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Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate.

McMahon SA, Zhu W, Graham S, Rambo R, White MF, Gloster TM.

Nat Commun. 2020 Jan 24;11(1):500. doi: 10.1038/s41467-019-14222-x.


An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity.

Athukoralage JS, McMahon SA, Zhang C, Grüschow S, Graham S, Krupovic M, Whitaker RJ, Gloster TM, White MF.

Nature. 2020 Jan;577(7791):572-575. doi: 10.1038/s41586-019-1909-5. Epub 2020 Jan 15.


Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.

Makarova KS, Wolf YI, Iranzo J, Shmakov SA, Alkhnbashi OS, Brouns SJJ, Charpentier E, Cheng D, Haft DH, Horvath P, Moineau S, Mojica FJM, Scott D, Shah SA, Siksnys V, Terns MP, Venclovas Č, White MF, Yakunin AF, Yan W, Zhang F, Garrett RA, Backofen R, van der Oost J, Barrangou R, Koonin EV.

Nat Rev Microbiol. 2020 Feb;18(2):67-83. doi: 10.1038/s41579-019-0299-x. Epub 2019 Dec 19. Review.


Asymmetric base-pair opening drives helicase unwinding dynamics.

Colizzi F, Perez-Gonzalez C, Fritzen R, Levy Y, White MF, Penedo JC, Bussi G.

Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22471-22477. doi: 10.1073/pnas.1901086116. Epub 2019 Oct 18.


Cyclic oligoadenylate signalling mediates Mycobacterium tuberculosis CRISPR defence.

Grüschow S, Athukoralage JS, Graham S, Hoogeboom T, White MF.

Nucleic Acids Res. 2019 Sep 26;47(17):9259-9270. doi: 10.1093/nar/gkz676.


A Type III CRISPR Ancillary Ribonuclease Degrades Its Cyclic Oligoadenylate Activator.

Athukoralage JS, Graham S, Grüschow S, Rouillon C, White MF.

J Mol Biol. 2019 Jul 12;431(15):2894-2899. doi: 10.1016/j.jmb.2019.04.041. Epub 2019 May 6.


Phosphorylation of Forkhead Protein FoxO1 at S253 Regulates Glucose Homeostasis in Mice.

Zhang K, Guo X, Yan H, Wu Y, Pan Q, Shen JZ, Li X, Chen Y, Li L, Qi Y, Xu Z, Xie W, Zhang W, Threadgill D, He L, Villarreal D, Sun Y, White MF, Zheng H, Guo S.

Endocrinology. 2019 May 1;160(5):1333-1347. doi: 10.1210/en.2018-00853.


Investigation of the cyclic oligoadenylate signaling pathway of type III CRISPR systems.

Rouillon C, Athukoralage JS, Graham S, Grüschow S, White MF.

Methods Enzymol. 2019;616:191-218. doi: 10.1016/bs.mie.2018.10.020. Epub 2019 Jan 12.


Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1-mediated p53/KLF4 complex stabilization.

Xi G, Shen X, Wai C, White MF, Clemmons DR.

J Biol Chem. 2019 Feb 15;294(7):2407-2421. doi: 10.1074/jbc.RA118.005398. Epub 2018 Dec 21.


Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate.

Athukoralage JS, Rouillon C, Graham S, Grüschow S, White MF.

Nature. 2018 Oct;562(7726):277-280. doi: 10.1038/s41586-018-0557-5. Epub 2018 Sep 19.


Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia.

Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF.

Nat Med. 2018 Oct;24(10):1628. doi: 10.1038/s41591-018-0129-0.


Control of cyclic oligoadenylate synthesis in a type III CRISPR system.

Rouillon C, Athukoralage JS, Graham S, Grüschow S, White MF.

Elife. 2018 Jul 2;7. pii: e36734. doi: 10.7554/eLife.36734.


Inactivating hepatic follistatin alleviates hyperglycemia.

Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF.

Nat Med. 2018 Jul;24(7):1058-1069. doi: 10.1038/s41591-018-0048-0. Epub 2018 Jun 4. Erratum in: Nat Med. 2018 Oct;24(10):1628.


DNA repair in the archaea-an emerging picture.

White MF, Allers T.

FEMS Microbiol Rev. 2018 Jul 1;42(4):514-526. doi: 10.1093/femsre/fuy020. Review.


Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis.

Xu H, Lee MS, Tsai PY, Adler AS, Curry NL, Challa S, Freinkman E, Hitchcock DS, Copps KD, White MF, Bronson RT, Marcotrigiano M, Wu Y, Clish CB, Kalaany NY.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4228-4233. doi: 10.1073/pnas.1718414115. Epub 2018 Apr 2.


Prespacer processing and specific integration in a Type I-A CRISPR system.

Rollie C, Graham S, Rouillon C, White MF.

Nucleic Acids Res. 2018 Feb 16;46(3):1007-1020. doi: 10.1093/nar/gkx1232.


Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity.

Cao J, Peng J, An H, He Q, Boronina T, Guo S, White MF, Cole PA, He L.

Nat Commun. 2017 Jul 25;8(1):131. doi: 10.1038/s41467-017-00163-w.


DNA-Interacting Characteristics of the Archaeal Rudiviral Protein SIRV2_Gp1.

Peeters E, Boon M, Rollie C, Willaert RG, Voet M, White MF, Prangishvili D, Lavigne R, Quax TEF.

Viruses. 2017 Jul 18;9(7). pii: E190. doi: 10.3390/v9070190.


Correction for Long et al., "Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways".

Long YC, Cheng Z, Copps KD, White MF.

Mol Cell Biol. 2017 Jul 14;37(15). pii: e00232-17. doi: 10.1128/MCB.00232-17. Print 2017 Aug 1. No abstract available.


High-affinity RNA binding by a hyperthermophilic single-stranded DNA-binding protein.

Morten MJ, Gamsjaeger R, Cubeddu L, Kariawasam R, Peregrina J, Penedo JC, White MF.

Extremophiles. 2017 Mar;21(2):369-379. doi: 10.1007/s00792-016-0910-2. Epub 2017 Jan 10.


Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.

Xi G, Wai C, White MF, Clemmons DR.

J Biol Chem. 2017 Feb 3;292(5):2009-2020. doi: 10.1074/jbc.M116.758987. Epub 2016 Dec 21.


A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction.

Han W, Li Y, Deng L, Feng M, Peng W, Hallstrøm S, Zhang J, Peng N, Liang YX, White MF, She Q.

Nucleic Acids Res. 2017 Feb 28;45(4):1983-1993. doi: 10.1093/nar/gkw1274.


IRS proteins and diabetic complications.

Lavin DP, White MF, Brazil DP.

Diabetologia. 2016 Nov;59(11):2280-2291. doi: 10.1007/s00125-016-4072-7. Epub 2016 Aug 11. Review.


Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma.

Metz HE, Kargl J, Busch SE, Kim KH, Kurland BF, Abberbock SR, Randolph-Habecker J, Knoblaugh SE, Kolls JK, White MF, Houghton AM.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8795-800. doi: 10.1073/pnas.1601989113. Epub 2016 Jul 20.


Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice.

Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MF.

JCI Insight. 2016;1(3). pii: e80749. Epub 2016 Mar 17.


Cpf1 shape-shifts for streamlined CRISPR cleavage.

White MF.

Nat Struct Mol Biol. 2016 May 4;23(5):365-6. doi: 10.1038/nsmb.3225. No abstract available.


Mechanism of DNA loading by the DNA repair helicase XPD.

Constantinescu-Aruxandei D, Petrovic-Stojanovska B, Penedo JC, White MF, Naismith JH.

Nucleic Acids Res. 2016 Apr 7;44(6):2806-15. doi: 10.1093/nar/gkw102. Epub 2016 Feb 20.


Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.

Copps KD, Hançer NJ, Qiu W, White MF.

J Biol Chem. 2016 Apr 15;291(16):8602-17. doi: 10.1074/jbc.M116.714915. Epub 2016 Feb 4.


Multiple nucleic acid cleavage modes in divergent type III CRISPR systems.

Zhang J, Graham S, Tello A, Liu H, White MF.

Nucleic Acids Res. 2016 Feb 29;44(4):1789-99. doi: 10.1093/nar/gkw020. Epub 2016 Jan 21.


Taking a molecular motor for a spin: helicase mechanism studied by spin labeling and PELDOR.

Constantinescu-Aruxandei D, Petrovic-Stojanovska B, Schiemann O, Naismith JH, White MF.

Nucleic Acids Res. 2016 Jan 29;44(2):954-68. doi: 10.1093/nar/gkv1373. Epub 2015 Dec 10.


Binding dynamics of a monomeric SSB protein to DNA: a single-molecule multi-process approach.

Morten MJ, Peregrina JR, Figueira-Gonzalez M, Ackermann K, Bode BE, White MF, Penedo JC.

Nucleic Acids Res. 2015 Dec 15;43(22):10907-24. doi: 10.1093/nar/gkv1225. Epub 2015 Nov 17.


An updated evolutionary classification of CRISPR-Cas systems.

Makarova KS, Wolf YI, Alkhnbashi OS, Costa F, Shah SA, Saunders SJ, Barrangou R, Brouns SJ, Charpentier E, Haft DH, Horvath P, Moineau S, Mojica FJ, Terns RM, Terns MP, White MF, Yakunin AF, Garrett RA, van der Oost J, Backofen R, Koonin EV.

Nat Rev Microbiol. 2015 Nov;13(11):722-36. doi: 10.1038/nrmicro3569. Epub 2015 Sep 28. Review.


Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition.

Rollie C, Schneider S, Brinkmann AS, Bolt EL, White MF.

Elife. 2015 Aug 18;4. doi: 10.7554/eLife.08716.


Longevity: Mapping the path to a longer life.

White MF.

Nature. 2015 Aug 13;524(7564):170-1. doi: 10.1038/524170a. No abstract available.


Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity.

Charpentier E, Richter H, van der Oost J, White MF.

FEMS Microbiol Rev. 2015 May;39(3):428-41. doi: 10.1093/femsre/fuv023. Epub 2015 May 19. Review.


Expression and Purification of the CMR (Type III-B) Complex in Sulfolobus solfataricus.

Zhang J, White MF.

Methods Mol Biol. 2015;1311:185-94. doi: 10.1007/978-1-4939-2687-9_12.


Functional characterization of a conserved archaeal viral operon revealing single-stranded DNA binding, annealing and nuclease activities.

Guo Y, Kragelund BB, White MF, Peng X.

J Mol Biol. 2015 Jun 19;427(12):2179-91. doi: 10.1016/j.jmb.2015.03.013. Epub 2015 Mar 29.


The structural basis of DNA binding by the single-stranded DNA-binding protein from Sulfolobus solfataricus.

Gamsjaeger R, Kariawasam R, Gimenez AX, Touma C, McIlwain E, Bernardo RE, Shepherd NE, Ataide SF, Dong Q, Richard DJ, White MF, Cubeddu L.

Biochem J. 2015 Jan 15;465(2):337-46. doi: 10.1042/BJ20141140.


IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity.

White MF.

Diabetes Obes Metab. 2014 Sep;16 Suppl 1:4-15. doi: 10.1111/dom.12347. Review.


Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.

Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED.

Mol Cell Biol. 2014 Sep 15;34(18):3450-60. doi: 10.1128/MCB.00426-14. Epub 2014 Jul 7.


APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.

Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ.

Cell Rep. 2014 May 22;7(4):1227-38. doi: 10.1016/j.celrep.2014.04.006. Epub 2014 May 10.


Cas6 specificity and CRISPR RNA loading in a complex CRISPR-Cas system.

Sokolowski RD, Graham S, White MF.

Nucleic Acids Res. 2014 Jun;42(10):6532-41. doi: 10.1093/nar/gku308. Epub 2014 Apr 20.


Protein-protein interactions leading to recruitment of the host DNA sliding clamp by the hyperthermophilic Sulfolobus islandicus rod-shaped virus 2.

Gardner AF, Bell SD, White MF, Prangishvili D, Krupovic M.

J Virol. 2014 Jun;88(12):7105-8. doi: 10.1128/JVI.00636-14. Epub 2014 Apr 2.


Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.

Hançer NJ, Qiu W, Cherella C, Li Y, Copps KD, White MF.

J Biol Chem. 2014 May 2;289(18):12467-84. doi: 10.1074/jbc.M114.554162. Epub 2014 Mar 20.


CRISPR-mediated targeted mRNA degradation in the archaeon Sulfolobus solfataricus.

Zebec Z, Manica A, Zhang J, White MF, Schleper C.

Nucleic Acids Res. 2014 Apr;42(8):5280-8. doi: 10.1093/nar/gku161. Epub 2014 Mar 6.


Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis.

Sadagurski M, Dong XC, Myers MG Jr, White MF.

Mol Metab. 2013 Oct 23;3(1):55-63. doi: 10.1016/j.molmet.2013.10.004. eCollection 2014 Feb.


Self-care guide for the heart failure patient.

White MF, Kirschner J, Hamilton MA.

Circulation. 2014 Jan 21;129(3):e293-4. doi: 10.1161/CIRCULATIONAHA.113.003991. No abstract available.


IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance.

Herrema H, Lee J, Zhou Y, Copps KD, White MF, Ozcan U.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):689-93. doi: 10.1016/j.bbrc.2013.12.023. Epub 2013 Dec 11.


Hot and crispy: CRISPR-Cas systems in the hyperthermophile Sulfolobus solfataricus.

Zhang J, White MF.

Biochem Soc Trans. 2013 Dec;41(6):1422-6. doi: 10.1042/BST20130031. Review.


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