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Items: 1 to 50 of 71


TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning.

Luo SX, Timbang L, Kim JI, Shang Y, Sandoval K, Tang AA, Whistler JL, Ding JB, Huang EJ.

Cell Rep. 2016 Dec 20;17(12):3233-3245. doi: 10.1016/j.celrep.2016.11.068.


Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins.

Johnson TA, Milan-Lobo L, Che T, Ferwerda M, Lambu E, McIntosh NL, Li F, He L, Lorig-Roach N, Crews P, Whistler JL.

ACS Chem Neurosci. 2017 Mar 15;8(3):473-485. doi: 10.1021/acschemneuro.6b00167. Epub 2016 Nov 22.


β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment.

Yang S, Ben-Shalom R, Ahn M, Liptak AT, van Rijn RM, Whistler JL, Bender KJ.

Cell Rep. 2016 Aug 9;16(6):1518-1526. doi: 10.1016/j.celrep.2016.06.098. Epub 2016 Jul 21.


Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit.

Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler JL, Bruchas MR, Kash TL.

Cell Rep. 2016 Mar 29;14(12):2774-83. doi: 10.1016/j.celrep.2016.02.069. Epub 2016 Mar 17.


Real-time trafficking and signaling of the glucagon-like peptide-1 receptor.

Roed SN, Wismann P, Underwood CR, Kulahin N, Iversen H, Cappelen KA, Schäffer L, Lehtonen J, Hecksher-Soerensen J, Secher A, Mathiesen JM, Bräuner-Osborne H, Whistler JL, Knudsen SM, Waldhoer M.

Mol Cell Endocrinol. 2014 Feb 15;382(2):938-49. doi: 10.1016/j.mce.2013.11.010. Epub 2013 Nov 22.


Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.

He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B.

Cell. 2013 Aug 29;154(5):1085-1099. doi: 10.1016/j.cell.2013.07.035. Epub 2013 Aug 15.


Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area.

Madhavan A, Argilli E, Bonci A, Whistler JL.

J Neurosci. 2013 Jul 24;33(30):12329-36. doi: 10.1523/JNEUROSCI.0809-13.2013.


Pharmacological traits of delta opioid receptors: pitfalls or opportunities?

van Rijn RM, Defriel JN, Whistler JL.

Psychopharmacology (Berl). 2013 Jul;228(1):1-18. doi: 10.1007/s00213-013-3129-2. Epub 2013 May 7. Review.


Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers.

Harvey JH, Long DH, England PM, Whistler JL.

ACS Med Chem Lett. 2012 Aug 9;3(8):640-644.


Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism.

Milan-Lobo L, Enquist J, van Rijn RM, Whistler JL.

PLoS One. 2013;8(3):e58362. doi: 10.1371/journal.pone.0058362. Epub 2013 Mar 15.


A FLIPR assay for evaluating agonists and antagonists of GPCR heterodimers.

Harvey JH, van Rijn RM, Whistler JL.

Methods Mol Biol. 2013;995:43-54. doi: 10.1007/978-1-62703-345-9_4.


Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling.

van Rijn RM, Harvey JH, Brissett DI, DeFriel JN, Whistler JL.

J Pharmacol Exp Ther. 2013 Jan;344(1):179-88. doi: 10.1124/jpet.112.198655. Epub 2012 Oct 24.


Chronic ethanol potentiates the effect of neuropeptide s in the basolateral amygdala and shows increased anxiolytic and anti-depressive effects.

Enquist J, Ferwerda M, Madhavan A, Hok D, Whistler JL.

Neuropsychopharmacology. 2012 Oct;37(11):2436-45. doi: 10.1038/npp.2012.102. Epub 2012 Jun 27.


The chemoselective reactions of tyrosine-containing G-protein-coupled receptor peptides with [Cp*Rh(H2O)3](OTf)2, including 2D NMR structures and the biological consequences.

Albada HB, Wieberneit F, Dijkgraaf I, Harvey JH, Whistler JL, Stoll R, Metzler-Nolte N, Fish RH.

J Am Chem Soc. 2012 Jun 27;134(25):10321-4. doi: 10.1021/ja303010k. Epub 2012 Jun 15.


PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.

Schröder R, Xue L, Konya V, Martini L, Kampitsch N, Whistler JL, Ulven T, Heinemann A, Pettipher R, Kostenis E.

PLoS One. 2012;7(3):e33329. doi: 10.1371/journal.pone.0033329. Epub 2012 Mar 19.


Contribution of mu and delta opioid receptors to the pharmacological profile of kappa opioid receptor subtypes.

Brissett DI, Whistler JL, van Rijn RM.

Eur J Pain. 2012 Mar;16(3):327-37. doi: 10.1002/j.1532-2149.2011.00022.x. Epub 2011 Dec 19.


Examining the role of mu opioid receptor endocytosis in the beneficial and side-effects of prolonged opioid use: from a symposium on new concepts in mu-opioid pharmacology.

Whistler JL.

Drug Alcohol Depend. 2012 Mar 1;121(3):189-204. doi: 10.1016/j.drugalcdep.2011.10.031. Epub 2012 Jan 9. Review.


Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.

Enquist J, Ferwerda M, Milan-Lobo L, Whistler JL.

J Pharmacol Exp Ther. 2012 Feb;340(2):386-92. doi: 10.1124/jpet.111.187583. Epub 2011 Nov 7.


Distinctive modulation of ethanol place preference by delta opioid receptor-selective agonists.

van Rijn RM, Brissett DI, Whistler JL.

Drug Alcohol Depend. 2012 Apr 1;122(1-2):156-9. doi: 10.1016/j.drugalcdep.2011.09.024. Epub 2011 Oct 21.


Emergence of functional spinal delta opioid receptors after chronic ethanol exposure.

van Rijn RM, Brissett DI, Whistler JL.

Biol Psychiatry. 2012 Feb 1;71(3):232-8. doi: 10.1016/j.biopsych.2011.07.015. Epub 2011 Sep 1.


The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.

Kargl J, Balenga NA, Platzer W, Martini L, Whistler JL, Waldhoer M.

Br J Pharmacol. 2012 Apr;165(8):2611-9. doi: 10.1111/j.1476-5381.2011.01562.x.


Morphine-induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use.

Berger AC, Whistler JL.

EMBO Mol Med. 2011 Jul;3(7):385-97. doi: 10.1002/emmm.201100144. Epub 2011 Jun 8.


Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis.

He L, Whistler JL.

PLoS One. 2011;6(5):e19372. doi: 10.1371/journal.pone.0019372. Epub 2011 May 13.


A novel knock-in mouse reveals mechanistically distinct forms of morphine tolerance.

Enquist J, Kim JA, Bartlett S, Ferwerda M, Whistler JL.

J Pharmacol Exp Ther. 2011 Aug;338(2):633-40. doi: 10.1124/jpet.111.179754. Epub 2011 May 11.


Heteromerization of the μ- and δ-opioid receptors produces ligand-biased antagonism and alters μ-receptor trafficking.

Milan-Lobo L, Whistler JL.

J Pharmacol Exp Ther. 2011 Jun;337(3):868-75. doi: 10.1124/jpet.111.179093. Epub 2011 Mar 21.


Trafficking properties of the D5 dopamine receptor.

Thompson D, Whistler JL.

Traffic. 2011 May;12(5):644-56. doi: 10.1111/j.1600-0854.2011.01179.x.


Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area.

Madhavan A, Bonci A, Whistler JL.

J Neurosci. 2010 Oct 20;30(42):14029-35. doi: 10.1523/JNEUROSCI.3366-10.2010.


G protein-coupled receptor-associated sorting protein 1 regulates the postendocytic sorting of seven-transmembrane-spanning G protein-coupled receptors.

Moser E, Kargl J, Whistler JL, Waldhoer M, Tschische P.

Pharmacology. 2010;86(1):22-9. doi: 10.1159/000314161. Epub 2010 Jun 26. Review.


Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety.

van Rijn RM, Brissett DI, Whistler JL.

J Pharmacol Exp Ther. 2010 Oct;335(1):133-9. doi: 10.1124/jpet.110.170969. Epub 2010 Jul 6.


Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine.

Thompson D, Martini L, Whistler JL.

PLoS One. 2010 Jun 9;5(6):e11038. doi: 10.1371/journal.pone.0011038.


How to design an opioid drug that causes reduced tolerance and dependence.

Berger AC, Whistler JL.

Ann Neurol. 2010 May;67(5):559-69. doi: 10.1002/ana.22002.


An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis.

Bonde MM, Yao R, Ma JN, Madabushi S, Haunsø S, Burstein ES, Whistler JL, Sheikh SP, Lichtarge O, Hansen JL.

Biochem Pharmacol. 2010 Jul 1;80(1):86-94. doi: 10.1016/j.bcp.2010.03.006. Epub 2010 Mar 21.


micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal.

Madhavan A, He L, Stuber GD, Bonci A, Whistler JL.

J Neurosci. 2010 Mar 3;30(9):3276-86. doi: 10.1523/JNEUROSCI.4634-09.2010.


Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1.

Martini L, Thompson D, Kharazia V, Whistler JL.

Neuropsychopharmacology. 2010 May;35(6):1363-73. doi: 10.1038/npp.2010.6. Epub 2010 Feb 17.


GPR55 ligands promote receptor coupling to multiple signalling pathways.

Henstridge CM, Balenga NA, Schröder R, Kargl JK, Platzer W, Martini L, Arthur S, Penman J, Whistler JL, Kostenis E, Waldhoer M, Irving AJ.

Br J Pharmacol. 2010 Jun;160(3):604-14. doi: 10.1111/j.1476-5381.2009.00625.x. Epub 2010 Feb 5.


The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28.

Tschische P, Moser E, Thompson D, Vischer HF, Parzmair GP, Pommer V, Platzer W, Schwarzbraun T, Schaider H, Smit MJ, Martini L, Whistler JL, Waldhoer M.

Traffic. 2010 May;11(5):660-74. doi: 10.1111/j.1600-0854.2010.1045.x.


Opioid-receptor-heteromer-specific trafficking and pharmacology.

van Rijn RM, Whistler JL, Waldhoer M.

Curr Opin Pharmacol. 2010 Feb;10(1):73-9. doi: 10.1016/j.coph.2009.09.007. Epub 2009 Oct 19. Review.


Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor.

He L, Kim JA, Whistler JL.

FASEB J. 2009 Dec;23(12):4327-34. doi: 10.1096/fj.09-133223. Epub 2009 Aug 13.


The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake.

van Rijn RM, Whistler JL.

Biol Psychiatry. 2009 Oct 15;66(8):777-84. doi: 10.1016/j.biopsych.2009.05.019. Epub 2009 Jul 3.


Functional characterization of human variants of the mu-opioid receptor gene.

Ravindranathan A, Joslyn G, Robertson M, Schuckit MA, Whistler JL, White RL.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10811-6. doi: 10.1073/pnas.0904509106. Epub 2009 Jun 15.


Methadone antinociception is dependent on peripheral opioid receptors.

He L, Kim J, Ou C, McFadden W, van Rijn RM, Whistler JL.

J Pain. 2009 Apr;10(4):369-79. doi: 10.1016/j.jpain.2008.09.011.


The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers?

van Rijn RM, Whistler JL.

Mol Interv. 2008 Dec;8(6):277-80. doi: 10.1124/mi.8.6.4. No abstract available.


Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence.

Kim JA, Bartlett S, He L, Nielsen CK, Chang AM, Kharazia V, Waldhoer M, Ou CJ, Taylor S, Ferwerda M, Cado D, Whistler JL.

Curr Biol. 2008 Jan 22;18(2):129-35. doi: 10.1016/j.cub.2007.12.057.


The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence.

Martini L, Whistler JL.

Curr Opin Neurobiol. 2007 Oct;17(5):556-64. Epub 2007 Dec 18. Review.


Changes in G protein-coupled receptor sorting protein affinity regulate postendocytic targeting of G protein-coupled receptors.

Thompson D, Pusch M, Whistler JL.

J Biol Chem. 2007 Oct 5;282(40):29178-85. Epub 2007 Jul 16.


Acute amphetamine exposure selectively desensitizes kappa-opioid receptors in the nucleus accumbens.

Xia YF, He L, Whistler JL, Hjelmstad GO.

Neuropsychopharmacology. 2008 Mar;33(4):892-900. Epub 2007 Jun 6.


Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice.

Lasek AW, Janak PH, He L, Whistler JL, Heberlein U.

Genes Brain Behav. 2007 Nov;6(8):728-35. Epub 2007 Mar 26.


The biochemical analysis of methadone modulation on morphine-induced tolerance and dependence in the rat brain.

He L, Whistler JL.

Pharmacology. 2007;79(4):193-202. Epub 2007 Mar 15.


Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1.

Martini L, Waldhoer M, Pusch M, Kharazia V, Fong J, Lee JH, Freissmuth C, Whistler JL.

FASEB J. 2007 Mar;21(3):802-11. Epub 2006 Dec 28.


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