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Oncogenic MYC amplifies mitotic perturbations.

Littler S, Sloss O, Geary B, Pierce A, Whetton AD, Taylor SS.

Open Biol. 2019 Aug 30;9(8):190136. doi: 10.1098/rsob.190136. Epub 2019 Aug 28.


Identification of a Biomarker Panel for Early Detection of Lung Cancer Patients.

Geary B, Walker MJ, Snow JT, Lee DCH, Pernemalm M, Maleki-Dizaji S, Azadbakht N, Apostolidou S, Barnes J, Krysiak P, Shah R, Booton R, Dive C, Crosbie PA, Whetton AD.

J Proteome Res. 2019 Sep 6;18(9):3369-3382. doi: 10.1021/acs.jproteome.9b00287. Epub 2019 Aug 21.


Diagnosis of epithelial ovarian cancer using a combined protein biomarker panel.

Russell MR, Graham C, D'Amato A, Gentry-Maharaj A, Ryan A, Kalsi JK, Whetton AD, Menon U, Jacobs I, Graham RLJ.

Br J Cancer. 2019 Sep;121(6):483-489. doi: 10.1038/s41416-019-0544-0. Epub 2019 Aug 7.


PTMProphet: Fast and Accurate Mass Modification Localization for the Trans-Proteomic Pipeline.

Shteynberg DD, Deutsch EW, Campbell DS, Hoopmann MR, Kusebauch U, Lee D, Mendoza L, Midha MK, Sun Z, Whetton AD, Moritz RL.

J Proteome Res. 2019 Jul 22. doi: 10.1021/acs.jproteome.9b00205. [Epub ahead of print]


Data Independent Acquisition Mass Spectrometry Can Identify Circulating Proteins That Predict Future Weight Loss with a Diet and Exercise Programme.

Malipatil N, Fachim HA, Siddals K, Geary B, Wark G, Porter N, Anderson S, Donn R, Harvie M, Whetton AD, Gibson MJ, Heald A.

J Clin Med. 2019 Jan 25;8(2). pii: E141. doi: 10.3390/jcm8020141.


Erratum: EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association.

Paredes R, Schneider M, Stevens A, White DJ, K Williamson AJ, Muter J, Pearson S, Kelly JR, Connors K, Wiseman DH, Chadwick JA, Löffler H, Teng HY, Lovell S, Unwin R, van de Vrugt HJ, Smith H, Kustikova O, Schambach A, P Somervaille TC, Pierce A, Whetton AD, Meyer S.

Nucleic Acids Res. 2018 Sep 19;46(16):8663. doi: 10.1093/nar/gky711. No abstract available.


EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association.

Paredes R, Schneider M, Stevens A, White DJ, Williamson AJK, Muter J, Pearson S, Kelly JR, Connors K, Wiseman DH, Chadwick JA, Löffler H, Teng HY, Lovell S, Unwin R, van de Vrugt HJ, Smith H, Kustikova O, Schambach A, Somervaille TCP, Pierce A, Whetton AD, Meyer S.

Nucleic Acids Res. 2018 Sep 6;46(15):7662-7674. doi: 10.1093/nar/gky536. Erratum in: Nucleic Acids Res. 2018 Sep 19;46(16):8663.


Candidate plasma biomarkers for predicting ascending aortic aneurysm in bicuspid aortic valve disease.

Harrison OJ, Cagampang F, Ohri SK, Torrens C, Salhiyyah K, Modi A, Moorjani N, Whetton AD, Townsend PA.

J Cardiothorac Surg. 2018 Jun 22;13(1):76. doi: 10.1186/s13019-018-0762-1.


hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival.

Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A, Abraham SA, Hair A, Helgason GV, Aspinall-O'Dea M, Bhatia R, Leone G, Kranc KR, Whetton AD, Holyoake TL.

Blood. 2018 Apr 5;131(14):1532-1544. doi: 10.1182/blood-2017-05-783845. Epub 2018 Feb 5.


Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches.

Pearson S, Williamson AJK, Blance R, Somervaille TCP, Taylor S, Azadbakht N, Whetton AD, Pierce A.

Leukemia. 2018 Feb;32(2):574. doi: 10.1038/leu.2017.333. Epub 2017 Dec 19.


A combined biomarker panel shows improved sensitivity for the early detection of ovarian cancer allowing the identification of the most aggressive type II tumours.

Russell MR, Graham C, D'Amato A, Gentry-Maharaj A, Ryan A, Kalsi JK, Ainley C, Whetton AD, Menon U, Jacobs I, Graham RLJ.

Br J Cancer. 2017 Aug 22;117(5):666-674. doi: 10.1038/bjc.2017.199. Epub 2017 Jun 29.


Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption.

Meyer S, Stevens A, Paredes R, Schneider M, Walker MJ, Williamson AJK, Gonzalez-Sanchez MB, Smetsers S, Dalal V, Teng HY, White DJ, Taylor S, Muter J, Pierce A, de Leonibus C, Rockx DAP, Rooimans MA, Spooncer E, Stauffer S, Biswas K, Godthelp B, Dorsman J, Clayton PE, Sharan SK, Whetton AD.

Cell Death Dis. 2017 Jun 15;8(6):e2875. doi: 10.1038/cddis.2017.264.


Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches.

Pearson S, Williamson AJK, Blance R, Somervaille TCP, Taylor S, Azadbakht N, Whetton AD, Pierce A.

Leukemia. 2017 Dec;31(12):2717-2725. doi: 10.1038/leu.2017.143. Epub 2017 May 23. Erratum in: Leukemia. 2017 Dec 19;:.


Novel risk models for early detection and screening of ovarian cancer.

Russell MR, D'Amato A, Graham C, Crosbie EJ, Gentry-Maharaj A, Ryan A, Kalsi JK, Fourkala EO, Dive C, Walker M, Whetton AD, Menon U, Jacobs I, Graham RL.

Oncotarget. 2017 Jan 3;8(1):785-797. doi: 10.18632/oncotarget.13648.


Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.

Dutta A, Potier DN, Walker MJ, Gray OJ, Parker C, Holland M, Williamson AJ, Pierce A, Unwin RD, Krishnan S, Saha V, Whetton AD.

Oncotarget. 2016 Oct 25;7(43):70822-70831. doi: 10.18632/oncotarget.12224.


Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells.

Abraham SA, Hopcroft LE, Carrick E, Drotar ME, Dunn K, Williamson AJ, Korfi K, Baquero P, Park LE, Scott MT, Pellicano F, Pierce A, Copland M, Nourse C, Grimmond SM, Vetrie D, Whetton AD, Holyoake TL.

Nature. 2016 Jun 16;534(7607):341-6. doi: 10.1038/nature18288. Epub 2016 Jun 8.


Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production.

Morgan DJ, Poolman TM, Williamson AJ, Wang Z, Clark NR, Ma'ayan A, Whetton AD, Brass A, Matthews LC, Ray DW.

Sci Rep. 2016 May 26;6:26419. doi: 10.1038/srep26419.


MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5.

Whetton AD, Azmi NC, Pearson S, Jaworska E, Zhang L, Blance R, Kendall AC, Nicolaou A, Taylor S, Williamson AJ, Pierce A.

Oncotarget. 2016 Mar 8;7(10):10739-55. doi: 10.18632/oncotarget.7639.


ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing.

Crosbie PA, Crosbie EJ, Aspinall-O'Dea M, Walker M, Harrison R, Pernemalm M, Shah R, Joseph L, Booton R, Pierce A, Whetton AD.

BMJ Open Respir Res. 2016 Feb 17;3(1):e000114. doi: 10.1136/bmjresp-2015-000114. eCollection 2016.


Protein Z: A putative novel biomarker for early detection of ovarian cancer.

Russell MR, Walker MJ, Williamson AJ, Gentry-Maharaj A, Ryan A, Kalsi J, Skates S, D'Amato A, Dive C, Pernemalm M, Humphryes PC, Fourkala EO, Whetton AD, Menon U, Jacobs I, Graham RL.

Int J Cancer. 2016 Jun 15;138(12):2984-92. doi: 10.1002/ijc.30020. Epub 2016 Feb 19.


Discovery and Validation of Predictive Biomarkers of Survival for Non-small Cell Lung Cancer Patients Undergoing Radical Radiotherapy: Two Proteins With Predictive Value.

Walker MJ, Zhou C, Backen A, Pernemalm M, Williamson AJ, Priest LJ, Koh P, Faivre-Finn C, Blackhall FH, Dive C, Whetton AD.

EBioMedicine. 2015 Jun 19;2(8):841-50. doi: 10.1016/j.ebiom.2015.06.013. eCollection 2015 Aug.


Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition.

Nicholson L, Evans CA, Matheson E, Minto L, Keilty C, Sanichar M, Case M, Schwab C, Williamson D, Rainer J, Harrison CJ, Kofler R, Hall AG, Redfern CP, Whetton AD, Irving JA.

Br J Haematol. 2015 Nov;171(4):595-605. doi: 10.1111/bjh.13647. Epub 2015 Aug 27.


Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood.

Piazzi M, Williamson A, Lee CF, Pearson S, Lacaud G, Kouskoff V, McCubrey JA, Cocco L, Whetton AD.

Oncotarget. 2015 May 10;6(13):10924-39.


Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.

Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJ, Whetton AD, Taylor SS, Tuckermann JP, White MR, Ray DW.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5479-84. doi: 10.1073/pnas.1411356112. Epub 2015 Apr 6.


Molecular histology of lung cancer: from targets to treatments.

Wood SL, Pernemalm M, Crosbie PA, Whetton AD.

Cancer Treat Rev. 2015 Apr;41(4):361-75. doi: 10.1016/j.ctrv.2015.02.008. Epub 2015 Feb 20. Review.


Comparative quantification of the surfaceome of human multipotent mesenchymal progenitor cells.

Holley RJ, Tai G, Williamson AJ, Taylor S, Cain SA, Richardson SM, Merry CL, Whetton AD, Kielty CM, Canfield AE.

Stem Cell Reports. 2015 Mar 10;4(3):473-88. doi: 10.1016/j.stemcr.2015.01.007. Epub 2015 Feb 13.


Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines.

Aspinall-O'Dea M, Pierce A, Pellicano F, Williamson AJ, Scott MT, Walker MJ, Holyoake TL, Whetton AD.

Nat Protoc. 2015 Jan;10(1):149-68. doi: 10.1038/nprot.2015.007. Epub 2014 Dec 18.


THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).

Tran DD, Saran S, Williamson AJ, Pierce A, Dittrich-Breiholz O, Wiehlmann L, Koch A, Whetton AD, Tamura T.

Nucleic Acids Res. 2014 Oct 29;42(19):12249-60. doi: 10.1093/nar/gku911. Epub 2014 Oct 1.


JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.

Gallipoli P, Cook A, Rhodes S, Hopcroft L, Wheadon H, Whetton AD, Jørgensen HG, Bhatia R, Holyoake TL.

Blood. 2014 Aug 28;124(9):1492-501. doi: 10.1182/blood-2013-12-545640. Epub 2014 Jun 23.


BCR-ABL affects STAT5A and STAT5B differentially.

Schaller-Schönitz M, Barzan D, Williamson AJ, Griffiths JR, Dallmann I, Battmer K, Ganser A, Whetton AD, Scherr M, Eder M.

PLoS One. 2014 May 16;9(5):e97243. doi: 10.1371/journal.pone.0097243. eCollection 2014.


The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors.

Pellicano F, Scott MT, Helgason GV, Hopcroft LE, Allan EK, Aspinall-O'Dea M, Copland M, Pierce A, Huntly BJ, Whetton AD, Holyoake TL.

Stem Cells. 2014 Sep;32(9):2324-37. doi: 10.1002/stem.1748.


Monocyte-derived dendritic cells from chronic myeloid leukaemia have abnormal maturation and cytoskeletal function that is associated with defective localisation and signalling by normal ABL1 protein.

Brown S, Hutchinson CV, Aspinall-O'Dea M, Whetton AD, Johnson SM, Rees-Unwin K, Burthem J.

Eur J Haematol. 2014 Aug;93(2):96-102. doi: 10.1111/ejh.12306. Epub 2014 Apr 10.


The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer.

Jangani M, Poolman TM, Matthews L, Yang N, Farrow SN, Berry A, Hanley N, Williamson AJ, Whetton AD, Donn R, Ray DW.

J Biol Chem. 2014 Mar 28;289(13):8931-46. doi: 10.1074/jbc.M113.540906. Epub 2014 Jan 31.


A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data.

Zhou C, Walker MJ, Williamson AJ, Pierce A, Berzuini C, Dive C, Whetton AD.

Bioinformatics. 2014 Feb 15;30(4):549-58. doi: 10.1093/bioinformatics/btt722. Epub 2013 Dec 15.


The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets.

Wood SL, Pernemalm M, Crosbie PA, Whetton AD.

Cancer Treat Rev. 2014 May;40(4):558-66. doi: 10.1016/j.ctrv.2013.10.001. Epub 2013 Oct 15. Review.


Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation.

Tran DD, Saran S, Dittrich-Breiholz O, Williamson AJ, Klebba-Färber S, Koch A, Kracht M, Whetton AD, Tamura T.

Cell Death Dis. 2013 Oct 24;4:e879. doi: 10.1038/cddis.2013.409.


A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.

Williamson AJ, Pierce A, Jaworska E, Zhou C, Aspinall-O'Dea M, Lancashire L, Unwin RD, Abraham SA, Walker MJ, Cadecco S, Spooncer E, Holyoake TL, Whetton AD.

Mol Cell Proteomics. 2013 Nov;12(11):3319-29. doi: 10.1074/mcp.M112.024604. Epub 2013 Sep 1.


Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis.

Takeda T, Robinson IM, Savoian MM, Griffiths JR, Whetton AD, McMahon HT, Glover DM.

Open Biol. 2013 Aug 7;3(8):130081. doi: 10.1098/rsob.130081.


A label-free selected reaction monitoring workflow identifies a subset of pregnancy specific glycoproteins as potential predictive markers of early-onset pre-eclampsia.

Blankley RT, Fisher C, Westwood M, North R, Baker PN, Walker MJ, Williamson A, Whetton AD, Lin W, McCowan L, Roberts CT, Cooper GJ, Unwin RD, Myers JE.

Mol Cell Proteomics. 2013 Nov;12(11):3148-59. doi: 10.1074/mcp.M112.026872. Epub 2013 Jul 29.


Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.

White DJ, Unwin RD, Bindels E, Pierce A, Teng HY, Muter J, Greystoke B, Somerville TD, Griffiths J, Lovell S, Somervaille TC, Delwel R, Whetton AD, Meyer S.

PLoS One. 2013 Jun 12;8(6):e66510. doi: 10.1371/journal.pone.0066510. Print 2013.


A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers.

Simpson KL, Cawthorne C, Zhou C, Hodgkinson CL, Walker MJ, Trapani F, Kadirvel M, Brown G, Dawson MJ, MacFarlane M, Williams KJ, Whetton AD, Dive C.

Cell Death Dis. 2013 May 2;4:e613. doi: 10.1038/cddis.2013.137.


Transglutaminase 2 expression in acute myeloid leukemia: association with adhesion molecule expression and leukemic blast motility.

Pierce A, Whetton AD, Meyer S, Ravandi-Kashani F, Borthakur G, Coombes KR, Zhang N, Kornblau S.

Proteomics. 2013 Jul;13(14):2216-2224. doi: 10.1002/pmic.201200471. Epub 2013 Jun 6.


Application of the MIDAS approach for analysis of lysine acetylation sites.

Evans CA, Griffiths JR, Unwin RD, Whetton AD, Corfe BM.

Methods Mol Biol. 2013;981:25-36. doi: 10.1007/978-1-62703-305-3_3.


Quantitative proteomics analysis of BMS-214662 effects on CD34 positive cells from chronic myeloid leukaemia patients.

Balabanov S, Evans CA, Abraham SA, Pellicano F, Copland M, Walker MJ, Whetton AD, Holyoake TL.

Proteomics. 2013 Jan;13(1):153-68. doi: 10.1002/pmic.201200022.


Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion.

Vaughan AA, Dunn WB, Allwood JW, Wedge DC, Blackhall FH, Whetton AD, Dive C, Goodacre R.

Anal Chem. 2012 Nov 20;84(22):9848-57. doi: 10.1021/ac302227c. Epub 2012 Oct 29.


A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.

Griaud F, Pierce A, Gonzalez Sanchez MB, Scott M, Abraham SA, Holyoake TL, Tran DD, Tamura T, Whetton AD.

Leukemia. 2013 Apr;27(4):932-40. doi: 10.1038/leu.2012.283. Epub 2012 Oct 3.


Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.

Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR.

Cell Stem Cell. 2012 Aug 3;11(2):179-94. doi: 10.1016/j.stem.2012.05.020.


The application of quantification techniques in proteomics for biomedical research.

Rodríguez-Suárez E, Whetton AD.

Mass Spectrom Rev. 2013 Jan-Feb;32(1):1-26. doi: 10.1002/mas.21347. Epub 2012 Jul 30. Review.


Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma.

Smetsers S, Muter J, Bristow C, Patel L, Chandler K, Bonney D, Wynn RF, Whetton AD, Will AM, Rockx D, Joenje H, Strathdee G, Shanks J, Klopocki E, Gille JJ, Dorsman J, Meyer S.

Fam Cancer. 2012 Dec;11(4):661-5. doi: 10.1007/s10689-012-9553-3.


An assessment of peptide enrichment methods employing mTRAQ quantification approaches.

Potier DN, Griffiths JR, Unwin RD, Walker MJ, Carrick E, Willamson AJ, Whetton AD.

Anal Chem. 2012 Jul 3;84(13):5604-10. doi: 10.1021/ac300584y. Epub 2012 Jun 19.


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