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Diet-Microbiome Interactions and the Risk of Pouchitis in Ileal Pouch-Anal Anastomosis.

Whelan K.

J Crohns Colitis. 2019 Oct 12. pii: jjz136. doi: 10.1093/ecco-jcc/jjz136. [Epub ahead of print] No abstract available.


Effects of Low-FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial.

Cox SR, Lindsay JO, Fromentin S, Stagg AJ, McCarthy NE, Galleron N, Ibraim SB, Roume H, Levenez F, Pons N, Maziers N, Lomer MC, Ehrlich SD, Irving PM, Whelan K.

Gastroenterology. 2019 Sep 27. pii: S0016-5085(19)41366-8. doi: 10.1053/j.gastro.2019.09.024. [Epub ahead of print]


The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor.

Aye JM, Stafman LL, Williams AP, Garner EF, Stewart JE, Anderson JC, Mruthyunjayappa S, Waldrop MG, Goolsby CD, Markert HR, Quinn C, Marayati R, Mroczek-Musulman E, Willey CD, Yoon KJ, Whelan KF, Beierle EA.

Oncotarget. 2019 Sep 17;10(53):5534-5548. doi: 10.18632/oncotarget.27165. eCollection 2019 Sep 17.


Focal Adhesion Kinase Inhibition Contributes to Tumor Cell Survival and Motility in Neuroblastoma Patient-Derived Xenografts.

Stafman LL, Williams AP, Marayati R, Aye JM, Markert HR, Garner EF, Quinn CH, Lallani SB, Stewart JE, Yoon KJ, Whelan K, Beierle EA.

Sci Rep. 2019 Sep 13;9(1):13259. doi: 10.1038/s41598-019-49853-z.


Persistent Basal Cell Hyperplasia is Associated with Clinical and Endoscopic Findings in Patients With Histologically Inactive Eosinophilic Esophagitis.

Whelan KA, Godwin BC, Wilkins B, Elci OU, Benitez A, DeMarshall M, Sharma M, Gross J, Klein-Szanto AJ, Liacouras CA, Dellon ES, Spergel JM, Falk GW, Muir AB, Nakagawa H.

Clin Gastroenterol Hepatol. 2019 Sep 6. pii: S1542-3565(19)30977-2. doi: 10.1016/j.cgh.2019.08.055. [Epub ahead of print]


A high prevalence of chronic gastrointestinal symptoms in adults with cystic fibrosis is detected using tools already validated in other GI disorders.

Hayee B, Watson KL, Campbell S, Simpson A, Farrell E, Hutchings P, Macedo P, Perrin F, Whelan K, Elston C.

United European Gastroenterol J. 2019 Aug;7(7):881-888. doi: 10.1177/2050640619841545.


Fermented Foods: Definitions and Characteristics, Impact on the Gut Microbiota and Effects on Gastrointestinal Health and Disease.

Dimidi E, Cox SR, Rossi M, Whelan K.

Nutrients. 2019 Aug 5;11(8). pii: E1806. doi: 10.3390/nu11081806. Review.


Probiotics and constipation: mechanisms of action, evidence for effectiveness and utilisation by patients and healthcare professionals - ERRATUM.

Dimidi E, Mark Scott S, Whelan K.

Proc Nutr Soc. 2019 Aug 1:1. doi: 10.1017/S0029665119001058. [Epub ahead of print] No abstract available.


Clinical and translational advances in esophageal squamous cell carcinoma.

Reichenbach ZW, Murray MG, Saxena R, Farkas D, Karassik EG, Klochkova A, Patel K, Tice C, Hall TM, Gang J, Parkman HP, Ward SJ, Tétreault MP, Whelan KA.

Adv Cancer Res. 2019;144:95-135. doi: 10.1016/bs.acr.2019.05.004. Epub 2019 Jun 10.


Fermentable carbohydrates in functional bowel disorders: New insights.

Vanner S, Whelan K.

Neurogastroenterol Motil. 2019 Aug;31(8):e13662. doi: 10.1111/nmo.13662. No abstract available.


Fermentable carbohydrates in functional bowel disorders: new insights.

Vanner S, Whelan K.

J Hum Nutr Diet. 2019 Aug;32(4):411-412. doi: 10.1111/jhn.12688. No abstract available.


Probiotics and constipation: mechanisms of action, evidence for effectiveness and utilisation by patients and healthcare professionals.

Dimidi E, Mark Scott S, Whelan K.

Proc Nutr Soc. 2019 Jul 2:1-11. doi: 10.1017/S0029665119000934. [Epub ahead of print]


Perceptions of Constipation Among the General Public and People With Constipation Differ Strikingly From Those of General and Specialist Doctors and the Rome IV Criteria.

Dimidi E, Cox C, Grant R, Scott SM, Whelan K.

Am J Gastroenterol. 2019 Jul;114(7):1116-1129. doi: 10.14309/ajg.0000000000000267.


Perceptions and psychosocial impact of food, nutrition, eating and drinking in people with inflammatory bowel disease: a qualitative investigation of food-related quality of life.

Czuber-Dochan W, Morgan M, Hughes LD, Lomer MCE, Lindsay JO, Whelan K.

J Hum Nutr Diet. 2019 May 26. doi: 10.1111/jhn.12668. [Epub ahead of print]


Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1.

Chatterji P, Williams PA, Whelan KA, Samper FC, Andres SF, Simon LA, Parham LR, Mizuno R, Lundsmith ET, Lee DS, Liang S, Wijeratne HS, Marti S, Chau L, Giroux V, Wilkins BJ, Wu GD, Shah P, Tartaglia GG, Hamilton KE.

EMBO Rep. 2019 Jun;20(6). pii: e47074. doi: 10.15252/embr.201847074. Epub 2019 May 6.


Nutrient Intake, Diet Quality, and Diet Diversity in Irritable Bowel Syndrome and the Impact of the Low FODMAP Diet.

Staudacher HM, Ralph FSE, Irving PM, Whelan K, Lomer MCE.

J Acad Nutr Diet. 2019 Apr 24. pii: S2212-2672(18)31829-X. doi: 10.1016/j.jand.2019.01.017. [Epub ahead of print]


KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF.

Shaverdashvili K, Padlo J, Weinblatt D, Jia Y, Jiang W, Rao D, Laczkó D, Whelan KA, Lynch JP, Muir AB, Katz JP.

PLoS One. 2019 Apr 18;14(4):e0215746. doi: 10.1371/journal.pone.0215746. eCollection 2019.


Nutrient, fibre, sorbitol and chlorogenic acid content of prunes (Prunus domestica): an updated analysis and comparison of different countries of origin and database values.

Gill SK, Lever E, Emery PW, Whelan K.

Int J Food Sci Nutr. 2019 Dec;70(8):924-931. doi: 10.1080/09637486.2019.1600664. Epub 2019 Apr 16.


β-Hydroxy-β-methylbutyrate and its impact on skeletal muscle mass and physical function in clinical practice: a systematic review and meta-analysis.

Bear DE, Langan A, Dimidi E, Wandrag L, Harridge SDR, Hart N, Connolly B, Whelan K.

Am J Clin Nutr. 2019 Apr 1;109(4):1119-1132. doi: 10.1093/ajcn/nqy373.


Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: a systematic review and meta-analysis of randomized controlled trials.

Wilson B, Rossi M, Dimidi E, Whelan K.

Am J Clin Nutr. 2019 Apr 1;109(4):1098-1111. doi: 10.1093/ajcn/nqy376.


The presence of PIM3 increases hepatoblastoma tumorigenesis and tumor initiating cell phenotype and is associated with decreased patient survival.

Stafman LL, Waldrop MG, Williams AP, Aye JM, Stewart JE, Mroczek-Musulman E, Yoon KJ, Whelan K, Beierle EA.

J Pediatr Surg. 2019 Jun;54(6):1206-1213. doi: 10.1016/j.jpedsurg.2019.02.029. Epub 2019 Feb 28.


Dried fruit and public health - what does the evidence tell us?

Sadler MJ, Gibson S, Whelan K, Ha MA, Lovegrove J, Higgs J.

Int J Food Sci Nutr. 2019 Sep;70(6):675-687. doi: 10.1080/09637486.2019.1568398. Epub 2019 Feb 27.


A unique phenotype of T-cell acute lymphoblastic leukemia in a patient with GATA2 haploinsufficiency.

Esparza O, Xavier AC, Atkinson TP, Hill BC, Whelan K.

Pediatr Blood Cancer. 2019 Jun;66(6):e27649. doi: 10.1002/pbc.27649. Epub 2019 Feb 25.


Probiotic use is common in constipation, but only a minority of general and specialist doctors recommend them and consider there to be an evidence base.

Dimidi E, Cox C, Scott SM, Whelan K.

Nutrition. 2019 May;61:157-163. doi: 10.1016/j.nut.2018.11.013. Epub 2018 Nov 23.


Competency-based Professional Advancement Model for Advanced Practice RNs.

Paul F, Abecassis L, Freiberger D, Hamilton S, Kelly P, Klements E, LaGrasta C, Lemire L, OʼDonnell E, Patisteas E, Phinney C, Conwell K, Saia T, Whelan K, Wood LJ, OʼBrien P.

J Nurs Adm. 2019 Feb;49(2):66-72. doi: 10.1097/NNA.0000000000000719.


Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms, and gut microbiology in chronic constipation.

Dimidi E, Zdanaviciene A, Christodoulides S, Taheri S, Louis P, Duncan PI, Emami N, Crabbé R, De Castro CA, McLean P, Bergonzelli GE, Whelan K, Mark Scott S.

Aliment Pharmacol Ther. 2019 Feb;49(3):251-264. doi: 10.1111/apt.15073. Epub 2018 Dec 25.


Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-α.

Kasagi Y, Dods K, Wang JX, Chandramouleeswaran PM, Benitez AJ, Gambanga F, Kluger J, Ashorobi T, Gross J, Tobias JW, Klein-Szanto AJ, Spergel JM, Cianferoni A, Falk GW, Whelan KA, Nakagawa H, Muir AB.

J Allergy Clin Immunol. 2019 Jul;144(1):171-182. doi: 10.1016/j.jaci.2018.10.067. Epub 2018 Dec 20.


RNA regulons are essential in intestinal homeostasis.

Parham LR, Williams PA, Chatterji P, Whelan KA, Hamilton KE.

Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G197-G204. doi: 10.1152/ajpgi.00403.2017. Epub 2018 Dec 6.


Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells.

Kijima T, Nakagawa H, Shimonosono M, Chandramouleeswaran PM, Hara T, Sahu V, Kasagi Y, Kikuchi O, Tanaka K, Giroux V, Muir AB, Whelan KA, Ohashi S, Naganuma S, Klein-Szanto AJ, Shinden Y, Sasaki K, Omoto I, Kita Y, Muto M, Bass AJ, Diehl JA, Ginsberg GG, Doki Y, Mori M, Uchikado Y, Arigami T, Avadhani NG, Basu D, Rustgi AK, Natsugoe S.

Cell Mol Gastroenterol Hepatol. 2018 Sep 14;7(1):73-91. doi: 10.1016/j.jcmgh.2018.09.003. eCollection 2019.


Targeting PIM Kinases Affects Maintenance of CD133 Tumor Cell Population in Hepatoblastoma.

Stafman LL, Williams AP, Garner EF, Aye JM, Stewart JE, Yoon KJ, Whelan K, Beierle EA.

Transl Oncol. 2019 Feb;12(2):200-208. doi: 10.1016/j.tranon.2018.10.008. Epub 2018 Nov 6.


Validation of the Revised Children's Anxiety and Depression Scales (RCADS) and RCADS short forms adapted for adults.

McKenzie K, Murray A, Freeston M, Whelan K, Rodgers J.

J Affect Disord. 2019 Feb 15;245:200-204. doi: 10.1016/j.jad.2018.10.362. Epub 2018 Nov 2.


Corruption of neuroblastoma patient derived xenografts with human T cell lymphoma.

Williams AP, Stewart JE, Stafman LL, Aye JM, Mroczek-Musulman E, Ren C, Yoon K, Whelan K, Beierle EA.

J Pediatr Surg. 2018 Oct 22. pii: S0022-3468(18)30681-X. doi: 10.1016/j.jpedsurg.2018.10.051. [Epub ahead of print]


Clinical application of dietary therapies in irritable bowel syndrome.

Rej A, Avery A, Ford AC, Holdoway A, Kurien M, McKenzie Y, Thompson J, Trott N, Whelan K, Williams M, Sanders DS.

J Gastrointestin Liver Dis. 2018 Sep;27(3):307-316. doi: 10.15403/jgld.2014.1121.273.avy. Review.


Quality Initiative to Improve time to Antibiotics for Febrile Pediatric Patients with Potential Neutropenia.

Monroe K, Cohen CT, Whelan K, King A, Maloney L, Deason J, Nichols JC, Friedman GK, Kutny M, Hayes L.

Pediatr Qual Saf. 2018 Aug 9;3(4):e095. doi: 10.1097/pq9.0000000000000095. eCollection 2018 Jul-Aug.


Nutritional status, the development and persistence of malnutrition and dietary intake in oesophago-gastric cancer: a longitudinal cohort study.

Grace EM, Shaw C, Lalji A, Mohammed K, Andreyev HJN, Whelan K.

J Hum Nutr Diet. 2018 Dec;31(6):785-792. doi: 10.1111/jhn.12588. Epub 2018 Jul 22.


Short-Term Daily Intake of Polydextrose Fiber Does Not Shorten Intestinal Transit Time in Constipated Adults: A Randomized Controlled Trial.

Duncan PI, Enters-Weijnen CF, Emami N, McLean P, Nunes T, Beaumont M, Crabbe R, Whelan K, Scott SM, deWit NJ, Weits T, Bergonzelli G, Grobbee DE.

Nutrients. 2018 Jul 19;10(7). pii: E920. doi: 10.3390/nu10070920.


The impact of contextual information on the emotion recognition of children with an intellectual disability.

Murray G, McKenzie K, Murray A, Whelan K, Cossar J, Murray K, Scotland J.

J Appl Res Intellect Disabil. 2019 Jan;32(1):152-158. doi: 10.1111/jar.12517. Epub 2018 Jul 16.


Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma.

Stafman LL, Mruthyunjayappa S, Waters AM, Garner EF, Aye JM, Stewart JE, Yoon KJ, Whelan K, Mroczek-Musulman E, Beierle EA.

Oncotarget. 2018 Apr 27;9(32):22665-22679. doi: 10.18632/oncotarget.25205. eCollection 2018 Apr 27.


Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis.

So D, Whelan K, Rossi M, Morrison M, Holtmann G, Kelly JT, Shanahan ER, Staudacher HM, Campbell KL.

Am J Clin Nutr. 2018 Jun 1;107(6):965-983. doi: 10.1093/ajcn/nqy041.


Esophageal 3D Culture Systems as Modeling Tools in Esophageal Epithelial Pathobiology and Personalized Medicine.

Whelan KA, Muir AB, Nakagawa H.

Cell Mol Gastroenterol Hepatol. 2018 Jan 31;5(4):461-478. doi: 10.1016/j.jcmgh.2018.01.011. eCollection 2018. Review.


CREATE Wellness: A multi-component behavioral intervention for patients not responding to traditional Cardiovascular disease management.

Miller-Rosales C, Sterling SA, Wood SB, Ross T, Makki M, Zamudio C, Kane IM, Richardson MC, Samayoa C, Charvat-Aguilar N, Lu WY, Vo M, Whelan K, Uratsu CS, Grant RW.

Contemp Clin Trials Commun. 2017 Oct 4;8:140-146. doi: 10.1016/j.conctc.2017.10.001. eCollection 2017 Dec.


Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma.

Hall TM, Tétreault MP, Hamilton KE, Whelan KA.

Curr Opin Pharmacol. 2018 Aug;41:12-19. doi: 10.1016/j.coph.2018.04.003. Epub 2018 Apr 17. Review.


The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes.

Kasagi Y, Chandramouleeswaran PM, Whelan KA, Tanaka K, Giroux V, Sharma M, Wang J, Benitez AJ, DeMarshall M, Tobias JW, Hamilton KE, Falk GW, Spergel JM, Klein-Szanto AJ, Rustgi AK, Muir AB, Nakagawa H.

Cell Mol Gastroenterol Hepatol. 2018 Jan 3;5(3):333-352. doi: 10.1016/j.jcmgh.2017.12.013. eCollection 2018 Mar.



Staudacher HM, Whelan K.

Gastroenterology. 2018 Apr;154(5):1548. doi: 10.1053/j.gastro.2018.03.016. Epub 2018 Mar 8. No abstract available.


The effect of prunes on stool output, gut transit time and gastrointestinal microbiota: A randomised controlled trial.

Lever E, Scott SM, Louis P, Emery PW, Whelan K.

Clin Nutr. 2019 Feb;38(1):165-173. doi: 10.1016/j.clnu.2018.01.003. Epub 2018 Feb 15.


Adequacy of nutrition support during extracorporeal membrane oxygenation.

MacGowan L, Smith E, Elliott-Hammond C, Sanderson B, Ong D, Daly K, Barrett NA, Whelan K, Bear DE.

Clin Nutr. 2019 Feb;38(1):324-331. doi: 10.1016/j.clnu.2018.01.012. Epub 2018 Feb 15.


The low FODMAP diet in the management of irritable bowel syndrome: an evidence-based review of FODMAP restriction, reintroduction and personalisation in clinical practice.

Whelan K, Martin LD, Staudacher HM, Lomer MCE.

J Hum Nutr Diet. 2018 Apr;31(2):239-255. doi: 10.1111/jhn.12530. Epub 2018 Jan 15. Review.


Quality of Life From Canadian Cancer Trials Group MA.17R: A Randomized Trial of Extending Adjuvant Letrozole to 10 Years.

Lemieux J, Brundage MD, Parulekar WR, Goss PE, Ingle JN, Pritchard KI, Celano P, Muss H, Gralow J, Strasser-Weippl K, Whelan K, Tu D, Whelan TJ.

J Clin Oncol. 2018 Feb 20;36(6):563-571. doi: 10.1200/JCO.2017.75.7500. Epub 2018 Jan 12. Erratum in: J Clin Oncol. 2018 May 20;36(15):1540.


Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study.

Healey G, Murphy R, Butts C, Brough L, Whelan K, Coad J.

Br J Nutr. 2018 Jan;119(2):176-189. doi: 10.1017/S0007114517003440. Epub 2018 Jan 8.


Evaluation of Well Designs to Improve Access to Safe and Clean Water in Rural Tanzania.

Kilungo A, Powers L, Arnold N, Whelan K, Paterson K, Young D.

Int J Environ Res Public Health. 2018 Jan 4;15(1). pii: E64. doi: 10.3390/ijerph15010064.

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