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Items: 47


An O-Antigen Glycoconjugate Vaccine Produced Using Protein Glycan Coupling Technology Is Protective in an Inhalational Rat Model of Tularemia.

Marshall LE, Nelson M, Davies CH, Whelan AO, Jenner DC, Moule MG, Denman C, Cuccui J, Atkins TP, Wren BW, Prior JL.

J Immunol Res. 2018 Nov 29;2018:8087916. doi: 10.1155/2018/8087916. eCollection 2018.


Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles.

Whelan AO, Flick-Smith HC, Homan J, Shen ZT, Carpenter Z, Khoshkenar P, Abraham A, Walker NJ, Levitz SM, Ostroff GR, Oyston PCF.

PLoS One. 2018 Oct 8;13(10):e0200213. doi: 10.1371/journal.pone.0200213. eCollection 2018.


Methodology and preliminary results of a systematic literature review of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis.

Downs SH, Parry JE, Upton PA, Broughan JM, Goodchild AV, Nuñez-Garcia J, Greiner M, Abernethy DA, Cameron AR, Cook AJ, de la Rua-Domenech R, Gunn J, Pritchard E, Rhodes S, Rolfe S, Sharp M, Vordermeier HM, Watson E, Welsh M, Whelan AO, Woolliams JA, More SJ, Clifton-Hadley RS.

Prev Vet Med. 2018 May 1;153:117-126. doi: 10.1016/j.prevetmed.2017.11.004. Epub 2017 Nov 9. Review.


Evaluation of the methodological quality of studies of the performance of diagnostic tests for bovine tuberculosis using QUADAS.

Downs SH, More SJ, Goodchild AV, Whelan AO, Abernethy DA, Broughan JM, Cameron A, Cook AJ, Ricardo de la Rua-Domenech R, Greiner M, Gunn J, Nuñez-Garcia J, Rhodes S, Rolfe S, Sharp M, Upton P, Watson E, Welsh M, Woolliams JA, Clifton-Hadley RS, Parry JE.

Prev Vet Med. 2018 May 1;153:108-116. doi: 10.1016/j.prevetmed.2017.03.006. Epub 2017 Mar 22.


Meta-analyses of the sensitivity and specificity of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland.

Nuñez-Garcia J, Downs SH, Parry JE, Abernethy DA, Broughan JM, Cameron AR, Cook AJ, de la Rua-Domenech R, Goodchild AV, Gunn J, More SJ, Rhodes S, Rolfe S, Sharp M, Upton PA, Vordermeier HM, Watson E, Welsh M, Whelan AO, Woolliams JA, Clifton-Hadley RS, Greiner M.

Prev Vet Med. 2018 May 1;153:94-107. doi: 10.1016/j.prevetmed.2017.02.017. Epub 2017 Mar 6.


Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination.

Maggioli MF, Palmer MV, Thacker TC, Vordermeier HM, McGill JL, Whelan AO, Larsen MH, Jacobs WR Jr, Waters WR.

Front Immunol. 2016 Oct 17;7:421. eCollection 2016.


Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle.

Dean GS, Clifford D, Whelan AO, Tchilian EZ, Beverley PC, Salguero FJ, Xing Z, Vordermeier HM, Villarreal-Ramos B.

PLoS One. 2015 Nov 6;10(11):e0142270. doi: 10.1371/journal.pone.0142270. eCollection 2015.


Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle.

Maggioli MF, Palmer MV, Vordermeier HM, Whelan AO, Fosse JM, Nonnecke BJ, Waters WR.

J Vis Exp. 2015 Jul 11;(101):e52833. doi: 10.3791/52833.


Burkholderia pseudomallei capsular polysaccharide conjugates provide protection against acute melioidosis.

Scott AE, Burtnick MN, Stokes MG, Whelan AO, Williamson ED, Atkins TP, Prior JL, Brett PJ.

Infect Immun. 2014 Aug;82(8):3206-13. doi: 10.1128/IAI.01847-14. Epub 2014 May 27.


Use of antigen-specific interleukin-2 to differentiate between cattle vaccinated with Mycobacterium bovis BCG and cattle infected with M. bovis.

Rhodes SG, McKinna LC, Steinbach S, Dean GS, Villarreal-Ramos B, Whelan AO, Pirson C, Jones GJ, Clifford D, Vordermeier HM.

Clin Vaccine Immunol. 2014 Jan;21(1):39-45. doi: 10.1128/CVI.00522-13. Epub 2013 Oct 30.


The consequences of vaccination with the Johne's disease vaccine, Gudair, on diagnosis of bovine tuberculosis.

Coad M, Clifford DJ, Vordermeier HM, Whelan AO.

Vet Rec. 2013 Mar 9;172(10):266. doi: 10.1136/vr.101201. Epub 2012 Dec 21.


A natural-transmission model of bovine tuberculosis provides novel disease insights.

Khatri BL, Coad M, Clifford DJ, Hewinson RG, Whelan AO, Vordermeier HM.

Vet Rec. 2012 Nov 3;171(18):448. doi: 10.1136/vr.101072. Epub 2012 Aug 30. No abstract available.


The duration of antigen-stimulation significantly alters the diversity of multifunctional CD4 T cells measured by intracellular cytokine staining.

Kaveh DA, Whelan AO, Hogarth PJ.

PLoS One. 2012;7(6):e38926. doi: 10.1371/journal.pone.0038926. Epub 2012 Jun 12.


Specificity of the tuberculin skin test is modified by use of a protein cocktail containing ESAT-6 and CFP-10 in cattle naturally infected with Mycobacterium bovis.

Flores-Villalva S, Suárez-Güemes F, Espitia C, Whelan AO, Vordermeier M, Gutiérrez-Pabello JA.

Clin Vaccine Immunol. 2012 May;19(5):797-803. doi: 10.1128/CVI.05668-11. Epub 2012 Mar 14.


Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers.

Aranday-Cortes E, Hogarth PJ, Kaveh DA, Whelan AO, Villarreal-Ramos B, Lalvani A, Vordermeier HM.

PLoS One. 2012;7(2):e30626. doi: 10.1371/journal.pone.0030626. Epub 2012 Feb 16.


Development of an antibody to bovine IL-2 reveals multifunctional CD4 T(EM) cells in cattle naturally infected with bovine tuberculosis.

Whelan AO, Villarreal-Ramos B, Vordermeier HM, Hogarth PJ.

PLoS One. 2011;6(12):e29194. doi: 10.1371/journal.pone.0029194. Epub 2011 Dec 22.


ELISPOT assays to enumerate bovine IFN-γ-secreting cells for the development of novel vaccines against bovine tuberculosis.

Vordermeier M, Whelan AO.

Methods Mol Biol. 2012;792:219-27. doi: 10.1007/978-1-61779-325-7_17.


DIVA reagents for bovine tuberculosis vaccines in cattle.

Vordermeier M, Jones GJ, Whelan AO.

Expert Rev Vaccines. 2011 Jul;10(7):1083-91. doi: 10.1586/erv.11.22. Review.


Lack of correlation between BCG-induced tuberculin skin test sensitisation and protective immunity in cattle.

Whelan AO, Coad M, Upadhyay BL, Clifford DJ, Hewinson RG, Vordermeier HM.

Vaccine. 2011 Jul 26;29(33):5453-8. doi: 10.1016/j.vaccine.2011.05.057. Epub 2011 Jun 2.


Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9.

Chambers MA, Whelan AO, Spallek R, Singh M, Coddeville B, Guerardel Y, Elass E.

Biochem Biophys Res Commun. 2010 Sep 24;400(3):403-8. doi: 10.1016/j.bbrc.2010.08.085. Epub 2010 Aug 26.


Development of a skin test for bovine tuberculosis for differentiating infected from vaccinated animals.

Whelan AO, Clifford D, Upadhyay B, Breadon EL, McNair J, Hewinson GR, Vordermeier MH.

J Clin Microbiol. 2010 Sep;48(9):3176-81. doi: 10.1128/JCM.00420-10. Epub 2010 Jun 30.


Performance of the Enferplex TB assay with cattle in Great Britain and assessment of its suitability as a test to distinguish infected and vaccinated animals.

Whelan C, Whelan AO, Shuralev E, Kwok HF, Hewinson G, Clarke J, Vordermeier HM.

Clin Vaccine Immunol. 2010 May;17(5):813-7. doi: 10.1128/CVI.00489-09. Epub 2010 Mar 10.


Bovine tuberculosis: effect of the tuberculin skin test on in vitro interferon gamma responses.

Schiller I, Vordermeier HM, Waters WR, Whelan AO, Coad M, Gormley E, Buddle BM, Palmer M, Thacker T, McNair J, Welsh M, Hewinson RG, Oesch B.

Vet Immunol Immunopathol. 2010 Jul;136(1-2):1-11. doi: 10.1016/j.vetimm.2010.02.007. Epub 2010 Feb 13. Review.


Revisiting host preference in the Mycobacterium tuberculosis complex: experimental infection shows M. tuberculosis H37Rv to be avirulent in cattle.

Whelan AO, Coad M, Cockle PJ, Hewinson G, Vordermeier M, Gordon SV.

PLoS One. 2010 Jan 1;5(1):e8527. doi: 10.1371/journal.pone.0008527.


Immune responses in cattle inoculated with Mycobacterium bovis, Mycobacterium tuberculosis, or Mycobacterium kansasii.

Waters WR, Whelan AO, Lyashchenko KP, Greenwald R, Palmer MV, Harris BN, Hewinson RG, Vordermeier HM.

Clin Vaccine Immunol. 2010 Feb;17(2):247-52. doi: 10.1128/CVI.00442-09. Epub 2009 Dec 9.


Repeat tuberculin skin testing leads to desensitisation in naturally infected tuberculous cattle which is associated with elevated interleukin-10 and decreased interleukin-1 beta responses.

Coad M, Clifford D, Rhodes SG, Hewinson RG, Vordermeier HM, Whelan AO.

Vet Res. 2010 Mar-Apr;41(2):14. doi: 10.1051/vetres/2009062. Epub 2009 Oct 20.


Isoniazid treatment of Mycobacterium bovis in cattle as a model for human tuberculosis.

Dean GS, Rhodes SG, Coad M, Whelan AO, Wheeler P, Villareal-Ramos B, Mead E, Johnson L, Clifford DJ, Hewinson RG, Vordermeier HM.

Tuberculosis (Edinb). 2008 Nov;88(6):586-94. doi: 10.1016/ Epub 2008 May 2.


Blood-based assays to detect Mycobacterium bovis-infected cattle missed by tuberculin skin testing.

Coad M, Downs SH, Durr PA, Clifton-Hadley RS, Hewinson RG, Vordermeier HM, Whelan AO.

Vet Rec. 2008 Mar 22;162(12):382-4. No abstract available.


Evidence for enhanced central memory priming by live Mycobacterium bovis BCG vaccine in comparison with killed BCG formulations.

Whelan AO, Wright DC, Chambers MA, Singh M, Hewinson RG, Vordermeier HM.

Vaccine. 2008 Jan 10;26(2):166-73. Epub 2007 Nov 26.


Influence of skin testing and blood storage on interferon-gamma production in cattle affected naturally with Mycobacterium bovis.

Coad M, Hewinson RG, Clifford D, Vordermeier HM, Whelan AO.

Vet Rec. 2007 May 12;160(19):660-2. No abstract available.


Is interleukin-4delta3 splice variant expression in bovine tuberculosis a marker of protective immunity?

Rhodes SG, Sawyer J, Whelan AO, Dean GS, Coad M, Ewer KJ, Waldvogel AS, Zakher A, Clifford DJ, Hewinson RG, Vordermeier HM.

Infect Immun. 2007 Jun;75(6):3006-13. Epub 2007 Mar 26.


Shedding of Mycobacterium bovis in the nasal mucus of cattle infected experimentally with tuberculosis by the intranasal and intratracheal routes.

McCorry T, Whelan AO, Welsh MD, McNair J, Walton E, Bryson DG, Hewinson RG, Vordermeier HM, Pollock JM.

Vet Rec. 2005 Nov 12;157(20):613-8. Erratum in: Vet Rec. 2005 Dec 24-31;157(26):849.


Minimum infective dose of Mycobacterium bovis in cattle.

Dean GS, Rhodes SG, Coad M, Whelan AO, Cockle PJ, Clifford DJ, Hewinson RG, Vordermeier HM.

Infect Immun. 2005 Oct;73(10):6467-71.


Influence of skin testing and overnight sample storage on blood-based diagnosis of bovine tuberculosis.

Whelan AO, Coad M, Peck ZA, Clifford D, Hewinson RG, Vordermeier HM.

Vet Rec. 2004 Aug 14;155(7):204-6. No abstract available.


Association of tuberculin-boosted antibody responses with pathology and cell-mediated immunity in cattle vaccinated with Mycobacterium bovis BCG and infected with M. bovis.

Lyashchenko K, Whelan AO, Greenwald R, Pollock JM, Andersen P, Hewinson RG, Vordermeier HM.

Infect Immun. 2004 May;72(5):2462-7.


Gamma interferon-based immunodiagnosis of tuberculosis: comparison between whole-blood and enzyme-linked immunospot methods.

Schölvinck E, Wilkinson KA, Whelan AO, Martineau AR, Levin M, Wilkinson RJ.

J Clin Microbiol. 2004 Feb;42(2):829-31.


Modulation of the bovine delayed-type hypersensitivity responses to defined mycobacterial antigens by a synthetic bacterial lipopeptide.

Whelan AO, Hope JC, Howard CJ, Clifford D, Hewinson RG, Vordermeier HM.

Infect Immun. 2003 Nov;71(11):6420-5.


Maturation of bovine dendritic cells by lipopeptides.

Hope JC, Whelan AO, Hewinson RG, Vordermeier M, Howard CJ.

Vet Immunol Immunopathol. 2003 Sep 15;95(1-2):21-31.


Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease.

Carr MD, Bloemink MJ, Dentten E, Whelan AO, Gordon SV, Kelly G, Frenkiel TA, Hewinson RG, Williamson RA.

J Biol Chem. 2003 Oct 31;278(44):43736-43. Epub 2003 Aug 12.


The MPB83 antigen from Mycobacterium bovis contains O-linked mannose and (1-->3)-mannobiose moieties.

Michell SL, Whelan AO, Wheeler PR, Panico M, Easton RL, Etienne AT, Haslam SM, Dell A, Morris HR, Reason AJ, Herrmann JL, Young DB, Hewinson RG.

J Biol Chem. 2003 May 2;278(18):16423-32. Epub 2003 Jan 6.


Generation of antibodies to the signal peptide of the MPT83 lipoprotein of Mycobacterium tuberculosis.

Harboe M, Whelan AO, Ulvund G, McNair J, Pollock JM, Hewinson RG, Wiker HG.

Scand J Immunol. 2002 Jan;55(1):82-7.


Effective DNA vaccination of cattle with the mycobacterial antigens MPB83 and MPB70 does not compromise the specificity of the comparative intradermal tuberculin skin test.

Vordermeier HM, Cockle PJ, Whelan AO, Rhodes S, Chambers MA, Clifford D, Huygen K, Tascon R, Lowrie D, Colston MJ, Hewinson RG.

Vaccine. 2000 Dec 8;19(9-10):1246-55.


Toward the development of diagnostic assays to discriminate between Mycobacterium bovis infection and bacille Calmette-Guérin vaccination in cattle.

Vordermeier HM, Cockle PJ, Whelan AO, Rhodes S, Hewinson RG.

Clin Infect Dis. 2000 Jun;30 Suppl 3:S291-8.


Antigen specificity in experimental bovine tuberculosis.

Rhodes SG, Gavier-Widen D, Buddle BM, Whelan AO, Singh M, Hewinson RG, Vordermeier HM.

Infect Immun. 2000 May;68(5):2573-8.

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