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DyeVertâ„¢ PLUS EZ System for Preventing Contrast-Induced Acute Kidney Injury in Patients Undergoing Diagnostic Coronary Angiography and/or Percutaneous Coronary Intervention: A UK-Based Cost-Utility Analysis.

Javanbakht M, Hemami MR, Mashayekhi A, Branagan-Harris M, Zaman A, Al-Najjar Y, O'Donoghue D, Fath-Ordoubadi F, Wheatcroft S.

Pharmacoecon Open. 2020 Jan 27. doi: 10.1007/s41669-020-00195-x. [Epub ahead of print]


Prescribing diabetes medication for cardiovascular risk reduction in patients admitted with acute coronary syndromes - a survey of cardiologists' attitudes and practice.

Slater TA, Drozd M, Palin V, Bowles C, Waduud MA, Khatib R, Ajjan RA, Wheatcroft SB.

Eur Heart J Cardiovasc Pharmacother. 2019 Nov 8. pii: pvz058. doi: 10.1093/ehjcvp/pvz058. [Epub ahead of print] No abstract available.


Real-world comparison of clopidogrel, prasugrel and ticagrelor in patients undergoing primary percutaneous coronary intervention.

Krishnamurthy A, Keeble C, Anderson M, Somers K, Burton-Wood N, Harland C, Baxter P, McLenachan J, Blaxill J, Blackman DJ, Malkin C, Wheatcroft S, Greenwood J.

Open Heart. 2019 Jun 29;6(1):e000951. doi: 10.1136/openhrt-2018-000951. eCollection 2019. Erratum in: Open Heart. 2019 Oct 9;6(2):e000951corr1.


Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function.

Fearnley GW, Abdul-Zani I, Latham AM, Hollstein MC, Ladbury JE, Wheatcroft SB, Odell AF, Ponnambalam S.

Biol Open. 2019 May 17;8(5). pii: bio034215. doi: 10.1242/bio.034215.


Insulin-like growth factor binding proteins and angiogenesis: from cancer to cardiovascular disease.

Slater T, Haywood NJ, Matthews C, Cheema H, Wheatcroft SB.

Cytokine Growth Factor Rev. 2019 Apr;46:28-35. doi: 10.1016/j.cytogfr.2019.03.005. Epub 2019 Mar 18.


TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice.

Rode B, Yuldasheva NY, Baxter PD, Sedo A, Ainscough JF, Shires M, Kearney MT, Bailey MA, Wheatcroft SB, Beech DJ.

Sci Rep. 2019 Jan 28;9(1):773. doi: 10.1038/s41598-018-37299-8.


Prospective observational cohort study of the association between antiplatelet therapy, bleeding and thrombosis in patients with coronary stents undergoing noncardiac surgery.

Howell SJ, Hoeks SE, West RM, Wheatcroft SB, Hoeft A; OBTAIN Investigators of European Society of Anaesthesiology (ESA) Clinical Trial Network.

Br J Anaesth. 2019 Feb;122(2):170-179. doi: 10.1016/j.bja.2018.09.029. Epub 2018 Dec 15.


The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes.

Haywood NJ, Slater TA, Matthews CJ, Wheatcroft SB.

Mol Metab. 2019 Jan;19:86-96. doi: 10.1016/j.molmet.2018.10.008. Epub 2018 Oct 24. Review.


Preservation of vascular endothelial repair in mice with diet-induced obesity.

Rashid ST, Haywood NJ, Yuldasheva NY, Smith J, Aziz A, Scott DJA, Kearney MT, Wheatcroft SB.

Obes Sci Pract. 2018 Jun 26;4(5):490-496. doi: 10.1002/osp4.282. eCollection 2018 Oct.


Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice.

Sengupta A, Patel PA, Yuldasheva NY, Mughal RS, Galloway S, Viswambharan H, Walker AMN, Aziz A, Smith J, Ali N, Mercer BN, Imrie H, Sukumar P, Wheatcroft SB, Kearney MT, Cubbon RM.

Endocrinology. 2018 Aug 1;159(8):2917-2925. doi: 10.1210/en.2018-00215.


Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance.

Aziz A, Haywood NJ, Cordell PA, Smith J, Yuldasheva NY, Sengupta A, Ali N, Mercer BN, Mughal RS, Riches K, Cubbon RM, Porter KE, Kearney MT, Wheatcroft SB.

Endocrinology. 2018 Feb 1;159(2):696-709. doi: 10.1210/en.2017-00572.


Acute and one-year clinical outcomes following implantation of bioresorbable vascular scaffolds: the ABSORB UK Registry.

Baumbach A, Zaman A, West NEJ, O'Kane P, Egred M, Johnson T, Wheatcroft S, Bowles R, de Belder A, Bouras G, Lansky A, Hill J, Mathur A, de Belder MA, Banning AP.

EuroIntervention. 2018 Jan 20;13(13):1554-1560. doi: 10.4244/EIJ-D-17-00886.


Transcoronary pacing to assess myocardial viability prior to percutaneous coronary intervention: Pilot study to assess feasibility.

O'Neill J, Hogarth AJ, Pearson I, Law H, Bowes R, Kidambi A, Wheatcroft S, Sivananthan UM, Tayebjee MH.

Catheter Cardiovasc Interv. 2018 Aug 1;92(2):269-273. doi: 10.1002/ccd.27349. Epub 2017 Oct 16.


Clinical outcomes following primary percutaneous coronary intervention for ST-elevation myocardial infarction according to sex and race.

Krishnamurthy A, Keeble C, Burton-Wood N, Somers K, Anderson M, Harland C, Baxter PD, McLenachan JM, Blaxill JM, Blackman DJ, Malkin CJ, Wheatcroft SB, Greenwood JP.

Eur Heart J Acute Cardiovasc Care. 2019 Apr;8(3):264-272. doi: 10.1177/2048872617735803. Epub 2017 Oct 5.


Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.

Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ.

Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3.


Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.

Watt NT, Gage MC, Patel PA, Viswambharan H, Sukumar P, Galloway S, Yuldasheva NY, Imrie H, Walker AMN, Griffin KJ, Makava N, Skromna A, Bridge K, Beech DJ, Schurmans S, Wheatcroft SB, Kearney MT, Cubbon RM.

Diabetes. 2017 Nov;66(11):2808-2821. doi: 10.2337/db17-0062. Epub 2017 Aug 22.


Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function.

Smith GA, Fearnley GW, Abdul-Zani I, Wheatcroft SB, Tomlinson DC, Harrison MA, Ponnambalam S.

Biol Open. 2017 Oct 15;6(10):1404-1415. doi: 10.1242/bio.027896.


Assessing Coronary Blood Flow Physiology in the Cardiac Catheterisation Laboratory.

Vijayan S, Barmby DS, Pearson IR, Davies AG, Wheatcroft SB, Sivananthan M.

Curr Cardiol Rev. 2017;13(3):232-243. doi: 10.2174/1573403X13666170525102618. Review.


Inhibition of plasmin-mediated TAFI activation may affect development but not progression of abdominal aortic aneurysms.

Bridge K, Revill C, Macrae F, Bailey M, Yuldasheva N, Wheatcroft S, Butlin R, Foster R, Scott DJ, Gils A, Ariens R.

PLoS One. 2017 May 4;12(5):e0177117. doi: 10.1371/journal.pone.0177117. eCollection 2017.


Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain.

Haywood NJ, Cordell PA, Tang KY, Makova N, Yuldasheva NY, Imrie H, Viswambharan H, Bruns AF, Cubbon RM, Kearney MT, Wheatcroft SB.

Diabetes. 2017 Feb;66(2):287-299. doi: 10.2337/db16-0997. Epub 2016 Nov 10.


Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop.

Viswambharan H, Yuldasheva NY, Sengupta A, Imrie H, Gage MC, Haywood N, Walker AM, Skromna A, Makova N, Galloway S, Shah P, Sukumar P, Porter KE, Grant PJ, Shah AM, Santos CX, Li J, Beech DJ, Wheatcroft SB, Cubbon RM, Kearney MT.

Circ Res. 2017 Mar 3;120(5):784-798. doi: 10.1161/CIRCRESAHA.116.309678. Epub 2016 Dec 5.


How We Measure Heart Rate: Does it Matter?

Mohee K, Morley C, Wheatcroft SB.

Am J Med. 2016 Sep;129(9):e213. doi: 10.1016/j.amjmed.2015.11.039. No abstract available.


VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis.

Fearnley GW, Smith GA, Abdul-Zani I, Yuldasheva N, Mughal NA, Homer-Vanniasinkam S, Kearney MT, Zachary IC, Tomlinson DC, Harrison MA, Wheatcroft SB, Ponnambalam S.

Biol Open. 2016 May 15;5(5):571-83. doi: 10.1242/bio.017434.


Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance.

Cubbon RM, Kearney MT, Wheatcroft SB.

Trends Endocrinol Metab. 2016 Feb;27(2):96-104. doi: 10.1016/j.tem.2015.11.009. Epub 2015 Dec 20. Review.


VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8.

Smith GA, Fearnley GW, Abdul-Zani I, Wheatcroft SB, Tomlinson DC, Harrison MA, Ponnambalam S.

Traffic. 2016 Jan;17(1):53-65. doi: 10.1111/tra.12341. Epub 2015 Dec 2.


Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics.

De Siqueira J, Abdul Zani I, Russell DA, Wheatcroft SB, Ponnambalam S, Homer-Vanniasinkam S.

J Cardiovasc Transl Res. 2015 Nov;8(8):458-65. doi: 10.1007/s12265-015-9655-z. Epub 2015 Sep 18. Review.


Detection and Quantification of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases in Primary Human Endothelial Cells.

Fearnley GW, Wheatcroft SB, Ponnambalam S.

Methods Mol Biol. 2015;1332:49-65. doi: 10.1007/978-1-4939-2917-7_4.


Scavenger receptor structure and function in health and disease.

Zani IA, Stephen SL, Mughal NA, Russell D, Homer-Vanniasinkam S, Wheatcroft SB, Ponnambalam S.

Cells. 2015 May 22;4(2):178-201. doi: 10.3390/cells4020178. Review.


VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration.

Fearnley GW, Bruns AF, Wheatcroft SB, Ponnambalam S.

Biol Open. 2015 Apr 24;4(6):731-42. doi: 10.1242/bio.201410884.


Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease.

Smith GA, Fearnley GW, Harrison MA, Tomlinson DC, Wheatcroft SB, Ponnambalam S.

J Inherit Metab Dis. 2015 Jul;38(4):753-63. doi: 10.1007/s10545-015-9838-4. Epub 2015 Apr 14. Review.


Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade.

Magwenzi S, Woodward C, Wraith KS, Aburima A, Raslan Z, Jones H, McNeil C, Wheatcroft S, Yuldasheva N, Febbriao M, Kearney M, Naseem KM.

Blood. 2015 Apr 23;125(17):2693-703. doi: 10.1182/blood-2014-05-574491. Epub 2015 Feb 20.


In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

Latham AM, Kankanala J, Fearnley GW, Gage MC, Kearney MT, Homer-Vanniasinkam S, Wheatcroft SB, Fishwick CW, Ponnambalam S.

PLoS One. 2014 Nov 13;9(11):e110997. doi: 10.1371/journal.pone.0110997. eCollection 2014.


Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype.

Yuldasheva NY, Rashid ST, Haywood NJ, Cordell P, Mughal R, Viswambharan H, Imrie H, Sukumar P, Cubbon RM, Aziz A, Gage M, Mbonye KA, Smith J, Galloway S, Skromna A, Scott DJ, Kearney MT, Wheatcroft SB.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2051-8. doi: 10.1161/ATVBAHA.114.304121. Epub 2014 Jul 10.


Cardiovascular risk in patients with small and medium abdominal aortic aneurysms, and no history of cardiovascular disease.

Sohrabi S, Wheatcroft S, Barth JH, Bailey MA, Johnson A, Bridge K, Griffin K, Baxter PD, Scott DJ.

Br J Surg. 2014 Sep;101(10):1238-43. doi: 10.1002/bjs.9567. Epub 2014 Jun 26.


VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions.

Fearnley GW, Odell AF, Latham AM, Mughal NA, Bruns AF, Burgoyne NJ, Homer-Vanniasinkam S, Zachary IC, Hollstein MC, Wheatcroft SB, Ponnambalam S.

Mol Biol Cell. 2014 Aug 15;25(16):2509-21. doi: 10.1091/mbc.E14-05-0962. Epub 2014 Jun 25.


Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.

Cubbon RM, Yuldasheva NY, Viswambharan H, Mercer BN, Baliga V, Stephen SL, Askham J, Sukumar P, Skromna A, Mughal RS, Walker AM, Bruns A, Bailey MA, Galloway S, Imrie H, Gage MC, Rakobowchuk M, Li J, Porter KE, Ponnambalam S, Wheatcroft SB, Beech DJ, Kearney MT.

Stem Cells. 2014 Oct;32(10):2714-23. doi: 10.1002/stem.1766.


Optimal medical therapy and percutaneous coronary intervention for stable angina: why patients should 'be taking' and 'keep taking' the tablets.

Mohee K, Wheatcroft SB.

J Clin Pharm Ther. 2014 Aug;39(4):331-3. doi: 10.1111/jcpt.12164. Epub 2014 Apr 23.


Does routine pressure wire assessment influence management strategy at coronary angiography for diagnosis of chest pain?: the RIPCORD study.

Curzen N, Rana O, Nicholas Z, Golledge P, Zaman A, Oldroyd K, Hanratty C, Banning A, Wheatcroft S, Hobson A, Chitkara K, Hildick-Smith D, McKenzie D, Calver A, Dimitrov BD, Corbett S.

Circ Cardiovasc Interv. 2014 Apr;7(2):248-55. doi: 10.1161/CIRCINTERVENTIONS.113.000978. Epub 2014 Mar 18.


Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells.

Fearnley GW, Smith GA, Odell AF, Latham AM, Wheatcroft SB, Harrison MA, Tomlinson DC, Ponnambalam S.

Methods Enzymol. 2014;535:265-92. doi: 10.1016/B978-0-12-397925-4.00016-X.


Reply to: "Zimarino M et al. The adequacy of myocardial revascularization in patients with multivessel coronary artery disease".

Mohee K, Kaul P, Wheatcroft S.

Int J Cardiol. 2013 Nov 5;169(3):e35. doi: 10.1016/j.ijcard.2013.08.111. Epub 2013 Sep 7. No abstract available.


Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species.

Gage MC, Yuldasheva NY, Viswambharan H, Sukumar P, Cubbon RM, Galloway S, Imrie H, Skromna A, Smith J, Jackson CL, Kearney MT, Wheatcroft SB.

Atherosclerosis. 2013 Sep;230(1):131-9. doi: 10.1016/j.atherosclerosis.2013.06.017. Epub 2013 Jun 29.


Is clopidogrel adequate in 2013?

Wheatcroft S.

Cardiovasc J Afr. 2013 Mar;24(2):45. No abstract available.


Ankle pressures in UK South Asians with diabetes mellitus: a case control study.

Kain K, Brockway M, Ishfaq T, Merrick M, Mahmood H, Ingoe JC, Law GR, Sohrabi S, Wheatcroft S, Scott DJ.

Heart. 2013 May;99(9):614-9. doi: 10.1136/heartjnl-2012-303217. Epub 2013 Feb 26.


Teaching an old drug new tricks: can paroxetine ease the burden of cardiovascular disease in diabetes?

Wheatcroft SB.

Diabetes. 2013 Mar;62(3):698-700. doi: 10.2337/db12-1530. No abstract available.


Bivalirudin in patients undergoing primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: outcomes in a large real-world population.

Shelton R, Eftychiou C, Somers K, Liu A, Burton-Wood N, Anderson M, Makri L, Blaxill J, McLenachan J, Wheatcroft S, Greenwood J, Blackman D.

EuroIntervention. 2013 May 20;9(1):118-24. doi: 10.4244/EIJV9I1A17.


Diurnal variation in vascular and metabolic function in diet-induced obesity: divergence of insulin resistance and loss of clock rhythm.

Prasai MJ, Mughal RS, Wheatcroft SB, Kearney MT, Grant PJ, Scott EM.

Diabetes. 2013 Jun;62(6):1981-9. doi: 10.2337/db11-1740. Epub 2013 Feb 4.


Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction.

Sukumar P, Viswambharan H, Imrie H, Cubbon RM, Yuldasheva N, Gage M, Galloway S, Skromna A, Kandavelu P, Santos CX, Gatenby VK, Smith J, Beech DJ, Wheatcroft SB, Channon KM, Shah AM, Kearney MT.

Diabetes. 2013 Jun;62(6):2130-4. doi: 10.2337/db12-1294. Epub 2013 Jan 24.


Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology.

Cubbon RM, Adams B, Rajwani A, Mercer BN, Patel PA, Gherardi G, Gale CP, Batin PD, Ajjan R, Kearney L, Wheatcroft SB, Sapsford RJ, Witte KK, Kearney MT.

Diab Vasc Dis Res. 2013 Jul;10(4):330-6. doi: 10.1177/1479164112471064. Epub 2013 Jan 24.


A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.

Bruns AF, Yuldasheva N, Latham AM, Bao L, Pellet-Many C, Frankel P, Stephen SL, Howell GJ, Wheatcroft SB, Kearney MT, Zachary IC, Ponnambalam S.

PLoS One. 2012;7(11):e48539. doi: 10.1371/journal.pone.0048539. Epub 2012 Nov 6.


The S100A6 calcium-binding protein regulates endothelial cell-cycle progression and senescence.

Bao L, Odell AF, Stephen SL, Wheatcroft SB, Walker JH, Ponnambalam S.

FEBS J. 2012 Dec;279(24):4576-88. doi: 10.1111/febs.12044. Epub 2012 Nov 22.

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