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Items: 1 to 50 of 224

1.

Parsing the IL-37-Mediated Suppression of Inflammasome Function.

Rudloff I, Ung HK, Dowling JK, Mansell A, D'Andrea L, Ellisdon AM, Whisstock JC, Berger PJ, Nold-Petry CA, Nold MF.

Cells. 2020 Jan 10;9(1). pii: E178. doi: 10.3390/cells9010178.

2.

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.

Pang SS, Bayly-Jones C, Radjainia M, Spicer BA, Law RHP, Hodel AW, Parsons ES, Ekkel SM, Conroy PJ, Ramm G, Venugopal H, Bird PI, Hoogenboom BW, Voskoboinik I, Gambin Y, Sierecki E, Dunstone MA, Whisstock JC.

Nat Commun. 2019 Sep 19;10(1):4288. doi: 10.1038/s41467-019-12279-2.

3.

Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.

Yuan Y, Ayinuola YA, Singh D, Ayinuola O, Mayfield JA, Quek A, Whisstock JC, Law RHP, Lee SW, Ploplis VA, Castellino FJ.

J Struct Biol. 2019 Oct 1;208(1):18-29. doi: 10.1016/j.jsb.2019.07.005. Epub 2019 Jul 10.

PMID:
31301349
4.

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding.

Quek AJH, Mazzitelli BA, Wu G, Leung EWW, Caradoc-Davies TT, Lloyd GJ, Jeevarajah D, Conroy PJ, Sanderson-Smith M, Yuan Y, Ayinuola YA, Castellino FJ, Whisstock JC, Law RHP.

J Mol Biol. 2019 Sep 6;431(19):3804-3813. doi: 10.1016/j.jmb.2019.07.003. Epub 2019 Jul 8.

PMID:
31295457
5.

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy.

Gorelick S, Buckley G, Gervinskas G, Johnson TK, Handley A, Caggiano MP, Whisstock JC, Pocock R, de Marco A.

Elife. 2019 Jul 1;8. pii: e45919. doi: 10.7554/eLife.45919.

6.

Control of growth factor signalling by MACPF proteins.

Bakopoulos D, Whisstock JC, Johnson TK.

Biochem Soc Trans. 2019 Jun 28;47(3):801-810. doi: 10.1042/BST20180179. Epub 2019 Jun 17. Review.

PMID:
31209154
7.

Structural studies of plasmin inhibition.

Wu G, Quek AJ, Caradoc-Davies TT, Ekkel SM, Mazzitelli B, Whisstock JC, Law RHP.

Biochem Soc Trans. 2019 Apr 30;47(2):541-557. doi: 10.1042/BST20180211. Epub 2019 Mar 5. Review.

PMID:
30837322
8.

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.

Wu G, Mazzitelli BA, Quek AJ, Veldman MJ, Conroy PJ, Caradoc-Davies TT, Ooms LM, Tuck KL, Schoenecker JG, Whisstock JC, Law RHP.

Blood Adv. 2019 Mar 12;3(5):729-733. doi: 10.1182/bloodadvances.2018025429. No abstract available.

9.

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.

Swedberg JE, Wu G, Mahatmanto T, Durek T, Caradoc-Davies TT, Whisstock JC, Law RHP, Craik DJ.

J Med Chem. 2019 Jan 24;62(2):552-560. doi: 10.1021/acs.jmedchem.8b01139. Epub 2018 Dec 26.

PMID:
30520638
10.

Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library.

Li CY, de Veer SJ, Law RHP, Whisstock JC, Craik DJ, Swedberg JE.

Chembiochem. 2019 Jan 2;20(1):46-50. doi: 10.1002/cbic.201800395. Epub 2018 Oct 24.

PMID:
30225958
11.

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3.

Traore DAK, Wisniewski JA, Flanigan SF, Conroy PJ, Panjikar S, Mok YF, Lao C, Griffin MDW, Adams V, Rood JI, Whisstock JC.

Nat Commun. 2018 Sep 13;9(1):3732. doi: 10.1038/s41467-018-06096-2.

12.

Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods.

Li F, Wang Y, Li C, Marquez-Lago TT, Leier A, Rawlings ND, Haffari G, Revote J, Akutsu T, Chou KC, Purcell AW, Pike RN, Webb GI, Ian Smith A, Lithgow T, Daly RJ, Whisstock JC, Song J.

Brief Bioinform. 2019 Nov 27;20(6):2150-2166. doi: 10.1093/bib/bby077.

13.

The first transmembrane region of complement component-9 acts as a brake on its self-assembly.

Spicer BA, Law RHP, Caradoc-Davies TT, Ekkel SM, Bayly-Jones C, Pang SS, Conroy PJ, Ramm G, Radjainia M, Venugopal H, Whisstock JC, Dunstone MA.

Nat Commun. 2018 Aug 15;9(1):3266. doi: 10.1038/s41467-018-05717-0.

14.
15.

Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signaling Pathway in Drosophila.

Henstridge MA, Aulsebrook L, Koyama T, Johnson TK, Whisstock JC, Tiganis T, Mirth CK, Warr CG.

Genetics. 2018 Apr;208(4):1523-1533. doi: 10.1534/genetics.117.300601. Epub 2018 Feb 13.

16.

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.

Brennan AJ, Law RHP, Conroy PJ, Noori T, Lukoyanova N, Saibil H, Yagita H, Ciccone A, Verschoor S, Whisstock JC, Trapani JA, Voskoboinik I.

Cell Death Differ. 2018 Aug;25(8):1517-1529. doi: 10.1038/s41418-018-0057-z. Epub 2018 Feb 7.

17.

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy.

Westwood JA, Ellis S, Danne J, Johnson C, Oorschot V, Ramm G, Tscharke DC, Davenport AJ, Whisstock JC, Darcy PK, Kershaw MH, Slaney CY.

Oncotarget. 2017 Dec 14;8(70):115215-115229. doi: 10.18632/oncotarget.23215. eCollection 2017 Dec 29.

18.

Genome-Wide Screen for New Components of the Drosophila melanogaster Torso Receptor Tyrosine Kinase Pathway.

Johns AR, Henstridge MA, Saligari MJ, Moore KA, Whisstock JC, Warr CG, Johnson TK.

G3 (Bethesda). 2018 Mar 2;8(3):761-769. doi: 10.1534/g3.117.300491.

19.

X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.

Law RHP, Wu G, Leung EWW, Hidaka K, Quek AJ, Caradoc-Davies TT, Jeevarajah D, Conroy PJ, Kirby NM, Norton RS, Tsuda Y, Whisstock JC.

Blood Adv. 2017 May 9;1(12):766-771. doi: 10.1182/bloodadvances.2016004150. eCollection 2017 May 9.

20.

The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.

Pang SS, Wijeyewickrema LC, Hor L, Tan S, Lameignere E, Conway EM, Blom AM, Mohlin FC, Liu X, Payne RJ, Whisstock JC, Pike RN.

J Immunol. 2017 Dec 1;199(11):3883-3891. doi: 10.4049/jimmunol.1700158. Epub 2017 Oct 23.

21.

An Essential Role of Maspin in Embryogenesis and Tumor Suppression-Letter.

Whisstock JC, Bird PI.

Cancer Res. 2017 Sep 15;77(18):5207. doi: 10.1158/0008-5472.CAN-17-0178. Epub 2017 Sep 6. No abstract available.

22.

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation.

House IG, House CM, Brennan AJ, Gilan O, Dawson MA, Whisstock JC, Law RH, Trapani JA, Voskoboinik I.

EMBO Rep. 2017 Oct;18(10):1775-1785. doi: 10.15252/embr.201744351. Epub 2017 Aug 14.

23.

Homodimerization attenuates the anti-inflammatory activity of interleukin-37.

Ellisdon AM, Nold-Petry CA, D'Andrea L, Cho SX, Lao JC, Rudloff I, Ngo D, Lo CY, Soares da Costa TP, Perugini MA, Conroy PJ, Whisstock JC, Nold MF.

Sci Immunol. 2017 Feb 10;2(8). pii: eaaj1548. doi: 10.1126/sciimmunol.aaj1548.

PMID:
28783685
24.

Perforin-A key (shaped) weapon in the immunological arsenal.

Spicer BA, Conroy PJ, Law RHP, Voskoboinik I, Whisstock JC.

Semin Cell Dev Biol. 2017 Dec;72:117-123. doi: 10.1016/j.semcdb.2017.07.033. Epub 2017 Jul 27. Review.

PMID:
28757431
25.

Maternal Torso-Like Coordinates Tissue Folding During Drosophila Gastrulation.

Johnson TK, Moore KA, Whisstock JC, Warr CG.

Genetics. 2017 Jul;206(3):1459-1468. doi: 10.1534/genetics.117.200576. Epub 2017 May 11.

26.

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice.

Yang ASP, O'Neill MT, Jennison C, Lopaticki S, Allison CC, Armistead JS, Erickson SM, Rogers KL, Ellisdon AM, Whisstock JC, Tweedell RE, Dinglasan RR, Douglas DN, Kneteman NM, Boddey JA.

Cell Rep. 2017 Mar 28;18(13):3105-3116. doi: 10.1016/j.celrep.2017.03.017.

27.

Real-time visualization of perforin nanopore assembly.

Leung C, Hodel AW, Brennan AJ, Lukoyanova N, Tran S, House CM, Kondos SC, Whisstock JC, Dunstone MA, Trapani JA, Voskoboinik I, Saibil HR, Hoogenboom BW.

Nat Nanotechnol. 2017 May;12(5):467-473. doi: 10.1038/nnano.2016.303. Epub 2017 Feb 6.

PMID:
28166206
28.

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets.

Conroy PJ, Law RH, Caradoc-Davies TT, Whisstock JC.

Methods. 2017 Mar 1;116:12-22. doi: 10.1016/j.ymeth.2017.01.003. Epub 2017 Jan 11. Review.

PMID:
28088364
29.

Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders.

Berkowicz SR, Featherby TJ, Whisstock JC, Bird PI.

Front Behav Neurosci. 2016 Oct 25;10:196. eCollection 2016.

30.

Smoothing a rugged protein folding landscape by sequence-based redesign.

Porebski BT, Keleher S, Hollins JJ, Nickson AA, Marijanovic EM, Borg NA, Costa MG, Pearce MA, Dai W, Zhu L, Irving JA, Hoke DE, Kass I, Whisstock JC, Bottomley SP, Webb GI, McGowan S, Buckle AM.

Sci Rep. 2016 Sep 26;6:33958. doi: 10.1038/srep33958.

31.

Development of the Cellular Immune System of Drosophila Requires the Membrane Attack Complex/Perforin-Like Protein Torso-Like.

Forbes-Beadle L, Crossman T, Johnson TK, Burke R, Warr CG, Whisstock JC.

Genetics. 2016 Oct;204(2):675-681. Epub 2016 Aug 17.

32.

Corrigendum: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin.

Smith AI, Rajapakse NW, Kleifeld O, Lomonte B, Sikanyika NL, Spicer AJ, Hodgson WC, Conroy PJ, Small DH, Kaye DM, Parkington HC, Whisstock JC, Kuruppu S.

Sci Rep. 2016 Apr 22;6:24333. doi: 10.1038/srep24333. No abstract available.

33.

Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density.

Berkowicz SR, Featherby TJ, Qu Z, Giousoh A, Borg NA, Heng JI, Whisstock JC, Bird PI.

Mol Autism. 2016 Mar 31;7:22. doi: 10.1186/s13229-016-0079-7. eCollection 2016.

34.

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin.

Smith AI, Rajapakse NW, Kleifeld O, Lomonte B, Sikanyika NL, Spicer AJ, Hodgson WC, Conroy PJ, Small DH, Kaye DM, Parkington HC, Whisstock JC, Kuruppu S.

Sci Rep. 2016 Mar 2;6:22413. doi: 10.1038/srep22413. Erratum in: Sci Rep. 2016 Apr 22;6:24333.

35.

Structure of the poly-C9 component of the complement membrane attack complex.

Dudkina NV, Spicer BA, Reboul CF, Conroy PJ, Lukoyanova N, Elmlund H, Law RH, Ekkel SM, Kondos SC, Goode RJ, Ramm G, Whisstock JC, Saibil HR, Dunstone MA.

Nat Commun. 2016 Feb 4;7:10588. doi: 10.1038/ncomms10588.

36.

Stonefish toxin defines an ancient branch of the perforin-like superfamily.

Ellisdon AM, Reboul CF, Panjikar S, Huynh K, Oellig CA, Winter KL, Dunstone MA, Hodgson WC, Seymour J, Dearden PK, Tweten RK, Whisstock JC, McGowan S.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15360-5. doi: 10.1073/pnas.1507622112. Epub 2015 Dec 1.

37.

Giant MACPF/CDC pore forming toxins: A class of their own.

Reboul CF, Whisstock JC, Dunstone MA.

Biochim Biophys Acta. 2016 Mar;1858(3):475-86. doi: 10.1016/j.bbamem.2015.11.017. Epub 2015 Nov 26. Review.

38.

TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens.

Wisniewski JA, Traore DA, Bannam TL, Lyras D, Whisstock JC, Rood JI.

Mol Microbiol. 2016 Mar;99(5):884-96. doi: 10.1111/mmi.13270. Epub 2015 Dec 1.

39.

Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding.

Stewart SE, Bird CH, Tabor RF, D'Angelo ME, Piantavigna S, Whisstock JC, Trapani JA, Martin LL, Bird PI.

J Biol Chem. 2015 Dec 25;290(52):31101-12. doi: 10.1074/jbc.M115.683078. Epub 2015 Nov 5.

40.

Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini.

Johnson TK, Henstridge MA, Herr A, Moore KA, Whisstock JC, Warr CG.

Nat Commun. 2015 Oct 28;6:8759. doi: 10.1038/ncomms9759.

41.

Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.

Yagi H, Conroy PJ, Leung EW, Law RH, Trapani JA, Voskoboinik I, Whisstock JC, Norton RS.

J Biol Chem. 2015 Oct 16;290(42):25213-26. doi: 10.1074/jbc.M115.668384. Epub 2015 Aug 25.

42.

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.

Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM.

J Biol Chem. 2015 Aug 21;290(34):20827-40. doi: 10.1074/jbc.M115.660456. Epub 2015 Jun 24.

43.

Preferential Acquisition and Activation of Plasminogen Glycoform II by PAM Positive Group A Streptococcal Isolates.

De Oliveira DM, Law RH, Ly D, Cook SM, Quek AJ, McArthur JD, Whisstock JC, Sanderson-Smith ML.

Biochemistry. 2015 Jun 30;54(25):3960-8. doi: 10.1021/acs.biochem.5b00130. Epub 2015 Jun 18.

PMID:
26029848
44.

Perforin and granzymes: function, dysfunction and human pathology.

Voskoboinik I, Whisstock JC, Trapani JA.

Nat Rev Immunol. 2015 Jun;15(6):388-400. Review.

PMID:
25998963
45.

Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development.

Giousoh A, Vaz R, Bryson-Richardson RJ, Whisstock JC, Verkade H, Bird PI.

Gene Expr Patterns. 2015 May-Jul;18(1-2):37-43. doi: 10.1016/j.gep.2015.05.002. Epub 2015 May 14.

PMID:
25981450
46.

Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase.

Cork AJ, Ericsson DJ, Law RH, Casey LW, Valkov E, Bertozzi C, Stamp A, Jovcevski B, Aquilina JA, Whisstock JC, Walker MJ, Kobe B.

PLoS One. 2015 Mar 25;10(3):e0121764. doi: 10.1371/journal.pone.0121764. eCollection 2015.

47.

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.

Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF.

Nat Immunol. 2015 Apr;16(4):354-65. doi: 10.1038/ni.3103. Epub 2015 Mar 2.

PMID:
25729923
48.

Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA.

PLoS Biol. 2015 Feb 5;13(2):e1002049. doi: 10.1371/journal.pbio.1002049. eCollection 2015 Feb.

49.

GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome.

Li F, Li C, Wang M, Webb GI, Zhang Y, Whisstock JC, Song J.

Bioinformatics. 2015 May 1;31(9):1411-9. doi: 10.1093/bioinformatics/btu852. Epub 2015 Jan 6.

PMID:
25568279
50.

A new model for pore formation by cholesterol-dependent cytolysins.

Reboul CF, Whisstock JC, Dunstone MA.

PLoS Comput Biol. 2014 Aug 21;10(8):e1003791. doi: 10.1371/journal.pcbi.1003791. eCollection 2014 Aug.

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