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Items: 46

1.

PRC2 Plays Red Light, Green Light with MHC-I and CD8+ T Cells.

Whetstine JR.

Cancer Cell. 2019 Oct 14;36(4):343-345. doi: 10.1016/j.ccell.2019.09.010.

PMID:
31614112
2.

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.

Etchegaray JP, Zhong L, Li C, Henriques T, Ablondi E, Nakadai T, Van Rechem C, Ferrer C, Ross KN, Choi JE, Samarakkody A, Ji F, Chang A, Sadreyev RI, Ramaswamy S, Nechaev S, Whetstine JR, Roeder RG, Adelman K, Goren A, Mostoslavsky R.

Mol Cell. 2019 Aug 22;75(4):683-699.e7. doi: 10.1016/j.molcel.2019.06.034. Epub 2019 Aug 6.

PMID:
31399344
3.

Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications.

Mishra S, Van Rechem C, Pal S, Clarke TL, Chakraborty D, Mahan SD, Black JC, Murphy SE, Lawrence MS, Daniels DL, Whetstine JR.

Cell. 2018 Nov 29;175(6):1716. doi: 10.1016/j.cell.2018.11.018. No abstract available.

4.

Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications.

Mishra S, Van Rechem C, Pal S, Clarke TL, Chakraborty D, Mahan SD, Black JC, Murphy SE, Lawrence MS, Daniels DL, Whetstine JR.

Cell. 2018 Aug 9;174(4):803-817.e16. doi: 10.1016/j.cell.2018.06.018. Epub 2018 Jul 26. Erratum in: Cell. 2018 Nov 29;175(6):1716.

5.

E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression.

Guarner A, Morris R, Korenjak M, Boukhali M, Zappia MP, Van Rechem C, Whetstine JR, Ramaswamy S, Zou L, Frolov MV, Haas W, Dyson NJ.

Dev Cell. 2017 Dec 18;43(6):689-703.e5. doi: 10.1016/j.devcel.2017.11.008. Epub 2017 Dec 7.

6.

Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway.

Wang M, Han J, Marcar L, Black J, Liu Q, Li X, Nagulapalli K, Sequist LV, Mak RH, Benes CH, Hong TS, Gurtner K, Krause M, Baumann M, Kang JX, Whetstine JR, Willers H.

Cancer Res. 2017 Apr 15;77(8):2018-2028. doi: 10.1158/0008-5472.CAN-16-0808. Epub 2017 Feb 15.

7.

Regulation of Transient Site-specific Copy Gain by MicroRNA.

Black JC, Zhang H, Kim J, Getz G, Whetstine JR.

J Biol Chem. 2016 Mar 4;291(10):4862-71. doi: 10.1074/jbc.M115.711648. Epub 2016 Jan 11.

8.

Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive.

Mishra S, Whetstine JR.

Mol Cell Biol. 2016 Jan 11;36(7):1050-63. doi: 10.1128/MCB.00652-15. Review.

9.

RNF2 E3 or Not to E3: Dual Roles of RNF2 Overexpression in Melanoma.

Black JC, Whetstine JR.

Cancer Discov. 2015 Dec;5(12):1241-3. doi: 10.1158/2159-8290.CD-15-1285.

10.

SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes.

Tajima K, Yae T, Javaid S, Tam O, Comaills V, Morris R, Wittner BS, Liu M, Engstrom A, Takahashi F, Black JC, Ramaswamy S, Shioda T, Hammell M, Haber DA, Whetstine JR, Maheswaran S.

Nat Commun. 2015 Sep 23;6:8257. doi: 10.1038/ncomms9257.

11.

Too little O2 Too much gain.

Black JC, Whetstine JR.

Cell Cycle. 2015;14(18):2869-70. doi: 10.1080/15384101.2015.1076659. Epub 2015 Jul 29. No abstract available.

12.

Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.

Black JC, Atabakhsh E, Kim J, Biette KM, Van Rechem C, Ladd B, Burrowes PD, Donado C, Mattoo H, Kleinstiver BP, Song B, Andriani G, Joung JK, Iliopoulos O, Montagna C, Pillai S, Getz G, Whetstine JR.

Genes Dev. 2015 May 15;29(10):1018-31. doi: 10.1101/gad.259796.115.

13.

A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR inhibitors.

Van Rechem C, Black JC, Greninger P, Zhao Y, Donado C, Burrowes PD, Ladd B, Christiani DC, Benes CH, Whetstine JR.

Cancer Discov. 2015 Mar;5(3):245-54. doi: 10.1158/2159-8290.CD-14-1159. Epub 2015 Jan 6.

14.

Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis.

Van Rechem C, Black JC, Boukhali M, Aryee MJ, Gräslund S, Haas W, Benes CH, Whetstine JR.

Cancer Discov. 2015 Mar;5(3):255-63. doi: 10.1158/2159-8290.CD-14-1326. Epub 2015 Jan 6.

15.

Methylation: a multifaceted modification - looking at transcription and beyond.

Whetstine JR.

Biochim Biophys Acta. 2014 Dec;1839(12):1351-2. doi: 10.1016/j.bbagrm.2014.09.005. Epub 2014 Sep 16. No abstract available.

PMID:
25225044
16.

Examining the impact of gene variants on histone lysine methylation.

Van Rechem C, Whetstine JR.

Biochim Biophys Acta. 2014 Dec;1839(12):1463-76. doi: 10.1016/j.bbagrm.2014.05.014. Epub 2014 May 23. Review.

17.

Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1.

Javaid S, Zhang J, Anderssen E, Black JC, Wittner BS, Tajima K, Ting DT, Smolen GA, Zubrowski M, Desai R, Maheswaran S, Ramaswamy S, Whetstine JR, Haber DA.

Cell Rep. 2013 Dec 26;5(6):1679-89. doi: 10.1016/j.celrep.2013.11.034. Epub 2013 Dec 19.

18.

Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.

Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM.

Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840.

19.

KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.

Black JC, Manning AL, Van Rechem C, Kim J, Ladd B, Cho J, Pineda CM, Murphy N, Daniels DL, Montagna C, Lewis PW, Glass K, Allis CD, Dyson NJ, Getz G, Whetstine JR.

Cell. 2013 Aug 1;154(3):541-55. doi: 10.1016/j.cell.2013.06.051. Epub 2013 Jul 18.

20.

Detection of impaired homologous recombination repair in NSCLC cells and tissues.

Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O'Hara C, Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H.

J Thorac Oncol. 2013 Mar;8(3):279-86. doi: 10.1097/JTO.0b013e31827ecf83.

21.

Histone lysine methylation dynamics: establishment, regulation, and biological impact.

Black JC, Van Rechem C, Whetstine JR.

Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006. Review.

22.

Tipping the lysine methylation balance in disease.

Black JC, Whetstine JR.

Biopolymers. 2013 Feb;99(2):127-35. doi: 10.1002/bip.22136. Review.

23.

RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.

Korenjak M, Anderssen E, Ramaswamy S, Whetstine JR, Dyson NJ.

Mol Cell Biol. 2012 Nov;32(21):4375-87. doi: 10.1128/MCB.00536-12. Epub 2012 Aug 27.

24.

LOX out, histones: a new enzyme is nipping at your tails.

Black JC, Whetstine JR.

Mol Cell. 2012 May 11;46(3):243-4. doi: 10.1016/j.molcel.2012.04.023.

25.

The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein.

Van Rechem C, Black JC, Abbas T, Allen A, Rinehart CA, Yuan GC, Dutta A, Whetstine JR.

J Biol Chem. 2011 Sep 2;286(35):30462-70. doi: 10.1074/jbc.M111.273508. Epub 2011 Jul 8.

26.

Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression.

Black JC, Allen A, Van Rechem C, Forbes E, Longworth M, Tschöp K, Rinehart C, Quiton J, Walsh R, Smallwood A, Dyson NJ, Whetstine JR.

Mol Cell. 2010 Dec 10;40(5):736-48. doi: 10.1016/j.molcel.2010.11.008.

27.

Chromatin landscape: methylation beyond transcription.

Black JC, Whetstine JR.

Epigenetics. 2011 Jan;6(1):9-15. doi: 10.4161/epi.6.1.13331. Epub 2011 Jan 1. Review.

28.

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.

Genes Dev. 2010 Jul 1;24(13):1403-17. doi: 10.1101/gad.1901210.

29.

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR, Price BD.

Nat Cell Biol. 2009 Nov;11(11):1376-82. doi: 10.1038/ncb1982. Epub 2009 Sep 27.

30.

The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span.

Chen S, Whetstine JR, Ghosh S, Hanover JA, Gali RR, Grosu P, Shi Y.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1496-501. doi: 10.1073/pnas.0802674106. Epub 2009 Jan 21.

31.

A histone H3 lysine 27 demethylase regulates animal posterior development.

Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.

Nature. 2007 Oct 11;449(7163):689-94. Epub 2007 Sep 12.

PMID:
17851529
32.

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y.

Cell. 2007 Mar 23;128(6):1077-88. Epub 2007 Feb 22.

33.

Dynamic regulation of histone lysine methylation by demethylases.

Shi Y, Whetstine JR.

Mol Cell. 2007 Jan 12;25(1):1-14. Review.

34.

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.

Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y.

Cell. 2006 May 5;125(3):467-81. Epub 2006 Apr 6.

35.

Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase.

Whetstine JR, Ceron J, Ladd B, Dufourcq P, Reinke V, Shi Y.

Mol Cell. 2005 May 13;18(4):483-90.

36.

Transcriptional regulation of the human reduced folate carrier promoter C: synergistic transactivation by Sp1 and C/EBP beta and identification of a downstream repressor.

Payton SG, Whetstine JR, Ge Y, Matherly LH.

Biochim Biophys Acta. 2005 Jan 21;1727(1):45-57. Epub 2004 Dec 31.

PMID:
15652157
37.

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.

Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y.

Cell. 2004 Dec 29;119(7):941-53.

38.

Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter.

Liu M, Whetstine JR, Payton SG, Ge Y, Flatley RM, Matherly LH.

Biochem J. 2004 Oct 15;383(Pt 2):249-57.

39.

Coordinated histone modifications mediated by a CtBP co-repressor complex.

Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y.

Nature. 2003 Apr 17;422(6933):735-8.

40.

Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells.

Gifford AJ, Haber M, Witt TL, Whetstine JR, Taub JW, Matherly LH, Norris MD.

Leukemia. 2002 Dec;16(12):2379-87.

41.
43.

Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers.

Whetstine JR, Gifford AJ, Witt T, Liu XY, Flatley RM, Norris M, Haber M, Taub JW, Ravindranath Y, Matherly LH.

Clin Cancer Res. 2001 Nov;7(11):3416-22.

44.

Repression of human reduced folate carrier gene expression by wild type p53.

Ding BC, Whetstine JR, Witt TL, Schuetz JD, Matherly LH.

J Biol Chem. 2001 Mar 23;276(12):8713-9. Epub 2000 Dec 5.

46.

Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans.

Whetstine JR, Yueh MF, McCarver DG, Williams DE, Park CS, Kang JH, Cha YN, Dolphin CT, Shephard EA, Phillips IR, Hines RN.

Toxicol Appl Pharmacol. 2000 Nov 1;168(3):216-24.

PMID:
11042094

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