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Neutrophil-Derived Microvesicle Induced Dysfunction of Brain Microvascular Endothelial Cells In Vitro.

Ajikumar A, Long MB, Heath PR, Wharton SB, Ince PG, Ridger VC, Simpson JE.

Int J Mol Sci. 2019 Oct 22;20(20). pii: E5227. doi: 10.3390/ijms20205227.


Response to "Liraglutide Effectiveness: Is There a Real-World Clinical Benefit?"

Wharton S, Liu A, Pakseresht A, Nørtoft E, Haase CL, Mancini J, Power GS, Vanderlelie S, Christensen RAG.

Obesity (Silver Spring). 2019 Nov;27(11):1728. doi: 10.1002/oby.22630. Epub 2019 Sep 23. No abstract available.


Effectiveness of a Community-Based Weight Management Program for Patients Taking Antidepressants and/or Antipsychotics.

Wharton S, Kuk JL, Petrova L, Rye PI, Taylor VH, Christensen RAG.

Obesity (Silver Spring). 2019 Sep;27(9):1539-1544. doi: 10.1002/oby.22567.


Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier.

Goodall EF, Leach V, Wang C, Cooper-Knock J, Heath PR, Baker D, Drew DR, Saffrey MJ, Simpson JE, Romero IA, Wharton SB.

Int J Mol Sci. 2019 Jun 25;20(12). pii: E3097. doi: 10.3390/ijms20123097.


Liraglutide 3.0 mg for the management of insufficient weight loss or excessive weight regain post-bariatric surgery.

Wharton S, Kuk JL, Luszczynski M, Kamran E, Christensen RAG.

Clin Obes. 2019 Aug;9(4):e12323. doi: 10.1111/cob.12323. Epub 2019 Jun 10. Erratum in: Clin Obes. 2019 Dec;9(6):e12338.


Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggests neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease.

Vazquez-Villaseñor I, Garwood CJ, Heath PR, Simpson JE, Ince PG, Wharton SB.

Neuropathol Appl Neurobiol. 2019 May 11. doi: 10.1111/nan.12559. [Epub ahead of print]


Real-World Clinical Effectiveness of Liraglutide 3.0 mg for Weight Management in Canada.

Wharton S, Liu A, Pakseresht A, Nørtoft E, Haase CL, Mancini J, Power GS, Vanderlelie S, Christensen RAG.

Obesity (Silver Spring). 2019 Jun;27(6):917-924. doi: 10.1002/oby.22462. Epub 2019 May 7.


The safety and effectiveness of commonly-marketed natural supplements for weight loss in populations with obesity: A critical review of the literature from 2006 to 2016.

Wharton S, Bonder R, Jeffery A, Christensen RAG.

Crit Rev Food Sci Nutr. 2019 Mar 21:1-17. doi: 10.1080/10408398.2019.1584873. [Epub ahead of print]


Absolute Weight Loss, and Not Weight Loss Rate, Is Associated with Better Improvements in Metabolic Health.

Kuk JL, Christensen RAG, Wharton S.

J Obes. 2019 Jan 29;2019:3609642. doi: 10.1155/2019/3609642. eCollection 2019.


The Time Course of Recognition Memory Impairment and Glial Pathology in the hAPP-J20 Mouse Model of Alzheimer's Disease.

Ameen-Ali KE, Simpson JE, Wharton SB, Heath PR, Sharp PS, Brezzo G, Berwick J.

J Alzheimers Dis. 2019;68(2):609-624. doi: 10.3233/JAD-181238.


Combined fused in sarcoma-positive (FUS+) basophilic inclusion body disease and atypical tauopathy presenting with an amyotrophic lateral sclerosis/motor neurone disease (ALS/MND)-plus phenotype.

Wharton SB, Verber NS, Wagner BE, Highley JR, Fillingham DJ, Waller R, Strand K, Ince PG, Shaw PJ.

Neuropathol Appl Neurobiol. 2019 Oct;45(6):586-596. doi: 10.1111/nan.12542. Epub 2019 Feb 19.


Pituitary apoplexy secondary to metastatic breast carcinoma into a gonadotroph cell adenoma of the pituitary.

Mills MT, Wharton SB, Connolly DJ, Mirza S, Sinha S.

Br J Neurosurg. 2018 Nov 26:1-4. doi: 10.1080/02688697.2018.1540766. [Epub ahead of print]


The Association between Antihypertensive Medication Use and Blood Pressure Is Influenced by Obesity.

Parikh JS, Randhawa AK, Wharton S, Edgell H, Kuk JL.

J Obes. 2018 Oct 1;2018:4573258. doi: 10.1155/2018/4573258. eCollection 2018.


Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update.

Tobe SW, Stone JA, Anderson T, Bacon S, Cheng AYY, Daskalopoulou SS, Ezekowitz JA, Gregoire JC, Gubitz G, Jain R, Keshavjee K, Lindsay P, L'Abbe M, Lau DCW, Leiter LA, O'Meara E, Pearson GJ, Rabi DM, Sherifali D, Selby P, Tu JV, Wharton S, Walker KM, Hua-Stewart D, Liu PP.

CMAJ. 2018 Oct 9;190(40):E1192-E1206. doi: 10.1503/cmaj.180194. No abstract available.


Does Continuous Positive Airway Pressure (CPAP) treatment of obstructive sleep apnoea (OSA) improve asthma-related clinical outcomes in patients with co-existing conditions?- A systematic review.

Davies SE, Bishopp A, Wharton S, Turner AM, Mansur AH.

Respir Med. 2018 Oct;143:18-30. doi: 10.1016/j.rmed.2018.08.004. Epub 2018 Aug 9.


Medications that cause weight gain and alternatives in Canada: a narrative review.

Wharton S, Raiber L, Serodio KJ, Lee J, Christensen RA.

Diabetes Metab Syndr Obes. 2018 Aug 21;11:427-438. doi: 10.2147/DMSO.S171365. eCollection 2018. Review.


Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial.

O'Neil PM, Birkenfeld AL, McGowan B, Mosenzon O, Pedersen SD, Wharton S, Carson CG, Jepsen CH, Kabisch M, Wilding JPH.

Lancet. 2018 Aug 25;392(10148):637-649. doi: 10.1016/S0140-6736(18)31773-2. Epub 2018 Aug 16.


Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain.

Waller R, Murphy M, Garwood CJ, Jennings L, Heath PR, Chambers A, Matthews FE, Brayne C, Ince PG, Wharton SB, Simpson JE; Cognitive Function and Ageing Neuropathology Study Group.

Glia. 2018 Nov;66(11):2316-2323. doi: 10.1002/glia.23465. Epub 2018 Aug 10.


Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons.

Ratcliffe LE, Vázquez Villaseñor I, Jennings L, Heath PR, Mortiboys H, Schwartzentruber A, Karyka E, Simpson JE, Ince PG, Garwood CJ, Wharton SB.

Neuroscience. 2018 Oct 15;390:46-59. doi: 10.1016/j.neuroscience.2018.07.029. Epub 2018 Jul 27.


Characterization of neutralizing epitopes in antigenic site B of recently circulating influenza A(H3N2) viruses.

Beer K, Dai M, Howell S, Rijal P, Townsend AR, Lin Y, Wharton SA, Daniels RS, McCauley JW.

J Gen Virol. 2018 Aug;99(8):1001-1011. doi: 10.1099/jgv.0.001101. Epub 2018 Jun 26.


Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes.

Morgan SV, Garwood CJ, Jennings L, Simpson JE, Castelli LM, Heath PR, Mihaylov SR, Vaquéz-Villaseñor I, Minshull TC, Ince PG, Dickman MJ, Hautbergue GM, Wharton SB.

Eur J Neurosci. 2018 Jun;47(12):1444-1456. doi: 10.1111/ejn.13933. Epub 2018 May 30.


Using imaging spectroscopy to detect variation in terrestrial ecosystem productivity across a water-stressed landscape.

DuBois S, Desai AR, Singh A, Serbin SP, Goulden ML, Baldocchi DD, Ma S, Oechel WC, Wharton S, Kruger EL, Townsend PA.

Ecol Appl. 2018 Jul;28(5):1313-1324. doi: 10.1002/eap.1733. Epub 2018 May 23.


Weight Management in Diabetes.

Diabetes Canada Clinical Practice Guidelines Expert Committee, Wharton S, Pedersen SD, Lau DCW, Sharma AM.

Can J Diabetes. 2018 Apr;42 Suppl 1:S124-S129. doi: 10.1016/j.jcjd.2017.10.015. No abstract available.


The association between asthma and obstructive sleep apnea (OSA): A systematic review.

Davies SE, Bishopp A, Wharton S, Turner AM, Mansur AH.

J Asthma. 2019 Feb;56(2):118-129. doi: 10.1080/02770903.2018.1444049. Epub 2018 Apr 11.


Association between cardiorespiratory fitness and metabolic risk factors in a population with mild to severe obesity.

Do K, Brown RE, Wharton S, Ardern CI, Kuk JL.

BMC Obes. 2018 Jan 31;5:5. doi: 10.1186/s40608-018-0183-7. eCollection 2018.


Immuno-Laser-Capture Microdissection for the Isolation of Enriched Glial Populations from Frozen Post-Mortem Human Brain.

Simpson JE, Wharton SB, Heath PR.

Methods Mol Biol. 2018;1723:273-284. doi: 10.1007/978-1-4939-7558-7_16.


Waist circumference at five common measurement sites in normal weight and overweight adults: which site is most optimal?

Brown RE, Randhawa AK, Canning KL, Fung M, Jiandani D, Wharton S, Kuk JL.

Clin Obes. 2018 Feb;8(1):21-29. doi: 10.1111/cob.12231. Epub 2017 Dec 8.


Weight loss medications in Canada - a new frontier or a repeat of past mistakes?

Wharton S, Lee J, Christensen RA.

Diabetes Metab Syndr Obes. 2017 Oct 4;10:413-417. doi: 10.2147/DMSO.S141571. eCollection 2017.


Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease.

Ameen-Ali KE, Wharton SB, Simpson JE, Heath PR, Sharp P, Berwick J.

Neuropathol Appl Neurobiol. 2017 Dec;43(7):553-570. doi: 10.1111/nan.12440. Review.


Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobágyi T, Ironside JW, King A, Kofler J, Kövari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ.

J Neuropathol Exp Neurol. 2017 Jul 1;76(7):605-619. doi: 10.1093/jnen/nlx041.


Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.

Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC.

Lancet Oncol. 2017 Jul;18(7):958-971. doi: 10.1016/S1470-2045(17)30243-7. Epub 2017 May 22.


Age-associated changes in the blood-brain barrier: comparative studies in human and mouse.

Goodall EF, Wang C, Simpson JE, Baker DJ, Drew DR, Heath PR, Saffrey MJ, Romero IA, Wharton SB.

Neuropathol Appl Neurobiol. 2018 Apr;44(3):328-340. doi: 10.1111/nan.12408. Epub 2017 May 29. Erratum in: Neuropathol Appl Neurobiol. 2018 Dec;44(7):747-748.


Role of Neuraminidase in Influenza A(H7N9) Virus Receptor Binding.

Benton DJ, Wharton SA, Martin SR, McCauley JW.

J Virol. 2017 May 12;91(11). pii: e02293-16. doi: 10.1128/JVI.02293-16. Print 2017 Jun 1.


Intracerebral Masson's Tumor-Slow-Filling Vascular Lesion Demonstrated by Indocyanine Green Video Angiography.

Bagga V, Kailaya-Vasan A, Wharton SB, Patel U.

World Neurosurg. 2017 May;101:812.e15-812.e19. doi: 10.1016/j.wneu.2017.03.075. Epub 2017 Mar 25.


The associations of resting metabolic rate with chronic conditions and weight loss.

Christensen RA, Raiber L, Wharton S, Rotondi MA, Kuk JL.

Clin Obes. 2017 Apr;7(2):70-76. doi: 10.1111/cob.12178. Epub 2017 Feb 7.


The characteristics and antigenic properties of recently emerged subclade 3C.3a and 3C.2a human influenza A(H3N2) viruses passaged in MDCK cells.

Lin Y, Wharton SA, Whittaker L, Dai M, Ermetal B, Lo J, Pontoriero A, Baumeister E, Daniels RS, McCauley JW.

Influenza Other Respir Viruses. 2017 May;11(3):263-274. doi: 10.1111/irv.12447. Epub 2017 Feb 28.


'Low grade glioma': an update for radiologists.

Larsen J, Wharton SB, McKevitt F, Romanowski C, Bridgewater C, Zaki H, Hoggard N.

Br J Radiol. 2017 Feb;90(1070):20160600. doi: 10.1259/bjr.20160600. Epub 2016 Dec 7. Review.


Microinfarcts in an older population-representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease.

Ince PG, Minett T, Forster G, Brayne C, Wharton SB; Medical Research Council Cognitive Function and Ageing Neuropathology Study.

Neuropathol Appl Neurobiol. 2017 Aug;43(5):409-418. doi: 10.1111/nan.12363. Epub 2016 Oct 28.


Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role.

Waller R, Woodroofe MN, Wharton SB, Ince PG, Francese S, Heath PR, Cudzich-Madry A, Thomas RH, Rounding N, Sharrack B, Simpson JE.

J Neuroimmunol. 2016 Oct 15;299:139-146. doi: 10.1016/j.jneuroim.2016.09.010. Epub 2016 Sep 14.


Post-mortem assessment in vascular dementia: advances and aspirations.

McAleese KE, Alafuzoff I, Charidimou A, De Reuck J, Grinberg LT, Hainsworth AH, Hortobagyi T, Ince P, Jellinger K, Gao J, Kalaria RN, Kovacs GG, Kövari E, Love S, Popovic M, Skrobot O, Taipa R, Thal DR, Werring D, Wharton SB, Attems J.

BMC Med. 2016 Aug 26;14(1):129. doi: 10.1186/s12916-016-0676-5. Review.


Receptivity to Bariatric Surgery in Qualified Patients.

Fung M, Wharton S, Macpherson A, Kuk JL.

J Obes. 2016;2016:5372190. doi: 10.1155/2016/5372190. Epub 2016 Jul 19.


Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role.

Garwood CJ, Ratcliffe LE, Simpson JE, Heath PR, Ince PG, Wharton SB.

Neuropathol Appl Neurobiol. 2017 Jun;43(4):281-298. doi: 10.1111/nan.12338. Review.


Expression microdissection isolation of enriched cell populations from archival brain tissue.

Appleby-Mallinder C, Wyles MD, Simpson JE, Wharton SB, Ince PG, Heath PR.

J Neurosci Methods. 2016 Aug 1;268:125-30. doi: 10.1016/j.jneumeth.2016.05.007. Epub 2016 May 10.


A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field.

Cronin MJ, Wharton S, Al-Radaideh A, Constantinescu C, Evangelou N, Bowtell R, Gowland PA.

MAGMA. 2016 Jun;29(3):543-57. doi: 10.1007/s10334-016-0560-5. Epub 2016 Apr 25.


Differences in weight change trajectory patterns in a publicly funded adult weight management centre.

Kuk JL, Wharton S.

Obes Sci Pract. 2016 Mar 23;2(2):215-223. doi: 10.1002/osp4.35. eCollection 2016 Jun.


Effects of egg-adaptation on receptor-binding and antigenic properties of recent influenza A (H3N2) vaccine viruses.

Parker L, Wharton SA, Martin SR, Cross K, Lin Y, Liu Y, Feizi T, Daniels RS, McCauley JW.

J Gen Virol. 2016 Jun;97(6):1333-1344. doi: 10.1099/jgv.0.000457. Epub 2016 Mar 14.


Predictors of early attrition and successful weight loss in patients attending an obesity management program.

Jiandani D, Wharton S, Rotondi MA, Ardern CI, Kuk JL.

BMC Obes. 2016 Mar 9;3:14. doi: 10.1186/s40608-016-0098-0. eCollection 2016.


Interest, views and perceived barriers to bariatric surgery in patients with morbid obesity.

Wharton S, Serodio KJ, Kuk JL, Sivapalan N, Craik A, Aarts MA.

Clin Obes. 2016 Apr;6(2):154-60. doi: 10.1111/cob.12131. Epub 2016 Feb 22.


Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study.

Wharton SB, Minett T, Drew D, Forster G, Matthews F, Brayne C, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study Group.

Acta Neuropathol Commun. 2016 Feb 8;4:11. doi: 10.1186/s40478-016-0275-x.


Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, Murray ME, Nelson PT, Takahashi H, Trojanowski JQ, Ansorge O, Arzberger T, Baborie A, Beach TG, Bieniek KF, Bigio EH, Bodi I, Dugger BN, Feany M, Gelpi E, Gentleman SM, Giaccone G, Hatanpaa KJ, Heale R, Hof PR, Hofer M, Hortobágyi T, Jellinger K, Jicha GA, Ince P, Kofler J, Kövari E, Kril JJ, Mann DM, Matej R, McKee AC, McLean C, Milenkovic I, Montine TJ, Murayama S, Lee EB, Rahimi J, Rodriguez RD, Rozemüller A, Schneider JA, Schultz C, Seeley W, Seilhean D, Smith C, Tagliavini F, Takao M, Thal DR, Toledo JB, Tolnay M, Troncoso JC, Vinters HV, Weis S, Wharton SB, White CL 3rd, Wisniewski T, Woulfe JM, Yamada M, Dickson DW.

Acta Neuropathol. 2016 Jan;131(1):87-102. doi: 10.1007/s00401-015-1509-x. Epub 2015 Dec 10. Review.

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