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Items: 42


Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor.

Ho J, Yang X, Nikou SA, Kichik N, Donkin A, Ponde NO, Richardson JP, Gratacap RL, Archambault LS, Zwirner CP, Murciano C, Henley-Smith R, Thavaraj S, Tynan CJ, Gaffen SL, Hube B, Wheeler RT, Moyes DL, Naglik JR.

Nat Commun. 2019 May 24;10(1):2297. doi: 10.1038/s41467-019-09915-2.


Intravital Imaging Reveals Divergent Cytokine and Cellular Immune Responses to Candida albicans and Candida parapsilosis.

Archambault LS, Trzilova D, Gonia S, Gale C, Wheeler RT.

MBio. 2019 May 14;10(3). pii: e00266-19. doi: 10.1128/mBio.00266-19.


Studies Into β-Glucan Recognition in Fish Suggests a Key Role for the C-Type Lectin Pathway.

Petit J, Bailey EC, Wheeler RT, de Oliveira CAF, Forlenza M, Wiegertjes GF.

Front Immunol. 2019 Feb 26;10:280. doi: 10.3389/fimmu.2019.00280. eCollection 2019.


Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits.

Wu Y, Du S, Johnson JL, Tung HY, Landers CT, Liu Y, Seman BG, Wheeler RT, Costa-Mattioli M, Kheradmand F, Zheng H, Corry DB.

Nat Commun. 2019 Jan 4;10(1):58. doi: 10.1038/s41467-018-07991-4.


The Zebrafish as a Model Host for Invasive Fungal Infections.

Rosowski EE, Knox BP, Archambault LS, Huttenlocher A, Keller NP, Wheeler RT, Davis JM.

J Fungi (Basel). 2018 Dec 13;4(4). pii: E136. doi: 10.3390/jof4040136. Review.


Epitope unmasking in vulvovaginal candidiasis is associated with hyphal growth and neutrophilic infiltration.

Pericolini E, Perito S, Castagnoli A, Gabrielli E, Mencacci A, Blasi E, Vecchiarelli A, Wheeler RT.

PLoS One. 2018 Jul 31;13(7):e0201436. doi: 10.1371/journal.pone.0201436. eCollection 2018.


Yeast and Filaments Have Specialized, Independent Activities in a Zebrafish Model of Candida albicans Infection.

Seman BG, Moore JL, Scherer AK, Blair BA, Manandhar S, Jones JM, Wheeler RT.

Infect Immun. 2018 Sep 21;86(10). pii: e00415-18. doi: 10.1128/IAI.00415-18. Print 2018 Oct.


Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection.

Tucey TM, Verma J, Harrison PF, Snelgrove SL, Lo TL, Scherer AK, Barugahare AA, Powell DR, Wheeler RT, Hickey MJ, Beilharz TH, Naderer T, Traven A.

Cell Metab. 2018 May 1;27(5):988-1006.e7. doi: 10.1016/j.cmet.2018.03.019.


Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion.

Hopke A, Brown AJP, Hall RA, Wheeler RT.

Trends Microbiol. 2018 Apr;26(4):284-295. doi: 10.1016/j.tim.2018.01.007. Epub 2018 Feb 13. Review.


Candida albicans and Pseudomonas aeruginosa Interact To Enhance Virulence of Mucosal Infection in Transparent Zebrafish.

Bergeron AC, Seman BG, Hammond JH, Archambault LS, Hogan DA, Wheeler RT.

Infect Immun. 2017 Oct 18;85(11). pii: e00475-17. doi: 10.1128/IAI.00475-17. Print 2017 Nov.


In vitro Detection of Neutrophil Traps and Post-attack Cell Wall Changes in Candida Hyphae.

Hopke A, Wheeler RT.

Bio Protoc. 2017 Apr 5;7(7). pii: e2213. doi: 10.21769/BioProtoc.2213.


Control of Mucosal Candidiasis in the Zebrafish Swim Bladder Depends on Neutrophils That Block Filament Invasion and Drive Extracellular-Trap Production.

Gratacap RL, Scherer AK, Seman BG, Wheeler RT.

Infect Immun. 2017 Aug 18;85(9). pii: e00276-17. doi: 10.1128/IAI.00276-17. Print 2017 Sep.


Candida parapsilosis Protects Premature Intestinal Epithelial Cells from Invasion and Damage by Candida albicans.

Gonia S, Archambault L, Shevik M, Altendahl M, Fellows E, Bliss JM, Wheeler RT, Gale CA.

Front Pediatr. 2017 Mar 22;5:54. doi: 10.3389/fped.2017.00054. eCollection 2017.


Polyclonal anti-Candida antibody improves phagocytosis and overall outcome in zebrafish model of disseminated candidiasis.

Bergeron AC, Barker SE, Brothers KM, Prasad BC, Wheeler RT.

Dev Comp Immunol. 2017 Mar;68:69-78. doi: 10.1016/j.dci.2016.11.017. Epub 2016 Nov 21.


β-(1,3)-Glucan Unmasking in Some Candida albicans Mutants Correlates with Increases in Cell Wall Surface Roughness and Decreases in Cell Wall Elasticity.

Hasim S, Allison DP, Retterer ST, Hopke A, Wheeler RT, Doktycz MJ, Reynolds TB.

Infect Immun. 2016 Dec 29;85(1). pii: e00601-16. doi: 10.1128/IAI.00601-16. Print 2017 Jan.


Phenotypic Plasticity Regulates Candida albicans Interactions and Virulence in the Vertebrate Host.

Mallick EM, Bergeron AC, Jones SK Jr, Newman ZR, Brothers KM, Creton R, Wheeler RT, Bennett RJ.

Front Microbiol. 2016 May 26;7:780. doi: 10.3389/fmicb.2016.00780. eCollection 2016.


Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans.

Leach MD, Farrer RA, Tan K, Miao Z, Walker LA, Cuomo CA, Wheeler RT, Brown AJ, Wong KH, Cowen LE.

Nat Commun. 2016 May 26;7:11704. doi: 10.1038/ncomms11704.


Neutrophil Attack Triggers Extracellular Trap-Dependent Candida Cell Wall Remodeling and Altered Immune Recognition.

Hopke A, Nicke N, Hidu EE, Degani G, Popolo L, Wheeler RT.

PLoS Pathog. 2016 May 25;12(5):e1005644. doi: 10.1371/journal.ppat.1005644. eCollection 2016 May.


Candidalysin is a fungal peptide toxin critical for mucosal infection.

Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR.

Nature. 2016 Apr 7;532(7597):64-8. doi: 10.1038/nature17625. Epub 2016 Mar 30.


A zebrafish larval model reveals early tissue-specific innate immune responses to Mucor circinelloides.

Voelz K, Gratacap RL, Wheeler RT.

Dis Model Mech. 2015 Nov;8(11):1375-88. doi: 10.1242/dmm.019992. Epub 2015 Aug 20.


Modeling mucosal candidiasis in larval zebrafish by swimbladder injection.

Gratacap RL, Bergeron AC, Wheeler RT.

J Vis Exp. 2014 Nov 27;(93):e52182. doi: 10.3791/52182.


Fungal Pathogens: Survival and Replication within Macrophages.

Gilbert AS, Wheeler RT, May RC.

Cold Spring Harb Perspect Med. 2014 Nov 10;5(7):a019661. doi: 10.1101/cshperspect.a019661. Review.


Masking of β(1-3)-glucan in the cell wall of Candida albicans from detection by innate immune cells depends on phosphatidylserine.

Davis SE, Hopke A, Minkin SC Jr, Montedonico AE, Wheeler RT, Reynolds TB.

Infect Immun. 2014 Oct;82(10):4405-13. doi: 10.1128/IAI.01612-14. Epub 2014 Aug 11.


The complex roles of NADPH oxidases in fungal infection.

Hogan D, Wheeler RT.

Cell Microbiol. 2014 Aug;16(8):1156-67. doi: 10.1111/cmi.12320. Epub 2014 Jul 7. Review.


Utilization of zebrafish for intravital study of eukaryotic pathogen-host interactions.

Gratacap RL, Wheeler RT.

Dev Comp Immunol. 2014 Sep;46(1):108-15. doi: 10.1016/j.dci.2014.01.020. Epub 2014 Feb 1. Review.


CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.

Lionakis MS, Swamydas M, Fischer BG, Plantinga TS, Johnson MD, Jaeger M, Green NM, Masedunskas A, Weigert R, Mikelis C, Wan W, Lee CC, Lim JK, Rivollier A, Yang JC, Laird GM, Wheeler RT, Alexander BD, Perfect JR, Gao JL, Kullberg BJ, Netea MG, Murphy PM.

J Clin Invest. 2013 Dec;123(12):5035-51. doi: 10.1172/JCI71307. Epub 2013 Nov 1.


NADPH oxidase-driven phagocyte recruitment controls Candida albicans filamentous growth and prevents mortality.

Brothers KM, Gratacap RL, Barker SE, Newman ZR, Norum A, Wheeler RT.

PLoS Pathog. 2013;9(10):e1003634. doi: 10.1371/journal.ppat.1003634. Epub 2013 Oct 3.


Mucosal candidiasis elicits NF-κB activation, proinflammatory gene expression and localized neutrophilia in zebrafish.

Gratacap RL, Rawls JF, Wheeler RT.

Dis Model Mech. 2013 Sep;6(5):1260-70. doi: 10.1242/dmm.012039. Epub 2013 May 29.


Candida albicans induces arginine biosynthetic genes in response to host-derived reactive oxygen species.

Jiménez-López C, Collette JR, Brothers KM, Shepardson KM, Cramer RA, Wheeler RT, Lorenz MC.

Eukaryot Cell. 2013 Jan;12(1):91-100. doi: 10.1128/EC.00290-12. Epub 2012 Nov 9.


Non-invasive imaging of disseminated candidiasis in zebrafish larvae.

Brothers KM, Wheeler RT.

J Vis Exp. 2012 Jul 30;(65). pii: 4051. doi: 10.3791/4051.


Zebrafish: a see-through host and a fluorescent toolbox to probe host-pathogen interaction.

Tobin DM, May RC, Wheeler RT.

PLoS Pathog. 2012 Jan;8(1):e1002349. doi: 10.1371/journal.ppat.1002349. Epub 2012 Jan 5. Review. No abstract available.


Live imaging of disseminated candidiasis in zebrafish reveals role of phagocyte oxidase in limiting filamentous growth.

Brothers KM, Newman ZR, Wheeler RT.

Eukaryot Cell. 2011 Jul;10(7):932-44. doi: 10.1128/EC.05005-11. Epub 2011 May 6.


Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p.

Moxley JF, Jewett MC, Antoniewicz MR, Villas-Boas SG, Alper H, Wheeler RT, Tong L, Hinnebusch AG, Ideker T, Nielsen J, Stephanopoulos G.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6477-82. doi: 10.1073/pnas.0811091106. Epub 2009 Apr 3.


Dynamic, morphotype-specific Candida albicans beta-glucan exposure during infection and drug treatment.

Wheeler RT, Kombe D, Agarwala SD, Fink GR.

PLoS Pathog. 2008 Dec;4(12):e1000227. doi: 10.1371/journal.ppat.1000227. Epub 2008 Dec 5.


Regulation of progenitor cell proliferation and granulocyte function by microRNA-223.

Johnnidis JB, Harris MH, Wheeler RT, Stehling-Sun S, Lam MH, Kirak O, Brummelkamp TR, Fleming MD, Camargo FD.

Nature. 2008 Feb 28;451(7182):1125-9. doi: 10.1038/nature06607. Epub 2008 Feb 17.


A drug-sensitive genetic network masks fungi from the immune system.

Wheeler RT, Fink GR.

PLoS Pathog. 2006 Apr;2(4):e35. Epub 2006 Apr 28.


A Saccharomyces cerevisiae mutant with increased virulence.

Wheeler RT, Kupiec M, Magnelli P, Abeijon C, Fink GR.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2766-70. Epub 2003 Feb 14.


Protein localization during the Caulobacter crescentus cell cycle.

Wheeler RT, Gober JW, Shapiro L.

Curr Opin Microbiol. 1998 Dec;1(6):636-42. Review.


Bacterial chromosome segregation: is there a mitotic apparatus?

Wheeler RT, Shapiro L.

Cell. 1997 Mar 7;88(5):577-9. Review. No abstract available.


Higher-order corrections to Coulomb fission.

Wheeler RT, Norbury JW.

Phys Rev C Nucl Phys. 1995 Mar;51(3):1566-1567. No abstract available.


The Influence of Baking-Powder Residues on Digestion.

Wheeler RT.

Science. 1890 Jan 3;15(361):14-6. No abstract available.


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