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Items: 1 to 50 of 154

1.

How many human proteoforms are there?

Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.

Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576.

PMID:
29443976
2.

Quantitative Analysis of Tyrosine Kinase Signaling Across Differentially Embedded Human Glioblastoma Tumors.

Johnson H, White FM.

Methods Mol Biol. 2018;1711:149-164. doi: 10.1007/978-1-4939-7493-1_8.

PMID:
29344889
3.

Hepatic Dysfunction Caused by Consumption of a High-Fat Diet.

Soltis AR, Kennedy NJ, Xin X, Zhou F, Ficarro SB, Yap YS, Matthews BJ, Lauffenburger DA, White FM, Marto JA, Davis RJ, Fraenkel E.

Cell Rep. 2017 Dec 12;21(11):3317-3328. doi: 10.1016/j.celrep.2017.11.059.

4.

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer.

Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC.

Cancer Discov. 2018 Mar;8(3):354-369. doi: 10.1158/2159-8290.CD-17-0679. Epub 2017 Dec 4.

PMID:
29203461
5.

Src homology 2 domains enhance tyrosine phosphorylation in vivo by protecting binding sites in their target proteins from dephosphorylation.

Jadwin JA, Curran TG, Lafontaine AT, White FM, Mayer BJ.

J Biol Chem. 2018 Jan 12;293(2):623-637. doi: 10.1074/jbc.M117.794412. Epub 2017 Nov 21.

PMID:
29162725
6.

Characterization of In Vivo Resistance to Osimertinib and JNJ-61186372, an EGFR/Met Bispecific Antibody, Reveals Unique and Consensus Mechanisms of Resistance.

Emdal KB, Dittmann A, Reddy RJ, Lescarbeau RS, Moores SL, Laquerre S, White FM.

Mol Cancer Ther. 2017 Nov;16(11):2572-2585. doi: 10.1158/1535-7163.MCT-17-0413. Epub 2017 Aug 22.

PMID:
28830985
7.

Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.

Ando K, Shah AK, Sachdev V, Kleinstiver BP, Taylor-Parker J, Welch MM, Hu Y, Salgia R, White FM, Parvin JD, Ozonoff A, Rameh LE, Joung JK, Bharti AK.

Oncotarget. 2017 Jul 4;8(27):43733-43751. doi: 10.18632/oncotarget.16376.

8.

Revealing disease-associated pathways by network integration of untargeted metabolomics.

Pirhaji L, Milani P, Leidl M, Curran T, Avila-Pacheco J, Clish CB, White FM, Saghatelian A, Fraenkel E.

Nat Methods. 2016 Sep;13(9):770-6. doi: 10.1038/nmeth.3940. Epub 2016 Aug 1.

9.

Network Modeling Identifies Patient-specific Pathways in Glioblastoma.

Tuncbag N, Milani P, Pokorny JL, Johnson H, Sio TT, Dalin S, Iyekegbe DO, White FM, Sarkaria JN, Fraenkel E.

Sci Rep. 2016 Jun 29;6:28668. doi: 10.1038/srep28668.

10.

Quantitative Phosphoproteomics Reveals Wee1 Kinase as a Therapeutic Target in a Model of Proneural Glioblastoma.

Lescarbeau RS, Lei L, Bakken KK, Sims PA, Sarkaria JN, Canoll P, White FM.

Mol Cancer Ther. 2016 Jun;15(6):1332-43. doi: 10.1158/1535-7163.MCT-15-0692. Epub 2016 May 17.

11.

Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases.

Jadwin JA, Oh D, Curran TG, Ogiue-Ikeda M, Jia L, White FM, Machida K, Yu J, Mayer BJ.

Elife. 2016 Apr 12;5:e11835. doi: 10.7554/eLife.11835.

12.

Methods for the Analysis of Protein Phosphorylation-Mediated Cellular Signaling Networks.

White FM, Wolf-Yadlin A.

Annu Rev Anal Chem (Palo Alto Calif). 2016 Jun 12;9(1):295-315. doi: 10.1146/annurev-anchem-071015-041542. Epub 2016 Mar 30. Review.

PMID:
27049636
13.

A Thermodynamic-Based Interpretation of Protein Expression Heterogeneity in Different Glioblastoma Multiforme Tumors Identifies Tumor-Specific Unbalanced Processes.

Kravchenko-Balasha N, Johnson H, White FM, Heath JR, Levine RD.

J Phys Chem B. 2016 Jul 7;120(26):5990-7. doi: 10.1021/acs.jpcb.6b01692. Epub 2016 Apr 12.

14.

Early signaling dynamics of the epidermal growth factor receptor.

Reddy RJ, Gajadhar AS, Swenson EJ, Rothenberg DA, Curran TG, White FM.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3114-9. doi: 10.1073/pnas.1521288113. Epub 2016 Feb 29.

15.

Measurement of Phosphorylated Peptides with Absolute Quantification.

Reddy RJ, Curran TG, Zhang Y, White FM.

Methods Mol Biol. 2016;1410:281-92. doi: 10.1007/978-1-4939-3524-6_17.

PMID:
26867751
16.

Identification of Direct Kinase Substrates Using Analogue-Sensitive Alleles.

Rothenberg DA, Gordon EA, White FM, Lourido S.

Methods Mol Biol. 2016;1355:71-84. doi: 10.1007/978-1-4939-3049-4_5.

PMID:
26584919
17.

CNS Anticancer Drug Discovery and Development Conference White Paper.

Levin VA, Tonge PJ, Gallo JM, Birtwistle MR, Dar AC, Iavarone A, Paddison PJ, Heffron TP, Elmquist WF, Lachowicz JE, Johnson TW, White FM, Sul J, Smith QR, Shen W, Sarkaria JN, Samala R, Wen PY, Berry DA, Petter RC.

Neuro Oncol. 2015 Nov;17 Suppl 6:vi1-26. doi: 10.1093/neuonc/nov169.

18.

Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.

McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD.

Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29.

19.

Quantitative Profiling of Lysine Acetylation Reveals Dynamic Crosstalk between Receptor Tyrosine Kinases and Lysine Acetylation.

Bryson BD, White FM.

PLoS One. 2015 May 15;10(5):e0126242. doi: 10.1371/journal.pone.0126242. eCollection 2015.

20.

Phosphotyrosine signaling analysis in human tumors is confounded by systemic ischemia-driven artifacts and intra-specimen heterogeneity.

Gajadhar AS, Johnson H, Slebos RJ, Shaddox K, Wiles K, Washington MK, Herline AJ, Levine DA, Liebler DC, White FM; Clinical Proteomic Tumor Analysis Consortium.

Cancer Res. 2015 Apr 1;75(7):1495-503. doi: 10.1158/0008-5472.CAN-14-2309. Epub 2015 Feb 10.

21.

Engineered bromodomains to explore the acetylproteome.

Bryson BD, Del Rosario AM, Gootenberg JS, Yaffe MB, White FM.

Proteomics. 2015 May;15(9):1470-5. doi: 10.1002/pmic.201400401. Epub 2015 Mar 5.

22.

MARQUIS: a multiplex method for absolute quantification of peptides and posttranslational modifications.

Curran TG, Zhang Y, Ma DJ, Sarkaria JN, White FM.

Nat Commun. 2015 Jan 12;6:5924. doi: 10.1038/ncomms6924.

23.

SirT1 is required in the male germ cell for differentiation and fecundity in mice.

Bell EL, Nagamori I, Williams EO, Del Rosario AM, Bryson BD, Watson N, White FM, Sassone-Corsi P, Guarente L.

Development. 2014 Sep;141(18):3495-504. doi: 10.1242/dev.110627. Epub 2014 Aug 19.

24.

Adaptive protein and phosphoprotein networks which promote therapeutic sensitivity or acquired resistance.

Haley J, White FM.

Biochem Soc Trans. 2014 Aug;42(4):758-64. doi: 10.1042/BST20140038. Review.

PMID:
25109954
25.

Quantitative analysis of signaling networks across differentially embedded tumors highlights interpatient heterogeneity in human glioblastoma.

Johnson H, White FM.

J Proteome Res. 2014 Nov 7;13(11):4581-93. doi: 10.1021/pr500418w. Epub 2014 Jun 24.

26.

System level dynamics of post-translational modifications.

Gajadhar AS, White FM.

Curr Opin Biotechnol. 2014 Aug;28:83-7. doi: 10.1016/j.copbio.2013.12.009. Epub 2014 Jan 15. Review.

27.

Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration.

Arneja A, Johnson H, Gabrovsek L, Lauffenburger DA, White FM.

J Immunol. 2014 Jan 1;192(1):123-35. doi: 10.4049/jimmunol.1302291. Epub 2013 Dec 2.

28.

A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern.

Berchowitz LE, Gajadhar AS, van Werven FJ, De Rosa AA, Samoylova ML, Brar GA, Xu Y, Xiao C, Futcher B, Weissman JS, White FM, Amon A.

Genes Dev. 2013 Oct 1;27(19):2147-63. doi: 10.1101/gad.224253.113.

29.

Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context.

Hang TC, Tedford NC, Reddy RJ, Rimchala T, Wells A, White FM, Kamm RD, Lauffenburger DA.

Mol Cell Proteomics. 2013 Dec;12(12):3704-18. doi: 10.1074/mcp.M113.030528. Epub 2013 Sep 9.

30.

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.

Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB.

Nature. 2013 Jun 13;498(7453):246-50. doi: 10.1038/nature12147. Epub 2013 Jun 2.

31.

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.

Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM.

Integr Biol (Camb). 2013 Jul 24;5(7):940-63. doi: 10.1039/c3ib40013a. Epub 2013 May 20.

32.

Computer aided manual validation of mass spectrometry-based proteomic data.

Curran TG, Bryson BD, Reigelhaupt M, Johnson H, White FM.

Methods. 2013 Jun 15;61(3):219-26. doi: 10.1016/j.ymeth.2013.03.004. Epub 2013 Mar 13.

33.

Phosphotyrosine profiling of NSCLC cells in response to EGF and HGF reveals network specific mediators of invasion.

Johnson H, Lescarbeau RS, Gutierrez JA, White FM.

J Proteome Res. 2013 Apr 5;12(4):1856-67. doi: 10.1021/pr301192t. Epub 2013 Mar 11.

34.

Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML.

Winter GE, Rix U, Carlson SM, Gleixner KV, Grebien F, Gridling M, Müller AC, Breitwieser FP, Bilban M, Colinge J, Valent P, Bennett KL, White FM, Superti-Furga G.

Nat Chem Biol. 2012 Nov;8(11):905-912. doi: 10.1038/nchembio.1085. Epub 2012 Sep 30.

35.

Molecular characterization of EGFR and EGFRvIII signaling networks in human glioblastoma tumor xenografts.

Johnson H, Del Rosario AM, Bryson BD, Schroeder MA, Sarkaria JN, White FM.

Mol Cell Proteomics. 2012 Dec;11(12):1724-40. doi: 10.1074/mcp.M112.019984. Epub 2012 Sep 10.

36.

Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions.

Naegle KM, White FM, Lauffenburger DA, Yaffe MB.

Mol Biosyst. 2012 Oct;8(10):2771-82. doi: 10.1039/c2mb25200g.

37.

Signaling for death: tyrosine phosphorylation in the response to glucose deprivation.

Bryson BD, White FM.

Mol Syst Biol. 2012 Jun 26;8:591. doi: 10.1038/msb.2012.27. No abstract available.

38.

Toward quantitative phosphotyrosine profiling in vivo.

Johnson H, White FM.

Semin Cell Dev Biol. 2012 Oct;23(8):854-62. doi: 10.1016/j.semcdb.2012.05.008. Epub 2012 Jun 5. Review.

39.

Labeling and identification of direct kinase substrates.

Carlson SM, White FM.

Sci Signal. 2012 Jun 5;5(227):pl3. doi: 10.1126/scisignal.2002568.

40.

Expanding applications of chemical genetics in signal transduction.

Carlson SM, White FM.

Cell Cycle. 2012 May 15;11(10):1903-9. doi: 10.4161/cc.19956. Epub 2012 May 15.

41.

Epidermal growth factor receptor downregulation by small heterodimeric binding proteins.

Hackel BJ, Neil JR, White FM, Wittrup KD.

Protein Eng Des Sel. 2012 Feb;25(2):47-57. doi: 10.1093/protein/gzr056. Epub 2011 Dec 9.

42.

Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3.

Carlson SM, Chouinard CR, Labadorf A, Lam CJ, Schmelzle K, Fraenkel E, White FM.

Sci Signal. 2011 Oct 25;4(196):rs11. doi: 10.1126/scisignal.2002010.

43.

Reply to Comment on "Sloppy models, parameter uncertainty, and the role of experimental design"

Hagen DR, Apgar JF, Witmer DK, White FM, Tidor B.

Mol Biosyst. 2011 Aug 1;7(8):2523-2524. No abstract available.

44.

MCAM: multiple clustering analysis methodology for deriving hypotheses and insights from high-throughput proteomic datasets.

Naegle KM, Welsch RE, Yaffe MB, White FM, Lauffenburger DA.

PLoS Comput Biol. 2011 Jul;7(7):e1002119. doi: 10.1371/journal.pcbi.1002119. Epub 2011 Jul 21.

45.

The potential cost of high-throughput proteomics.

White FM.

Sci Signal. 2011 Feb 15;4(160):pe8. doi: 10.1126/scisignal.2001813.

PMID:
21325204
46.

CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis.

Liu H, Ong SE, Badu-Nkansah K, Schindler J, White FM, Hynes RO.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1379-84. doi: 10.1073/pnas.1017228108. Epub 2011 Jan 10.

47.

Using small molecules and chemical genetics to interrogate signaling networks.

Carlson SM, White FM.

ACS Chem Biol. 2011 Jan 21;6(1):75-85. doi: 10.1021/cb1002834. Epub 2010 Nov 29. Review.

PMID:
21077690
48.

Integrated data management and validation platform for phosphorylated tandem mass spectrometry data.

Lahesmaa-Korpinen AM, Carlson SM, White FM, Hautaniemi S.

Proteomics. 2010 Oct;10(19):3515-24. doi: 10.1002/pmic.200900727.

49.

EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism.

Pines G, Huang PH, Zwang Y, White FM, Yarden Y.

Oncogene. 2010 Oct 28;29(43):5850-60. doi: 10.1038/onc.2010.313. Epub 2010 Aug 2.

50.

PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies.

Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB, Lauffenburger DA, White FM.

Mol Cell Proteomics. 2010 Nov;9(11):2558-70. doi: 10.1074/mcp.M110.001206. Epub 2010 Jul 14.

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