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Elevated Cerebrospinal Fluid Sodium in Hypertensive Human Subjects with a Family History of Alzheimer's Disease.

Souza LA, Trebak F, Kumar V, Satou R, Kehoe PG, Yang W, Wharton W, Feng Earley Y.

Physiol Genomics. 2020 Jan 21. doi: 10.1152/physiolgenomics.00093.2019. [Epub ahead of print]


Effects of Combined Aerobic Exercise and Cognitive Training on Verbal Fluency in Older Adults.

Nocera JR, Mammino K, Kommula Y, Wharton W, Crosson B, McGregor KM.

Gerontol Geriatr Med. 2020 Jan 8;6:2333721419896884. doi: 10.1177/2333721419896884. eCollection 2020 Jan-Dec.


Interleukin 9 alterations linked to alzheimer disease in african americans.

Wharton W, Kollhoff AL, Gangishetti U, Verble DD, Upadhya S, Zetterberg H, Kumar V, Watts KD, Kippels AJ, Gearing M, Howell JC, Parker MW, Hu WT.

Ann Neurol. 2019 Sep;86(3):407-418. doi: 10.1002/ana.25543. Epub 2019 Jul 22.


Neurofibrillary Tangles and Conversion to Mild Cognitive Impairment with Certain Antihypertensives.

Wharton W, Zhao L, Steenland K, Goldstein FC, Schneider JA, Barnes LL, Gearing M, Yasar S.

J Alzheimers Dis. 2019;70(1):153-161. doi: 10.3233/JAD-190011.


Rationale and Design of a Clinical Trial of Adapted Tango to Improve Negative Health Impacts in Middle Aged African-American Female Caregivers of Persons with Alzheimer's Disease (ACT Trial).

Hackney ME, McCullough LE, Bay AA, Silverstein HA, Hart AR, Shin RJ, Wharton W.

J Alzheimers Dis. 2019;68(2):767-775. doi: 10.3233/JAD-181130.


Diet as a Risk Factor for Cognitive Decline in African Americans and Caucasians with a Parental History of Alzheimer's Disease: A Cross-Sectional Pilot Study Dietary Patterns.

Nutaitis AC, Tharwani SD, Serra MC, Goldstein FC, Zhao L, Sher SS, Verble DD, Wharton W.

J Prev Alzheimers Dis. 2019;6(1):50-55. doi: 10.14283/jpad.2018.44.


The association of multiple anti-hypertensive medication classes with Alzheimer's disease incidence across sex, race, and ethnicity.

Barthold D, Joyce G, Wharton W, Kehoe P, Zissimopoulos J.

PLoS One. 2018 Nov 1;13(11):e0206705. doi: 10.1371/journal.pone.0206705. eCollection 2018.


Photojournalism-Based Intervention Reduces Caregiver Burden and Depression in Alzheimer's Disease Family Caregivers.

Wharton W, Epps F, Kovaleva M, Bridwell L, Tate RC, Dorbin CD, Hepburn K.

J Holist Nurs. 2019 Sep;37(3):214-224. doi: 10.1177/0898010118801636. Epub 2018 Oct 4.


Rationale and Design of the Mechanistic Potential of Antihypertensives in Preclinical Alzheimer's (HEART) Trial.

Wharton W, Goldstein FC, Tansey MG, Brown AL, Tharwani SD, Verble DD, Cintron A, Kehoe PG.

J Alzheimers Dis. 2018;61(2):815-824. doi: 10.3233/JAD-161198.


Effects of oral versus transdermal menopausal hormone treatments on self-reported sleep domains and their association with vasomotor symptoms in recently menopausal women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS).

Cintron D, Lahr BD, Bailey KR, Santoro N, Lloyd R, Manson JE, Neal-Perry G, Pal L, Taylor HS, Wharton W, Naftolin F, Harman SM, Miller VM.

Menopause. 2018 Feb;25(2):145-153. doi: 10.1097/GME.0000000000000971.


Proton Pump Inhibitors and Risk of Mild Cognitive Impairment and Dementia.

Goldstein FC, Steenland K, Zhao L, Wharton W, Levey AI, Hajjar I.

J Am Geriatr Soc. 2017 Sep;65(9):1969-1974. doi: 10.1111/jgs.14956. Epub 2017 Jun 7.


Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronized progesterone versus placebo: the Kronos Early Estrogen Prevention Study.

Santoro N, Allshouse A, Neal-Perry G, Pal L, Lobo RA, Naftolin F, Black DM, Brinton EA, Budoff MJ, Cedars MI, Dowling NM, Dunn M, Gleason CE, Hodis HN, Isaac B, Magnani M, Manson JE, Miller VM, Taylor HS, Wharton W, Wolff E, Zepeda V, Harman SM.

Menopause. 2017 Mar;24(3):238-246. doi: 10.1097/GME.0000000000000756.


The Relationship Between Cognitive Functioning and the JNC-8 Guidelines for Hypertension in Older Adults.

Goldstein FC, Hajjar IM, Dunn CB, Levey AI, Wharton W.

J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):121-126. Epub 2016 Sep 27.


Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss.

Basaria S, Jasuja R, Huang G, Wharton W, Pan H, Pencina K, Li Z, Travison TG, Bhawan J, Gonthier R, Labrie F, Dury AY, Serra C, Papazian A, O'Leary M, Amr S, Storer TW, Stern E, Bhasin S.

J Clin Endocrinol Metab. 2016 Dec;101(12):4669-4680. Epub 2016 Sep 23.


Effects of hormone therapy on brain structure: A randomized controlled trial.

Kantarci K, Tosakulwong N, Lesnick TG, Zuk SM, Gunter JL, Gleason CE, Wharton W, Dowling NM, Vemuri P, Senjem ML, Shuster LT, Bailey KR, Rocca WA, Jack CR Jr, Asthana S, Miller VM.

Neurology. 2016 Aug 30;87(9):887-96. doi: 10.1212/WNL.0000000000002970. Epub 2016 Jul 29.


Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells.

Durfee PN, Lin YS, Dunphy DR, Muñiz AJ, Butler KS, Humphrey KR, Lokke AJ, Agola JO, Chou SS, Chen IM, Wharton W, Townson JL, Willman CL, Brinker CJ.

ACS Nano. 2016 Sep 27;10(9):8325-45. doi: 10.1021/acsnano.6b02819. Epub 2016 Jul 25.


Effects of long-term testosterone administration on cognition in older men with low or low-to-normal testosterone concentrations: a prespecified secondary analysis of data from the randomised, double-blind, placebo-controlled TEAAM trial.

Huang G, Wharton W, Bhasin S, Harman SM, Pencina KM, Tsitouras P, Li Z, Hally KA, Asthana S, Storer TW, Basaria S.

Lancet Diabetes Endocrinol. 2016 Aug;4(8):657-665. doi: 10.1016/S2213-8587(16)30102-4. Epub 2016 Jul 1.


Effect of a Clinical Practice Guideline for Pediatric Complicated Appendicitis.

Willis ZI, Duggan EM, Bucher BT, Pietsch JB, Milovancev M, Wharton W, Gillon J, Lovvorn HN 3rd, O'Neill JA Jr, Di Pentima MC, Blakely ML.

JAMA Surg. 2016 May 18;151(5):e160194. doi: 10.1001/jamasurg.2016.0194. Epub 2016 May 18.


Differential effects of hormone therapy on serotonin, vascular function and mood in the KEEPS.

Raz L, Hunter LV, Dowling NM, Wharton W, Gleason CE, Jayachandran M, Anderson L, Asthana S, Miller VM.

Climacteric. 2016;19(1):49-59. doi: 10.3109/13697137.2015.1116504. Epub 2015 Dec 10.


A Meta-Analysis of Alzheimer's Disease Incidence and Prevalence Comparing African-Americans and Caucasians.

Steenland K, Goldstein FC, Levey A, Wharton W.

J Alzheimers Dis. 2016;50(1):71-6. doi: 10.3233/JAD-150778.


Modulation of Renin-Angiotensin System May Slow Conversion from Mild Cognitive Impairment to Alzheimer's Disease.

Wharton W, Goldstein FC, Zhao L, Steenland K, Levey AI, Hajjar I.

J Am Geriatr Soc. 2015 Sep;63(9):1749-56. doi: 10.1111/jgs.13627.


Racial Disparity in Cognitive and Functional Disability in Hypertension and All-Cause Mortality.

Hajjar I, Wharton W, Mack WJ, Levey AI, Goldstein FC.

Am J Hypertens. 2016 Feb;29(2):185-93. doi: 10.1093/ajh/hpv084. Epub 2015 Jul 1.


Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS-Cognitive and Affective Study.

Gleason CE, Dowling NM, Wharton W, Manson JE, Miller VM, Atwood CS, Brinton EA, Cedars MI, Lobo RA, Merriam GR, Neal-Perry G, Santoro NF, Taylor HS, Black DM, Budoff MJ, Hodis HN, Naftolin F, Harman SM, Asthana S.

PLoS Med. 2015 Jun 2;12(6):e1001833; discussion e1001833. doi: 10.1371/journal.pmed.1001833. eCollection 2015 Jun.


Effects of testosterone administration on cognitive function in hysterectomized women with low testosterone levels: a dose-response randomized trial.

Huang G, Wharton W, Travison TG, Ho MH, Gleason C, Asthana S, Bhasin S, Basaria S.

J Endocrinol Invest. 2015 Apr;38(4):455-61. doi: 10.1007/s40618-014-0213-3. Epub 2014 Nov 28.


The KEEPS-Cognitive and Affective Study: baseline associations between vascular risk factors and cognition.

Wharton W, Gleason CE, Dowling NM, Carlsson CM, Brinton EA, Santoro MN, Neal-Perry G, Taylor H, Naftolin F, Lobo RA, Merriam G, Manson JE, Cedars MI, Miller VM, Black DM, Budoff M, Hodis HN, Harman SM, Asthana S.

J Alzheimers Dis. 2014;40(2):331-41. doi: 10.3233/JAD-130245.


Neurobiological Underpinnings of the Estrogen - Mood Relationship.

Wharton W, Gleason CE, Olson SR, Carlsson CM, Asthana S.

Curr Psychiatry Rev. 2012 Aug 1;8(3):247-256.


Characterization of vascular disease risk in postmenopausal women and its association with cognitive performance.

Dowling NM, Gleason CE, Manson JE, Hodis HN, Miller VM, Brinton EA, Neal-Perry G, Santoro MN, Cedars M, Lobo R, Merriam GR, Wharton W, Naftolin F, Taylor H, Harman SM, Asthana S.

PLoS One. 2013 Jul 17;8(7):e68741. doi: 10.1371/journal.pone.0068741. Print 2013.


Rationale and design of the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS Cognitive and Affective sub study (KEEPS Cog).

Wharton W, Gleason CE, Miller VM, Asthana S.

Brain Res. 2013 Jun 13;1514:12-7. doi: 10.1016/j.brainres.2013.04.011. Epub 2013 Apr 17.


A nucleosomal region important for ensuring proper interactions between the transcription elongation factor Spt16 and transcribed genes in Saccharomyces cerevisiae.

Nguyen HT, Wharton W 2nd, Harper JA, Dornhoffer JR, Duina AA.

G3 (Bethesda). 2013 Jun 21;3(6):929-40. doi: 10.1534/g3.113.005926.


Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer's disease.

Okonkwo OC, Xu G, Oh JM, Dowling NM, Carlsson CM, Gallagher CL, Birdsill AC, Palotti M, Wharton W, Hermann BP, LaRue A, Bendlin BB, Rowley HA, Asthana S, Sager MA, Johnson SC.

Cereb Cortex. 2014 Apr;24(4):978-88. doi: 10.1093/cercor/bhs381. Epub 2012 Dec 12.


Delivery of ricin toxin a-chain by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.

Epler K, Padilla D, Phillips G, Crowder P, Castillo R, Wilkinson D, Wilkinson B, Burgard C, Kalinich R, Townson J, Chackerian B, Willman C, Peabody D, Wharton W, Brinker CJ, Ashley C, Carnes E.

Adv Healthc Mater. 2012 May;1(3):348-53. doi: 10.1002/adhm.201200022. Epub 2012 Apr 2.


The effects of ramipril in individuals at risk for Alzheimer's disease: results of a pilot clinical trial.

Wharton W, Stein JH, Korcarz C, Sachs J, Olson SR, Zetterberg H, Dowling M, Ye S, Gleason CE, Underbakke G, Jacobson LE, Johnson SC, Sager MA, Asthana S, Carlsson CM.

J Alzheimers Dis. 2012;32(1):147-56.


Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study.

Chen IM, Harvey RC, Mullighan CG, Gastier-Foster J, Wharton W, Kang H, Borowitz MJ, Camitta BM, Carroll AJ, Devidas M, Pullen DJ, Payne-Turner D, Tasian SK, Reshmi S, Cottrell CE, Reaman GH, Bowman WP, Carroll WL, Loh ML, Winick NJ, Hunger SP, Willman CL.

Blood. 2012 Apr 12;119(15):3512-22. doi: 10.1182/blood-2011-11-394221. Epub 2012 Feb 24.


Delivery of small interfering RNA by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.

Ashley CE, Carnes EC, Epler KE, Padilla DP, Phillips GK, Castillo RE, Wilkinson DC, Wilkinson BS, Burgard CA, Kalinich RM, Townson JL, Chackerian B, Willman CL, Peabody DS, Wharton W, Brinker CJ.

ACS Nano. 2012 Mar 27;6(3):2174-88. doi: 10.1021/nn204102q. Epub 2012 Feb 14.


Using predictors of hormone therapy use to model the healthy user bias: how does healthy user status influence cognitive effects of hormone therapy?

Gleason CE, Dowling NM, Friedman E, Wharton W, Asthana S.

Menopause. 2012 May;19(5):524-33. doi: 10.1097/gme.0b013e318238ff2c.


Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial.

Wharton W, Baker LD, Gleason CE, Dowling M, Barnet JH, Johnson S, Carlsson C, Craft S, Asthana S.

J Alzheimers Dis. 2011;26(3):495-505. doi: 10.3233/JAD-2011-110341.


Cell-specific delivery of diverse cargos by bacteriophage MS2 virus-like particles.

Ashley CE, Carnes EC, Phillips GK, Durfee PN, Buley MD, Lino CA, Padilla DP, Phillips B, Carter MB, Willman CL, Brinker CJ, Caldeira Jdo C, Chackerian B, Wharton W, Peabody DS.

ACS Nano. 2011 Jul 26;5(7):5729-45. doi: 10.1021/nn201397z. Epub 2011 Jun 7.


The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers.

Ashley CE, Carnes EC, Phillips GK, Padilla D, Durfee PN, Brown PA, Hanna TN, Liu J, Phillips B, Carter MB, Carroll NJ, Jiang X, Dunphy DR, Willman CL, Petsev DN, Evans DG, Parikh AN, Chackerian B, Wharton W, Peabody DS, Brinker CJ.

Nat Mater. 2011 May;10(5):389-97. doi: 10.1038/nmat2992. Epub 2011 Apr 17. Erratum in: Nat Mater. 2011 Jun;10(6):476.


Prospective clinical trial comparing outcome measures between Furlow and von Langenbeck Palatoplasties for UCLP.

Williams WN, Seagle MB, Pegoraro-Krook MI, Souza TV, Garla L, Silva ML, Machado Neto JS, Dutka JC, Nackashi J, Boggs S, Shuster J, Moorhead J, Wharton W, Graciano MI, Pimentel MC, Feniman M, Piazentin-Penna SH, Kemker J, Zimmermann MC, Bento-Gonçalvez C, Borgo H, Marques IL, Martinelli AP, Jorge JC, Antonelli P, Neves JF, Whitaker ME.

Ann Plast Surg. 2011 Feb;66(2):154-63. doi: 10.1097/SAP.0b013e3181d60763.


Awareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairment.

Lin F, Wharton W, Dowling NM, Ries ML, Johnson SC, Carlsson CM, Asthana S, Gleason CE.

Dement Geriatr Cogn Disord. 2010;30(1):83-92. doi: 10.1159/000318752. Epub 2010 Aug 12.


Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome.

Harvey RC, Mullighan CG, Wang X, Dobbin KK, Davidson GS, Bedrick EJ, Chen IM, Atlas SR, Kang H, Ar K, Wilson CS, Wharton W, Murphy M, Devidas M, Carroll AJ, Borowitz MJ, Bowman WP, Downing JR, Relling M, Yang J, Bhojwani D, Carroll WL, Camitta B, Reaman GH, Smith M, Hunger SP, Willman CL.

Blood. 2010 Dec 2;116(23):4874-84. doi: 10.1182/blood-2009-08-239681. Epub 2010 Aug 10.


Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.

Harvey RC, Mullighan CG, Chen IM, Wharton W, Mikhail FM, Carroll AJ, Kang H, Liu W, Dobbin KK, Smith MA, Carroll WL, Devidas M, Bowman WP, Camitta BM, Reaman GH, Hunger SP, Downing JR, Willman CL.

Blood. 2010 Jul 1;115(26):5312-21. doi: 10.1182/blood-2009-09-245944. Epub 2010 Feb 4.


Midlife predictors of Alzheimer's disease.

Bendlin BB, Carlsson CM, Gleason CE, Johnson SC, Sodhi A, Gallagher CL, Puglielli L, Engelman CD, Ries ML, Xu G, Wharton W, Asthana S.

Maturitas. 2010 Feb;65(2):131-7. doi: 10.1016/j.maturitas.2009.12.014. Epub 2009 Dec 30. Review.


Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease.

Wharton W, Gleason CE, Lorenze KR, Markgraf TS, Ries ML, Carlsson CM, Asthana S.

Am J Transl Res. 2009 Jan 20;1(2):131-47.


Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia.

Kang H, Chen IM, Wilson CS, Bedrick EJ, Harvey RC, Atlas SR, Devidas M, Mullighan CG, Wang X, Murphy M, Ar K, Wharton W, Borowitz MJ, Bowman WP, Bhojwani D, Carroll WL, Camitta BM, Reaman GH, Smith MA, Downing JR, Hunger SP, Willman CL.

Blood. 2010 Feb 18;115(7):1394-405. doi: 10.1182/blood-2009-05-218560. Epub 2009 Oct 30.


Cognitive benefits of hormone therapy: cardiovascular factors and healthy-user bias.

Wharton W, Dowling M, Khosropour CM, Carlsson C, Asthana S, Gleason CE.

Maturitas. 2009 Nov 20;64(3):182-7. doi: 10.1016/j.maturitas.2009.09.014. Epub 2009 Oct 29.


LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kappaB.

Dokladny K, Lobb R, Wharton W, Ma TY, Moseley PL.

Cell Stress Chaperones. 2010 Mar;15(2):153-63. doi: 10.1007/s12192-009-0129-6. Epub 2009 Jun 24.


Oral contraceptives and androgenicity: influences on visuospatial task performance in younger individuals.

Wharton W, Hirshman E, Merritt P, Doyle L, Paris S, Gleason C.

Exp Clin Psychopharmacol. 2008 Apr;16(2):156-64. doi: 10.1037/1064-1297.16.2.156.


Lack of cross-tolerance following heat and cadmium exposure in functional MDCK monolayers.

Dokladny K, Wharton W, Ma TY, Moseley PL.

J Appl Toxicol. 2008 Oct;28(7):885-94. doi: 10.1002/jat.1352.


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