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Natural Transmission of Helicobacter saguini Causes Multigenerational Inflammatory Bowel Disease in C57/129 IL-10-/- Mice.

Mannion A, Shen Z, Feng Y, Puglisi D, Muthupalani S, Whary MT, Fox JG.

mSphere. 2020 Mar 25;5(2). pii: e00011-20. doi: 10.1128/mSphere.00011-20.


The development of colitis in Il10-/- mice is dependent on IL-22.

Gunasekera DC, Ma J, Vacharathit V, Shah P, Ramakrishnan A, Uprety P, Shen Z, Sheh A, Brayton CF, Whary MT, Fox JG, Bream JH.

Mucosal Immunol. 2020 Jan 13. doi: 10.1038/s41385-019-0252-3. [Epub ahead of print]


Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.

Cheng CW, Biton M, Haber AL, Gunduz N, Eng G, Gaynor LT, Tripathi S, Calibasi-Kocal G, Rickelt S, Butty VL, Moreno-Serrano M, Iqbal AM, Bauer-Rowe KE, Imada S, Ulutas MS, Mylonas C, Whary MT, Levine SS, Basbinar Y, Hynes RO, Mino-Kenudson M, Deshpande V, Boyer LA, Fox JG, Terranova C, Rai K, Piwnica-Worms H, Mihaylova MM, Regev A, Yilmaz ÖH.

Cell. 2019 Aug 22;178(5):1115-1131.e15. doi: 10.1016/j.cell.2019.07.048.


High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome.

Münch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, Sahm V, Wiethaler M, Baumeister T, Wein F, Einwächter H, Bolze F, Klingenspor M, Haller D, Kavanagh M, Lysaght J, Friedman R, Dannenberg AJ, Pollak M, Holt PR, Muthupalani S, Fox JG, Whary MT, Lee Y, Ren TY, Elliot R, Fitzgerald R, Steiger K, Schmid RM, Wang TC, Quante M.

Gastroenterology. 2019 Aug;157(2):492-506.e2. doi: 10.1053/j.gastro.2019.04.013. Epub 2019 Apr 15.


Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.

Jin C, Lagoudas GK, Zhao C, Bullman S, Bhutkar A, Hu B, Ameh S, Sandel D, Liang XS, Mazzilli S, Whary MT, Meyerson M, Germain R, Blainey PC, Fox JG, Jacks T.

Cell. 2019 Feb 21;176(5):998-1013.e16. doi: 10.1016/j.cell.2018.12.040. Epub 2019 Jan 31.


Author Correction: Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma.

Chen H, Cho KS, Vu THK, Shen CH, Kaur M, Chen G, Mathew R, McHam ML, Fazelat A, Lashkari K, Au NPB, Tse JKY, Li Y, Yu H, Yang L, Stein-Streilein J, Ma CHE, Woolf CJ, Whary MT, Jager MJ, Fox JG, Chen J, Chen DF.

Nat Commun. 2018 Sep 20;9(1):3914. doi: 10.1038/s41467-018-06428-2.


Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma.

Chen H, Cho KS, Vu THK, Shen CH, Kaur M, Chen G, Mathew R, McHam ML, Fazelat A, Lashkari K, Au NPB, Tse JKY, Li Y, Yu H, Yang L, Stein-Streilein J, Ma CHE, Woolf CJ, Whary MT, Jager MJ, Fox JG, Chen J, Chen DF.

Nat Commun. 2018 Aug 10;9(1):3209. doi: 10.1038/s41467-018-05681-9. Erratum in: Nat Commun. 2018 Sep 20;9(1):3914.


Helicobacter pylori-infected C57BL/6 mice with different gastrointestinal microbiota have contrasting gastric pathology, microbial and host immune responses.

Ge Z, Sheh A, Feng Y, Muthupalani S, Ge L, Wang C, Kurnick S, Mannion A, Whary MT, Fox JG.

Sci Rep. 2018 May 22;8(1):8014. doi: 10.1038/s41598-018-25927-2.


Helicobacter saguini, a Novel Helicobacter Isolated from Cotton-Top Tamarins with Ulcerative Colitis, Has Proinflammatory Properties and Induces Typhlocolitis and Dysplasia in Gnotobiotic IL-10-/- Mice.

Shen Z, Mannion A, Whary MT, Muthupalani S, Sheh A, Feng Y, Gong G, Vandamme P, Holcombe HR, Paster BJ, Fox JG.

Infect Immun. 2016 Jul 21;84(8):2307-2316. doi: 10.1128/IAI.00235-16. Print 2016 Aug.


Male Syrian Hamsters Experimentally Infected with Helicobacter spp. of the H. bilis Cluster Develop MALT-Associated Gastrointestinal Lymphomas.

Woods SE, Ek C, Shen Z, Feng Y, Ge Z, Muthupalani S, Whary MT, Fox JG.

Helicobacter. 2016 Jun;21(3):201-17. doi: 10.1111/hel.12265. Epub 2015 Sep 8.


Impaired cholecystokinin-induced gallbladder emptying incriminated in spontaneous "black" pigment gallstone formation in germfree Swiss Webster mice.

Woods SE, Leonard MR, Hayden JA, Brophy MB, Bernert KR, Lavoie B, Muthupalani S, Whary MT, Mawe GM, Nolan EM, Carey MC, Fox JG.

Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G335-49. doi: 10.1152/ajpgi.00314.2014. Epub 2014 Dec 4.


Helicobacter hepaticus cholesterol-α-glucosyltransferase is essential for establishing colonization in male A/JCr mice.

Ge Z, Feng Y, Muthupalani S, Whary MT, Versalovic J, Fox JG.

Helicobacter. 2014 Aug;19(4):280-8. doi: 10.1111/hel.12135. Epub 2014 May 23.


Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota.

Whary MT, Muthupalani S, Ge Z, Feng Y, Lofgren J, Shi HN, Taylor NS, Correa P, Versalovic J, Wang TC, Fox JG.

Microbes Infect. 2014 Apr;16(4):345-55. doi: 10.1016/j.micinf.2014.01.005. Epub 2014 Feb 8.


Detection of Campylobacter in stool and determination of significance by culture, enzyme immunoassay, and PCR in developing countries.

Platts-Mills JA, Liu J, Gratz J, Mduma E, Amour C, Swai N, Taniuchi M, Begum S, Peñataro Yori P, Tilley DH, Lee G, Shen Z, Whary MT, Fox JG, McGrath M, Kosek M, Haque R, Houpt ER.

J Clin Microbiol. 2014 Apr;52(4):1074-80. doi: 10.1128/JCM.02935-13. Epub 2014 Jan 22.


Helicobacter pylori infection does not promote hepatocellular cancer in a transgenic mouse model of hepatitis C virus pathogenesis.

García A, Feng Y, Parry NM, McCabe A, Mobley MW, Lertpiriyapong K, Whary MT, Fox JG.

Gut Microbes. 2013 Nov-Dec;4(6):577-90. doi: 10.4161/gmic.26042. Epub 2013 Aug 7.


An analysis of the role of the indigenous microbiota in cholesterol gallstone pathogenesis.

Fremont-Rahl JJ, Ge Z, Umana C, Whary MT, Taylor NS, Muthupalani S, Carey MC, Fox JG, Maurer KJ.

PLoS One. 2013 Jul 29;8(7):e70657. doi: 10.1371/journal.pone.0070657. Print 2013.


Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis.

Lertpiriyapong K, Whary MT, Muthupalani S, Lofgren JL, Gamazon ER, Feng Y, Ge Z, Wang TC, Fox JG.

Gut. 2014 Jan;63(1):54-63. doi: 10.1136/gutjnl-2013-305178. Epub 2013 Jun 28.


Prevalence of murine Helicobacter spp. Infection is reduced by restocking research colonies with Helicobacter-free mice.

Lofgren JL, Esmail M, Mobley M, McCabe A, Taylor NS, Shen Z, Erdman S, Hewes C, Whary MT, Fox JG.

J Am Assoc Lab Anim Sci. 2012 Jul;51(4):436-42.


Natural and experimental Helicobacter pullorum infection in Brown Norway rats.

Cacioppo LD, Turk ML, Shen Z, Ge Z, Parry N, Whary MT, Boutin SR, Klein HJ, Fox JG.

J Med Microbiol. 2012 Sep;61(Pt 9):1319-1323. doi: 10.1099/jmm.0.042374-0. Epub 2012 May 11.


Serologic evidence that ascaris and toxoplasma infections impact inflammatory responses to Helicobacter pylori in Colombians.

Ek C, Whary MT, Ihrig M, Bravo LE, Correa P, Fox JG.

Helicobacter. 2012 Apr;17(2):107-15. doi: 10.1111/j.1523-5378.2011.00916.x.


Persistent Helicobacter pullorum colonization in C57BL/6NTac mice: a new mouse model for an emerging zoonosis.

Turk ML, Cacioppo LD, Ge Z, Shen Z, Whary MT, Parry N, Boutin SR, Klein HJ, Fox JG.

J Med Microbiol. 2012 May;61(Pt 5):720-728. doi: 10.1099/jmm.0.040055-0. Epub 2012 Feb 2.


Coinfection with Enterohepatic Helicobacter species can ameliorate or promote Helicobacter pylori-induced gastric pathology in C57BL/6 mice.

Ge Z, Feng Y, Muthupalani S, Eurell LL, Taylor NS, Whary MT, Fox JG.

Infect Immun. 2011 Oct;79(10):3861-71. doi: 10.1128/IAI.05357-11. Epub 2011 Jul 25.


17 β-estradiol suppresses Helicobacter pylori-induced gastric pathology in male hypergastrinemic INS-GAS mice.

Ohtani M, Ge Z, García A, Rogers AB, Muthupalani S, Taylor NS, Xu S, Watanabe K, Feng Y, Marini RP, Whary MT, Wang TC, Fox JG.

Carcinogenesis. 2011 Aug;32(8):1244-50. doi: 10.1093/carcin/bgr072. Epub 2011 May 11.


Lactobacillus reuteri promotes Helicobacter hepaticus-associated typhlocolitis in gnotobiotic B6.129P2-IL-10(tm1Cgn) (IL-10(-/-) ) mice.

Whary MT, Taylor NS, Feng Y, Ge Z, Muthupalani S, Versalovic J, Fox JG.

Immunology. 2011 Jun;133(2):165-78. doi: 10.1111/j.1365-2567.2011.03423.x. Epub 2011 Mar 23.


Bacterial infection causes stress-induced memory dysfunction in mice.

Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ, Macqueen G, Sherman PM.

Gut. 2011 Mar;60(3):307-17. doi: 10.1136/gut.2009.202515. Epub 2010 Oct 21.


Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.

Lofgren JL, Whary MT, Ge Z, Muthupalani S, Taylor NS, Mobley M, Potter A, Varro A, Eibach D, Suerbaum S, Wang TC, Fox JG.

Gastroenterology. 2011 Jan;140(1):210-20. doi: 10.1053/j.gastro.2010.09.048. Epub 2010 Oct 13.


Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer.

Fox JG, Ge Z, Whary MT, Erdman SE, Horwitz BH.

Mucosal Immunol. 2011 Jan;4(1):22-30. doi: 10.1038/mi.2010.61. Epub 2010 Oct 13. Review.


Brugia filariasis differentially modulates persistent Helicobacter pylori gastritis in the gerbil model.

Martin HR, Shakya KP, Muthupalani S, Ge Z, Klei TR, Whary MT, Fox JG.

Microbes Infect. 2010 Sep;12(10):748-58. doi: 10.1016/j.micinf.2010.05.005. Epub 2010 May 31.


Persistent infection of rhesus monkeys with 'Helicobacter macacae' and its isolation from an animal with intestinal adenocarcinoma.

Marini RP, Muthupalani S, Shen Z, Buckley EM, Alvarado C, Taylor NS, Dewhirst FE, Whary MT, Patterson MM, Fox JG.

J Med Microbiol. 2010 Aug;59(Pt 8):961-9. doi: 10.1099/jmm.0.019117-0. Epub 2010 Apr 22.


Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia.

Shibata W, Takaishi S, Muthupalani S, Pritchard DM, Whary MT, Rogers AB, Fox JG, Betz KS, Kaestner KH, Karin M, Wang TC.

Gastroenterology. 2010 Mar;138(3):1022-34.e1-10. doi: 10.1053/j.gastro.2009.11.054. Epub 2009 Dec 4.


Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice.

Takaishi S, Tu S, Dubeykovskaya ZA, Whary MT, Muthupalani S, Rickman BH, Rogers AB, Lertkowit N, Varro A, Fox JG, Wang TC.

Am J Pathol. 2009 Jul;175(1):365-75. doi: 10.2353/ajpath.2009.081165.


Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-deficient mice.

Shen Z, Feng Y, Rogers AB, Rickman B, Whary MT, Xu S, Clapp KM, Boutin SR, Fox JG.

Infect Immun. 2009 Jun;77(6):2508-16. doi: 10.1128/IAI.00166-09. Epub 2009 Mar 23.


Concurrent Helicobacter bilis infection in C57BL/6 mice attenuates proinflammatory H. pylori-induced gastric pathology.

Lemke LB, Ge Z, Whary MT, Feng Y, Rogers AB, Muthupalani S, Fox JG.

Infect Immun. 2009 May;77(5):2147-58. doi: 10.1128/IAI.01395-08. Epub 2009 Feb 17.


Cross-reactivity between immune responses to Helicobacter bilis and Helicobacter pylori in a population in Thailand at high risk of developing cholangiocarcinoma.

Pisani P, Whary MT, Nilsson I, Sriamporn S, Wadström T, Fox JG, Ljungh A, Forman D.

Clin Vaccine Immunol. 2008 Sep;15(9):1363-8. doi: 10.1128/CVI.00132-08. Epub 2008 Jul 2.


Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice.

Ge Z, Sterzenbach T, Whary MT, Rickman BH, Rogers AB, Shen Z, Taylor NS, Schauer DB, Josenhans C, Suerbaum S, Fox JG.

Microbes Infect. 2008 Jun;10(7):726-33. doi: 10.1016/j.micinf.2008.03.011. Epub 2008 Apr 4.


Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice.

Ge Z, Lee A, Whary MT, Rogers AB, Maurer KJ, Taylor NS, Schauer DB, Fox JG.

Microb Pathog. 2008 Jul;45(1):18-24. doi: 10.1016/j.micpath.2008.02.003. Epub 2008 Mar 27.


Vitamin C supplementation does not protect L-gulono-gamma-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancy.

Lee CW, Wang XD, Chien KL, Ge Z, Rickman BH, Rogers AB, Varro A, Whary MT, Wang TC, Fox JG.

Int J Cancer. 2008 Mar 1;122(5):1068-76.


Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice.

Fox JG, Rogers AB, Whary MT, Ge Z, Ohtani M, Jones EK, Wang TC.

Am J Pathol. 2007 Nov;171(5):1520-8.


Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice.

Ohtani M, García A, Rogers AB, Ge Z, Taylor NS, Xu S, Watanabe K, Marini RP, Whary MT, Wang TC, Fox JG.

Carcinogenesis. 2007 Dec;28(12):2597-604. Epub 2007 Aug 27.


Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses.

Kurt-Jones EA, Cao L, Sandor F, Rogers AB, Whary MT, Nambiar PR, Cerny A, Bowen G, Yan J, Takaishi S, Chi AL, Reed G, Houghton J, Fox JG, Wang TC.

Infect Immun. 2007 Jan;75(1):471-80. Epub 2006 Nov 13.


Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora.

Whary MT, Danon SJ, Feng Y, Ge Z, Sundina N, Ng V, Taylor NS, Rogers AB, Fox JG.

Infect Immun. 2006 Dec;74(12):6615-23. Epub 2006 Sep 18.


Clostridium piliforme infection in two farm-raised white-tailed deer fawns (Odocoileus virginianus) and association with copper toxicosis.

Brooks JW, Whary MT, Hattel AL, Shaw DP, Ge Z, Fox JG, Poppenga RH.

Vet Pathol. 2006 Sep;43(5):765-8.


Detection, eradication, and research implications of Helicobacter infections in laboratory rodents.

Whary MT, Fox JG.

Lab Anim (NY). 2006 Jul-Aug;35(7):25-7, 30-6. Review.


Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice.

Rogers AB, Taylor NS, Whary MT, Stefanich ED, Wang TC, Fox JG.

Cancer Res. 2005 Dec 1;65(23):10709-15.


p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice.

Kuzushita N, Rogers AB, Monti NA, Whary MT, Park MJ, Aswad BI, Shirin H, Koff A, Eguchi H, Moss SF.

Gastroenterology. 2005 Nov;129(5):1544-56.


Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis.

Whary MT, Sundina N, Bravo LE, Correa P, Quinones F, Caro F, Fox JG.

Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1464-9.


Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.

Takaishi S, Cui G, Frederick DM, Carlson JE, Houghton J, Varro A, Dockray GJ, Ge Z, Whary MT, Rogers AB, Fox JG, Wang TC.

Gastroenterology. 2005 Jun;128(7):1965-83.


Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice.

Ge Z, Feng Y, Whary MT, Nambiar PR, Xu S, Ng V, Taylor NS, Fox JG.

Infect Immun. 2005 Jun;73(6):3559-67.

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