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On meta- and mega-analyses for gene-environment interactions.

Huang J, Liu Y, Vitale S, Penning TM, Whitehead AS, Blair IA, Vachani A, Clapper ML, Muscat JE, Lazarus P, Scheet P, Moore JH, Chen Y.

Genet Epidemiol. 2017 Dec;41(8):876-886. doi: 10.1002/gepi.22085. Epub 2017 Nov 7.


Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer.

Bagley SJ, Vitale S, Zhang S, Aggarwal C, Evans TL, Alley EW, Cohen RB, Langer CJ, Blair IA, Vachani A, Whitehead AS.

Clin Lung Cancer. 2017 Mar;18(2):e143-e149. doi: 10.1016/j.cllc.2016.10.010. Epub 2016 Oct 26.


Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population.

Zanetti KA, Wang Z, Aldrich M, Amos CI, Blot WJ, Bowman ED, Burdette L, Cai Q, Caporaso N, Chung CC, Gillanders EM, Haiman CA, Hansen HM, Henderson BE, Kolonel LN, Marchand LL, Li S, McNeill LH, Ryan BM, Schwartz AG, Sison JD, Spitz MR, Tucker M, Wenzlaff AS, Wiencke JK, Wilkens L, Wrensch MR, Wu X, Zheng W, Zhou W, Christiani D, Palmer JR, Penning TM, Rieber AG, Rosenberg L, Ruiz-Narvaez EA, Su L, Vachani A, Wei Y, Whitehead AS, Chanock SJ, Harris CC.

Lung Cancer. 2016 Aug;98:33-42. doi: 10.1016/j.lungcan.2016.05.008. Epub 2016 May 13.


Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells.

Summers CM, Hammons AL, Arora J, Zhang S, Jochems J, Blair IA, Whitehead AS.

Eur J Pharmacol. 2014 Jun 5;732:60-7. doi: 10.1016/j.ejphar.2014.03.004. Epub 2014 Mar 18.


Development of a genotyping microarray for studying the role of gene-environment interactions in risk for lung cancer.

Baldwin DA, Sarnowski CP, Reddy SA, Blair IA, Clapper M, Lazarus P, Li M, Muscat JE, Penning TM, Vachani A, Whitehead AS.

J Biomol Tech. 2013 Dec;24(4):198-217. doi: 10.7171/jbt.13-2404-004.


Pemetrexed alters folate phenotype and inflammatory profile in EA.hy 926 cells grown under low-folate conditions.

Hammons AL, Summers CM, Jochems J, Arora JS, Zhang S, Blair IA, Whitehead AS.

Eur J Pharmacol. 2012 Dec 5;696(1-3):12-7. doi: 10.1016/j.ejphar.2012.08.008. Epub 2012 Sep 5.


The transcobalamin (TCN2) 776C>G polymorphism affects homocysteine concentrations among subjects with low vitamin B(12) status.

Stanisławska-Sachadyn A, Woodside JV, Sayers CM, Yarnell JW, Young IS, Evans AE, Mitchell LE, Whitehead AS.

Eur J Clin Nutr. 2010 Nov;64(11):1338-43. doi: 10.1038/ejcn.2010.157. Epub 2010 Sep 1.


Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women.

Summers CM, Mitchell LE, Stanislawska-Sachadyn A, Baido SF, Blair IA, Von Feldt JM, Whitehead AS.

Birth Defects Res A Clin Mol Teratol. 2010 Aug;88(8):679-88. doi: 10.1002/bdra.20683.


BELFAST centenarians: a case of optimised cardiovascular risk?

Bennati E, Murphy A, Cambien F, Whitehead AS, Archbold GP, Young IS, Rea IM.

Curr Pharm Des. 2010;16(7):789-95.


The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women.

Stanisławska-Sachadyn A, Mitchell LE, Woodside JV, Buckley PT, Kealey C, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS.

Ann Hum Genet. 2009 Sep;73(Pt 5):484-91. doi: 10.1111/j.1469-1809.2009.00529.x. Epub 2009 Jul 28.


Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.

Hammons AL, Summers CM, Woodside JV, McNulty H, Strain JJ, Young IS, Murray L, Boreham CA, Scott JM, Mitchell LE, Whitehead AS.

Clin Immunol. 2009 Oct;133(1):132-7. doi: 10.1016/j.clim.2009.06.008. Epub 2009 Jul 21.


Folate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data.

Mitchell LE, Morales M, Khartulyari S, Huang Y, Murphy K, Mei M, Von Feldt JM, Blair IA, Whitehead AS.

Clin Biochem. 2009 Aug;42(12):1275-81. doi: 10.1016/j.clinbiochem.2009.04.014. Epub 2009 May 8.


Thiol and cardiovascular risk factor status in a male northern Irish population.

Edgar KS, Woodside JV, Skidmore P, Cardwell C, Farelll K, McKinley MC, Young IS, Whitehead AS, Gey KF, Yarnell JW, Evans A.

Int J Vitam Nutr Res. 2008 Jul-Sep;78(4-5):208-16. doi: 10.1024/0300-9831.78.45.208.


The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway.

Lu ZY, Jensen LE, Huang Y, Kealey C, Blair IA, Whitehead AS.

Atherosclerosis. 2009 Jul;205(1):48-54. doi: 10.1016/j.atherosclerosis.2008.12.008. Epub 2008 Dec 13.


Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.

Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, Li M, Derohannessian S, de Bakker PI, Bailey SD, Montpetit A, Edmondson AC, Taylor K, Gai X, Wang SS, Fornage M, Shaikh T, Groop L, Boehnke M, Hall AS, Hattersley AT, Frackelton E, Patterson N, Chiang CW, Kim CE, Fabsitz RR, Ouwehand W, Price AL, Munroe P, Caulfield M, Drake T, Boerwinkle E, Reich D, Whitehead AS, Cappola TP, Samani NJ, Lusis AJ, Schadt E, Wilson JG, Koenig W, McCarthy MI, Kathiresan S, Gabriel SB, Hakonarson H, Anand SS, Reilly M, Engert JC, Nickerson DA, Rader DJ, Hirschhorn JN, Fitzgerald GA.

PLoS One. 2008;3(10):e3583. doi: 10.1371/journal.pone.0003583. Epub 2008 Oct 31.


Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor.

Lu ZY, Morales M, Khartulyari S, Mei M, Murphy KM, Stanislawska-Sachadyn A, Summers CM, Huang Y, Von Feldt JM, Blair IA, Mitchell LE, Whitehead AS.

Birth Defects Res A Clin Mol Teratol. 2008 Oct;82(10):736-41. doi: 10.1002/bdra.20507.


Alcohol increases homocysteine and reduces B vitamin concentration in healthy male volunteers--a randomized, crossover intervention study.

Gibson A, Woodside JV, Young IS, Sharpe PC, Mercer C, Patterson CC, McKinley MC, Kluijtmans LA, Whitehead AS, Evans A.

QJM. 2008 Nov;101(11):881-7. doi: 10.1093/qjmed/hcn112. Epub 2008 Sep 12.


Functional polymorphisms of folate-metabolizing enzymes in relation to homocysteine concentrations in systemic lupus erythematosus.

Summers CM, Cucchiara AJ, Nackos E, Hammons AL, Mohr E, Whitehead AS, Von Feldt JM.

J Rheumatol. 2008 Nov;35(11):2179-86. Epub 2008 Sep 1.


Quantification of key red blood cell folates from subjects with defined MTHFR 677C>T genotypes using stable isotope dilution liquid chromatography/mass spectrometry.

Huang Y, Khartulyari S, Morales ME, Stanislawska-Sachadyn A, Von Feldt JM, Whitehead AS, Blair IA.

Rapid Commun Mass Spectrom. 2008 Aug;22(16):2403-12. doi: 10.1002/rcm.3624.


Dosing algorithms to predict warfarin maintenance dose in Caucasians and African Americans.

Schelleman H, Chen J, Chen Z, Christie J, Newcomb CW, Brensinger CM, Price M, Whitehead AS, Kealey C, Thorn CF, Samaha FF, Kimmel SE.

Clin Pharmacol Ther. 2008 Sep;84(3):332-9. doi: 10.1038/clpt.2008.101. Epub 2008 Jul 2.


Influence of the cystathionine beta-synthase 844ins68 and methylenetetrahydrofolate reductase 677C>T polymorphisms on folate and homocysteine concentrations.

Summers CM, Hammons AL, Mitchell LE, Woodside JV, Yarnell JW, Young IS, Evans A, Whitehead AS.

Eur J Hum Genet. 2008 Aug;16(8):1010-3. doi: 10.1038/ejhg.2008.69. Epub 2008 Apr 9.


An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women.

Stanisławska-Sachadyn A, Brown KS, Mitchell LE, Woodside JV, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS.

Hum Genet. 2008 Apr;123(3):289-95. doi: 10.1007/s00439-008-0475-y. Epub 2008 Feb 5.


Evidence for sex differences in the determinants of homocysteine concentrations.

Stanisławska-Sachadyn A, Woodside JV, Brown KS, Young IS, Murray L, McNulty H, Strain JJ, Boreham CA, Scott JM, Whitehead AS, Mitchell LE.

Mol Genet Metab. 2008 Apr;93(4):355-62. doi: 10.1016/j.ymgme.2007.11.004. Epub 2008 Jan 3.


Cytotoxic doses of ketoconazole affect expression of a subset of hepatic genes.

Casley WL, Ogrodowczyk C, Larocque L, Jaentschke B, LeBlanc-Westwood C, Menzies JA, Whitehouse L, Hefford MA, Aubin RA, Thorn CF, Whitehead AS, Li X.

J Toxicol Environ Health A. 2007 Nov;70(22):1946-55.


Association of methylenetetrahydrofolate reductase polymorphism and the risk of squamous cell carcinoma in renal transplant patients.

Laing ME, Dicker P, Moloney FJ, Ho WL, Murphy GM, Conlon P, Whitehead AS, Shields DC.

Transplantation. 2007 Jul 15;84(1):113-6.


Monocyte chemoattractant protein-1: plasma concentrations and A(-2518)G promoter polymorphism of its gene in systemic lupus erythematosus.

Brown KS, Nackos E, Morthala S, Jensen LE, Whitehead AS, Von Feldt JM.

J Rheumatol. 2007 Apr;34(4):740-6.


Warfarin response and vitamin K epoxide reductase complex 1 in African Americans and Caucasians.

Schelleman H, Chen Z, Kealey C, Whitehead AS, Christie J, Price M, Brensinger CM, Newcomb CW, Thorn CF, Samaha FF, Kimmel SE.

Clin Pharmacol Ther. 2007 May;81(5):742-7. Epub 2007 Feb 28.


Apolipoprotein E genotype and warfarin dosing among Caucasians and African Americans.

Kimmel SE, Christie J, Kealey C, Chen Z, Price M, Thorn CF, Brensinger CM, Newcomb CW, Whitehead AS.

Pharmacogenomics J. 2008 Feb;8(1):53-60. Epub 2007 Feb 27.


Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivity.

Kealey C, Chen Z, Christie J, Thorn CF, Whitehead AS, Price M, Samaha FF, Kimmel SE.

Pharmacogenomics. 2007 Mar;8(3):217-25.


Quantification of intracellular homocysteine by stable isotope dilution liquid chromatography/tandem mass spectrometry.

Huang Y, Lu ZY, Brown KS, Whitehead AS, Blair IA.

Biomed Chromatogr. 2007 Jan;21(1):107-12.


Association between the NAT1 1095C > A polymorphism and homocysteine concentration.

Stanisławska-Sachadyn A, Jensen LE, Kealey C, Woodside JV, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS.

Am J Med Genet A. 2006 Nov 1;140(21):2374-7. No abstract available.


Homocysteine levels and disease duration independently correlate with coronary artery calcification in patients with systemic lupus erythematosus.

Von Feldt JM, Scalzi LV, Cucchiara AJ, Morthala S, Kealey C, Flagg SD, Genin A, Van Dyke AL, Nackos E, Chander A, Gehrie E, Cron RQ, Whitehead AS.

Arthritis Rheum. 2006 Jul;54(7):2220-7.


Loss of function polymorphisms in NAT1 protect against spina bifida.

Jensen LE, Hoess K, Mitchell LE, Whitehead AS.

Hum Genet. 2006 Aug;120(1):52-7. Epub 2006 May 6.


Maternal genotype for the monocyte chemoattractant protein 1 A(-2518)G promoter polymorphism is associated with the risk of spina bifida in offspring.

Jensen LE, Etheredge AJ, Brown KS, Mitchell LE, Whitehead AS.

Am J Med Genet A. 2006 May 15;140(10):1114-8. No abstract available.


Mild folate deficiency induces a proatherosclerotic phenotype in endothelial cells.

Brown KS, Huang Y, Lu ZY, Jian W, Blair IA, Whitehead AS.

Atherosclerosis. 2006 Nov;189(1):133-41. Epub 2006 Feb 15.


The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida.

Jensen LE, Hoess K, Whitehead AS, Mitchell LE.

Birth Defects Res A Clin Mol Teratol. 2005 Jul;73(7):512-6.


A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations.

Kealey C, Brown KS, Woodside JV, Young I, Murray L, Boreham CA, McNulty H, Strain JJ, McPartlin J, Scott JM, Whitehead AS.

Hum Genet. 2005 Apr;116(5):347-53. Epub 2005 Jan 29.


The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland.

Kelly CB, McDonnell AP, Johnston TG, Mulholland C, Cooper SJ, McMaster D, Evans A, Whitehead AS.

J Psychopharmacol. 2004 Dec;18(4):567-71.


Spina bifida.

Mitchell LE, Adzick NS, Melchionne J, Pasquariello PS, Sutton LN, Whitehead AS.

Lancet. 2004 Nov 20-26;364(9448):1885-95. Review.


Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults.

Woodside JV, McMahon R, Gallagher AM, Cran GW, Boreham CA, Murray LJ, Strain JJ, McNulty H, Robson PJ, Brown KS, Whitehead AS, Savage M, Young IS.

Atherosclerosis. 2004 Dec;177(2):337-44.


The human T locus and spina bifida risk.

Jensen LE, Barbaux S, Hoess K, Fraterman S, Whitehead AS, Mitchell LE.

Hum Genet. 2004 Nov;115(6):475-82. Epub 2004 Sep 24.


Quantitation of metalloproteinase gene expression in rheumatoid and psoriatic arthritis synovial tissue distal and proximal to the cartilage-pannus junction.

Kane D, Jensen LE, Grehan S, Whitehead AS, Bresnihan B, Fitzgerald O.

J Rheumatol. 2004 Jul;31(7):1274-80.


A common ABCC2 promoter polymorphism is not a determinant of the risk of spina bifida.

Jensen LE, Wall AM, Cook M, Hoess K, Thorn CF, Whitehead AS, Mitchell LE.

Birth Defects Res A Clin Mol Teratol. 2004 Jun;70(6):396-9.


TGF-β down-regulates IL-1α-induced TLR2 expression in murine hepatocytes.

Matsumura T, Hayashi H, Takii T, Thorn CF, Whitehead AS, Inoue JI, Onozaki K.

J Leukoc Biol. 2004 Jun;75(6):1056-1061. doi: 10.1189/jlb.0104108.


The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine.

Brown KS, Kluijtmans LA, Young IS, Murray L, McMaster D, Woodside JV, Yarnell JW, Boreham CA, McNulty H, Strain JJ, McPartlin J, Scott JM, Mitchell LE, Whitehead AS.

Atherosclerosis. 2004 Jun;174(2):315-22.


Evidence that the risk of spina bifida is influenced by genetic variation at the NOS3 locus.

Brown KS, Cook M, Hoess K, Whitehead AS, Mitchell LE.

Birth Defects Res A Clin Mol Teratol. 2004 Mar;70(3):101-6.


TGF-beta down-regulates IL-1alpha-induced TLR2 expression in murine hepatocytes.

Matsumura T, Hayashi H, Takii T, Thorn CF, Whitehead AS, Inoue J, Onozaki K.

J Leukoc Biol. 2004 Jun;75(6):1056-61. Epub 2004 Mar 23.


Phase I trial of UFT/leucovorin and irinotecan in patients with advanced cancer.

Veronese ML, Stevenson JP, Sun W, Redlinger M, Algazy K, Giantonio B, Hahn S, Vaughn D, Thorn C, Whitehead AS, Haller DG, O'Dwyer PJ.

Eur J Cancer. 2004 Mar;40(4):508-14.


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