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Items: 39


Regulation of vesicle transport and cell motility by Golgi-localized Dbs.

Fitzpatrick ER, Hu T, Ciccarelli BT, Whitehead IP.

Small GTPases. 2014;5(4):1-12. doi: 10.4161/sgtp.28570.


Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity.

Pannucci NL, Li D, Sahay S, Thomas EK, Chen R, Tala I, Hu T, Ciccarelli BT, Megjugorac NJ, Adams Iii HC, Rodriguez PL, Fitzpatrick ER, Lagunoff D, Williams DA, Whitehead IP.

Blood Cancer J. 2013 Aug 16;3:e135. doi: 10.1038/bcj.2013.36.


Ubiquitin-mediated interaction of p210 BCR/ABL with β-catenin supports disease progression in a murine model for chronic myelogenous leukemia.

Chen R, Hu T, Mahon GM, Tala I, Pannucci NL, Ozer HL, Whitehead IP.

Blood. 2013 Sep 19;122(12):2114-24. doi: 10.1182/blood-2013-01-481184. Epub 2013 Aug 15.


Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression.

Tala I, Chen R, Hu T, Fitzpatrick ER, Williams DA, Whitehead IP.

Leukemia. 2013 Apr;27(5):1080-9. doi: 10.1038/leu.2012.351. Epub 2012 Dec 4.


Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein.

Adams HC 3rd, Chen R, Liu Z, Whitehead IP.

Breast Cancer Res. 2010;12(5):R69. doi: 10.1186/bcr2637. Epub 2010 Sep 6.


The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration.

Liu Z, Adams HC 3rd, Whitehead IP.

J Biol Chem. 2009 Jun 5;284(23):15771-80. doi: 10.1074/jbc.M901853200. Epub 2009 Apr 14.


The RhoGEF domain of p210 Bcr-Abl activates RhoA and is required for transformation.

Sahay S, Pannucci NL, Mahon GM, Rodriguez PL, Megjugorac NJ, Kostenko EV, Ozer HL, Whitehead IP.

Oncogene. 2008 Mar 27;27(14):2064-71. Epub 2007 Oct 8.


ROCK I-mediated activation of NF-kappaB by RhoB.

Rodriguez PL, Sahay S, Olabisi OO, Whitehead IP.

Cell Signal. 2007 Nov;19(11):2361-9. Epub 2007 Aug 8.


Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs.

Kostenko EV, Olabisi OO, Sahay S, Rodriguez PL, Whitehead IP.

Mol Cell Biol. 2006 Dec;26(23):8964-75. Epub 2006 Sep 25.


Transformation by the Rho-specific guanine nucleotide exchange factor Dbs requires ROCK I-mediated phosphorylation of myosin light chain.

Liu Z, Kostenko EV, Mahon GM, Olabisi OO, Whitehead IP.

J Biol Chem. 2006 Jun 9;281(23):16043-51. Epub 2006 Apr 13.


XGef mediates early CPEB phosphorylation during Xenopus oocyte meiotic maturation.

Martínez SE, Yuan L, Lacza C, Ransom H, Mahon GM, Whitehead IP, Hake LE.

Mol Biol Cell. 2005 Mar;16(3):1152-64. Epub 2005 Jan 5.


The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.

Kostenko EV, Mahon GM, Cheng L, Whitehead IP.

J Biol Chem. 2005 Jan 28;280(4):2807-17. Epub 2004 Nov 5.


Bone marrow stroma influences transforming growth factor-beta production in breast cancer cells to regulate c-myc activation of the preprotachykinin-I gene in breast cancer cells.

Oh HS, Moharita A, Potian JG, Whitehead IP, Livingston JC, Castro TA, Patel PS, Rameshwar P.

Cancer Res. 2004 Sep 1;64(17):6327-36.


Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1.

Cheng L, Mahon GM, Kostenko EV, Whitehead IP.

J Biol Chem. 2004 Mar 26;279(13):12786-93. Epub 2003 Dec 30.


XGef is a CPEB-interacting protein involved in Xenopus oocyte maturation.

Reverte CG, Yuan L, Keady BT, Lacza C, Attfield KR, Mahon GM, Freeman B, Whitehead IP, Hake LE.

Dev Biol. 2003 Mar 15;255(2):383-98.


Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation.

Rossman KL, Cheng L, Mahon GM, Rojas RJ, Snyder JT, Whitehead IP, Sondek J.

J Biol Chem. 2003 May 16;278(20):18393-400. Epub 2003 Mar 13.


The c-Myc Oncoprotein Interacts with Bcr.

Mahon GM, Wang Y, Korus M, Kostenko E, Cheng L, Sun T, Arlinghaus RB, Whitehead IP.

Curr Biol. 2003 Mar 4;13(5):437-41.


Functional analysis of cdc42 residues required for Guanine nucleotide exchange.

Rossman KL, Worthylake DK, Snyder JT, Cheng L, Whitehead IP, Sondek J.

J Biol Chem. 2002 Dec 27;277(52):50893-8. Epub 2002 Oct 24.


RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity.

Cheng L, Rossman KL, Mahon GM, Worthylake DK, Korus M, Sondek J, Whitehead IP.

Mol Cell Biol. 2002 Oct;22(19):6895-905.


p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr.

Korus M, Mahon GM, Cheng L, Whitehead IP.

Oncogene. 2002 Jul 11;21(30):4601-12.


Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways.

Lutchman M, Kim AC, Cheng L, Whitehead IP, Oh SS, Hanspal M, Boukharov AA, Hanada T, Chishti AH.

Eur J Biochem. 2002 Jan;269(2):638-49.


The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways.

Martin CB, Mahon GM, Klinger MB, Kay RJ, Symons M, Der CJ, Whitehead IP.

Oncogene. 2001 Apr 12;20(16):1953-63.


Rho GTPase-dependent transformation by G protein-coupled receptors.

Whitehead IP, Zohn IE, Der CJ.

Oncogene. 2001 Mar 26;20(13):1547-55. Review.


Retrovirus cDNA expression library screening for oncogenes.

Mahon GM, Whitehead IP.

Methods Enzymol. 2001;332:211-21. No abstract available.


Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF.

Zhang H, Wang L, Kao S, Whitehead IP, Hart MJ, Liu B, Duus K, Burridge K, Der CJ, Su L.

Curr Biol. 1999 Nov 4;9(21):1271-4.


Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation.

Whitehead IP, Lambert QT, Glaven JA, Abe K, Rossman KL, Mahon GM, Trzaskos JM, Kay R, Campbell SL, Der CJ.

Mol Cell Biol. 1999 Nov;19(11):7759-70.


Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity.

Abe K, Whitehead IP, O'Bryan JP, Der CJ.

J Biol Chem. 1999 Oct 22;274(43):30410-8.


Regulation of RasGRP via a phorbol ester-responsive C1 domain.

Tognon CE, Kirk HE, Passmore LA, Whitehead IP, Der CJ, Kay RJ.

Mol Cell Biol. 1998 Dec;18(12):6995-7008.


Suppressors of position-effect variegation in Drosophila melanogaster affect expression of the heterochromatic gene light in the absence of a chromosome rearrangement.

Clegg NJ, Honda BM, Whitehead IP, Grigliatti TA, Wakimoto B, Brock HW, Lloyd VK, Sinclair DA.

Genome. 1998 Aug;41(4):495-503.


CDC42 and FGD1 cause distinct signaling and transforming activities.

Whitehead IP, Abe K, Gorski JL, Der CJ.

Mol Cell Biol. 1998 Aug;18(8):4689-97.


Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise LV.

Nature. 1997 Dec 11;390(6660):632-6.


Unique gene organization: alternative splicing in Drosophila produces two structurally unrelated proteins.

Mottus RC, Whitehead IP, O'Grady M, Sobel RE, Burr RH, Spiegelman GB, Grigliatti TA.

Gene. 1997 Oct 1;198(1-2):229-36.


Dbl family proteins.

Whitehead IP, Campbell S, Rossman KL, Der CJ.

Biochim Biophys Acta. 1997 Feb 22;1332(1):F1-23. Review. No abstract available.


Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein.

Glaven JA, Whitehead IP, Nomanbhoy T, Kay R, Cerione RA.

J Biol Chem. 1996 Nov 1;271(44):27374-81.


Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors.

Whitehead IP, Khosravi-Far R, Kirk H, Trigo-Gonzalez G, Der CJ, Kay R.

J Biol Chem. 1996 Aug 2;271(31):18643-50.


A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster.

Clegg NJ, Whitehead IP, Williams JA, Spiegelman GB, Grigliatti TA.

Genome. 1993 Aug;36(4):676-85.


A cytogenetic analysis of chromosomal region 31 of Drosophila melanogaster.

Clegg NJ, Whitehead IP, Brock JK, Sinclair DA, Mottus R, Stromotich G, Harrington MJ, Grigliatti TA.

Genetics. 1993 May;134(1):221-30.

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