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Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes.

Carlström KE, Ewing E, Granqvist M, Gyllenberg A, Aeinehband S, Enoksson SL, Checa A, Badam TVS, Huang J, Gomez-Cabrero D, Gustafsson M, Al Nimer F, Wheelock CE, Kockum I, Olsson T, Jagodic M, Piehl F.

Nat Commun. 2019 Jul 12;10(1):3081. doi: 10.1038/s41467-019-11139-3.


Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells.

Bergqvist F, Ossipova E, Idborg H, Raouf J, Checa A, Englund K, Englund P, Khoonsari PE, Kultima K, Wheelock CE, Larsson K, Korotkova M, Jakobsson PJ.

Front Pharmacol. 2019 Jun 7;10:636. doi: 10.3389/fphar.2019.00636. eCollection 2019.


Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective.

Chu SH, Huang M, Kelly RS, Benedetti E, Siddiqui JK, Zeleznik OA, Pereira A, Herrington D, Wheelock CE, Krumsiek J, McGeachie M, Moore SC, Kraft P, Mathé E, Lasky-Su J; Consortium of Metabolomics Studies Statistics Working Group.

Metabolites. 2019 Jun 18;9(6). pii: E117. doi: 10.3390/metabo9060117. Review.


Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium.

Zhang P, Arora M, Chaleckis R, Isobe T, Jain M, Meister I, Melén E, Perzanowski M, Torta F, Wenk MR, Wheelock CE.

Metabolites. 2019 Jun 6;9(6). pii: E106. doi: 10.3390/metabo9060106.


Effect of Spironolactone for One Year on Endothelial Function and Vascular Inflammation Biomarkers in Renal Transplant Recipients.

Mortensen LA, Bistrup C, Stubbe J, Carlström M, Checa A, Wheelock CE, Palarasah Y, Bladbjerg EM, Thiesson HC, Jensen BL.

Am J Physiol Renal Physiol. 2019 Jun 5. doi: 10.1152/ajprenal.00025.2019. [Epub ahead of print]


Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.

Idborg H, Zandian A, Ossipova E, Wigren E, Preger C, Mobarrez F, Checa A, Sohrabian A, Pucholt P, Sandling JK, Fernandes-Cerqueira C, Rönnelid J, Oke V, Grosso G, Kvarnström M, Larsson A, Wheelock CE, Syvänen AC, Rönnblom L, Kultima K, Persson H, Gräslund S, Gunnarsson I, Nilsson P, Svenungsson E, Jakobsson PJ.

Front Immunol. 2019 May 17;10:1029. doi: 10.3389/fimmu.2019.01029. eCollection 2019.


Metabolomics of neonatal blood spots reveal distinct phenotypes of pediatric acute lymphoblastic leukemia and potential effects of early-life nutrition.

Petrick LM, Schiffman C, Edmands WMB, Yano Y, Perttula K, Whitehead T, Metayer C, Wheelock CE, Arora M, Grigoryan H, Carlsson H, Dudoit S, Rappaport SM.

Cancer Lett. 2019 Jun 28;452:71-78. doi: 10.1016/j.canlet.2019.03.007. Epub 2019 Mar 20.


Quantitative metabolic profiling of urinary eicosanoids for clinical phenotyping.

Gómez C, Gonzalez-Riano C, Barbas C, Kolmert J, Hyung Ryu M, Carlsten C, Dahlén SE, Wheelock CE.

J Lipid Res. 2019 Jun;60(6):1164-1173. doi: 10.1194/jlr.D090571. Epub 2019 Mar 6.


Effect of psychiatric drugs on Daphnia magna oxylipin profiles.

Garreta-Lara E, Checa A, Fuchs D, Tauler R, Lacorte S, Wheelock CE, Barata C.

Sci Total Environ. 2018 Dec 10;644:1101-1109. doi: 10.1016/j.scitotenv.2018.06.333. Epub 2018 Jul 11.


Inflammatory response to dietary linoleic acid depends on FADS1 genotype.

Lankinen MA, Fauland A, Shimizu BI, Ågren J, Wheelock CE, Laakso M, Schwab U, Pihlajamäki J.

Am J Clin Nutr. 2019 Jan 1;109(1):165-175. doi: 10.1093/ajcn/nqy287.


Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation.

Maric J, Ravindran A, Mazzurana L, Van Acker A, Rao A, Kokkinou E, Ekoff M, Thomas D, Fauland A, Nilsson G, Wheelock CE, Dahlén SE, Ferreirós N, Geisslinger G, Friberg D, Heinemann A, Konya V, Mjösberg J.

J Allergy Clin Immunol. 2019 Jun;143(6):2202-2214.e5. doi: 10.1016/j.jaci.2018.10.069. Epub 2018 Dec 19.


Exosomes and cells from lung cancer pleural exudates transform LTC4 to LTD4, promoting cell migration and survival via CysLT1.

Lukic A, Wahlund CJE, Gómez C, Brodin D, Samuelsson B, Wheelock CE, Gabrielsson S, Rådmark O.

Cancer Lett. 2019 Mar 1;444:1-8. doi: 10.1016/j.canlet.2018.11.033. Epub 2018 Dec 1.


Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study.

Sjödin MOD, Checa A, Yang M, Dahlén SE, Wheelock ÅM, Eklund A, Grunewald J, Wheelock CE.

Respir Res. 2018 Dec 3;19(1):236. doi: 10.1186/s12931-018-0939-0.


OnPLS-Based Multi-Block Data Integration: A Multivariate Approach to Interrogating Biological Interactions in Asthma.

Reinke SN, Galindo-Prieto B, Skotare T, Broadhurst DI, Singhania A, Horowitz D, Djukanović R, Hinks TSC, Geladi P, Trygg J, Wheelock CE.

Anal Chem. 2018 Nov 20;90(22):13400-13408. doi: 10.1021/acs.analchem.8b03205. Epub 2018 Nov 2.


The influence of culture media upon observed cell secretome metabolite profiles: The balance between cell viability and data interpretability.

Daskalaki E, Pillon NJ, Krook A, Wheelock CE, Checa A.

Anal Chim Acta. 2018 Dec 11;1037:338-350. doi: 10.1016/j.aca.2018.04.034. Epub 2018 Apr 18.


Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort.

Emma R, Bansal AT, Kolmert J, Wheelock CE, Dahlen SE, Loza MJ, De Meulder B, Lefaudeux D, Auffray C, Dahlen B, Bakke PS, Chanez P, Fowler SJ, Horvath I, Montuschi P, Krug N, Sanak M, Sandstrom T, Shaw DE, Fleming LJ, Djukanovic R, Howarth PH, Singer F, Sousa AR, Sterk PJ, Corfield J, Pandis I, Chung KF, Adcock IM, Lutter R, Fabbella L, Caruso M; U-BIOPRED Study Group.

PLoS One. 2018 Sep 21;13(9):e0203874. doi: 10.1371/journal.pone.0203874. eCollection 2018.


Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment.

Dyczynski M, Vesterlund M, Björklund AC, Zachariadis V, Janssen J, Gallart-Ayala H, Daskalaki E, Wheelock CE, Lehtiö J, Grandér D, Tamm KP, Nilsson R.

Cell Death Dis. 2018 Aug 28;9(9):846. doi: 10.1038/s41419-018-0625-7.


Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy.

Mahdi A, Kövamees O, Checa A, Wheelock CE, von Heijne M, Alvarsson M, Pernow J.

J Intern Med. 2018 Oct;284(4):388-398. doi: 10.1111/joim.12785. Epub 2018 Aug 27.


Challenges, progress and promises of metabolite annotation for LC-MS-based metabolomics.

Chaleckis R, Meister I, Zhang P, Wheelock CE.

Curr Opin Biotechnol. 2019 Feb;55:44-50. doi: 10.1016/j.copbio.2018.07.010. Epub 2018 Aug 20. Review.


AsthmaMap: An expert-driven computational representation of disease mechanisms.

Mazein A, Knowles RG, Adcock I, Chung KF, Wheelock CE, Maitland-van der Zee AH, Sterk PJ, Auffray C; AsthmaMap Project Team.

Clin Exp Allergy. 2018 Aug;48(8):916-918. doi: 10.1111/cea.13211. No abstract available.


MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines.

Burla B, Arita M, Arita M, Bendt AK, Cazenave-Gassiot A, Dennis EA, Ekroos K, Han X, Ikeda K, Liebisch G, Lin MK, Loh TP, Meikle PJ, Orešič M, Quehenberger O, Shevchenko A, Torta F, Wakelam MJO, Wheelock CE, Wenk MR.

J Lipid Res. 2018 Oct;59(10):2001-2017. doi: 10.1194/jlr.S087163. Epub 2018 Aug 16.


An LC-MS/MS workflow to characterize 16 regio- and stereoisomeric trihydroxyoctadecenoic acids.

Fuchs D, Hamberg M, Sköld CM, Wheelock ÅM, Wheelock CE.

J Lipid Res. 2018 Oct;59(10):2025-2033. doi: 10.1194/jlr.D087429. Epub 2018 Jul 31.


Lipid Mediator Quantification in Isolated Human and Guinea Pig Airways: An Expanded Approach for Respiratory Research.

Kolmert J, Fauland A, Fuchs D, Säfholm J, Gómez C, Adner M, Dahlén SE, Wheelock CE.

Anal Chem. 2018 Sep 4;90(17):10239-10248. doi: 10.1021/acs.analchem.8b01651. Epub 2018 Aug 20.


Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model.

Kolmert J, Piñeiro-Hermida S, Hamberg M, Gregory JA, López IP, Fauland A, Wheelock CE, Dahlén SE, Pichel JG, Adner M.

Prostaglandins Other Lipid Mediat. 2018 Jul;137:20-29. doi: 10.1016/j.prostaglandins.2018.05.005. Epub 2018 May 12.


ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages.

Laguna-Fernandez A, Checa A, Carracedo M, Artiach G, Petri MH, Baumgartner R, Forteza MJ, Jiang X, Andonova T, Walker ME, Dalli J, Arnardottir H, Gisterå A, Thul S, Wheelock CE, Paulsson-Berne G, Ketelhuth DFJ, Hansson GK, Bäck M.

Circulation. 2018 Oct 16;138(16):1693-1705. doi: 10.1161/CIRCULATIONAHA.117.032801.


Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients.

Checa A, Malmqvist A, Flyckt L, Schwieler L, Samuelsson M, Skogh E, Cervenka S, Dahl ML, Piehl F; Karolinska Schizophrenia Project (KaSP) Consortium, Erhardt S, Wheelock CE.

Schizophr Res. 2018 Sep;199:438-441. doi: 10.1016/j.schres.2018.03.029. Epub 2018 Apr 4. No abstract available.


Integration of multi-omics datasets enables molecular classification of COPD.

Li CX, Wheelock CE, Sköld CM, Wheelock ÅM.

Eur Respir J. 2018 May 10;51(5). pii: 1701930. doi: 10.1183/13993003.01930-2017. Print 2018 May.


Leukotriene E4 induces airflow obstruction and mast cell activation through the cysteinyl leukotriene type 1 receptor.

Lazarinis N, Bood J, Gomez C, Kolmert J, Lantz AS, Gyllfors P, Davis A, Wheelock CE, Dahlén SE, Dahlén B.

J Allergy Clin Immunol. 2018 Oct;142(4):1080-1089. doi: 10.1016/j.jaci.2018.02.024. Epub 2018 Mar 5.


LC-MS-Based Metabolomics of Biofluids Using All-Ion Fragmentation (AIF) Acquisition.

Chaleckis R, Naz S, Meister I, Wheelock CE.

Methods Mol Biol. 2018;1730:45-58. doi: 10.1007/978-1-4939-7592-1_3.


Different Lipid Regulation in Ovarian Cancer: Inhibition of the Immune System.

Wefers C, Duiveman-de Boer T, Zusterzeel PLM, Massuger LFAG, Fuchs D, Torensma R, Wheelock CE, de Vries IJM.

Int J Mol Sci. 2018 Jan 17;19(1). pii: E273. doi: 10.3390/ijms19010273.


Increased Levels of Circulating Fatty Acids Are Associated with Protective Effects against Future Cardiovascular Events in Nondiabetics.

Kamleh MA, McLeod O, Checa A, Baldassarre D, Veglia F, Gertow K, Humphries SE, Rauramaa R, de Faire U, Smit AJ, Giral P, Kurl S, Mannarino E, Tremoli E, Silveira A, Örvik J, Hamsten A, Wheelock CE.

J Proteome Res. 2018 Feb 2;17(2):870-878. doi: 10.1021/acs.jproteome.7b00671. Epub 2018 Jan 22.


Aronia-citrus juice (polyphenol-rich juice) intake and elite triathlon training: a lipidomic approach using representative oxylipins in urine.

García-Flores LA, Medina S, Gómez C, Wheelock CE, Cejuela R, Martínez-Sanz JM, Oger C, Galano JM, Durand T, Hernández-Sáez Á, Ferreres F, Gil-Izquierdo Á.

Food Funct. 2018 Jan 24;9(1):463-475. doi: 10.1039/c7fo01409k.


Changes in arterial pressure and markers of nitric oxide homeostasis and oxidative stress following surgical correction of hydronephrosis in children.

Al-Mashhadi A, Checa A, Wåhlin N, Neveus T, Fossum M, Wheelock CE, Karanikas B, Stenberg A, Persson AEG, Carlstrom M.

Pediatr Nephrol. 2018 Apr;33(4):639-649. doi: 10.1007/s00467-017-3848-4. Epub 2017 Dec 1.


Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance.

Petrus P, Bialesova L, Checa A, Kerr A, Naz S, Bäckdahl J, Gracia A, Toft S, Dahlman-Wright K, Hedén P, Dahlman I, Wheelock CE, Arner P, Mejhert N, Gao H, Rydén M.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):710-721. doi: 10.1210/jc.2017-01382.


Deciphering lipid structures based on platform-independent decision rules.

Hartler J, Triebl A, Ziegl A, Trötzmüller M, Rechberger GN, Zeleznik OA, Zierler KA, Torta F, Cazenave-Gassiot A, Wenk MR, Fauland A, Wheelock CE, Armando AM, Quehenberger O, Zhang Q, Wakelam MJO, Haemmerle G, Spener F, Köfeler HC, Thallinger GG.

Nat Methods. 2017 Dec;14(12):1171-1174. doi: 10.1038/nmeth.4470. Epub 2017 Oct 23.


Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S.

J Lipid Res. 2017 Dec;58(12):2275-2288. doi: 10.1194/jlr.M079012. Epub 2017 Oct 6.


The Eicosanoids, Redox-Regulated Lipid Mediators in Immunometabolic Disorders.

Araújo AC, Wheelock CE, Haeggström JZ.

Antioxid Redox Signal. 2018 Jul 20;29(3):275-296. doi: 10.1089/ars.2017.7332. Epub 2017 Dec 11.


Kynurenine aminotransferase activity of Aro8/Aro9 engage tryptophan degradation by producing kynurenic acid in Saccharomyces cerevisiae.

Ohashi K, Chaleckis R, Takaine M, Wheelock CE, Yoshida S.

Sci Rep. 2017 Sep 22;7(1):12180. doi: 10.1038/s41598-017-12392-6.


Renal denervation attenuates hypertension and renal dysfunction in a model of cardiovascular and renal disease, which is associated with reduced NADPH and xanthine oxidase activity.

Peleli M, Flacker P, Zhuge Z, Gomez C, Wheelock CE, Persson AEG, Carlstrom M.

Redox Biol. 2017 Oct;13:522-527. doi: 10.1016/j.redox.2017.06.013. Epub 2017 Jul 5.


Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD.

Naz S, Kolmert J, Yang M, Reinke SN, Kamleh MA, Snowden S, Heyder T, Levänen B, Erle DJ, Sköld CM, Wheelock ÅM, Wheelock CE.

Eur Respir J. 2017 Jun 22;49(6). pii: 1602322. doi: 10.1183/13993003.02322-2016. Print 2017 Jun.


Development of a Liquid Chromatography-High Resolution Mass Spectrometry Metabolomics Method with High Specificity for Metabolite Identification Using All Ion Fragmentation Acquisition.

Naz S, Gallart-Ayala H, Reinke SN, Mathon C, Blankley R, Chaleckis R, Wheelock CE.

Anal Chem. 2017 Aug 1;89(15):7933-7942. doi: 10.1021/acs.analchem.7b00925. Epub 2017 Jul 12.


GM-CSF- and M-CSF-primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures.

Lukic A, Larssen P, Fauland A, Samuelsson B, Wheelock CE, Gabrielsson S, Radmark O.

FASEB J. 2017 Oct;31(10):4370-4381. doi: 10.1096/fj.201700319R. Epub 2017 Jun 21.


Peri-ovulatory endocrine regulation of the prostanoid pathways in the bovine uterus at early dioestrus.

Oliveira ML, D'Alexandri FL, Pugliesi G, Van Hoeck V, Mesquita FS, Membrive CMB, Negrão JA, Wheelock CE, Binelli M.

Reprod Fertil Dev. 2017 Mar;29(3):544-556. doi: 10.1071/RD15269.


Metabolomics analysis identifies different metabotypes of asthma severity.

Reinke SN, Gallart-Ayala H, Gómez C, Checa A, Fauland A, Naz S, Kamleh MA, Djukanović R, Hinks TS, Wheelock CE.

Eur Respir J. 2017 Mar 29;49(3). pii: 1601740. doi: 10.1183/13993003.01740-2016. Print 2017 Mar.


A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing.

Roci I, Gallart-Ayala H, Watrous J, Jain M, Wheelock CE, Nilsson R.

J Vis Exp. 2017 Feb 4;(120). doi: 10.3791/55011.


Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study.

Checa A, Idborg H, Zandian A, Sar DG, Surowiec I, Trygg J, Svenungsson E, Jakobsson PJ, Nilsson P, Gunnarsson I, Wheelock CE.

Lupus. 2017 Sep;26(10):1023-1033. doi: 10.1177/0961203316686707. Epub 2017 Jan 29.


Aspirin-triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E-/- mice.

Petri MH, Laguna-Fernandez A, Arnardottir H, Wheelock CE, Perretti M, Hansson GK, Bäck M.

Br J Pharmacol. 2017 Nov;174(22):4043-4054. doi: 10.1111/bph.13707. Epub 2017 Feb 14.


New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia.

González-Peña D, Checa A, de Ancos B, Wheelock CE, Sánchez-Moreno C.

Redox Biol. 2017 Apr;11:205-212. doi: 10.1016/j.redox.2016.12.002. Epub 2016 Dec 9.


Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus.

Kövamees O, Shemyakin A, Checa A, Wheelock CE, Lundberg JO, Östenson CG, Pernow J.

J Clin Endocrinol Metab. 2016 Nov;101(11):3952-3958. Epub 2016 Jul 11.


Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation.

Hezel M, Peleli M, Liu M, Zollbrecht C, Jensen BL, Checa A, Giulietti A, Wheelock CE, Lundberg JO, Weitzberg E, Carlström M.

Free Radic Biol Med. 2016 Oct;99:87-98. doi: 10.1016/j.freeradbiomed.2016.07.025. Epub 2016 Jul 26.


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