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Structure of a rabies virus polymerase complex from electron cryo-microscopy.

Horwitz JA, Jenni S, Harrison SC, Whelan SPJ.

Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2099-2107. doi: 10.1073/pnas.1918809117. Epub 2020 Jan 17.


A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation.

de Wispelaere M, Carocci M, Burri DJ, Neidermyer WJ Jr, Olson CM, Roggenbach I, Liang Y, Wang J, Whelan SPJ, Gray NS, Yang PL.

J Biol Chem. 2020 Feb 7;295(6):1694-1703. doi: 10.1074/jbc.RA119.011132. Epub 2019 Dec 30.


Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor.

Jenni S, Bloyet LM, Diaz-Avalos R, Liang B, Whelan SPJ, Grigorieff N, Harrison SC.

Cell Rep. 2020 Jan 7;30(1):53-60.e5. doi: 10.1016/j.celrep.2019.12.024.


Endotoxin Engages Mitochondrial Quality Control via an iNOS-Reactive Oxygen Species Signaling Pathway in Hepatocytes.

Cyr A, Chambers L, Waltz PK, Whelan SP, Kohut L, Carchman E, Dyer M, Luciano J, Kautza B, Gomez HD, Otterbein LE, Rosengart MR, Shiva S, Zuckerbraun BS.

Oxid Med Cell Longev. 2019 Oct 24;2019:4745067. doi: 10.1155/2019/4745067. eCollection 2019.


Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State.

Kueck T, Bloyet LM, Cassella E, Zang T, Schmidt F, Brusic V, Tekes G, Pornillos O, Whelan SPJ, Bieniasz PD.

J Virol. 2019 Nov 26;93(24). pii: e01372-19. doi: 10.1128/JVI.01372-19. Print 2019 Dec 15.


Global analysis of polysome-associated mRNA in vesicular stomatitis virus infected cells.

Neidermyer WJ Jr, Whelan SPJ.

PLoS Pathog. 2019 Jun 21;15(6):e1007875. doi: 10.1371/journal.ppat.1007875. eCollection 2019 Jun.


Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells.

Tao L, Tian S, Zhang J, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M.

Nat Microbiol. 2019 Oct;4(10):1760-1769. doi: 10.1038/s41564-019-0464-z. Epub 2019 Jun 3.


Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry.

Caì Y, Yú S, Jangra RK, Postnikova EN, Wada J, Tesh RB, Whelan SPJ, Lauck M, Wiley MR, Finch CL, Radoshitzky SR, O'Connor DH, Palacios G, Chandran K, Chiu CY, Kuhn JH.

Front Microbiol. 2019 Apr 26;10:856. doi: 10.3389/fmicb.2019.00856. eCollection 2019.


RNA ligands activate the Machupo virus polymerase and guide promoter usage.

Pyle JD, Whelan SPJ.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10518-10524. doi: 10.1073/pnas.1900790116. Epub 2019 May 9.


Phase Transitions Drive the Formation of Vesicular Stomatitis Virus Replication Compartments.

Heinrich BS, Maliga Z, Stein DA, Hyman AA, Whelan SPJ.

mBio. 2018 Sep 4;9(5). pii: e02290-17. doi: 10.1128/mBio.02290-17.


Reconstruction of the cell entry pathway of an extinct virus.

Robinson-McCarthy LR, McCarthy KR, Raaben M, Piccinotti S, Nieuwenhuis J, Stubbs SH, Bakkers MJG, Whelan SPJ.

PLoS Pathog. 2018 Aug 6;14(8):e1007123. doi: 10.1371/journal.ppat.1007123. eCollection 2018 Aug.


STING-dependent translation inhibition restricts RNA virus replication.

Franz KM, Neidermyer WJ, Tan YJ, Whelan SPJ, Kagan JC.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2058-E2067. doi: 10.1073/pnas.1716937115. Epub 2018 Feb 12.


NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

Raaben M, Jae LT, Herbert AS, Kuehne AI, Stubbs SH, Chou YY, Blomen VA, Kirchhausen T, Dye JM, Brummelkamp TR, Whelan SP.

Cell Host Microbe. 2017 Nov 8;22(5):688-696.e5. doi: 10.1016/j.chom.2017.10.002.


Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.

Hanke L, Schmidt FI, Knockenhauer KE, Morin B, Whelan SP, Schwartz TU, Ploegh HL.

EMBO Rep. 2017 Jun;18(6):1027-1037. doi: 10.15252/embr.201643764. Epub 2017 Apr 10.


Mechanism of membrane fusion induced by vesicular stomatitis virus G protein.

Kim IS, Jenni S, Stanifer ML, Roth E, Whelan SP, van Oijen AM, Harrison SC.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):E28-E36. doi: 10.1073/pnas.1618883114. Epub 2016 Dec 14.


An In Vitro RNA Synthesis Assay for Rabies Virus Defines Ribonucleoprotein Interactions Critical for Polymerase Activity.

Morin B, Liang B, Gardner E, Ross RA, Whelan SPJ.

J Virol. 2016 Dec 16;91(1). pii: e01508-16. doi: 10.1128/JVI.01508-16. Print 2017 Jan 1.


Phenotypic lentivirus screens to identify functional single domain antibodies.

Schmidt FI, Hanke L, Morin B, Brewer R, Brusic V, Whelan SP, Ploegh HL.

Nat Microbiol. 2016 Jun 20;1(8):16080. doi: 10.1038/nmicrobiol.2016.80.


Intermediate filaments enable pathogen docking to trigger type 3 effector translocation.

Russo BC, Stamm LM, Raaben M, Kim CM, Kahoud E, Robinson LR, Bose S, Queiroz AL, Herrera BB, Baxt LA, Mor-Vaknin N, Fu Y, Molina G, Markovitz DM, Whelan SP, Goldberg MB.

Nat Microbiol. 2016 Mar 7;1:16025. doi: 10.1038/nmicrobiol.2016.25.


Rabies Internalizes into Primary Peripheral Neurons via Clathrin Coated Pits and Requires Fusion at the Cell Body.

Piccinotti S, Whelan SP.

PLoS Pathog. 2016 Jul 27;12(7):e1005753. doi: 10.1371/journal.ppat.1005753. eCollection 2016 Jul.


Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector.

Taylor TJ, Diaz F, Colgrove RC, Bernard KA, DeLuca NA, Whelan SPJ, Knipe DM.

Virology. 2016 Sep;496:186-193. doi: 10.1016/j.virol.2016.06.006. Epub 2016 Jun 20.


A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.

Ndungo E, Herbert AS, Raaben M, Obernosterer G, Biswas R, Miller EH, Wirchnianski AS, Carette JE, Brummelkamp TR, Whelan SP, Dye JM, Chandran K.

mSphere. 2016 Mar 30;1(2). pii: e00007-16. doi: 10.1128/mSphere.00007-16. eCollection 2016 Mar-Apr.


Correction for Soh and Whelan, Tracking the Fate of Genetically Distinct Vesicular Stomatitis Virus Matrix Proteins Highlights the Role for Late Domains in Assembly.

Soh TK, Whelan SPJ.

J Virol. 2016 May 27;90(12):5847. doi: 10.1128/JVI.00633-16. Print 2016 Jun 15. No abstract available.


A New Transferrin Receptor Aptamer Inhibits New World Hemorrhagic Fever Mammarenavirus Entry.

Maier KE, Jangra RK, Shieh KR, Cureton DK, Xiao H, Snapp EL, Whelan SP, Chandran K, Levy M.

Mol Ther Nucleic Acids. 2016 May 24;5:e321. doi: 10.1038/mtna.2016.32.


Repeatable Population Dynamics among Vesicular Stomatitis Virus Lineages Evolved under High Co-infection.

Williams ES, Morales NM, Wasik BR, Brusic V, Whelan SP, Turner PE.

Front Microbiol. 2016 Mar 31;7:370. doi: 10.3389/fmicb.2016.00370. eCollection 2016.


Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor.

Chou YY, Cuevas C, Carocci M, Stubbs SH, Ma M, Cureton DK, Chao L, Evesson F, He K, Yang PL, Whelan SP, Ross SR, Kirchhausen T, Gaudin R.

J Virol. 2016 Apr 14;90(9):4494-4510. doi: 10.1128/JVI.00103-16. Print 2016 May.


Infectious Entry Pathway Mediated by the Human Endogenous Retrovirus K Envelope Protein.

Robinson LR, Whelan SP.

J Virol. 2016 Jan 20;90(7):3640-9. doi: 10.1128/JVI.03136-15.


Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy.

Liang B, Li Z, Jenni S, Rahmeh AA, Morin BM, Grant T, Grigorieff N, Harrison SC, Whelan SPJ.

Cell. 2015 Jul 16;162(2):314-327. doi: 10.1016/j.cell.2015.06.018. Epub 2015 Jul 2.


Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.

Herbert AS, Davidson C, Kuehne AI, Bakken R, Braigen SZ, Gunn KE, Whelan SP, Brummelkamp TR, Twenhafel NA, Chandran K, Walkley SU, Dye JM.

mBio. 2015 May 26;6(3):e00565-15. doi: 10.1128/mBio.00565-15.


Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era--a Conference at Harvard Medical School.

Knipe DM, Whelan SP.

J Virol. 2015 Aug;89(15):7446-8. doi: 10.1128/JVI.01251-15. Epub 2015 May 20.


Recoding of the vesicular stomatitis virus L gene by computer-aided design provides a live, attenuated vaccine candidate.

Wang B, Yang C, Tekes G, Mueller S, Paul A, Whelan SP, Wimmer E.

mBio. 2015 Mar 31;6(2). pii: e00237-15. doi: 10.1128/mBio.00237-15.


Virus entry. Lassa virus entry requires a trigger-induced receptor switch.

Jae LT, Raaben M, Herbert AS, Kuehne AI, Wirchnianski AS, Soh TK, Stubbs SH, Janssen H, Damme M, Saftig P, Whelan SP, Dye JM, Brummelkamp TR.

Science. 2014 Jun 27;344(6191):1506-10. doi: 10.1126/science.1252480.


A genome-wide small interfering RNA screen identifies host factors required for vesicular stomatitis virus infection.

Lee AS, Burdeinick-Kerr R, Whelan SP.

J Virol. 2014 Aug;88(15):8355-60. doi: 10.1128/JVI.00642-14. Epub 2014 May 14.


mRNA cap methylation influences pathogenesis of vesicular stomatitis virus in vivo.

Ma Y, Wei Y, Zhang X, Zhang Y, Cai H, Zhu Y, Shilo K, Oglesbee M, Krakowka S, Whelan SP, Li J.

J Virol. 2014 Mar;88(5):2913-26. doi: 10.1128/JVI.03420-13. Epub 2013 Dec 26.


Polymicrobial sepsis is associated with decreased hepatic oxidative phosphorylation and an altered metabolic profile.

Whelan SP, Carchman EH, Kautza B, Nassour I, Mollen K, Escobar D, Gomez H, Rosengart MA, Shiva S, Zuckerbraun BS.

J Surg Res. 2014 Jan;186(1):297-303. doi: 10.1016/j.jss.2013.08.007. Epub 2013 Aug 30.


Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin.

Piccinotti S, Kirchhausen T, Whelan SP.

J Virol. 2013 Nov;87(21):11637-47. doi: 10.1128/JVI.01648-13. Epub 2013 Aug 21.


Mitochondrial signaling: forwards, backwards, and in between.

Whelan SP, Zuckerbraun BS.

Oxid Med Cell Longev. 2013;2013:351613. doi: 10.1155/2013/351613. Epub 2013 May 29. Review.


The polymerase of negative-stranded RNA viruses.

Morin B, Kranzusch PJ, Rahmeh AA, Whelan SP.

Curr Opin Virol. 2013 Apr;3(2):103-10. doi: 10.1016/j.coviro.2013.03.008. Epub 2013 Apr 18. Review.


Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates.

Ivanovic T, Choi JL, Whelan SP, van Oijen AM, Harrison SC.

Elife. 2013 Feb 19;2:e00333. doi: 10.7554/eLife.00333.


Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.

Jae LT, Raaben M, Riemersma M, van Beusekom E, Blomen VA, Velds A, Kerkhoven RM, Carette JE, Topaloglu H, Meinecke P, Wessels MW, Lefeber DJ, Whelan SP, van Bokhoven H, Brummelkamp TR.

Science. 2013 Apr 26;340(6131):479-83. doi: 10.1126/science.1233675. Epub 2013 Mar 21.


Methods to study RNA virus molecular biology.

Semler BL, Whelan SP.

Methods. 2013 Feb;59(2):165-6. doi: 10.1016/j.ymeth.2013.02.013. No abstract available.


Niemann-Pick C1 (NPC1)/NPC1-like1 chimeras define sequences critical for NPC1's function as a flovirus entry receptor.

Krishnan A, Miller EH, Herbert AS, Ng M, Ndungo E, Whelan SP, Dye JM, Chandran K.

Viruses. 2012 Oct 25;4(11):2471-84. doi: 10.3390/v4112471.


A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs.

Lee AS, Burdeinick-Kerr R, Whelan SP.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):324-9. doi: 10.1073/pnas.1216454109. Epub 2012 Nov 19.


Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus.

Rahmeh AA, Morin B, Schenk AD, Liang B, Heinrich BS, Brusic V, Walz T, Whelan SP.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14628-33. doi: 10.1073/pnas.1209147109. Epub 2012 Aug 20.


Architecture and regulation of negative-strand viral enzymatic machinery.

Kranzusch PJ, Whelan SP.

RNA Biol. 2012 Jul;9(7):941-8. doi: 10.4161/rna.20345. Epub 2012 Jul 1.


Structural properties of the C terminus of vesicular stomatitis virus N protein dictate N-RNA complex assembly, encapsidation, and RNA synthesis.

Heinrich BS, Morin B, Rahmeh AA, Whelan SP.

J Virol. 2012 Aug;86(16):8720-9. doi: 10.1128/JVI.00990-12. Epub 2012 Jun 6.


Ebola virus entry requires the host-programmed recognition of an intracellular receptor.

Miller EH, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A, Ndungo E, Sandesara RG, Carette JE, Kuehne AI, Ruthel G, Pfeffer SR, Dye JM, Whelan SP, Brummelkamp TR, Chandran K.

EMBO J. 2012 Apr 18;31(8):1947-60. doi: 10.1038/emboj.2012.53. Epub 2012 Mar 6.


Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase.

Morin B, Rahmeh AA, Whelan SP.

EMBO J. 2012 Mar 7;31(5):1320-9. doi: 10.1038/emboj.2011.483. Epub 2012 Jan 13.


Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex.

Kranzusch PJ, Whelan SP.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19743-8. doi: 10.1073/pnas.1112742108. Epub 2011 Nov 21.

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