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Items: 36

1.

Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.

Vi L, Baht GS, Soderblom EJ, Whetstone H, Wei Q, Furman B, Puviindran V, Nadesan P, Foster M, Poon R, White JP, Yahara Y, Ng A, Barrientos T, Grynpas M, Mosely MA, Alman BA.

Nat Commun. 2018 Dec 5;9(1):5191. doi: 10.1038/s41467-018-07666-0.

2.

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression.

Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan JJ, Yin WC, Min HK, Hu M, Draghici D, Dou W, Li F, Coutinho FJ, Whetstone H, Kushida MM, Dirks PB, Song Y, Hui CC, Sun Y, Wang LY, Li X, Huang X.

Neuron. 2018 Nov 21;100(4):799-815.e7. doi: 10.1016/j.neuron.2018.09.046. Epub 2018 Oct 18.

PMID:
30344046
3.

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.

Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O'Connor M, Lan X, Whetstone H, Coutinho FJ, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai H, Atwal G, Kushida M, Clarke ID, Voisin V, Cusimano MD, Bernstein M, Das S, Bader G, Arrowsmith CH, Angers S, Huang X, Lupien M, Dirks PB.

Cell Stem Cell. 2017 Sep 7;21(3):411. doi: 10.1016/j.stem.2017.08.008. No abstract available.

4.

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.

Lan X, Jörg DJ, Cavalli FMG, Richards LM, Nguyen LV, Vanner RJ, Guilhamon P, Lee L, Kushida MM, Pellacani D, Park NI, Coutinho FJ, Whetstone H, Selvadurai HJ, Che C, Luu B, Carles A, Moksa M, Rastegar N, Head R, Dolma S, Prinos P, Cusimano MD, Das S, Bernstein M, Arrowsmith CH, Mungall AJ, Moore RA, Ma Y, Gallo M, Lupien M, Pugh TJ, Taylor MD, Hirst M, Eaves CJ, Simons BD, Dirks PB.

Nature. 2017 Sep 14;549(7671):227-232. doi: 10.1038/nature23666. Epub 2017 Aug 30.

5.

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.

Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O'Connor M, Lan X, Whetstone H, Coutinho FJ, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai H, Atwal G, Kushida M, Clarke ID, Voisin V, Cusimano MD, Bernstein M, Das S, Bader G, Arrowsmith CH, Angers S, Huang X, Lupien M, Dirks PB.

Cell Stem Cell. 2017 Aug 3;21(2):209-224.e7. doi: 10.1016/j.stem.2017.06.004. Epub 2017 Jul 14. Erratum in: Cell Stem Cell. 2017 Sep 7;21(3):411.

6.

Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.

Sato S, Tang YJ, Wei Q, Hirata M, Weng A, Han I, Okawa A, Takeda S, Whetstone H, Nadesan P, Kirsch DG, Wunder JS, Alman BA.

Cell Rep. 2016 Jul 26;16(4):917-927. doi: 10.1016/j.celrep.2016.06.058. Epub 2016 Jul 14.

7.

β-Catenin modulation in neurofibromatosis type 1 bone repair: therapeutic implications.

Ghadakzadeh S, Kannu P, Whetstone H, Howard A, Alman BA.

FASEB J. 2016 Sep;30(9):3227-37. doi: 10.1096/fj.201500190RR. Epub 2016 Jun 15.

PMID:
27306335
8.

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.

Dolma S, Selvadurai HJ, Lan X, Lee L, Kushida M, Voisin V, Whetstone H, So M, Aviv T, Park N, Zhu X, Xu C, Head R, Rowland KJ, Bernstein M, Clarke ID, Bader G, Harrington L, Brumell JH, Tyers M, Dirks PB.

Cancer Cell. 2016 Jun 13;29(6):859-873. doi: 10.1016/j.ccell.2016.05.002.

9.

Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis.

Rockel JS, Yu C, Whetstone H, Craft AM, Reilly K, Ma H, Tsushima H, Puviindran V, Al-Jazrawe M, Keller GM, Alman BA.

J Clin Invest. 2016 May 2;126(5):1649-63. doi: 10.1172/JCI80205. Epub 2016 Mar 28.

10.

Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia.

Gray MJ, Kannu P, Sharma S, Neyt C, Zhang D, Paria N, Daniel PB, Whetstone H, Sprenger HG, Hammerschmidt P, Weng A, Dupuis L, Jobling R, Mendoza-Londono R, Dray M, Su P, Wilson MJ, Kapur RP, McCarthy EF, Alman BA, Howard A, Somers GR, Marshall CR, Manners S, Flanagan AM, Rathjen KE, Karol LA, Crawford H, Markie DM, Rios JJ, Wise CA, Robertson SP.

Am J Hum Genet. 2015 Dec 3;97(6):837-47. doi: 10.1016/j.ajhg.2015.11.001.

11.

Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma.

Wei Q, Tang YJ, Voisin V, Sato S, Hirata M, Whetstone H, Han I, Ailles L, Bader GD, Wunder J, Alman BA.

Oncotarget. 2015 Nov 24;6(37):40283-94. doi: 10.18632/oncotarget.5375.

12.

Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage.

Ali SA, Al-Jazrawe M, Ma H, Whetstone H, Poon R, Farr S, Naples M, Adeli K, Alman BA.

Arthritis Rheumatol. 2016 Jan;68(1):127-37. doi: 10.1002/art.39337.

13.

Erratum: Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin.

Baht GS, Silkstone D, Vi L, Nadesan P, Amani Y, Whetstone H, Wei Q, Alman BA.

Nat Commun. 2015 Aug 26;6:7761. doi: 10.1038/ncomms8761. No abstract available.

14.

Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin.

Baht GS, Silkstone D, Vi L, Nadesan P, Amani Y, Whetstone H, Wei Q, Alman BA.

Nat Commun. 2015 May 19;6:7131. doi: 10.1038/ncomms8131. Erratum in: Nat Commun. 2015;6:7761.

15.

Mutant IDH is sufficient to initiate enchondromatosis in mice.

Hirata M, Sasaki M, Cairns RA, Inoue S, Puviindran V, Li WY, Snow BE, Jones LD, Wei Q, Sato S, Tang YJ, Nadesan P, Rockel J, Whetstone H, Poon R, Weng A, Gross S, Straley K, Gliser C, Xu Y, Wunder J, Mak TW, Alman BA.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2829-34. doi: 10.1073/pnas.1424400112. Epub 2015 Feb 17.

16.

Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis.

Vi L, Baht GS, Whetstone H, Ng A, Wei Q, Poon R, Mylvaganam S, Grynpas M, Alman BA.

J Bone Miner Res. 2015 Jun;30(6):1090-102. doi: 10.1002/jbmr.2422.

17.

β-Catenin-regulated myeloid cell adhesion and migration determine wound healing.

Amini-Nik S, Cambridge E, Yu W, Guo A, Whetstone H, Nadesan P, Poon R, Hinz B, Alman BA.

J Clin Invest. 2014 Jun;124(6):2599-610. doi: 10.1172/JCI62059. Epub 2014 May 16.

18.

Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.

Campbell VT, Nadesan P, Ali SA, Wang CY, Whetstone H, Poon R, Wei Q, Keilty J, Proctor J, Wang LW, Apte SS, McGovern K, Alman BA, Wunder JS.

Mol Cancer Ther. 2014 May;13(5):1259-69. doi: 10.1158/1535-7163.MCT-13-0731. Epub 2014 Mar 14.

19.

Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation.

Baht GS, Silkstone D, Nadesan P, Whetstone H, Alman BA.

J Orthop Res. 2014 Apr;32(4):581-6. doi: 10.1002/jor.22562. Epub 2013 Dec 17.

20.

T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair.

Nam D, Mau E, Wang Y, Wright D, Silkstone D, Whetstone H, Whyne C, Alman B.

PLoS One. 2012;7(6):e40044. doi: 10.1371/journal.pone.0040044. Epub 2012 Jun 29.

21.

Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas.

Wang CY, Wei Q, Han I, Sato S, Ghanbari-Azarnier R, Whetstone H, Poon R, Hu J, Zheng F, Zhang P, Wang W, Wunder JS, Alman BA.

Cancer Res. 2012 Feb 15;72(4):1013-22. doi: 10.1158/0008-5472.CAN-11-2531. Epub 2012 Jan 9.

22.

Pax7 expressing cells contribute to dermal wound repair, regulating scar size through a β-catenin mediated process.

Amini-Nik S, Glancy D, Boimer C, Whetstone H, Keller C, Alman BA.

Stem Cells. 2011 Sep;29(9):1371-9. doi: 10.1002/stem.688.

23.

Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing.

Bielefeld KA, Amini-Nik S, Whetstone H, Poon R, Youn A, Wang J, Alman BA.

J Biol Chem. 2011 Aug 5;286(31):27687-97. doi: 10.1074/jbc.M111.261677. Epub 2011 Jun 7.

24.

Modulating hedgehog signaling can attenuate the severity of osteoarthritis.

Lin AC, Seeto BL, Bartoszko JM, Khoury MA, Whetstone H, Ho L, Hsu C, Ali SA, Alman BA.

Nat Med. 2009 Dec;15(12):1421-5. doi: 10.1038/nm.2055. Epub 2009 Nov 15. Erratum in: Nat Med. 2010 Jan;16(1):129. Ali, Amanda S [corrected to Ali, S Amanda].

PMID:
19915594
25.

Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.

Ho L, Stojanovski A, Whetstone H, Wei QX, Mau E, Wunder JS, Alman B.

Cancer Cell. 2009 Aug 4;16(2):126-36. doi: 10.1016/j.ccr.2009.05.013.

26.

Side population cells isolated from mesenchymal neoplasms have tumor initiating potential.

Wu C, Wei Q, Utomo V, Nadesan P, Whetstone H, Kandel R, Wunder JS, Alman BA.

Cancer Res. 2007 Sep 1;67(17):8216-22.

27.

Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing.

Chen Y, Whetstone HC, Lin AC, Nadesan P, Wei Q, Poon R, Alman BA.

PLoS Med. 2007 Jul 31;4(7):e249.

28.
29.

Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation.

Chen Y, Whetstone HC, Youn A, Nadesan P, Chow EC, Lin AC, Alman BA.

J Biol Chem. 2007 Jan 5;282(1):526-33. Epub 2006 Nov 3.

30.

Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing.

Cheon SS, Wei Q, Gurung A, Youn A, Bright T, Poon R, Whetstone H, Guha A, Alman BA.

FASEB J. 2006 Apr;20(6):692-701.

PMID:
16581977
31.

3'Sulfogalactolipid binding specifically inhibits Hsp70 ATPase activity in vitro.

Whetstone H, Lingwood C.

Biochemistry. 2003 Feb 18;42(6):1611-7.

PMID:
12578374
32.

Hsp70s contain a specific sulfogalactolipid binding site. Differential aglycone influence on sulfogalactosyl ceramide binding by recombinant prokaryotic and eukaryotic hsp70 family members.

Mamelak D, Mylvaganam M, Whetstone H, Hartmann E, Lennarz W, Wyrick PB, Raulston J, Han H, Hoffman P, Lingwood CA.

Biochemistry. 2001 Mar 27;40(12):3572-82.

PMID:
11297423
33.

Abomasal pH, nutrient digestibility, and growth of Holstein bull calves fed acidified milk replacer.

Woodford ST, Whetstone HD, Murphy MR, Davis CL.

J Dairy Sci. 1987 Apr;70(4):888-91.

34.

Identification and characterization of a fatty acid binding protein in bovine mammary gland.

Whetstone HD, Hurley WL, Davis CL.

Comp Biochem Physiol B. 1986;85(3):687-92.

PMID:
3791968
35.
36.

Effect of monensin on breakdown of protein by ruminal microorganisms in vitro.

Whetstone HD, Davis CL, Bryant MP.

J Anim Sci. 1981 Sep;53(3):803-9.

PMID:
7319956

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