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Items: 45

1.

DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas.

Liu C, Fennell LJ, Bettington ML, Walker NI, Dwine J, Leggett BA, Whitehall VLJ.

Clin Epigenetics. 2019 Jun 14;11(1):90. doi: 10.1186/s13148-019-0691-4.

2.

CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function.

Mittal D, Lepletier A, Madore J, Aguilera AR, Stannard K, Blake SJ, Whitehall VLJ, Liu C, Bettington ML, Takeda K, Long GV, Scolyer RA, Lan R, Siemers N, Korman A, Teng MWL, Johnston RJ, Dougall WC, Smyth MJ.

Cancer Immunol Res. 2019 Apr;7(4):559-571. doi: 10.1158/2326-6066.CIR-18-0637. Epub 2019 Mar 20.

3.

How the BRAF V600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications.

Bond CE, Whitehall VLJ.

Gastroenterol Res Pract. 2018 Nov 26;2018:9250757. doi: 10.1155/2018/9250757. eCollection 2018. Review.

4.

CpG Island Methylation in Sessile Serrated Adenomas Increases With Age, Indicating Lower Risk of Malignancy in Young Patients.

Liu C, Bettington ML, Walker NI, Dwine J, Hartel GF, Leggett BA, Whitehall VLJ.

Gastroenterology. 2018 Nov;155(5):1362-1365.e2. doi: 10.1053/j.gastro.2018.07.012. Epub 2018 Oct 4.

PMID:
30009818
5.

Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.

Lannagan TRM, Lee YK, Wang T, Roper J, Bettington ML, Fennell L, Vrbanac L, Jonavicius L, Somashekar R, Gieniec K, Yang M, Ng JQ, Suzuki N, Ichinose M, Wright JA, Kobayashi H, Putoczki TL, Hayakawa Y, Leedham SJ, Abud HE, Yilmaz ÖH, Marker J, Klebe S, Wirapati P, Mukherjee S, Tejpar S, Leggett BA, Whitehall VLJ, Worthley DL, Woods SL.

Gut. 2019 Apr;68(4):684-692. doi: 10.1136/gutjnl-2017-315920. Epub 2018 Apr 17.

6.

Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia.

Bond CE, Liu C, Kawamata F, McKeone DM, Fernando W, Jamieson S, Pearson SA, Kane A, Woods SL, Lannagan TRM, Somashekar R, Lee Y, Dumenil T, Hartel G, Spring KJ, Borowsky J, Fennell L, Bettington M, Lee J, Worthley DL, Leggett BA, Whitehall VLJ.

Epigenetics. 2018;13(1):40-48. doi: 10.1080/15592294.2017.1411446. Epub 2018 Feb 19.

7.

Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours.

Scarpa A, Chang DK, Nones K, Corbo V, Patch AM, Bailey P, Lawlor RT, Johns AL, Miller DK, Mafficini A, Rusev B, Scardoni M, Antonello D, Barbi S, Sikora KO, Cingarlini S, Vicentini C, McKay S, Quinn MCJ, Bruxner TJC, Christ AN, Harliwong I, Idrisoglu S, McLean S, Nourse C, Nourbakhsh E, Wilson PJ, Anderson MJ, Fink JL, Newell F, Waddell N, Holmes O, Kazakoff SH, Leonard C, Wood S, Xu Q, Hiriyur Nagaraj S, Amato E, Dalai I, Bersani S, Cataldo I, Dei Tos AP, Capelli P, Vittoria Davì M, Landoni L, Malpaga A, Miotto M, Whitehall VLJ, Leggett BA, Harris JL, Harris J, Jones MD, Humphris J, Chantrill LA, Chin V, Nagrial AM, Pajic M, Scarlett CJ, Pinho A, Rooman I, Toon C, Wu J, Pinese M, Cowley M, Barbour A, Mawson A, Humphrey ES, Colvin EK, Chou A, Lovell JA, Jamieson NB, Duthie F, Gingras MC, Fisher WE, Dagg RA, Lau LMS, Lee M, Pickett HA, Reddel RR, Samra JS, Kench JG, Merrett ND, Epari K, Nguyen NQ, Zeps N, Falconi M, Simbolo M, Butturini G, Van Buren G, Partelli S, Fassan M; Australian Pancreatic Cancer Genome Initiative, Khanna KK, Gill AJ, Wheeler DA, Gibbs RA, Musgrove EA, Bassi C, Tortora G, Pederzoli P, Pearson JV, Waddell N, Biankin AV, Grimmond SM.

Nature. 2017 Oct 26;550(7677):548. doi: 10.1038/nature24026. Epub 2017 Sep 27.

PMID:
28953865
8.

Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry.

Liu C, Walker NI, Leggett BA, Whitehall VL, Bettington ML, Rosty C.

Mod Pathol. 2017 Dec;30(12):1728-1738. doi: 10.1038/modpathol.2017.92. Epub 2017 Jul 28.

9.

RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers.

Fennell LJ, Clendenning M, McKeone DM, Jamieson SH, Balachandran S, Borowsky J, Liu J, Kawamata F, Bond CE, Rosty C, Burge ME, Buchanan DD, Leggett BA, Whitehall VLJ.

Fam Cancer. 2018 Jan;17(1):63-69. doi: 10.1007/s10689-017-0003-0.

10.

Whole-genome landscape of pancreatic neuroendocrine tumours.

Scarpa A, Chang DK, Nones K, Corbo V, Patch AM, Bailey P, Lawlor RT, Johns AL, Miller DK, Mafficini A, Rusev B, Scardoni M, Antonello D, Barbi S, Sikora KO, Cingarlini S, Vicentini C, McKay S, Quinn MC, Bruxner TJ, Christ AN, Harliwong I, Idrisoglu S, McLean S, Nourse C, Nourbakhsh E, Wilson PJ, Anderson MJ, Fink JL, Newell F, Waddell N, Holmes O, Kazakoff SH, Leonard C, Wood S, Xu Q, Nagaraj SH, Amato E, Dalai I, Bersani S, Cataldo I, Dei Tos AP, Capelli P, Davì MV, Landoni L, Malpaga A, Miotto M, Whitehall VL, Leggett BA, Harris JL, Harris J, Jones MD, Humphris J, Chantrill LA, Chin V, Nagrial AM, Pajic M, Scarlett CJ, Pinho A, Rooman I, Toon C, Wu J, Pinese M, Cowley M, Barbour A, Mawson A, Humphrey ES, Colvin EK, Chou A, Lovell JA, Jamieson NB, Duthie F, Gingras MC, Fisher WE, Dagg RA, Lau LM, Lee M, Pickett HA, Reddel RR, Samra JS, Kench JG, Merrett ND, Epari K, Nguyen NQ, Zeps N, Falconi M, Simbolo M, Butturini G, Van Buren G, Partelli S, Fassan M; Australian Pancreatic Cancer Genome Initiative, Khanna KK, Gill AJ, Wheeler DA, Gibbs RA, Musgrove EA, Bassi C, Tortora G, Pederzoli P, Pearson JV, Waddell N, Biankin AV, Grimmond SM.

Nature. 2017 Mar 2;543(7643):65-71. doi: 10.1038/nature21063. Epub 2017 Feb 15. Erratum in: Nature. 2017 Sep 27;:.

PMID:
28199314
11.

GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features.

Liu C, McKeone DM, Walker NI, Bettington ML, Leggett BA, Whitehall VLJ.

Histopathology. 2017 Jun;70(7):1079-1088. doi: 10.1111/his.13180. Epub 2017 Mar 22.

PMID:
28164369
12.

RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.

Bond CE, McKeone DM, Kalimutho M, Bettington ML, Pearson SA, Dumenil TD, Wockner LF, Burge M, Leggett BA, Whitehall VL.

Oncotarget. 2016 Oct 25;7(43):70589-70600. doi: 10.18632/oncotarget.12130.

13.

Brain-specific epigenetic markers of schizophrenia.

Wockner LF, Morris CP, Noble EP, Lawford BR, Whitehall VL, Young RM, Voisey J.

Transl Psychiatry. 2015 Nov 17;5:e680. doi: 10.1038/tp.2015.177.

14.

Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups.

Bond CE, Bettington ML, Pearson SA, McKeone DM, Leggett BA, Whitehall VL.

BMC Cancer. 2015 Jan 23;15:20. doi: 10.1186/s12885-015-1011-9.

15.

Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype.

Whitehall VL, Dumenil TD, McKeone DM, Bond CE, Bettington ML, Buttenshaw RL, Bowdler L, Montgomery GW, Wockner LF, Leggett BA.

Epigenetics. 2014 Nov;9(11):1454-60. doi: 10.4161/15592294.2014.971624.

16.

A clinicopathological and molecular analysis of 200 traditional serrated adenomas.

Bettington ML, Walker NI, Rosty C, Brown IS, Clouston AD, McKeone DM, Pearson SA, Klein K, Leggett BA, Whitehall VL.

Mod Pathol. 2015 Mar;28(3):414-27. doi: 10.1038/modpathol.2014.122. Epub 2014 Sep 12.

17.

Genome-wide DNA methylation analysis of formalin-fixed paraffin embedded colorectal cancer tissue.

Dumenil TD, Wockner LF, Bettington M, McKeone DM, Klein K, Bowdler LM, Montgomery GW, Leggett BA, Whitehall VL.

Genes Chromosomes Cancer. 2014 Jul;53(7):537-48. doi: 10.1002/gcc.22164. Epub 2014 Mar 28.

PMID:
24677610
18.

Microsatellite stable colorectal cancers stratified by the BRAF V600E mutation show distinct patterns of chromosomal instability.

Bond CE, Nancarrow DJ, Wockner LF, Wallace L, Montgomery GW, Leggett BA, Whitehall VL.

PLoS One. 2014 Mar 20;9(3):e91739. doi: 10.1371/journal.pone.0091739. eCollection 2014.

19.

Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients.

Wockner LF, Noble EP, Lawford BR, Young RM, Morris CP, Whitehall VL, Voisey J.

Transl Psychiatry. 2014 Jan 7;4:e339. doi: 10.1038/tp.2013.111.

20.

Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.

Rosty C, Hewett DG, Brown IS, Leggett BA, Whitehall VL.

J Gastroenterol. 2013 Mar;48(3):287-302. doi: 10.1007/s00535-012-0720-y. Epub 2012 Dec 4. Review.

21.

Chromosomal instability in BRAF mutant, microsatellite stable colorectal cancers.

Bond CE, Umapathy A, Buttenshaw RL, Wockner L, Leggett BA, Whitehall VL.

PLoS One. 2012;7(10):e47483. doi: 10.1371/journal.pone.0047483. Epub 2012 Oct 22.

22.

Oncogenic PIK3CA mutations in colorectal cancers and polyps.

Whitehall VL, Rickman C, Bond CE, Ramsnes I, Greco SA, Umapathy A, McKeone D, Faleiro RJ, Buttenshaw RL, Worthley DL, Nayler S, Zhao ZZ, Montgomery GW, Mallitt KA, Jass JR, Matsubara N, Notohara K, Ishii T, Leggett BA.

Int J Cancer. 2012 Aug 15;131(4):813-20. doi: 10.1002/ijc.26440. Epub 2011 Nov 19.

23.

p53 mutation is common in microsatellite stable, BRAF mutant colorectal cancers.

Bond CE, Umapathy A, Ramsnes I, Greco SA, Zhen Zhao Z, Mallitt KA, Buttenshaw RL, Montgomery GW, Leggett BA, Whitehall VL.

Int J Cancer. 2012 Apr 1;130(7):1567-76. doi: 10.1002/ijc.26175. Epub 2011 Aug 3.

24.

The effects from DNA extraction methods on the evaluation of microbial diversity associated with human colonic tissue.

Ó Cuív P, Aguirre de Cárcer D, Jones M, Klaassens ES, Worthley DL, Whitehall VL, Kang S, McSweeney CS, Leggett BA, Morrison M.

Microb Ecol. 2011 Feb;61(2):353-62. doi: 10.1007/s00248-010-9771-x. Epub 2010 Dec 14.

PMID:
21153634
25.

Thrombospondin-4 is a putative tumour-suppressor gene in colorectal cancer that exhibits age-related methylation.

Greco SA, Chia J, Inglis KJ, Cozzi SJ, Ramsnes I, Buttenshaw RL, Spring KJ, Boyle GM, Worthley DL, Leggett BA, Whitehall VL.

BMC Cancer. 2010 Sep 16;10:494. doi: 10.1186/1471-2407-10-494.

26.

DNA methylation in the rectal mucosa is associated with crypt proliferation and fecal short-chain fatty acids.

Worthley DL, Whitehall VL, Le Leu RK, Irahara N, Buttenshaw RL, Mallitt KA, Greco SA, Ramsnes I, Winter J, Hu Y, Ogino S, Young GP, Leggett BA.

Dig Dis Sci. 2011 Feb;56(2):387-96. doi: 10.1007/s10620-010-1312-4. Epub 2010 Jul 16.

PMID:
20635146
27.

Re: Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study.

Worthley DL, Hewett DG, Spring KJ, Whitehall VL, Leggett BA.

J Natl Cancer Inst. 2010 Jul 7;102(13):990; author reply 990-1. doi: 10.1093/jnci/djq189. Epub 2010 Jun 1. No abstract available.

PMID:
20516399
28.

Hyperplastic polyposis syndrome is associated with cigarette smoking, which may be a modifiable risk factor.

Walker RG, Landmann JK, Hewett DG, Worthley DL, Buttenshaw RL, Knight N, Webb PM, Whiteman DC, Whitehall VL, Leggett BA.

Am J Gastroenterol. 2010 Jul;105(7):1642-7. doi: 10.1038/ajg.2009.757. Epub 2010 Feb 2.

PMID:
20125129
29.

Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling.

Hinoue T, Weisenberger DJ, Pan F, Campan M, Kim M, Young J, Whitehall VL, Leggett BA, Laird PW.

PLoS One. 2009 Dec 21;4(12):e8357. doi: 10.1371/journal.pone.0008357.

30.

DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer.

Worthley DL, Whitehall VL, Buttenshaw RL, Irahara N, Greco SA, Ramsnes I, Mallitt KA, Le Leu RK, Winter J, Hu Y, Ogino S, Young GP, Leggett BA.

Oncogene. 2010 Mar 18;29(11):1653-62. doi: 10.1038/onc.2009.449. Epub 2009 Dec 7.

PMID:
19966864
31.

A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer.

Worthley DL, Le Leu RK, Whitehall VL, Conlon M, Christophersen C, Belobrajdic D, Mallitt KA, Hu Y, Irahara N, Ogino S, Leggett BA, Young GP.

Am J Clin Nutr. 2009 Sep;90(3):578-86. doi: 10.3945/ajcn.2009.28106. Epub 2009 Jul 29.

PMID:
19640954
32.

Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development.

Loh K, Chia JA, Greco S, Cozzi SJ, Buttenshaw RL, Bond CE, Simms LA, Pike T, Young JP, Jass JR, Spring KJ, Leggett BA, Whitehall VL.

Genes Chromosomes Cancer. 2008 Jun;47(6):449-60. doi: 10.1002/gcc.20552.

PMID:
18311777
33.

Colorectal carcinogenesis: road maps to cancer.

Worthley DL, Whitehall VL, Spring KJ, Leggett BA.

World J Gastroenterol. 2007 Jul 28;13(28):3784-91. Review.

34.

High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy.

Spring KJ, Zhao ZZ, Karamatic R, Walsh MD, Whitehall VL, Pike T, Simms LA, Young J, James M, Montgomery GW, Appleyard M, Hewett D, Togashi K, Jass JR, Leggett BA.

Gastroenterology. 2006 Nov;131(5):1400-7. Epub 2006 Aug 18.

PMID:
17101316
35.

SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers.

Chia JA, Simms LA, Cozzi SJ, Young J, Jass JR, Walsh MD, Spring KJ, Leggett BA, Whitehall VL.

BMC Cancer. 2006 Oct 24;6:252.

36.

Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer.

Young J, Barker MA, Simms LA, Walsh MD, Biden KG, Buchanan D, Buttenshaw R, Whitehall VL, Arnold S, Jackson L, Kambara T, Spring KJ, Jenkins MA, Walker GJ, Hopper JL, Leggett BA, Jass JR.

Clin Gastroenterol Hepatol. 2005 Mar;3(3):254-63.

PMID:
15765445
37.

Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer.

McGivern A, Wynter CV, Whitehall VL, Kambara T, Spring KJ, Walsh MD, Barker MA, Arnold S, Simms LA, Leggett BA, Young J, Jass JR.

Fam Cancer. 2004;3(2):101-7.

PMID:
15340260
38.

BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum.

Kambara T, Simms LA, Whitehall VL, Spring KJ, Wynter CV, Walsh MD, Barker MA, Arnold S, McGivern A, Matsubara N, Tanaka N, Higuchi T, Young J, Jass JR, Leggett BA.

Gut. 2004 Aug;53(8):1137-44.

39.

Role of inherited defects of MYH in the development of sporadic colorectal cancer.

Kambara T, Whitehall VL, Spring KJ, Barker MA, Arnold S, Wynter CV, Matsubara N, Tanaka N, Young JP, Leggett BA, Jass JR.

Genes Chromosomes Cancer. 2004 May;40(1):1-9.

PMID:
15034862
40.

APC mutation and tumour budding in colorectal cancer.

Jass JR, Barker M, Fraser L, Walsh MD, Whitehall VL, Gabrielli B, Young J, Leggett BA.

J Clin Pathol. 2003 Jan;56(1):69-73.

41.

Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer.

Whitehall VL, Wynter CV, Walsh MD, Simms LA, Purdie D, Pandeya N, Young J, Meltzer SJ, Leggett BA, Jass JR.

Cancer Res. 2002 Nov 1;62(21):6011-4. Erratum in: Cancer Res 2002 Dec 1;62(23):7132.

42.

Correspondence re: P. Laiho et al., Low-level microsatellite instability in most colorectal carcinomas. Cancer Res., 62: 1166-1170, 2002.

Jass JR, Whitehall VL, Young J, Leggett B, Meltzer SJ, Matsubara N, Fishel R.

Cancer Res. 2002 Oct 15;62(20):5988-9; author reply 5989-90. No abstract available.

43.

Emerging concepts in colorectal neoplasia.

Jass JR, Whitehall VL, Young J, Leggett BA.

Gastroenterology. 2002 Sep;123(3):862-76. Review.

PMID:
12198712
44.
45.

p73 is up-regulated in a subset of hepatocellular carcinomas.

Herath NI, Kew MC, Whitehall VL, Walsh MD, Jass JR, Khanna KK, Young J, Powell LW, Leggett BA, Macdonald GA.

Hepatology. 2000 Mar;31(3):601-5.

PMID:
10706549

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