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Items: 1 to 50 of 163

1.

Re Gatti et al (Eur J Haematol 2017 Mar 23. Doi: 10.1111/ejh.12885).

Sutherland DR, Illingworth AJ, Whitby L, Marinov I.

Eur J Haematol. 2018 Aug 20. doi: 10.1111/ejh.13163. [Epub ahead of print]

PMID:
30126043
2.

ICCS/ESCCA consensus guidelines to detect GPI-deficient cells in paroxysmal nocturnal hemoglobinuria (PNH) and related disorders part 4 - assay validation and quality assurance.

Oldaker T, Whitby L, Saber M, Holden J, Wallace PK, Litwin V.

Cytometry B Clin Cytom. 2018 Jan;94(1):67-81. doi: 10.1002/cyto.b.21615.

PMID:
29251828
3.

Paroxysmal nocturnal haemoglobinuria testing in blood transfusion laboratories: do they go with the flow?

Whitby L, White J, Fletcher M, Whitby A, Milkins C, Barnett D.

Transfus Med. 2017 Aug 18. doi: 10.1111/tme.12449. [Epub ahead of print]

PMID:
28833743
4.

Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites.

Whitby LR, Obach RS, Simon GM, Hayward MM, Cravatt BF.

ACS Chem Biol. 2017 Aug 18;12(8):2040-2050. doi: 10.1021/acschembio.7b00346. Epub 2017 Jun 21.

5.

Laboratory Accuracy Improvement in the UK NEQAS Leucocyte Immunophenotyping Immune Monitoring Program: An Eleven-Year Review via Longitudinal Mixed Effects Modeling.

Bainbridge J, Rountree W, Louzao R, Wong J, Whitby L, Denny TN, Barnett D.

Cytometry B Clin Cytom. 2018 Mar;94(2):250-256. doi: 10.1002/cyto.b.21531. Epub 2017 May 16.

PMID:
28480599
6.

Measurement of BCR-ABL1 by RT-qPCR in chronic myeloid leukaemia: findings from an International EQA Programme.

Scott S, Travis D, Whitby L, Bainbridge J, Cross NCP, Barnett D.

Br J Haematol. 2017 May;177(3):414-422. doi: 10.1111/bjh.14557. Epub 2017 Mar 14.

PMID:
28295199
7.

Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible Inhibitors.

Zaro BW, Whitby LR, Lum KM, Cravatt BF.

J Am Chem Soc. 2016 Dec 14;138(49):15841-15844. Epub 2016 Dec 5.

8.

Small-Molecule Fusion Inhibitors Bind the pH-Sensing Stable Signal Peptide-GP2 Subunit Interface of the Lassa Virus Envelope Glycoprotein.

Shankar S, Whitby LR, Casquilho-Gray HE, York J, Boger DL, Nunberg JH.

J Virol. 2016 Jul 11;90(15):6799-807. doi: 10.1128/JVI.00597-16. Print 2016 Aug 1.

9.

Current international flow cytometric practices for the detection and monitoring of paroxysmal nocturnal haemoglobinuria clones: A UK NEQAS survey.

Fletcher M, Whitby L, Whitby A, Barnett D.

Cytometry B Clin Cytom. 2017 Jul;92(4):266-274. doi: 10.1002/cyto.b.21368. Epub 2016 Apr 18.

10.

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.

Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM, Huang H, Shi H, Choi JH, Wang KW, Moresco EM, Berger M, Zhan X, Zhang H, Boger DL, Beutler B.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E884-93. doi: 10.1073/pnas.1525639113. Epub 2016 Feb 1. Erratum in: Proc Natl Acad Sci U S A. 2016 Apr 5;113(14 ):E2096.

11.

Current laboratory practices in flow cytometry for the enumeration of CD 4(+) T-lymphocyte subsets.

Whitby L, Whitby A, Fletcher M, Barnett D.

Cytometry B Clin Cytom. 2015 Sep-Oct;88(5):305-11. doi: 10.1002/cyto.b.21241. Epub 2015 Jul 6.

12.

Quantification of cells with specific phenotypes II: determination of CD4 expression level on reconstituted lyophilized human PBMC labelled with anti-CD4 FITC antibody.

Wang L, Stebbings R, Gaigalas AK, Sutherland J, Kammel M, John M, Roemer B, Kuhne M, Schneider RJ, Braun M, Engel A, Dikshit D, Abbasi F, Marti GE, Sassi M, Revel L, Kim SK, Baradez M, Lekishvili T, Marshall D, Whitby L, Jing W, Ost V, Vonsky M, Neukammer J.

Cytometry A. 2015 Mar;87(3):254-61. doi: 10.1002/cyto.a.22634. Epub 2015 Feb 5.

13.

Quantification of cells with specific phenotypes I: determination of CD4+ cell count per microliter in reconstituted lyophilized human PBMC prelabeled with anti-CD4 FITC antibody.

Stebbings R, Wang L, Sutherland J, Kammel M, Gaigalas AK, John M, Roemer B, Kuhne M, Schneider RJ, Braun M, Engel A, Dikshit DK, Abbasi F, Marti GE, Sassi MP, Revel L, Kim SK, Baradez MO, Lekishvili T, Marshall D, Whitby L, Jing W, Ost V, Vonsky M, Neukammer J.

Cytometry A. 2015 Mar;87(3):244-53. doi: 10.1002/cyto.a.22614. Epub 2015 Feb 5.

14.

Monitoring of chimerism following allogeneic haematopoietic stem cell transplantation (HSCT): technical recommendations for the use of short tandem repeat (STR) based techniques, on behalf of the United Kingdom National External Quality Assessment Service for Leucocyte Immunophenotyping Chimerism Working Group.

Clark JR, Scott SD, Jack AL, Lee H, Mason J, Carter GI, Pearce L, Jackson T, Clouston H, Sproul A, Keen L, Molloy K, Folarin N, Whitby L, Snowden JA, Reilly JT, Barnett D; United Kingdom National External Quality Assessment Service for Leucocyte Immunophenotyping Chimerism Working Group.

Br J Haematol. 2015 Jan;168(1):26-37. doi: 10.1111/bjh.13073. Epub 2014 Aug 22.

PMID:
25145701
15.

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors.

Lanning BR, Whitby LR, Dix MM, Douhan J, Gilbert AM, Hett EC, Johnson TO, Joslyn C, Kath JC, Niessen S, Roberts LR, Schnute ME, Wang C, Hulce JJ, Wei B, Whiteley LO, Hayward MM, Cravatt BF.

Nat Chem Biol. 2014 Sep;10(9):760-767. doi: 10.1038/nchembio.1582. Epub 2014 Jul 13.

16.

Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative.

Sanchez-Cespedes J, Moyer CL, Whitby LR, Boger DL, Nemerow GR.

Antiviral Res. 2014 Aug;108:65-73. doi: 10.1016/j.antiviral.2014.05.010. Epub 2014 Jun 4.

17.

Standardizing leucocyte PNH clone detection: an international study.

Fletcher M, Sutherland DR, Whitby L, Whitby A, Richards SJ, Acton E, Keeney M, Borowitz M, Illingworth A, Reilly JT, Barnett D.

Cytometry B Clin Cytom. 2014 Sep;86(5):311-8. doi: 10.1002/cyto.b.21174. Epub 2014 Apr 9.

18.

Standardizing Leucocyte PNH clone detection: An international study.

Fletcher M, Sutherland DR, Whitby L, Whitby A, Richards SJ, Acton E, Keeney M, Borowitz M, Illingworth A, Reilly JT, Barnett D.

Cytometry B Clin Cytom. 2014 Mar 22. doi: 10.1002/cytob.21174. [Epub ahead of print]

19.

Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6).

Hsu KL, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF.

J Med Chem. 2013 Nov 14;56(21):8270-9. doi: 10.1021/jm400899c. Epub 2013 Oct 23.

20.

Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.

Hsu KL, Tsuboi K, Whitby LR, Speers AE, Pugh H, Inloes J, Cravatt BF.

J Med Chem. 2013 Nov 14;56(21):8257-69. doi: 10.1021/jm400898x. Epub 2013 Oct 23.

21.

NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41.

Gochin M, Whitby LR, Phillips AH, Boger DL.

J Comput Aided Mol Des. 2013 Jul;27(7):569-82. doi: 10.1007/s10822-013-9662-6. Epub 2013 Jul 27.

22.

Comparison of methodological data measurement limits in CD4⁺ T lymphocyte flow cytometric enumeration and their clinical impact on HIV management.

Whitby L, Whitby A, Fletcher M, Helbert M, Reilly JT, Barnett D.

Cytometry B Clin Cytom. 2013 Jul-Aug;84(4):248-54. doi: 10.1002/cyto.b.21094. Epub 2013 Apr 23.

23.

Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2).

Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):839-43. doi: 10.1016/j.bmcl.2012.11.061. Epub 2012 Dec 2.

24.

Comprehensive peptidomimetic libraries targeting protein-protein interactions.

Whitby LR, Boger DL.

Acc Chem Res. 2012 Oct 16;45(10):1698-709. doi: 10.1021/ar300025n. Epub 2012 Jul 16.

25.

Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library.

Whitby LR, Boyle KE, Cai L, Yu X, Gochin M, Boger DL.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2861-5. doi: 10.1016/j.bmcl.2012.02.062. Epub 2012 Mar 3.

26.

VERITAS?: A time for VERIQAS™ and a new approach to training, education, and the quality assessment of CD4+ T lymphocyte counting (I).

Barnett D, Whitby L, Wong J, Louzao R, Reilly JT, Denny TN.

Cytometry B Clin Cytom. 2012 Mar;82(2):93-100. doi: 10.1002/cyto.b.20624. Epub 2011 Oct 13.

27.

ISHAGE protocol: are we doing it correctly?

Whitby A, Whitby L, Fletcher M, Reilly JT, Sutherland DR, Keeney M, Barnett D.

Cytometry B Clin Cytom. 2012 Jan;82(1):9-17. doi: 10.1002/cyto.b.20612. Epub 2011 Sep 13.

28.

Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions.

Whitby LR, Ando Y, Setola V, Vogt PK, Roth BL, Boger DL.

J Am Chem Soc. 2011 Jul 6;133(26):10184-94. doi: 10.1021/ja201878v. Epub 2011 Jun 15.

29.

Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport.

Ambrus G, Whitby LR, Singer EL, Trott O, Choi E, Olson AJ, Boger DL, Gerace L.

Bioorg Med Chem. 2010 Nov 1;18(21):7611-20. doi: 10.1016/j.bmc.2010.08.038. Epub 2010 Aug 21.

30.

Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries.

Chang MW, Giffin MJ, Muller R, Savage J, Lin YC, Hong S, Jin W, Whitby LR, Elder JH, Boger DL, Torbett BE.

Biochem J. 2010 Aug 1;429(3):527-32. doi: 10.1042/BJ20091645.

31.

Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation.

Shi J, Stover JS, Whitby LR, Vogt PK, Boger DL.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6038-41. doi: 10.1016/j.bmcl.2009.09.044. Epub 2009 Sep 17.

32.

Characterization of lassa virus cell entry inhibitors: determination of the active enantiomer by asymmetric synthesis.

Whitby LR, Lee AM, Kunz S, Oldstone MB, Boger DL.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3771-4. doi: 10.1016/j.bmcl.2009.04.098. Epub 2009 May 3.

33.

Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a multi-center setting.

Irving J, Jesson J, Virgo P, Case M, Minto L, Eyre L, Noel N, Johansson U, Macey M, Knotts L, Helliwell M, Davies P, Whitby L, Barnett D, Hancock J, Goulden N, Lawson S; UKALL Flow MRD Group; UK MRD steering Group.

Haematologica. 2009 Jun;94(6):870-4. doi: 10.3324/haematol.2008.000414. Epub 2009 Apr 18.

34.

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.

Shaginian A, Whitby LR, Hong S, Hwang I, Farooqi B, Searcey M, Chen J, Vogt PK, Boger DL.

J Am Chem Soc. 2009 Apr 22;131(15):5564-72. doi: 10.1021/ja810025g.

35.

Development and evaluation of a stabilized whole-blood preparation as a process control material for screening of paroxysmal nocturnal hemoglobinuria by flow cytometry.

Richards SJ, Whitby L, Cullen MJ, Dickinson AJ, Granger V, Reilly JT, Hillmen P, Barnett D.

Cytometry B Clin Cytom. 2009 Jan;76(1):47-55. doi: 10.1002/cyto.b.20438. Epub 2008 Sep 5.

36.

Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification.

Puthenveetil S, Whitby L, Ren J, Kelnar K, Krebs JF, Beal PA.

Nucleic Acids Res. 2006;34(17):4900-11. Epub 2006 Sep 18.

37.

Flow rate calibration. III. The use of stabilized biostandards to calibrate the flow rate and calculate absolute CD4+ T-cell counts.

Walker CL, Whitby L, Granger V, Storie I, Reilly JT, Barnett D.

Cytometry B Clin Cytom. 2006 May;70(3):154-62.

38.

Diagnosis of plasma cell leukaemia: findings of the UK NEQAS for Leucocyte Immunophenotyping scheme.

van Veen JJ, Reilly JT, Richards SJ, Whitby L, Goodfellow K, Granger V, Rees DC, Barnett D.

Clin Lab Haematol. 2004 Feb;26(1):37-42.

PMID:
14738436
39.

Perfect count: a novel approach for the single platform enumeration of absolute CD4+ T-lymphocytes.

Storie I, Sawle A, Goodfellow K, Whitby L, Granger V, Ward RY, Peel J, Smart T, Reilly JT, Barnett D.

Cytometry B Clin Cytom. 2004 Jan;57(1):47-52.

40.

Flow rate calibration II: a clinical evaluation study using PanLeucoGating as a single-platform protocol.

Storie I, Sawle A, Whitby L, Goodfellow K, Granger V, Reilly JT, Barnett D.

Cytometry B Clin Cytom. 2003 Sep;55(1):8-13.

41.

Flow rate calibration I: a novel approach for performing absolute cell counts.

Storie I, Sawle A, Goodfellow K, Whitby L, Granger V, Reilly JT, Barnett D.

Cytometry B Clin Cytom. 2003 Sep;55(1):1-7.

42.

Small molecule inhibitors of the RNA-dependent protein kinase.

Jammi NV, Whitby LR, Beal PA.

Biochem Biophys Res Commun. 2003 Aug 15;308(1):50-7.

PMID:
12890478
43.

The United Kingdom National External Quality Assessment Scheme gating and standardization strategy for use in residual WBC counting of WBC-reduced blood components.

Goodfellow KJ, Storie I, Granger V, Whitby L, Antcliffe J, Reilly JT, Barnett D.

Transfusion. 2002 Jun;42(6):738-46.

PMID:
12147027
44.
45.

Low level leucocyte counting: a critical variable in the validation of leucodepleted blood transfusion components as highlighted by an external quality assessment study.

Barnett D, Goodfellow K, Ginnever J, Granger V, Whitby L, Reilly JT.

Clin Lab Haematol. 2001 Feb;23(1):43-51.

PMID:
11422230
46.

Standardization of lymphocyte antibody binding capacity - a multi-centre study.

Barnett D, Storie I, Granger V, Whitby L, Reilly JT, Brough S, Garner S, Lawry J, Richards S, Bell AE, Shenton BK.

Clin Lab Haematol. 2000 Apr;22(2):89-96.

PMID:
10792398
48.

Absolute CD4+ T-lymphocyte and CD34+ stem cell counts by single-platform flow cytometry: the way forward.

Barnett D, Granger V, Whitby L, Storie I, Reilly JT.

Br J Haematol. 1999 Sep;106(4):1059-62.

PMID:
10520014
49.

Consequences of the provision of laboratory services for the National Health Service by commercial firms: a view from the university sector.

Whitby LG, Bird CC, Collee JG, McDicken WN.

J Clin Pathol. 1990 Jun;43(6):441-4. No abstract available.

50.

Improving success rates of kidney transplantation.

Terasaki PI, Perdue ST, Sasaki N, Mickey MR, Whitby L.

JAMA. 1983 Aug 26;250(8):1065-8.

PMID:
6348321

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