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Items: 1 to 50 of 122

1.

Exosomes and cells from lung cancer pleura exudates transform LTC4 to LTD4, promoting cell migration and survival via CysLT1.

Lukic A, Wahlund CJE, Gomez C, Brodin D, Samuelsson B, Wheelock CE, Gabrielsson S, Radmark O.

Cancer Lett. 2018 Nov 30. pii: S0304-3835(18)30699-2. doi: 10.1016/j.canlet.2018.11.033. [Epub ahead of print]

PMID:
30508568
2.

Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study.

Sjödin MOD, Checa A, Yang M, Dahlén SE, Wheelock ÅM, Eklund A, Grunewald J, Wheelock CE.

Respir Res. 2018 Dec 3;19(1):236. doi: 10.1186/s12931-018-0939-0.

3.

OnPLS-Based Multi-Block Data Integration: A Multivariate Approach to Interrogating Biological Interactions in Asthma.

Reinke SN, Galindo-Prieto B, Skotare T, Broadhurst DI, Singhania A, Horowitz D, Djukanović R, Hinks TSC, Geladi P, Trygg J, Wheelock CE.

Anal Chem. 2018 Nov 20;90(22):13400-13408. doi: 10.1021/acs.analchem.8b03205. Epub 2018 Nov 2.

4.

The influence of culture media upon observed cell secretome metabolite profiles: The balance between cell viability and data interpretability.

Daskalaki E, Pillon NJ, Krook A, Wheelock CE, Checa A.

Anal Chim Acta. 2018 Dec 11;1037:338-350. doi: 10.1016/j.aca.2018.04.034. Epub 2018 Apr 18.

PMID:
30292310
5.

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort.

Emma R, Bansal AT, Kolmert J, Wheelock CE, Dahlen SE, Loza MJ, De Meulder B, Lefaudeux D, Auffray C, Dahlen B, Bakke PS, Chanez P, Fowler SJ, Horvath I, Montuschi P, Krug N, Sanak M, Sandstrom T, Shaw DE, Fleming LJ, Djukanovic R, Howarth PH, Singer F, Sousa AR, Sterk PJ, Corfield J, Pandis I, Chung KF, Adcock IM, Lutter R, Fabbella L, Caruso M; U-BIOPRED Study Group.

PLoS One. 2018 Sep 21;13(9):e0203874. doi: 10.1371/journal.pone.0203874. eCollection 2018.

6.

Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment.

Dyczynski M, Vesterlund M, Björklund AC, Zachariadis V, Janssen J, Gallart-Ayala H, Daskalaki E, Wheelock CE, Lehtiö J, Grandér D, Tamm KP, Nilsson R.

Cell Death Dis. 2018 Aug 28;9(9):846. doi: 10.1038/s41419-018-0625-7.

7.

Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy.

Mahdi A, Kövamees O, Checa A, Wheelock CE, von Heijne M, Alvarsson M, Pernow J.

J Intern Med. 2018 Oct;284(4):388-398. doi: 10.1111/joim.12785. Epub 2018 Aug 27.

PMID:
30151846
8.

Challenges, progress and promises of metabolite annotation for LC-MS-based metabolomics.

Chaleckis R, Meister I, Zhang P, Wheelock CE.

Curr Opin Biotechnol. 2018 Aug 20;55:44-50. doi: 10.1016/j.copbio.2018.07.010. [Epub ahead of print] Review.

PMID:
30138778
9.

AsthmaMap: An expert-driven computational representation of disease mechanisms.

Mazein A, Knowles RG, Adcock I, Chung KF, Wheelock CE, Maitland-van der Zee AH, Sterk PJ, Auffray C; AsthmaMap Project Team.

Clin Exp Allergy. 2018 Aug;48(8):916-918. doi: 10.1111/cea.13211. No abstract available.

PMID:
30133857
10.

MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines.

Burla B, Arita M, Arita M, Bendt AK, Cazenave-Gassiot A, Dennis EA, Ekroos K, Han X, Ikeda K, Liebisch G, Lin MK, Loh TP, Meikle PJ, Orešič M, Quehenberger O, Shevchenko A, Torta F, Wakelam MJO, Wheelock CE, Wenk MR.

J Lipid Res. 2018 Oct;59(10):2001-2017. doi: 10.1194/jlr.S087163. Epub 2018 Aug 16.

11.

An LC-MS/MS workflow to characterize 16 regio- and stereoisomeric trihydroxyoctadecenoic acids.

Fuchs D, Hamberg M, Sköld CM, Wheelock ÅM, Wheelock CE.

J Lipid Res. 2018 Oct;59(10):2025-2033. doi: 10.1194/jlr.D087429. Epub 2018 Jul 31.

PMID:
30065010
12.

Lipid Mediator Quantification in Isolated Human and Guinea Pig Airways: An Expanded Approach for Respiratory Research.

Kolmert J, Fauland A, Fuchs D, Säfholm J, Gómez C, Adner M, Dahlén SE, Wheelock CE.

Anal Chem. 2018 Sep 4;90(17):10239-10248. doi: 10.1021/acs.analchem.8b01651. Epub 2018 Aug 20.

PMID:
30056696
13.

Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model.

Kolmert J, Piñeiro-Hermida S, Hamberg M, Gregory JA, López IP, Fauland A, Wheelock CE, Dahlén SE, Pichel JG, Adner M.

Prostaglandins Other Lipid Mediat. 2018 Jul;137:20-29. doi: 10.1016/j.prostaglandins.2018.05.005. Epub 2018 May 12.

PMID:
29763661
14.

ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages.

Laguna-Fernandez A, Checa A, Carracedo M, Artiach G, Petri MH, Baumgartner R, Forteza MJ, Jiang X, Andonova T, Walker ME, Dalli J, Arnardottir H, Gisterå A, Thul S, Wheelock CE, Paulsson-Berne G, Ketelhuth DFJ, Hansson GK, Bäck M.

Circulation. 2018 Oct 16;138(16):1693-1705. doi: 10.1161/CIRCULATIONAHA.117.032801.

15.

Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients.

Checa A, Malmqvist A, Flyckt L, Schwieler L, Samuelsson M, Skogh E, Cervenka S, Dahl ML, Piehl F; Karolinska Schizophrenia Project (KaSP) Consortium, Erhardt S, Wheelock CE.

Schizophr Res. 2018 Sep;199:438-441. doi: 10.1016/j.schres.2018.03.029. Epub 2018 Apr 4. No abstract available.

PMID:
29627172
16.

Integration of multi-omics datasets enables molecular classification of COPD.

Li CX, Wheelock CE, Sköld CM, Wheelock ÅM.

Eur Respir J. 2018 May 10;51(5). pii: 1701930. doi: 10.1183/13993003.01930-2017. Print 2018 May.

PMID:
29545283
17.

Leukotriene E4 induces airflow obstruction and mast cell activation through the cysteinyl leukotriene type 1 receptor.

Lazarinis N, Bood J, Gomez C, Kolmert J, Lantz AS, Gyllfors P, Davis A, Wheelock CE, Dahlén SE, Dahlén B.

J Allergy Clin Immunol. 2018 Oct;142(4):1080-1089. doi: 10.1016/j.jaci.2018.02.024. Epub 2018 Mar 5.

PMID:
29518425
18.

LC-MS-Based Metabolomics of Biofluids Using All-Ion Fragmentation (AIF) Acquisition.

Chaleckis R, Naz S, Meister I, Wheelock CE.

Methods Mol Biol. 2018;1730:45-58. doi: 10.1007/978-1-4939-7592-1_3.

PMID:
29363064
19.

Different Lipid Regulation in Ovarian Cancer: Inhibition of the Immune System.

Wefers C, Duiveman-de Boer T, Zusterzeel PLM, Massuger LFAG, Fuchs D, Torensma R, Wheelock CE, de Vries IJM.

Int J Mol Sci. 2018 Jan 17;19(1). pii: E273. doi: 10.3390/ijms19010273.

20.

Increased Levels of Circulating Fatty Acids Are Associated with Protective Effects against Future Cardiovascular Events in Nondiabetics.

Kamleh MA, McLeod O, Checa A, Baldassarre D, Veglia F, Gertow K, Humphries SE, Rauramaa R, de Faire U, Smit AJ, Giral P, Kurl S, Mannarino E, Tremoli E, Silveira A, Örvik J, Hamsten A, Wheelock CE.

J Proteome Res. 2018 Feb 2;17(2):870-878. doi: 10.1021/acs.jproteome.7b00671. Epub 2018 Jan 22.

PMID:
29235871
21.

Aronia-citrus juice (polyphenol-rich juice) intake and elite triathlon training: a lipidomic approach using representative oxylipins in urine.

García-Flores LA, Medina S, Gómez C, Wheelock CE, Cejuela R, Martínez-Sanz JM, Oger C, Galano JM, Durand T, Hernández-Sáez Á, Ferreres F, Gil-Izquierdo Á.

Food Funct. 2018 Jan 24;9(1):463-475. doi: 10.1039/c7fo01409k.

PMID:
29231216
22.

Changes in arterial pressure and markers of nitric oxide homeostasis and oxidative stress following surgical correction of hydronephrosis in children.

Al-Mashhadi A, Checa A, Wåhlin N, Neveus T, Fossum M, Wheelock CE, Karanikas B, Stenberg A, Persson AEG, Carlstrom M.

Pediatr Nephrol. 2018 Apr;33(4):639-649. doi: 10.1007/s00467-017-3848-4. Epub 2017 Dec 1.

23.

Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance.

Petrus P, Bialesova L, Checa A, Kerr A, Naz S, Bäckdahl J, Gracia A, Toft S, Dahlman-Wright K, Hedén P, Dahlman I, Wheelock CE, Arner P, Mejhert N, Gao H, Rydén M.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):710-721. doi: 10.1210/jc.2017-01382.

PMID:
29121255
24.

Deciphering lipid structures based on platform-independent decision rules.

Hartler J, Triebl A, Ziegl A, Trötzmüller M, Rechberger GN, Zeleznik OA, Zierler KA, Torta F, Cazenave-Gassiot A, Wenk MR, Fauland A, Wheelock CE, Armando AM, Quehenberger O, Zhang Q, Wakelam MJO, Haemmerle G, Spener F, Köfeler HC, Thallinger GG.

Nat Methods. 2017 Dec;14(12):1171-1174. doi: 10.1038/nmeth.4470. Epub 2017 Oct 23.

25.

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S.

J Lipid Res. 2017 Dec;58(12):2275-2288. doi: 10.1194/jlr.M079012. Epub 2017 Oct 6.

26.

The Eicosanoids, Redox-Regulated Lipid Mediators in Immunometabolic Disorders.

Araújo AC, Wheelock CE, Haeggström JZ.

Antioxid Redox Signal. 2018 Jul 20;29(3):275-296. doi: 10.1089/ars.2017.7332. Epub 2017 Dec 11.

PMID:
28978222
27.

Kynurenine aminotransferase activity of Aro8/Aro9 engage tryptophan degradation by producing kynurenic acid in Saccharomyces cerevisiae.

Ohashi K, Chaleckis R, Takaine M, Wheelock CE, Yoshida S.

Sci Rep. 2017 Sep 22;7(1):12180. doi: 10.1038/s41598-017-12392-6.

28.

Renal denervation attenuates hypertension and renal dysfunction in a model of cardiovascular and renal disease, which is associated with reduced NADPH and xanthine oxidase activity.

Peleli M, Flacker P, Zhuge Z, Gomez C, Wheelock CE, Persson AEG, Carlstrom M.

Redox Biol. 2017 Oct;13:522-527. doi: 10.1016/j.redox.2017.06.013. Epub 2017 Jul 5.

29.

Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD.

Naz S, Kolmert J, Yang M, Reinke SN, Kamleh MA, Snowden S, Heyder T, Levänen B, Erle DJ, Sköld CM, Wheelock ÅM, Wheelock CE.

Eur Respir J. 2017 Jun 22;49(6). pii: 1602322. doi: 10.1183/13993003.02322-2016. Print 2017 Jun.

30.

Development of a Liquid Chromatography-High Resolution Mass Spectrometry Metabolomics Method with High Specificity for Metabolite Identification Using All Ion Fragmentation Acquisition.

Naz S, Gallart-Ayala H, Reinke SN, Mathon C, Blankley R, Chaleckis R, Wheelock CE.

Anal Chem. 2017 Aug 1;89(15):7933-7942. doi: 10.1021/acs.analchem.7b00925. Epub 2017 Jul 12.

31.

GM-CSF- and M-CSF-primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures.

Lukic A, Larssen P, Fauland A, Samuelsson B, Wheelock CE, Gabrielsson S, Radmark O.

FASEB J. 2017 Oct;31(10):4370-4381. doi: 10.1096/fj.201700319R. Epub 2017 Jun 21.

PMID:
28637652
32.

Peri-ovulatory endocrine regulation of the prostanoid pathways in the bovine uterus at early dioestrus.

Oliveira ML, D'Alexandri FL, Pugliesi G, Van Hoeck V, Mesquita FS, Membrive CMB, Negrão JA, Wheelock CE, Binelli M.

Reprod Fertil Dev. 2017 Mar;29(3):544-556. doi: 10.1071/RD15269.

PMID:
28442063
33.

Metabolomics analysis identifies different metabotypes of asthma severity.

Reinke SN, Gallart-Ayala H, Gómez C, Checa A, Fauland A, Naz S, Kamleh MA, Djukanović R, Hinks TS, Wheelock CE.

Eur Respir J. 2017 Mar 29;49(3). pii: 1601740. doi: 10.1183/13993003.01740-2016. Print 2017 Mar.

34.

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing.

Roci I, Gallart-Ayala H, Watrous J, Jain M, Wheelock CE, Nilsson R.

J Vis Exp. 2017 Feb 4;(120). doi: 10.3791/55011.

PMID:
28190056
35.

Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study.

Checa A, Idborg H, Zandian A, Sar DG, Surowiec I, Trygg J, Svenungsson E, Jakobsson PJ, Nilsson P, Gunnarsson I, Wheelock CE.

Lupus. 2017 Sep;26(10):1023-1033. doi: 10.1177/0961203316686707. Epub 2017 Jan 29.

PMID:
28134039
36.

Aspirin-triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E-/- mice.

Petri MH, Laguna-Fernandez A, Arnardottir H, Wheelock CE, Perretti M, Hansson GK, Bäck M.

Br J Pharmacol. 2017 Nov;174(22):4043-4054. doi: 10.1111/bph.13707. Epub 2017 Feb 14.

37.

New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia.

González-Peña D, Checa A, de Ancos B, Wheelock CE, Sánchez-Moreno C.

Redox Biol. 2017 Apr;11:205-212. doi: 10.1016/j.redox.2016.12.002. Epub 2016 Dec 9.

38.

Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus.

Kövamees O, Shemyakin A, Checa A, Wheelock CE, Lundberg JO, Östenson CG, Pernow J.

J Clin Endocrinol Metab. 2016 Nov;101(11):3952-3958. Epub 2016 Jul 11.

PMID:
27399350
39.

Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation.

Hezel M, Peleli M, Liu M, Zollbrecht C, Jensen BL, Checa A, Giulietti A, Wheelock CE, Lundberg JO, Weitzberg E, Carlström M.

Free Radic Biol Med. 2016 Oct;99:87-98. doi: 10.1016/j.freeradbiomed.2016.07.025. Epub 2016 Jul 26.

PMID:
27474450
40.

Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.

Paquin-Proulx D, Gibbs A, Bächle SM, Checa A, Introini A, Leeansyah E, Wheelock CE, Nixon DF, Broliden K, Tjernlund A, Moll M, Sandberg JK.

J Immunol. 2016 Sep 1;197(5):1843-51. doi: 10.4049/jimmunol.1600556. Epub 2016 Aug 1.

41.

Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension.

Yang T, Zollbrecht C, Winerdal ME, Zhuge Z, Zhang XM, Terrando N, Checa A, Sällström J, Wheelock CE, Winqvist O, Harris RA, Larsson E, Persson AE, Fredholm BB, Carlström M.

J Am Heart Assoc. 2016 Jul 18;5(7). pii: e003868. doi: 10.1161/JAHA.116.003868.

42.

Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia.

Carlström M, Cananau C, Checa A, Wide K, Sartz L, Svensson A, Wheelock CE, Westphal S, Békássy Z, Bárány P, Lundberg JO, Hansson S, Weitzberg E, Krmar RT.

Nitric Oxide. 2016 Aug 31;58:1-9. doi: 10.1016/j.niox.2016.05.005. Epub 2016 May 24.

PMID:
27234508
43.

Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.

Balgoma D, Yang M, Sjödin M, Snowden S, Karimi R, Levänen B, Merikallio H, Kaarteenaho R, Palmberg L, Larsson K, Erle DJ, Dahlén SE, Dahlén B, Sköld CM, Wheelock ÅM, Wheelock CE.

Eur Respir J. 2016 Jun;47(6):1645-56. doi: 10.1183/13993003.01080-2015. Epub 2016 Mar 10.

44.

Metabolite Profiling and Stable Isotope Tracing in Sorted Subpopulations of Mammalian Cells.

Roci I, Gallart-Ayala H, Schmidt A, Watrous J, Jain M, Wheelock CE, Nilsson R.

Anal Chem. 2016 Mar 1;88(5):2707-13. doi: 10.1021/acs.analchem.5b04071. Epub 2016 Feb 17.

PMID:
26855138
45.

Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen-induced pulmonary inflammation in mice.

Frei RB, Luschnig P, Parzmair GP, Peinhaupt M, Schranz S, Fauland A, Wheelock CE, Heinemann A, Sturm EM.

Allergy. 2016 Jul;71(7):944-56. doi: 10.1111/all.12858. Epub 2016 Mar 16.

46.

Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung.

Jandl K, Stacher E, Bálint Z, Sturm EM, Maric J, Peinhaupt M, Luschnig P, Aringer I, Fauland A, Konya V, Dahlen SE, Wheelock CE, Kratky D, Olschewski A, Marsche G, Schuligoi R, Heinemann A.

J Allergy Clin Immunol. 2016 Mar;137(3):833-43. doi: 10.1016/j.jaci.2015.11.012. Epub 2016 Jan 12.

47.

Gene expression signatures, pathways and networks in carotid atherosclerosis.

Perisic L, Aldi S, Sun Y, Folkersen L, Razuvaev A, Roy J, Lengquist M, Åkesson S, Wheelock CE, Maegdefessel L, Gabrielsen A, Odeberg J, Hansson GK, Paulsson-Berne G, Hedin U.

J Intern Med. 2016 Mar;279(3):293-308. doi: 10.1111/joim.12448. Epub 2015 Nov 30.

48.

Lipid mediator profile in vernix caseosa reflects skin barrier development.

Checa A, Holm T, Sjödin MO, Reinke SN, Alm J, Scheynius A, Wheelock CE.

Sci Rep. 2015 Nov 2;5:15740. doi: 10.1038/srep15740.

49.

Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment.

Checa A, Xu N, Sar DG, Haeggström JZ, Ståhle M, Wheelock CE.

Sci Rep. 2015 Jul 15;5:12017. doi: 10.1038/srep12017.

50.

Urinary excretion of lipid mediators in response to repeated eucapnic voluntary hyperpnea in asthmatic subjects.

Bood JR, Sundblad BM, Delin I, Sjödin M, Larsson K, Anderson SD, Wheelock CE, Dahlén SE, Dahlén B.

J Appl Physiol (1985). 2015 Aug 1;119(3):272-9. doi: 10.1152/japplphysiol.00301.2015. Epub 2015 Jun 25.

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