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Items: 40

1.

Metabolism of LY654322, a growth hormone secretagogue, to an unusual diimidazopyridine metabolite.

Borel AG, Jones TM, Barbuch RJ, Jackson DA, Kulanthaivel P, Mattiuz E, Klimkowski VJ, Wheeler WJ, Rener GA.

Drug Metab Dispos. 2011 May;39(5):740-9. doi: 10.1124/dmd.110.037598. Epub 2011 Feb 23.

2.

Bioavailability of oral carisoprodol 250 and 350 mg and metabolism to meprobamate: A single-dose crossover study.

Simon S, D'Andrea C, Wheeler WJ, Sacks H.

Curr Ther Res Clin Exp. 2010 Feb;71(1):50-9. doi: 10.1016/j.curtheres.2010.02.003.

3.

Randomized, double-blind trial of carisoprodol 250 mg compared with placebo and carisoprodol 350 mg for the treatment of low back spasm.

Serfer GT, Wheeler WJ, Sacks HJ.

Curr Med Res Opin. 2010 Jan;26(1):91-9. doi: 10.1185/03007990903382428.

PMID:
19908948
4.

Double-blind, placebo-controlled trial of reformulated azelastine nasal spray in patients with seasonal allergic rhinitis.

Bernstein JA, Prenner B, Ferguson BJ, Portnoy J, Wheeler WJ, Sacks HJ.

Am J Rhinol Allergy. 2009 Sep-Oct;23(5):512-7. doi: 10.2500/ajra.2009.23.3396.

PMID:
19807985
5.

Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response.

Wheeler DS, Zingarelli B, Wheeler WJ, Wong HR.

Recent Pat Inflamm Allergy Drug Discov. 2009 Jun;3(2):96-112. Review.

6.

Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: comparison with the distribution of mu, delta and kappa binding sites.

Gackenheimer SL, Suter TM, Pintar JE, Quimby SJ, Wheeler WJ, Mitch CH, Gehlert DR, Statnick MA.

Neuropeptides. 2005 Dec;39(6):559-67. Epub 2005 Nov 9.

PMID:
16289278
7.

Simultaneous quantification of atomoxetine as well as its primary oxidative and O-glucuronide metabolites in human plasma and urine using liquid chromatography tandem mass spectrometry (LC/MS/MS).

Mullen JH, Shugert RL, Ponsler GD, Li Q, Sundaram B, Coales HL, Yakupkovic JE, Lelacheur RM, Wheeler WJ, Belas FJ, Sauer JM.

J Pharm Biomed Anal. 2005 Jul 15;38(4):720-33.

PMID:
15967301
8.
9.

(2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors.

Wheeler WJ, Clodfelter DK, Collado I, Kulanthaivel P, Pedregal C, Stoddard EA, Wright RA, Schoepp DD.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):349-51.

PMID:
15603952
10.

Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine.

LaForce CF, Corren J, Wheeler WJ, Berger WE; Rhinitis Study Group.

Ann Allergy Asthma Immunol. 2004 Aug;93(2):154-9.

PMID:
15328675
11.

Synthesis and biological activity of some known and putative duloxetine metabolites.

Kuo F, Gillespie TA, Kulanthaivel P, Lantz RJ, Ma TW, Nelson DL, Threlkeld PG, Wheeler WJ, Yi P, Zmijewski M.

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3481-6. Erratum in: Bioorg Med Chem Lett. 2004 Oct 18;14(20):5233.

PMID:
15177457
12.

Na+-dependent high affinity binding of [3H]LY515300, a 3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid receptor inverse agonist.

Statnick MA, Suter TM, Gackenheimer SL, Emmerson PJ, Quimby SJ, Gehlert DR, Wheeler WJ, Mitch CH.

Eur J Pharmacol. 2003 Dec 15;482(1-3):139-50.

PMID:
14660015
13.

Preclinical characterization of 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]benzoic acid metabolism: in vitro species comparison and in vivo disposition in rats.

Perkins EJ, Cramer JW, Farid NA, Gadberry MG, Jackson DA, Mattiuz EL, O'Bannon DD, Weiss HJ, Wheeler WJ, Wood PG, Cassidy KC.

Drug Metab Dispos. 2003 Nov;31(11):1382-90.

14.

Evaluation of [3H]LY341495 for labeling group II metabotropic glutamate receptors in vivo.

Waterhouse RN, Schmidt ME, Sultana A, Schoepp DD, Wheeler WJ, Mozley PD, Laruelle M.

Nucl Med Biol. 2003 Feb;30(2):187-90.

PMID:
12623118
15.

Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog.

Mattiuz EL, Ponsler GD, Barbuch RJ, Wood PG, Mullen JH, Shugert RL, Li Q, Wheeler WJ, Kuo F, Conrad PC, Sauer JM.

Drug Metab Dispos. 2003 Jan;31(1):88-97.

16.

The disposition, metabolism, and pharmacokinetics of a selective metabotropic glutamate receptor agonist in rats and dogs.

Johnson JT, Mattiuz EL, Chay SH, Herman JL, Wheeler WJ, Kassahun K, Swanson SP, Phillips DL.

Drug Metab Dispos. 2002 Jan;30(1):27-33.

17.

[3H]N-2-(4-(N-benzamido)phenyl)propyl-2-propanesulfonamide: a novel AMPA receptor potentiator and radioligand.

Zarrinmayeh H, Bleakman D, Gates MR, Yu H, Zimmerman DM, Ornstein PL, McKennon T, Arnold MB, Wheeler WJ, Skolnick P.

J Med Chem. 2001 Feb 1;44(3):302-4. No abstract available.

PMID:
11462971
18.

[3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain.

Wright RA, Arnold MB, Wheeler WJ, Ornstein PL, Schoepp DD.

J Pharmacol Exp Ther. 2001 Aug;298(2):453-60.

19.

Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors.

Lindén AM, Yu H, Zarrinmayeh H, Wheeler WJ, Skolnick P.

Neuropharmacology. 2001 Jun;40(8):1010-8.

PMID:
11406192
20.
21.
22.

[3H]LY341495, a highly potent, selective and novel radioligand for labeling Group II metabotropic glutamate receptors.

Ornstein PL, Arnold MB, Bleisch TJ, Wright RA, Wheeler WJ, Schoepp DD.

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1919-22.

PMID:
9873459
23.

Synthesis of [11C]dapoxetine.HCl, a serotonin re-uptake inhibitor: biodistribution in rat and preliminary PET imaging in the monkey.

Livni E, Satterlee W, Robey RL, Alt CA, Van Meter EE, Babich JW, Wheeler WJ, O'Bannon DD, Thrall JH, Fischman AJ.

Nucl Med Biol. 1994 May;21(4):669-75.

PMID:
9234326
24.

Biotransformation of the antiviral agent 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and characteristics of a mesoionic ribose metabolite.

Ehlhardt WJ, Wheeler WJ, Breau AP, Chay SH, Birch GM.

Drug Metab Dispos. 1993 Jan-Feb;21(1):162-70.

PMID:
8095212
25.
26.

Mitotic inhibition and chromosome displacement induced by estradiol in Chinese hamster cells.

Wheeler WJ, Hsu TC, Tousson A, Brinkley BR.

Cell Motil Cytoskeleton. 1987;7(3):235-47.

PMID:
3594578
27.

The synthesis and biological evaluation of some novel aminoheterocyclic methoxime monobactam derivatives.

Wheeler WJ, Finley DR, Ott JL.

J Antibiot (Tokyo). 1986 Nov;39(11):1611-4. No abstract available.

28.
29.

The synthesis and biological evaluation of 7 beta-[2-(2-aminooxazol-4-yl)-2-Z-methoximinoacetamido]-cep halosporin antibiotics.

Wheeler WJ, Finley DR, Messenger RJ, Koehler R, Ott JT.

J Antibiot (Tokyo). 1986 Jan;39(1):121-7.

30.

The synthesis and biological evaluation of 7 beta-[2-(5-amino-[1,2,4] oxadiazol-3-yl)-2-Z-methoximinoacetamido]-cephalosporin derivatives.

Wheeler WJ, Deeter JB, Finley DR, Kinnick MD, Koehler R, Obsorne HE, Ott JT, Swartzendruber JK, Wishka DG.

J Antibiot (Tokyo). 1986 Jan;39(1):111-20.

31.
32.

Inhibition of estrogen-induced renal carcinoma in Syrian hamsters by vitamin C.

Liehr JG, Wheeler WJ.

Cancer Res. 1983 Oct;43(10):4638-42.

33.

Bis-trimethylsilylcefamandole: an unusually stable trimethylsilyl-intermediate.

Wheeler WJ, Finley DR, Osborne HE.

J Antibiot (Tokyo). 1980 Jan;33(1):72-5.

34.

Orally active esters of cephalosporin antibiotics. II. Synthesis and biological properties of the acetoxymethyl ester of cefamandole.

Wright WE, Wheeler WJ, Line VD, Frogge JA, Finley DR.

J Antibiot (Tokyo). 1979 Nov;32(11):1155-60.

36.

Cephalosporins and other beta-lactam antibiotics.

Wheeler WJ.

Lloydia. 1977 Nov-Dec;40(6):519-42. No abstract available.

PMID:
600022
38.

Substituent effects upon the base hydrolysis of penicillins and cephalosporins. Competitive intramolecular nucleophilic amino attack in cephalosporins.

Indelicato JM, Norvilas TT, Pfeiffer RR, Wheeler WJ, Wilham WL.

J Med Chem. 1974 May;17(5):523-7. No abstract available.

PMID:
4830254
39.

Rigid analogs of indomethacin.

Olson DR, Wheeler WJ, Wells JN.

J Med Chem. 1974 Feb;17(2):167-71. No abstract available.

PMID:
4809252
40.

A facile synthesis of 3-acylaminoisocoumarins.

Wells JN, Wheeler WJ, Davisson LM.

J Org Chem. 1971 Jun 4;36(11):1503-6. No abstract available.

PMID:
5574815

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