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Items: 42

1.

Improving immunological insights into the ferret model of human viral infectious disease.

Wong J, Layton D, Wheatley AK, Kent SJ.

Influenza Other Respir Viruses. 2019 Oct 3. doi: 10.1111/irv.12687. [Epub ahead of print] Review.

2.

Immunomodulation Induced by Host Pathogen Interaction.

Yassine HM, Moin SM, Cyprian FS, Wheatley AK, Nasrallah GK.

J Immunol Res. 2019 Aug 29;2019:9710910. doi: 10.1155/2019/9710910. eCollection 2019. No abstract available.

3.

Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles.

Weiss ACG, Kelly HG, Faria M, Besford QA, Wheatley AK, Ang CS, Crampin EJ, Caruso F, Kent SJ.

ACS Nano. 2019 May 28;13(5):4980-4991. doi: 10.1021/acsnano.9b00552. Epub 2019 Apr 18.

PMID:
30998312
4.

Inducible Bronchus-Associated Lymphoid Tissues (iBALT) Serve as Sites of B Cell Selection and Maturation Following Influenza Infection in Mice.

Tan HX, Esterbauer R, Vanderven HA, Juno JA, Kent SJ, Wheatley AK.

Front Immunol. 2019 Mar 29;10:611. doi: 10.3389/fimmu.2019.00611. eCollection 2019.

5.

Author Correction: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses.

Kanekiyo M, Joyce MG, Gillespie RA, Gallagher JR, Andrews SF, Yassine HM, Wheatley AK, Fisher BE, Ambrozak DR, Creanga A, Leung K, Yang ES, Boyoglu-Barnum S, Georgiev IS, Tsybovsky Y, Prabhakaran MS, Andersen H, Kong WP, Baxa U, Zephir KL, Ledgerwood JE, Koup RA, Kwong PD, Harris AK, McDermott AB, Mascola JR, Graham BS.

Nat Immunol. 2019 Jun;20(6):765. doi: 10.1038/s41590-019-0395-0.

PMID:
30980067
6.

Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies.

Cui J, Ju Y, Houston ZH, Glass JJ, Fletcher NL, Alcantara S, Dai Q, Howard CB, Mahler SM, Wheatley AK, De Rose R, Brannon PT, Paterson BM, Donnelly PS, Thurecht KJ, Caruso F, Kent SJ.

Adv Healthc Mater. 2019 May;8(9):e1801607. doi: 10.1002/adhm.201801607. Epub 2019 Mar 14.

PMID:
30868751
7.

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages.

Corbett KS, Moin SM, Yassine HM, Cagigi A, Kanekiyo M, Boyoglu-Barnum S, Myers SI, Tsybovsky Y, Wheatley AK, Schramm CA, Gillespie RA, Shi W, Wang L, Zhang Y, Andrews SF, Joyce MG, Crank MC, Douek DC, McDermott AB, Mascola JR, Graham BS, Boyington JC.

MBio. 2019 Feb 26;10(1). pii: e02810-18. doi: 10.1128/mBio.02810-18.

8.

Identification of murine antigen-specific T follicular helper cells using an activation-induced marker assay.

Jiang W, Wragg KM, Tan HX, Kelly HG, Wheatley AK, Kent SJ, Juno JA.

J Immunol Methods. 2019 Apr;467:48-57. doi: 10.1016/j.jim.2019.02.008. Epub 2019 Feb 22.

PMID:
30802449
9.

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses.

Kanekiyo M, Joyce MG, Gillespie RA, Gallagher JR, Andrews SF, Yassine HM, Wheatley AK, Fisher BE, Ambrozak DR, Creanga A, Leung K, Yang ES, Boyoglu-Barnum S, Georgiev IS, Tsybovsky Y, Prabhakaran MS, Andersen H, Kong WP, Baxa U, Zephir KL, Ledgerwood JE, Koup RA, Kwong PD, Harris AK, McDermott AB, Mascola JR, Graham BS.

Nat Immunol. 2019 Mar;20(3):362-372. doi: 10.1038/s41590-018-0305-x. Epub 2019 Feb 11. Erratum in: Nat Immunol. 2019 Apr 12;:.

10.

Immunological basis for enhanced immunity of nanoparticle vaccines.

Kelly HG, Kent SJ, Wheatley AK.

Expert Rev Vaccines. 2019 Mar;18(3):269-280. doi: 10.1080/14760584.2019.1578216. Epub 2019 Feb 14. Review.

PMID:
30707635
11.

Cross-lineage protection by human antibodies binding the influenza B hemagglutinin.

Liu Y, Tan HX, Koutsakos M, Jegaskanda S, Esterbauer R, Tilmanis D, Aban M, Kedzierska K, Hurt AC, Kent SJ, Wheatley AK.

Nat Commun. 2019 Jan 18;10(1):324. doi: 10.1038/s41467-018-08165-y.

12.

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA.

Nat Med. 2019 Jan;25(1):188-189. doi: 10.1038/s41591-018-0315-0.

PMID:
30552419
13.

Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem.

Tan HX, Jegaskanda S, Juno JA, Esterbauer R, Wong J, Kelly HG, Liu Y, Tilmanis D, Hurt AC, Yewdell JW, Kent SJ, Wheatley AK.

J Clin Invest. 2019 Feb 1;129(2):850-862. doi: 10.1172/JCI123366. Epub 2019 Jan 22.

14.

Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques.

Parsons MS, Lee WS, Kristensen AB, Amarasena T, Khoury G, Wheatley AK, Reynaldi A, Wines BD, Hogarth PM, Davenport MP, Kent SJ.

J Clin Invest. 2019 Jan 2;129(1):182-191. doi: 10.1172/JCI122466. Epub 2018 Nov 26.

15.

Anti-Influenza Hyperimmune Immunoglobulin Enhances Fc-Functional Antibody Immunity During Human Influenza Infection.

Vanderven HA, Wragg K, Ana-Sosa-Batiz F, Kristensen AB, Jegaskanda S, Wheatley AK, Wentworth D, Wines BD, Hogarth PM, Rockman S, Kent SJ; INSIGHT FLU005 Pilot Study Writing Group.

J Infect Dis. 2018 Sep 22;218(9):1383-1393. doi: 10.1093/infdis/jiy328.

PMID:
29860297
16.

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA.

Nat Med. 2018 May;24(4):408-416. doi: 10.1038/nm.4512. Epub 2018 Mar 19. Erratum in: Nat Med. 2019 Jan;25(1):188-189.

17.

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity.

Koutsakos M, Wheatley AK, Loh L, Clemens EB, Sant S, Nüssing S, Fox A, Chung AW, Laurie KL, Hurt AC, Rockman S, Lappas M, Loudovaris T, Mannering SI, Westall GP, Elliot M, Tangye SG, Wakim LM, Kent SJ, Nguyen THO, Kedzierska K.

Sci Transl Med. 2018 Feb 14;10(428). pii: eaan8405. doi: 10.1126/scitranslmed.aan8405.

PMID:
29444980
18.

Intranasal Live Influenza Vaccine Priming Elicits Localized B Cell Responses in Mediastinal Lymph Nodes.

Jegaskanda S, Mason RD, Andrews SF, Wheatley AK, Zhang R, Reynoso GV, Ambrozak DR, Santos CP, Luke CJ, Matsuoka Y, Brenchley JM, Hickman HD, Talaat KR, Permar SR, Liao HX, Yewdell JW, Koup RA, Roederer M, McDermott AB, Subbarao K.

J Virol. 2018 Apr 13;92(9). pii: e01970-17. doi: 10.1128/JVI.01970-17. Print 2018 May 1.

19.

Induction of vaginal-resident HIV-specific CD8 T cells with mucosal prime-boost immunization.

Tan HX, Wheatley AK, Esterbauer R, Jegaskanda S, Glass JJ, Masopust D, De Rose R, Kent SJ.

Mucosal Immunol. 2018 May;11(3):994-1007. doi: 10.1038/mi.2017.89. Epub 2017 Oct 25.

PMID:
29067995
20.

Antibody-dependent phagocytosis (ADP) responses following trivalent inactivated influenza vaccination of younger and older adults.

Ana-Sosa-Batiz F, Johnston APR, Hogarth PM, Wines BD, Barr I, Wheatley AK, Kent SJ.

Vaccine. 2017 Nov 7;35(47):6451-6458. doi: 10.1016/j.vaccine.2017.09.062. Epub 2017 Oct 10.

PMID:
29029940
21.

Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.

Andrews SF, Joyce MG, Chambers MJ, Gillespie RA, Kanekiyo M, Leung K, Yang ES, Tsybovsky Y, Wheatley AK, Crank MC, Boyington JC, Prabhakaran MS, Narpala SR, Chen X, Bailer RT, Chen G, Coates E, Kwong PD, Koup RA, Mascola JR, Graham BS, Ledgerwood JE, McDermott AB.

Sci Immunol. 2017 Jul 14;2(13). pii: eaan2676. doi: 10.1126/sciimmunol.aan2676.

PMID:
28783708
22.

Fc or not Fc; that is the question: Antibody Fc-receptor interactions are key to universal influenza vaccine design.

Jegaskanda S, Vanderven HA, Wheatley AK, Kent SJ.

Hum Vaccin Immunother. 2017 Jun 3;13(6):1-9. doi: 10.1080/21645515.2017.1290018. Epub 2017 Mar 23. Review.

23.

Longitudinal dynamics of the HIV-specific B cell response during intermittent treatment of primary HIV infection.

de Bree GJ, Wheatley AK, Lynch RM, Prabhakaran M, Grijsen ML, Prins JM, Schmidt SD, Koup RA, Mascola JR, McDermott AB.

PLoS One. 2017 Mar 15;12(3):e0173577. doi: 10.1371/journal.pone.0173577. eCollection 2017.

24.

Defining B cell immunodominance to viruses.

Angeletti D, Gibbs JS, Angel M, Kosik I, Hickman HD, Frank GM, Das SR, Wheatley AK, Prabhakaran M, Leggat DJ, McDermott AB, Yewdell JW.

Nat Immunol. 2017 Apr;18(4):456-463. doi: 10.1038/ni.3680. Epub 2017 Feb 13.

25.

Antibody-dependent cellular cytotoxicity and influenza virus.

Vanderven HA, Jegaskanda S, Wheatley AK, Kent SJ.

Curr Opin Virol. 2017 Feb;22:89-96. doi: 10.1016/j.coviro.2016.12.002. Epub 2017 Jan 11. Review.

PMID:
28088123
26.

Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery.

Gause KT, Wheatley AK, Cui J, Yan Y, Kent SJ, Caruso F.

ACS Nano. 2017 Jan 24;11(1):54-68. doi: 10.1021/acsnano.6b07343. Epub 2017 Jan 11. Review.

PMID:
28075558
27.

The aryl hydrocarbon receptor controls cell-fate decisions in B cells.

Vaidyanathan B, Chaudhry A, Yewdell WT, Angeletti D, Yen WF, Wheatley AK, Bradfield CA, McDermott AB, Yewdell JW, Rudensky AY, Chaudhuri J.

J Exp Med. 2017 Jan;214(1):197-208. doi: 10.1084/jem.20160789. Epub 2016 Dec 23.

28.

Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation.

Villar RF, Patel J, Weaver GC, Kanekiyo M, Wheatley AK, Yassine HM, Costello CE, Chandler KB, McTamney PM, Nabel GJ, McDermott AB, Mascola JR, Carr SA, Lingwood D.

Sci Rep. 2016 Oct 31;6:36298. doi: 10.1038/srep36298.

29.

Twist in the Tail: Escape from HIV Neutralising Antibodies at a Single Site Confers Broad Susceptibility to Others.

Wheatley AK, Kent SJ.

EBioMedicine. 2016 Oct;12:14-15. doi: 10.1016/j.ebiom.2016.09.019. Epub 2016 Sep 20. No abstract available.

30.

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses.

Joyce MG, Wheatley AK, Thomas PV, Chuang GY, Soto C, Bailer RT, Druz A, Georgiev IS, Gillespie RA, Kanekiyo M, Kong WP, Leung K, Narpala SN, Prabhakaran MS, Yang ES, Zhang B, Zhang Y, Asokan M, Boyington JC, Bylund T, Darko S, Lees CR, Ransier A, Shen CH, Wang L, Whittle JR, Wu X, Yassine HM, Santos C, Matsuoka Y, Tsybovsky Y, Baxa U; NISC Comparative Sequencing Program, Mullikin JC, Subbarao K, Douek DC, Graham BS, Koup RA, Ledgerwood JE, Roederer M, Shapiro L, Kwong PD, Mascola JR, McDermott AB.

Cell. 2016 Jul 28;166(3):609-623. doi: 10.1016/j.cell.2016.06.043. Epub 2016 Jul 21.

31.

HIV-dependent depletion of influenza-specific memory B cells impacts B cell responsiveness to seasonal influenza immunisation.

Wheatley AK, Kristensen AB, Lay WN, Kent SJ.

Sci Rep. 2016 May 25;6:26478. doi: 10.1038/srep26478.

32.

Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine.

Kristensen AB, Lay WN, Ana-Sosa-Batiz F, Vanderven HA, Madhavi V, Laurie KL, Carolan L, Wines BD, Hogarth M, Wheatley AK, Kent SJ.

J Virol. 2016 May 27;90(12):5724-5734. doi: 10.1128/JVI.00285-16. Print 2016 Jun 15.

33.

A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus.

Frank GM, Angeletti D, Ince WL, Gibbs JS, Khurana S, Wheatley AK, Max EE, McDermott AB, Golding H, Stevens J, Bennink JR, Yewdell JW.

MBio. 2015 Aug 4;6(4):e01156. doi: 10.1128/mBio.01156-15.

34.

Prospects for antibody-based universal influenza vaccines in the context of widespread pre-existing immunity.

Wheatley AK, Kent SJ.

Expert Rev Vaccines. 2015;14(9):1227-39. doi: 10.1586/14760584.2015.1068125. Epub 2015 Jul 15. Review.

PMID:
26175180
35.

H5N1 Vaccine-Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin Stem.

Wheatley AK, Whittle JR, Lingwood D, Kanekiyo M, Yassine HM, Ma SS, Narpala SR, Prabhakaran MS, Matus-Nicodemos RA, Bailer RT, Nabel GJ, Graham BS, Ledgerwood JE, Koup RA, McDermott AB.

J Immunol. 2015 Jul 15;195(2):602-10. doi: 10.4049/jimmunol.1402835. Epub 2015 Jun 15.

36.

Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals.

Kardava L, Moir S, Shah N, Wang W, Wilson R, Buckner CM, Santich BH, Kim LJ, Spurlin EE, Nelson AK, Wheatley AK, Harvey CJ, McDermott AB, Wucherpfennig KW, Chun TW, Tsang JS, Li Y, Fauci AS.

J Clin Invest. 2014 Jul;124(7):3252-62. doi: 10.1172/JCI74351. Epub 2014 Jun 2.

37.

Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages.

Whittle JR, Wheatley AK, Wu L, Lingwood D, Kanekiyo M, Ma SS, Narpala SR, Yassine HM, Frank GM, Yewdell JW, Ledgerwood JE, Wei CJ, McDermott AB, Graham BS, Koup RA, Nabel GJ.

J Virol. 2014 Apr;88(8):4047-57. doi: 10.1128/JVI.03422-13. Epub 2014 Feb 5.

38.

Utility of the Sindbis replicon system as an Env-targeted HIV vaccine.

Center RJ, Miller A, Wheatley AK, Campbell SM, Siebentritt C, Purcell DF.

Vaccine. 2013 Apr 26;31(18):2260-6. doi: 10.1016/j.vaccine.2013.02.064. Epub 2013 Mar 13.

PMID:
23499600
39.

Hyperimmune bovine colostrum as a low-cost, large-scale source of antibodies with broad neutralizing activity for HIV-1 envelope with potential use in microbicides.

Kramski M, Center RJ, Wheatley AK, Jacobson JC, Alexander MR, Rawlin G, Purcell DF.

Antimicrob Agents Chemother. 2012 Aug;56(8):4310-9. doi: 10.1128/AAC.00453-12. Epub 2012 Jun 4.

40.

Co-expression of miRNA targeting the expression of PERK, but not PKR, enhances cellular immunity from an HIV-1 Env DNA vaccine.

Wheatley AK, Kramski M, Alexander MR, Toe JG, Center RJ, Purcell DF.

PLoS One. 2011 Mar 25;6(3):e18225. doi: 10.1371/journal.pone.0018225.

41.

Efficient transcription through an intron requires the binding of an Sm-type U1 snRNP with intact stem loop II to the splice donor.

Alexander MR, Wheatley AK, Center RJ, Purcell DF.

Nucleic Acids Res. 2010 May;38(9):3041-53. doi: 10.1093/nar/gkp1224. Epub 2010 Jan 13.

42.

Induction of HIV-1 subtype B and AE-specific neutralizing antibodies in mice and macaques with DNA prime and recombinant gp140 protein boost regimens.

Center RJ, Wheatley AK, Campbell SM, Gaeguta AJ, Peut V, Alcantara S, Siebentritt C, Kent SJ, Purcell DF.

Vaccine. 2009 Nov 5;27(47):6605-12. doi: 10.1016/j.vaccine.2009.08.016. Epub 2009 Aug 25.

PMID:
19712773

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