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Items: 1 to 50 of 65

1.

Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.

Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Roedel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML.

Sci Transl Med. 2019 Nov 27;11(520). pii: eaaw3521. doi: 10.1126/scitranslmed.aaw3521.

PMID:
31776290
2.

Biomarkers of cavernous angioma with symptomatic hemorrhage.

Lyne SB, Girard R, Koskimäki J, Zeineddine HA, Zhang D, Cao Y, Li Y, Stadnik A, Moore T, Lightle R, Shi C, Shenkar R, Carrión-Penagos J, Polster SP, Romanos S, Akers A, Lopez-Ramirez M, Whitehead KJ, Kahn ML, Ginsberg MH, Marchuk DA, Awad IA.

JCI Insight. 2019 Jun 20;4(12). pii: 128577. doi: 10.1172/jci.insight.128577. eCollection 2019 Jun 20.

3.

A novel phosphoglucomutase-deficient mouse model reveals aberrant glycosylation and early embryonic lethality.

Balakrishnan B, Verheijen J, Lupo A, Raymond K, Turgeon C, Yang Y, Carter KL, Whitehead KJ, Kozicz T, Morava E, Lai K.

J Inherit Metab Dis. 2019 Sep;42(5):998-1007. doi: 10.1002/jimd.12110. Epub 2019 Jun 21.

PMID:
31077402
4.

Localization and age distribution of telangiectases in children and adolescents with hereditary hemorrhagic telangiectasia: A retrospective cohort study.

Gonzalez CD, Cipriano SD, Topham CA, Stevenson DA, Whitehead KJ, Vanderhooft S, Presson AP, McDonald J.

J Am Acad Dermatol. 2019 Oct;81(4):950-955. doi: 10.1016/j.jaad.2018.11.014. Epub 2019 Feb 25.

PMID:
30819528
5.

Murine Adherent and Invasive E. coli Induces Chronic Inflammation and Immune Responses in the Small and Large Intestines of Monoassociated IL-10-/- Mice Independent of Long Polar Fimbriae Adhesin A.

Schmitz JM, Tonkonogy SL, Dogan B, Leblond A, Whitehead KJ, Kim SC, Simpson KW, Sartor RB.

Inflamm Bowel Dis. 2019 Apr 11;25(5):875-885. doi: 10.1093/ibd/izy386.

PMID:
30576451
6.

Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.

Polster SP, Stadnik A, Akers AL, Cao Y, Christoforidis GA, Fam MD, Flemming KD, Girard R, Hobson N, Koenig JI, Koskimäki J, Lane K, Liao JK, Lee C, Lyne SB, McBee N, Morrison L, Piedad K, Shenkar R, Sorrentino M, Thompson RE, Whitehead KJ, Zeineddine HA, Hanley DF, Awad IA.

Neurosurgery. 2019 Dec 1;85(6):843-853. doi: 10.1093/neuros/nyy539.

PMID:
30476251
7.

Genome sequencing reveals a deep intronic splicing ACVRL1 mutation hotspot in Hereditary Haemorrhagic Telangiectasia.

Wooderchak-Donahue WL, McDonald J, Farrell A, Akay G, Velinder M, Johnson P, VanSant-Webb C, Margraf R, Briggs E, Whitehead KJ, Thomson J, Lin AE, Pyeritz RE, Marth G, Bayrak-Toydemir P.

J Med Genet. 2018 Dec;55(12):824-830. doi: 10.1136/jmedgenet-2018-105561. Epub 2018 Sep 22.

PMID:
30244195
8.

The effects of nasal closure on quality of life in patients with hereditary hemorrhagic telangiectasia.

Thomson RS, Molin NL, Whitehead KJ, Ashby S, Johnson L, Ward PD, McRae BR, Wilson KF, McDonald J.

Laryngoscope Investig Otolaryngol. 2018 Apr 19;3(3):178-181. doi: 10.1002/lio2.157. eCollection 2018 Jun.

9.

Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth.

Girard R, Zeineddine HA, Koskimäki J, Fam MD, Cao Y, Shi C, Moore T, Lightle R, Stadnik A, Chaudagar K, Polster S, Shenkar R, Duggan R, Leclerc D, Whitehead KJ, Li DY, Awad IA.

Circ Res. 2018 Jun 8;122(12):1716-1721. doi: 10.1161/CIRCRESAHA.118.312680. Epub 2018 May 2.

10.

Nonmicrobicidal Small Molecule Inhibition of Polysaccharide Metabolism in Human Gut Microbes: A Potential Therapeutic Avenue.

Santilli AD, Dawson EM, Whitehead KJ, Whitehead DC.

ACS Chem Biol. 2018 May 18;13(5):1165-1172. doi: 10.1021/acschembio.8b00309. Epub 2018 Apr 20.

PMID:
29660284
11.

Clinical presentation and treatment paradigms of brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia.

Gamboa NT, Joyce EJ, Eli I, Park MS, Taussky P, Schmidt RH, McDonald J, Whitehead KJ, Kalani MYS.

J Clin Neurosci. 2018 May;51:22-28. doi: 10.1016/j.jocn.2018.01.019. Epub 2018 Feb 23.

PMID:
29483005
12.

Clinical presentation and treatment paradigms in patients with hereditary hemorrhagic telangiectasia and spinal vascular malformations.

Eli I, Gamboa NT, Joyce EJ, Park MS, Taussky P, Schmidt RH, Couldwell WT, McDonald J, Whitehead KJ, Kalani MYS.

J Clin Neurosci. 2018 Apr;50:51-57. doi: 10.1016/j.jocn.2018.01.010. Epub 2018 Feb 3.

PMID:
29398197
13.

Epistaxis in children and adolescents with hereditary hemorrhagic telangiectasia.

Gonzalez CD, Mcdonald J, Stevenson DA, Whitehead KJ, Petersen MG, Presson AP, Ding Q, Wilson KF.

Laryngoscope. 2018 Jul;128(7):1714-1719. doi: 10.1002/lary.27015. Epub 2017 Nov 24.

PMID:
29171658
14.

Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations.

Girard R, Zeineddine HA, Fam MD, Mayampurath A, Cao Y, Shi C, Shenkar R, Polster SP, Jesselson M, Duggan R, Mikati AG, Christoforidis G, Andrade J, Whitehead KJ, Li DY, Awad IA.

Transl Stroke Res. 2018 Feb;9(1):34-43. doi: 10.1007/s12975-017-0561-3. Epub 2017 Aug 17.

15.

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.

Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML.

Nature. 2017 May 18;545(7654):305-310. doi: 10.1038/nature22075. Epub 2017 May 10.

16.

Effect of Topical Intranasal Therapy on Epistaxis Frequency in Patients With Hereditary Hemorrhagic Telangiectasia: A Randomized Clinical Trial.

Whitehead KJ, Sautter NB, McWilliams JP, Chakinala MM, Merlo CA, Johnson MH, James M, Everett EM, Clancy MS, Faughnan ME, Oh SP, Olitsky SE, Pyeritz RE, Gossage JR.

JAMA. 2016 Sep 6;316(9):943-51. doi: 10.1001/jama.2016.11724.

PMID:
27599329
17.

Corrigendum: Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML.

Nature. 2016 Aug 25;536(7617):488. doi: 10.1038/nature18311. Epub 2016 May 25. No abstract available.

PMID:
27281211
18.

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML.

Nature. 2016 Apr 7;532(7597):122-6. doi: 10.1038/nature17178. Epub 2016 Mar 30. Erratum in: Nature. 2016 May 25;536(7617):488.

19.

Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease.

Girard R, Khanna O, Shenkar R, Zhang L, Wu M, Jesselson M, Zeineddine HA, Gangal A, Fam MD, Gibson CC, Whitehead KJ, Li DY, Liao JK, Shi C, Awad IA.

Biomark Med. 2016;10(3):255-64. doi: 10.2217/bmm.15.118. Epub 2016 Feb 9.

20.

Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.

Chrzanowska-Wodnicka M, White GC 2nd, Quilliam LA, Whitehead KJ.

PLoS One. 2015 Dec 29;10(12):e0145689. doi: 10.1371/journal.pone.0145689. eCollection 2015.

21.

Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4.

Johansson P, Aoude LG, Wadt K, Glasson WJ, Warrier SK, Hewitt AW, Kiilgaard JF, Heegaard S, Isaacs T, Franchina M, Ingvar C, Vermeulen T, Whitehead KJ, Schmidt CW, Palmer JM, Symmons J, Gerdes AM, Jönsson G, Hayward NK.

Oncotarget. 2016 Jan 26;7(4):4624-31. doi: 10.18632/oncotarget.6614.

22.

An evaluation of the severity and progression of epistaxis in hereditary hemorrhagic telangiectasia 1 versus hereditary hemorrhagic telangiectasia 2.

Hunter BN, Timmins BH, McDonald J, Whitehead KJ, Ward PD, Wilson KF.

Laryngoscope. 2016 Apr;126(4):786-90. doi: 10.1002/lary.25604. Epub 2015 Sep 15.

23.

The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.

Zhou Z, Rawnsley DR, Goddard LM, Pan W, Cao XJ, Jakus Z, Zheng H, Yang J, Arthur JS, Whitehead KJ, Li D, Zhou B, Garcia BA, Zheng X, Kahn ML.

Dev Cell. 2015 Jan 26;32(2):168-80. doi: 10.1016/j.devcel.2014.12.009.

24.

Brain arteriovenous malformations.

Lawton MT, Rutledge WC, Kim H, Stapf C, Whitehead KJ, Li DY, Krings T, terBrugge K, Kondziolka D, Morgan MK, Moon K, Spetzler RF.

Nat Rev Dis Primers. 2015 May 28;1:15008. doi: 10.1038/nrdp.2015.8. Review.

PMID:
27188382
25.

Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.

Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY.

Circulation. 2015 Jan 20;131(3):289-99. doi: 10.1161/CIRCULATIONAHA.114.010403. Epub 2014 Dec 8.

26.

Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy.

Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS.

Cardiovasc Res. 2013 Oct 1;100(1):63-73. doi: 10.1093/cvr/cvt150. Epub 2013 Jun 12.

27.

Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.

Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED.

PLoS One. 2013;8(1):e54221. doi: 10.1371/journal.pone.0054221. Epub 2013 Jan 14.

28.

Arteriovenous malformations and other vascular malformation syndromes.

Whitehead KJ, Smith MC, Li DY.

Cold Spring Harb Perspect Med. 2013 Feb 1;3(2):a006635. doi: 10.1101/cshperspect.a006635. Review.

29.

Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training.

Gounder SS, Kannan S, Devadoss D, Miller CJ, Whitehead KJ, Odelberg SJ, Firpo MA, Paine R 3rd, Hoidal JR, Abel ED, Rajasekaran NS.

PLoS One. 2012;7(9):e45697. doi: 10.1371/journal.pone.0045697. Epub 2012 Sep 24. Erratum in: PLoS One. 2012;7(10). doi:10.1371/annotation/8690bb36-3c5d-48a6-b3be-39a2b50896e1. Whitehead, Kevin S [corrected to Whitehead, Kevin J]. PLoS One. 2013;8(6). doi: 10.1371/annotation/684807c2-1777-4008-9eda-c6036553b082.

30.

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.

Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY.

J Clin Invest. 2011 May;121(5):1871-81. doi: 10.1172/JCI44393. Epub 2011 Apr 1. Erratum in: J Clin Invest. 2012 May 1;122(5):1948.

31.

Evaluating strategies for the treatment of cerebral cavernous malformations.

Li DY, Whitehead KJ.

Stroke. 2010 Oct;41(10 Suppl):S92-4. doi: 10.1161/STROKEAHA.110.594929. Review.

32.

The pathogenetic features of cerebral cavernous malformations: a comprehensive review with therapeutic implications.

Krisht KM, Whitehead KJ, Niazi T, Couldwell WT.

Neurosurg Focus. 2010 Sep;29(3):E2. doi: 10.3171/2010.6.FOCUS10135. Review.

PMID:
20809760
33.

Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart.

Drakos SG, Kfoury AG, Hammond EH, Reid BB, Revelo MP, Rasmusson BY, Whitehead KJ, Salama ME, Selzman CH, Stehlik J, Clayson SE, Bristow MR, Renlund DG, Li DY.

J Am Coll Cardiol. 2010 Jul 27;56(5):382-91. doi: 10.1016/j.jacc.2010.04.019.

34.

Reply to a letter to editor "Nickel allergy, Amplatzer atrial septal occluder device, and the risk of Kounis syndrome".

Michaels AD, Powell DL, Whitehead KJ.

Clin Cardiol. 2010 Apr;33(4):E61. doi: 10.1002/clc.20743. No abstract available.

35.

Mechanisms of vascular stability and the relationship to human disease.

Smith MC, Li DY, Whitehead KJ.

Curr Opin Hematol. 2010 May;17(3):237-44. doi: 10.1097/MOH.0b013e3283386750. Review.

36.

Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype.

Chan AC, Li DY, Berg MJ, Whitehead KJ.

FEBS J. 2010 Mar;277(5):1076-83. doi: 10.1111/j.1742-4658.2009.07536.x. Epub 2010 Jan 22. Review.

37.

Dynamic regulation of spinal pro-inflammatory cytokine release in the rat in vivo following peripheral nerve injury.

Whitehead KJ, Smith CG, Delaney SA, Curnow SJ, Salmon M, Hughes JP, Chessell IP.

Brain Behav Immun. 2010 May;24(4):569-76. doi: 10.1016/j.bbi.2009.12.007. Epub 2009 Dec 24.

PMID:
20035858
38.

Unusual presentation of nickel allergy requiring explantation of an Amplatzer atrial septal occluder device.

Rabkin DG, Whitehead KJ, Michaels AD, Powell DL, Karwande SV.

Clin Cardiol. 2009 Aug;32(8):E55-7. doi: 10.1002/clc.20427.

39.

Endogenous endothelial cell signaling systems maintain vascular stability.

London NR, Whitehead KJ, Li DY.

Angiogenesis. 2009;12(2):149-58. doi: 10.1007/s10456-009-9130-z. Epub 2009 Jan 27. Review.

40.

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases.

Whitehead KJ, Chan AC, Navankasattusas S, Koh W, London NR, Ling J, Mayo AH, Drakos SG, Jones CA, Zhu W, Marchuk DA, Davis GE, Li DY.

Nat Med. 2009 Feb;15(2):177-84. doi: 10.1038/nm.1911. Epub 2009 Jan 18. Erratum in: Nat Med. 2009 Apr;15(4):462. Jones, Christopher A [added]; Zhu, Weiquan [added].

41.

The netrin receptor UNC5B promotes angiogenesis in specific vascular beds.

Navankasattusas S, Whitehead KJ, Suli A, Sorensen LK, Lim AH, Zhao J, Park KW, Wythe JD, Thomas KR, Chien CB, Li DY.

Development. 2008 Feb;135(4):659-67. doi: 10.1242/dev.013623.

42.
43.

Monolithic column-based reversed-phase liquid chromatography separation for amino acid assay in microdialysates and cerebral spinal fluid.

Devall AJ, Blake R, Langman N, Smith CG, Richards DA, Whitehead KJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Apr 1;848(2):323-8. Epub 2006 Nov 13.

PMID:
17101306
44.

Eosinophilic angiocentric fibrosis: an unusual entity producing complete lacrimal duct obstruction.

Valenzuela AA, Whitehead KJ, Brown I, Sullivan TJ.

Orbit. 2006 Jun;25(2):159-61.

PMID:
16754230
45.

Ocular adnexal pseudo-cyst formation as a characteristic feature of perineural spread in squamous cell carcinoma.

Valenzuela AA, Whitehead KJ, Sullivan TJ.

Ophthalmic Plast Reconstr Surg. 2006 May-Jun;22(3):201-5.

PMID:
16714930
46.

Adrenaline increases carotid body CO2 sensitivity: an in vivo study.

Maskell PD, Rusius CJ, Whitehead KJ, Kumar P.

Adv Exp Med Biol. 2006;580:245-50; discussion 351-9. No abstract available.

PMID:
16683727
47.

Clinical features and management of tumors affecting the lacrimal drainage apparatus.

Valenzuela AA, McNab AA, Selva D, O'Donnell BA, Whitehead KJ, Sullivan TJ.

Ophthalmic Plast Reconstr Surg. 2006 Mar-Apr;22(2):96-101.

PMID:
16550051
48.

Selective serotonin re-uptake inhibition attenuates evoked glutamate release in the dorsal horn of the anaesthetised rat in vivo.

Langman NJ, Smith CG, Whitehead KJ.

Pharmacol Res. 2006 Feb;53(2):149-55. Epub 2005 Nov 8.

PMID:
16280247
49.

Positive N-methyl-D-aspartate receptor modulation by selective glycine transporter-1 inhibition in the rat dorsal spinal cord in vivo.

Whitehead KJ, Pearce SM, Walker G, Sundaram H, Hill D, Bowery NG.

Neuroscience. 2004;126(2):381-90.

PMID:
15207356
50.

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