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Items: 23

1.

CiliaCarta: An integrated and validated compendium of ciliary genes.

van Dam TJP, Kennedy J, van der Lee R, de Vrieze E, Wunderlich KA, Rix S, Dougherty GW, Lambacher NJ, Li C, Jensen VL, Leroux MR, Hjeij R, Horn N, Texier Y, Wissinger Y, van Reeuwijk J, Wheway G, Knapp B, Scheel JF, Franco B, Mans DA, van Wijk E, Képès F, Slaats GG, Toedt G, Kremer H, Omran H, Szymanska K, Koutroumpas K, Ueffing M, Nguyen TT, Letteboer SJF, Oud MM, van Beersum SEC, Schmidts M, Beales PL, Lu Q, Giles RH, Szklarczyk R, Russell RB, Gibson TJ, Johnson CA, Blacque OE, Wolfrum U, Boldt K, Roepman R, Hernandez-Hernandez V, Huynen MA.

PLoS One. 2019 May 16;14(5):e0216705. doi: 10.1371/journal.pone.0216705. eCollection 2019.

2.

661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies.

Wheway G, Nazlamova L, Turner D, Cross S.

Front Genet. 2019 Apr 5;10:308. doi: 10.3389/fgene.2019.00308. eCollection 2019.

3.

A Combined in silico, in vitro and Clinical Approach to Characterize Novel Pathogenic Missense Variants in PRPF31 in Retinitis Pigmentosa.

Wheway G, Nazlamova L, Meshad N, Hunt S, Jackson N, Churchill A.

Front Genet. 2019 Mar 22;10:248. doi: 10.3389/fgene.2019.00248. eCollection 2019.

4.

The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5.

Abdelhamed ZA, Abdelmottaleb DI, El-Asrag ME, Natarajan S, Wheway G, Inglehearn CF, Toomes C, Johnson CA.

Sci Rep. 2019 Apr 1;9(1):5446. doi: 10.1038/s41598-019-41940-5.

5.

Opportunities and Challenges for Molecular Understanding of Ciliopathies-The 100,000 Genomes Project.

Wheway G, Mitchison HM.

Front Genet. 2019 Mar 11;10:127. doi: 10.3389/fgene.2019.00127. eCollection 2019. Review.

6.

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Przyborski S, Zwolinski S, Al-Aama J, Alharthi S, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali RR, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Lührmann R, Grellscheid SN, Johnson CA, Lako M.

Nat Commun. 2018 Oct 12;9(1):4234. doi: 10.1038/s41467-018-06448-y.

7.

Development and biological evaluation of fluorophosphonate-modified hydroxyapatite for orthopaedic applications.

Neary G, Blom AW, Shiel AI, Wheway G, Mansell JP.

J Mater Sci Mater Med. 2018 Jul 21;29(8):122. doi: 10.1007/s10856-018-6130-9.

PMID:
30032456
8.

Signaling through the Primary Cilium.

Wheway G, Nazlamova L, Hancock JT.

Front Cell Dev Biol. 2018 Feb 8;6:8. doi: 10.3389/fcell.2018.00008. eCollection 2018. Review.

9.

Meckel-Gruber Syndrome: An Update on Diagnosis, Clinical Management, and Research Advances.

Hartill V, Szymanska K, Sharif SM, Wheway G, Johnson CA.

Front Pediatr. 2017 Nov 20;5:244. doi: 10.3389/fped.2017.00244. eCollection 2017. Review.

10.

Particle sorting by Paramecium cilia arrays.

Mayne R, Whiting JGH, Wheway G, Melhuish C, Adamatzky A.

Biosystems. 2017 Jun - Jul;156-157:46-52. doi: 10.1016/j.biosystems.2017.04.001. Epub 2017 Apr 12.

PMID:
28410875
11.

Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis.

Slaats GG, Wheway G, Foletto V, Szymanska K, van Balkom BW, Logister I, Den Ouden K, Keijzer-Veen MG, Lilien MR, Knoers NV, Johnson CA, Giles RH.

J Cell Sci. 2015 Dec 15;128(24):4550-9. doi: 10.1242/jcs.176065. Epub 2015 Nov 6.

12.

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.

Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TT, Racher H, Phelps IG, Toedt G, Kennedy J, Wunderlich KA, Sorusch N, Abdelhamed ZA, Natarajan S, Herridge W, van Reeuwijk J, Horn N, Boldt K, Parry DA, Letteboer SJF, Roosing S, Adams M, Bell SM, Bond J, Higgins J, Morrison EE, Tomlinson DC, Slaats GG, van Dam TJP, Huang L, Kessler K, Giessl A, Logan CV, Boyle EA, Shendure J, Anazi S, Aldahmesh M, Al Hazzaa S, Hegele RA, Ober C, Frosk P, Mhanni AA, Chodirker BN, Chudley AE, Lamont R, Bernier FP, Beaulieu CL, Gordon P, Pon RT, Donahue C, Barkovich AJ, Wolf L, Toomes C, Thiel CT, Boycott KM, McKibbin M, Inglehearn CF; UK10K Consortium; University of Washington Center for Mendelian Genomics, Stewart F, Omran H, Huynen MA, Sergouniotis PI, Alkuraya FS, Parboosingh JS, Innes AM, Willoughby CE, Giles RH, Webster AR, Ueffing M, Blacque O, Gleeson JG, Wolfrum U, Beales PL, Gibson T, Doherty D, Mitchison HM, Roepman R, Johnson CA.

Nat Cell Biol. 2015 Aug;17(8):1074-1087. doi: 10.1038/ncb3201. Epub 2015 Jul 13.

13.

The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway.

Abdelhamed ZA, Natarajan S, Wheway G, Inglehearn CF, Toomes C, Johnson CA, Jagger DJ.

Dis Model Mech. 2015 Jun;8(6):527-41. doi: 10.1242/dmm.019083. Epub 2015 Apr 7.

14.

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.

Goggolidou P, Stevens JL, Agueci F, Keynton J, Wheway G, Grimes DT, Patel SH, Hilton H, Morthorst SK, DiPaolo A, Williams DJ, Sanderson J, Khoronenkova SV, Powles-Glover N, Ermakov A, Esapa CT, Romero R, Dianov GL, Briscoe J, Johnson CA, Pedersen LB, Norris DP.

Development. 2014 Oct;141(20):3966-77. doi: 10.1242/dev.107755.

15.

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.

Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R; UK10K Consortium, Duchen MR, Muntoni F, Sheridan E.

Nat Genet. 2014 Feb;46(2):188-93. doi: 10.1038/ng.2851. Epub 2013 Dec 15.

PMID:
24336167
16.

The role of primary cilia in the development and disease of the retina.

Wheway G, Parry DA, Johnson CA.

Organogenesis. 2014 Jan 1;10(1):69-85. doi: 10.4161/org.26710. Epub 2013 Oct 25. Review.

17.

The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium.

van Dam TJ, Wheway G, Slaats GG; SYSCILIA Study Group, Huynen MA, Giles RH.

Cilia. 2013 May 31;2(1):7. doi: 10.1186/2046-2530-2-7.

18.

Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndrome.

Wheway G, Abdelhamed Z, Natarajan S, Toomes C, Inglehearn C, Johnson CA.

Dev Biol. 2013 May 1;377(1):55-66. doi: 10.1016/j.ydbio.2013.02.015. Epub 2013 Feb 27.

19.

Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel-Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects.

Abdelhamed ZA, Wheway G, Szymanska K, Natarajan S, Toomes C, Inglehearn C, Johnson CA.

Hum Mol Genet. 2013 Apr 1;22(7):1358-72. doi: 10.1093/hmg/dds546. Epub 2013 Jan 2.

20.

Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies.

Elmehdawi F, Wheway G, Szymanska K, Adams M, High AS, Johnson CA, Robinson PA.

Exp Cell Res. 2013 Feb 1;319(3):161-72. doi: 10.1016/j.yexcr.2012.10.002. Epub 2012 Oct 8.

PMID:
23059369
21.

A meckelin-filamin A interaction mediates ciliogenesis.

Adams M, Simms RJ, Abdelhamed Z, Dawe HR, Szymanska K, Logan CV, Wheway G, Pitt E, Gull K, Knowles MA, Blair E, Cross SH, Sayer JA, Johnson CA.

Hum Mol Genet. 2012 Mar 15;21(6):1272-86. doi: 10.1093/hmg/ddr557. Epub 2011 Nov 25.

22.

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.

Dawe HR, Adams M, Wheway G, Szymanska K, Logan CV, Noegel AA, Gull K, Johnson CA.

J Cell Sci. 2009 Aug 1;122(Pt 15):2716-26. doi: 10.1242/jcs.043794. Epub 2009 Jul 13.

23.

Reach distances between two horizontal photoelectric beams.

Lee JF, Wheway G.

Ergonomics. 1986 Jan;29(1):87-97. No abstract available.

PMID:
3948847

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