell.2014.04.054.

25.

α-Granules at the BEACH.

Whiteheart SW.

Blood. 2013 Nov 7;122(19):3247-8. doi: 10.1182/blood-2013-07-516880. No abstract available.

PMID:
24203928
26.

Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway.

Xiang B, Zhang G, Guo L, Li XA, Morris AJ, Daugherty A, Whiteheart SW, Smyth SS, Li Z.

Nat Commun. 2013;4:2657. doi: 10.1038/ncomms3657.

27.

IκB kinase phosphorylation of SNAP-23 controls platelet secretion.

Karim ZA, Zhang J, Banerjee M, Chicka MC, Al Hawas R, Hamilton TR, Roche PA, Whiteheart SW.

Blood. 2013 May 30;121(22):4567-74. doi: 10.1182/blood-2012-11-470468. Epub 2013 Apr 23.

28.

Platelet secretion is kinetically heterogeneous in an agonist-responsive manner.

Jonnalagadda D, Izu LT, Whiteheart SW.

Blood. 2012 Dec 20;120(26):5209-16. doi: 10.1182/blood-2012-07-445080. Epub 2012 Oct 18.

29.

The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation.

Xiang B, Zhang G, Stefanini L, Bergmeier W, Gartner TK, Whiteheart SW, Li Z.

J Biol Chem. 2012 Nov 30;287(49):41277-87. doi: 10.1074/jbc.M112.393124. Epub 2012 Oct 12.

30.

Munc18b/STXBP2 is required for platelet secretion.

Al Hawas R, Ren Q, Ye S, Karim ZA, Filipovich AH, Whiteheart SW.

Blood. 2012 Sep 20;120(12):2493-500. Epub 2012 Jul 12.

31.

Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion.

Ye S, Karim ZA, Al Hawas R, Pessin JE, Filipovich AH, Whiteheart SW.

Blood. 2012 Sep 20;120(12):2484-92. Epub 2012 Jul 5.

32.

Nucleotide-dependent conformational changes in the N-Ethylmaleimide Sensitive Factor (NSF) and their potential role in SNARE complex disassembly.

Moeller A, Zhao C, Fried MG, Wilson-Kubalek EM, Carragher B, Whiteheart SW.

J Struct Biol. 2012 Feb;177(2):335-43. doi: 10.1016/j.jsb.2011.12.018. Epub 2012 Jan 5.

33.

Reduction of vesicle-associated membrane protein 2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy.

Matveeva EA, Price DA, Whiteheart SW, Vanaman TC, Gerhardt GA, Slevin JT.

Neuroscience. 2012 Jan 27;202:77-86. doi: 10.1016/j.neuroscience.2011.11.055. Epub 2011 Dec 13.

34.

Kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes correlates with enhanced glutamate release.

Matveeva EA, Davis VA, Whiteheart SW, Vanaman TC, Gerhardt GA, Slevin JT.

Epilepsia. 2012 Jan;53(1):157-67. doi: 10.1111/j.1528-1167.2011.03345.x. Epub 2011 Dec 9.

35.

Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling.

Zhang G, Xiang B, Ye S, Chrzanowska-Wodnicka M, Morris AJ, Gartner TK, Whiteheart SW, White GC 2nd, Smyth SS, Li Z.

J Biol Chem. 2011 Nov 11;286(45):39466-77. doi: 10.1074/jbc.M111.239608. Epub 2011 Sep 22.

36.

Platelet granules: surprise packages.

Whiteheart SW.

Blood. 2011 Aug 4;118(5):1190-1. doi: 10.1182/blood-2011-06-359836. No abstract available.

PMID:
21816838
37.

Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF).

Zhao C, Smith EC, Whiteheart SW.

Biochim Biophys Acta. 2012 Jan;1823(1):159-71. doi: 10.1016/j.bbamcr.2011.06.003. Epub 2011 Jun 13. Review.

38.

A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing.

Feng W, Madajka M, Kerr BA, Mahabeleshwar GH, Whiteheart SW, Byzova TV.

Blood. 2011 Apr 7;117(14):3893-902. doi: 10.1182/blood-2010-08-304808. Epub 2011 Jan 11. Erratum in: Blood. 2011 Jun 30;117(26):7187.

39.

Histidine-tag-directed chromophores for tracer analyses in the analytical ultracentrifuge.

Hellman LM, Zhao C, Melikishvili M, Tao X, Hopper JE, Whiteheart SW, Fried MG.

Methods. 2011 May;54(1):31-8. doi: 10.1016/j.ymeth.2010.12.033. Epub 2010 Dec 25. Review.

40.

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.

Ren Q, Wimmer C, Chicka MC, Ye S, Ren Y, Hughson FM, Whiteheart SW.

Blood. 2010 Aug 12;116(6):869-77. doi: 10.1182/blood-2010-02-270934. Epub 2010 Apr 30.

41.

Protein expression in platelets from six species that differ in their open canalicular system.

Choi W, Karim ZA, Whiteheart SW.

Platelets. 2010;21(3):167-75. doi: 10.3109/09537101003611385.

42.

Hexahistidine-tag-specific optical probes for analyses of proteins and their interactions.

Zhao C, Hellman LM, Zhan X, Bowman WS, Whiteheart SW, Fried MG.

Anal Biochem. 2010 Apr 15;399(2):237-45. doi: 10.1016/j.ab.2009.12.028. Epub 2009 Dec 28.

43.

VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA.

Kondkar AA, Bray MS, Leal SM, Nagalla S, Liu DJ, Jin Y, Dong JF, Ren Q, Whiteheart SW, Shaw C, Bray PF.

J Thromb Haemost. 2010 Feb;8(2):369-78. doi: 10.1111/j.1538-7836.2009.03700.x. Epub 2009 Nov 23.

44.

Dissecting the N-ethylmaleimide-sensitive factor: required elements of the N and D1 domains.

Zhao C, Matveeva EA, Ren Q, Whiteheart SW.

J Biol Chem. 2010 Jan 1;285(1):761-72. doi: 10.1074/jbc.M109.056739. Epub 2009 Nov 3.

45.

Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo.

Graham GJ, Ren Q, Dilks JR, Blair P, Whiteheart SW, Flaumenhaft R.

Blood. 2009 Jul 30;114(5):1083-90. doi: 10.1182/blood-2009-03-210211. Epub 2009 Apr 24.

46.

PKCalpha regulates platelet granule secretion and thrombus formation in mice.

Konopatskaya O, Gilio K, Harper MT, Zhao Y, Cosemans JM, Karim ZA, Whiteheart SW, Molkentin JD, Verkade P, Watson SP, Heemskerk JW, Poole AW.

J Clin Invest. 2009 Feb;119(2):399-407. doi: 10.1172/JCI34665. Epub 2009 Jan 19.

47.

The platelet release reaction: just when you thought platelet secretion was simple.

Ren Q, Ye S, Whiteheart SW.

Curr Opin Hematol. 2008 Sep;15(5):537-41. doi: 10.1097/MOH.0b013e328309ec74. Review.

48.

Levetiracetam prevents kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes.

Matveeva EA, Vanaman TC, Whiteheart SW, Slevin JT.

Epilepsia. 2008 Oct;49(10):1749-58. doi: 10.1111/j.1528-1167.2008.01687.x. Epub 2008 May 29.

49.

Murine platelets are not regulated by O-linked beta-N-acetylglucosamine.

Crawford GL, Hart GW, Whiteheart SW.

Arch Biochem Biophys. 2008 Jun 1;474(1):220-4. doi: 10.1016/j.abb.2008.03.014. Epub 2008 Mar 21.

50.

Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation.

Karim ZA, Choi W, Whiteheart SW.

J Biol Chem. 2008 May 2;283(18):11995-2003. doi: 10.1074/jbc.M800146200. Epub 2008 Mar 7.

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